Ligand: UKI (Surufatinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 66.7% 8JMZA
DFGout BBAminus 1 33.3% 8JOTA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR CSF1R CSF1R_HUMAN 8JOTA P07333 543 914 972.0 UKI:1001 Type1 Inactive DFGout 11.79 10.172 BBAminus -152.53, -164.7 -132.78, 111.2 -118.89, 28.73 306.09, 111.3 -53.84, -35.65 in-in in 7.947 Saltbr-in 2.677 HRD-in -85.99, -51.0 73.56, 2.04 in-out-in SNCioi out-in ActLoopNT-out 17.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.76, 114.95 APE9-dihe-in -118.98, 139.94 APE8-dihe-in -78.88, 70.02 APE8-rot-na 34.05 APE67-dihe-in -68.92, -12.46 -61.18, -37.88 APE12-dist-na 999.0 APE11-dist-na 16.081 APE10-dist-na 12.73 APE9-dist-in 7.639 C667T,C830S,C907T None None XRAY 1.69 0.18 0.207 A 354 306 26 0 0 1 [[582, 912]] 1.0 8jot TYR_CSF1R_HUMAN TYR 1.2e-104 356.1 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
TYR FGFR1 FGFR1_HUMAN 8JMZA P11362 460 765 822.0 UKI:60801 Type1 Inactive DFGin 5.159 13.289 BLAplus -113.58, 162.96 62.0, 28.58 -83.36, -13.84 56.58, 89.17 -102.65, 12.75 in-in in 7.859 Saltbr-in 2.835 HRD-in -72.3, -51.47 78.17, -4.24 in-out-out SNCioo out-out ActLoopNT-out 7.981 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.22, 148.56 APE9-dihe-in -107.32, 99.52 APE8-dihe-out -56.46, -18.86 APE8-rot-na 328.17 APE67-dihe-in -74.96, -9.03 -56.04, -27.86 APE12-dist-na 16.425 APE11-dist-na 18.997 APE10-dist-na 16.223 APE9-dist-out 11.021 C584S None None XRAY 1.988 0.166 0.205 A 310 306 0 0 0 0 [[478, 756]] 1.0 8jmz TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 8JMZB P11362 458 763 822.0 UKI:60801 Type1 Inactive DFGin 5.259 13.007 BLAplus -114.88, 158.62 61.68, 33.22 -84.25, -18.02 53.38, 88.43 -92.93, -0.34 in-in in 7.767 Saltbr-in 2.924 HRD-in -72.45, -50.78 74.31, -4.23 in-out-out SNCioo out-out ActLoopNT-out 8.354 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.73, 168.34 APE9-dihe-in -103.17, 113.28 APE8-dihe-out -51.14, -25.22 APE8-rot-na 328.21 APE67-dihe-in -74.28, -2.47 -57.8, -24.89 APE12-dist-na 20.439 APE11-dist-na 21.401 APE10-dist-na 20.065 APE9-dist-out 11.501 C584S None None XRAY 1.988 0.166 0.205 B 310 290 16 0 0 3 [[478, 756]] 1.0 8jmz TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

Ligand: UKI (Surufatinib)

Total number of chains: 3
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 2 66.7% 8JMZA
DFGout BBAminus 1 33.3% 8JOTA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR CSF1R CSF1R_HUMAN 8JOTA P07333 543 914 972.0 UKI:1001 Type1 Inactive DFGout 11.79 10.172 BBAminus -152.53, -164.7 -132.78, 111.2 -118.89, 28.73 306.09, 111.3 -53.84, -35.65 in-in in 7.947 Saltbr-in 2.677 HRD-in -85.99, -51.0 73.56, 2.04 in-out-in SNCioi out-in ActLoopNT-out 17.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.76, 114.95 APE9-dihe-in -118.98, 139.94 APE8-dihe-in -78.88, 70.02 APE8-rot-na 34.05 APE67-dihe-in -68.92, -12.46 -61.18, -37.88 APE12-dist-na 999.0 APE11-dist-na 16.081 APE10-dist-na 12.73 APE9-dist-in 7.639 C667T,C830S,C907T None None XRAY 1.69 0.18 0.207 A 354 306 26 0 0 1 [[582, 912]] 1.0 8jot Homo sapiens TYR_CSF1R_HUMAN TYR 1.2e-104 356.1 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
TYR FGFR1 FGFR1_HUMAN 8JMZA P11362 460 765 822.0 UKI:60801 Type1 Inactive DFGin 5.159 13.289 BLAplus -113.58, 162.96 62.0, 28.58 -83.36, -13.84 56.58, 89.17 -102.65, 12.75 in-in in 7.859 Saltbr-in 2.835 HRD-in -72.3, -51.47 78.17, -4.24 in-out-out SNCioo out-out ActLoopNT-out 7.981 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.22, 148.56 APE9-dihe-in -107.32, 99.52 APE8-dihe-out -56.46, -18.86 APE8-rot-na 328.17 APE67-dihe-in -74.96, -9.03 -56.04, -27.86 APE12-dist-na 16.425 APE11-dist-na 18.997 APE10-dist-na 16.223 APE9-dist-out 11.021 C584S None None XRAY 1.988 0.166 0.205 A 310 306 0 0 0 0 [[478, 756]] 1.0 8jmz Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 8JMZB P11362 458 763 822.0 UKI:60801 Type1 Inactive DFGin 5.259 13.007 BLAplus -114.88, 158.62 61.68, 33.22 -84.25, -18.02 53.38, 88.43 -92.93, -0.34 in-in in 7.767 Saltbr-in 2.924 HRD-in -72.45, -50.78 74.31, -4.23 in-out-out SNCioo out-out ActLoopNT-out 8.354 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.73, 168.34 APE9-dihe-in -103.17, 113.28 APE8-dihe-out -51.14, -25.22 APE8-rot-na 328.21 APE67-dihe-in -74.28, -2.47 -57.8, -24.89 APE12-dist-na 20.439 APE11-dist-na 21.401 APE10-dist-na 20.065 APE9-dist-out 11.501 C584S None None XRAY 1.988 0.166 0.205 B 310 290 16 0 0 3 [[478, 756]] 1.0 8jmz Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

Ligand: UKI (Surufatinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name