Ligand: STI (Imatinib)

Total number of chains: 26
Active chains: 1
Total number of genes: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 21 80.8% 8S16A
DFGin BLAminus 2 7.7% 7N9GB
DFGinter None 2 7.7% 7N9GA
DFGout None 1 3.8% 3HECA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC MAPK14 MK14_HUMAN 3HECA Q16539 5 352 360.0 STI:1 Type2 Inactive DFGout 15.7975 11.0354 None -130.2, -167.81 -152.58, 126.29 -77.67, 999.0 267.8, 49.04 999.0, 999.0 in-in in 8.8977 Saltbr-in 3.2136 HRD-in -65.98, -59.44 85.44, -17.29 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.24 APE8-dihe-out -59.5, -40.66 APE8-rot-in 292.4 APE67-dihe-in -54.55, -30.33 -64.97, -31.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9353 None None None XRAY 2.5 0.222 0.3 A 348.0 329.0 19 25 11 14 [[24, 308]] 1.0 3hec CMGC_MAPK14_HUMAN CMGC 5.2e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TYR ABL1 ABL1_HUMAN 7N9GB P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.7541 13.4449 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.8072 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.0408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.9514 APE11-dist-na 10.1213 APE10-dist-na 12.2789 APE9-dist-in 7.1369 None None None XRAY 2.2 0.219 0.251 B 271.0 264.0 2 29 29 0 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.4212 8.1868 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.8784 Saltbr-out 9.7861 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.5443 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.8503 None None None XRAY 2.2 0.219 0.251 A 271.0 250.0 16 29 16 13 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.7618 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.4392 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.4779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.8914 None None None XRAY 2.2 0.219 0.251 C 271.0 233.0 33 29 24 5 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYA P00519 235 498 1130.0 STI:600 Type2 Inactive DFGout 13.4478 10.9363 BBAminus -136.71, -169.54 -156.86, 107.67 -99.35, 1.46 307.94, 127.18 66.47, 52.08 in-in in 8.2395 Saltbr-in 3.0042 HRD-in -68.42, -63.13 91.16, -9.54 in-out-in SNCioi out-in ActLoopNT-out 16.0994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.4, 131.38 APE9-dihe-in -122.46, 141.0 APE8-dihe-in -82.09, 92.82 APE8-rot-na 22.51 APE67-dihe-in -74.51, -8.92 -44.66, -47.4 APE12-dist-na 14.4582 APE11-dist-na 11.9011 APE10-dist-na 8.4151 APE9-dist-in 7.3935 None None None XRAY 2.4 0.208 0.267 A 273.0 263.0 1 29 29 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYB P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6073 10.8376 BBAminus -140.46, -179.87 -145.37, 104.9 -88.0, -4.17 302.17, 134.32 68.19, 47.44 in-in in 8.468 Saltbr-in 2.9739 HRD-in -72.33, -53.74 81.02, -14.85 in-out-in SNCioi out-in ActLoopNT-out 15.7155 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.08, 127.85 APE9-dihe-in -116.06, 145.63 APE8-dihe-in -88.84, 91.14 APE8-rot-na 22.78 APE67-dihe-in -77.2, -5.94 -46.52, -42.21 APE12-dist-na 14.4786 APE11-dist-na 11.9487 APE10-dist-na 8.4213 APE9-dist-in 7.4165 None None None XRAY 2.4 0.208 0.267 B 273.0 265.0 1 29 29 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYC P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.817 11.1447 BBAminus -136.58, -170.43 -156.15, 102.72 -91.16, -2.19 306.71, 138.1 61.3, 49.16 in-in in 8.2912 Saltbr-in 3.4095 HRD-in -75.29, -48.77 83.65, -17.42 in-out-in SNCioi out-in ActLoopNT-out 15.6362 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.7, 128.89 APE9-dihe-in -132.69, 141.39 APE8-dihe-in -86.44, 89.34 APE8-rot-na 30.23 APE67-dihe-in -75.71, -10.45 -48.99, -40.28 APE12-dist-na 15.6276 APE11-dist-na 13.5323 APE10-dist-na 8.7762 APE9-dist-in 7.5146 None None None XRAY 2.4 0.208 0.267 C 273.0 262.0 4 29 26 3 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYD P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6269 11.0079 BBAminus -135.11, -170.82 -155.12, 109.43 -96.64, 9.5 309.68, 132.23 60.03, 43.1 in-in in 8.0089 Saltbr-in 2.7581 HRD-in -69.95, -55.57 86.15, -21.95 in-out-in SNCioi out-in ActLoopNT-out 15.3354 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 121.23 APE9-dihe-in -126.0, 140.68 APE8-dihe-in -79.93, 90.29 APE8-rot-na 35.26 APE67-dihe-in -80.44, -14.01 -57.15, -31.16 APE12-dist-na 15.6748 APE11-dist-na 13.4748 APE10-dist-na 8.574 APE9-dist-in 7.5548 None None None XRAY 2.4 0.208 0.267 D 273.0 264.0 2 29 29 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3PYYA P00519 232 500 1130.0 STI:60003,3YY:60538 Type2,Allosteric Inactive DFGout 13.6472 11.2623 BBAminus -130.42, -173.45 -148.82, 100.51 -87.29, -2.92 301.78, 132.98 62.26, 50.77 in-in in 8.1427 Saltbr-in 2.677 HRD-in -77.84, -60.13 91.69, -13.02 in-out-in SNCioi out-in ActLoopNT-out 15.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.57, 117.7 APE9-dihe-in -121.79, 141.76 APE8-dihe-in -85.05, 87.91 APE8-rot-na 30.64 APE67-dihe-in -73.12, -6.21 -47.76, -45.73 APE12-dist-na 16.5248 APE11-dist-na 12.81 APE10-dist-na 8.6957 APE9-dist-in 7.7291 None None None XRAY 1.85 0.189 0.204 A 298.0 265.0 4 29 29 0 [[242, 495]] 1.0 3pyy TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3PYYB P00519 233 510 1130.0 STI:60004,3YY:60532 Type2,Allosteric Inactive DFGout 13.9702 11.0172 BBAminus -132.59, -172.42 -152.94, 105.37 -94.38, -50.82 313.04, 135.61 93.2, 999.0 in-in in 8.1 Saltbr-in 2.5706 HRD-in -81.0, -57.03 86.3, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -127.99, 138.02 APE9-dihe-in -152.66, 146.9 APE8-dihe-in -80.16, 79.64 APE8-rot-na 29.64 APE67-dihe-in -75.32, -11.37 -49.83, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.258 None None None XRAY 1.85 0.189 0.204 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 3pyy TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPEA P00519 232 500 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.751 11.2768 BBAminus -132.09, -171.87 -150.82, 100.43 -86.72, -1.03 301.5, 131.9 61.32, 51.13 in-in in 8.1711 Saltbr-in 2.7788 HRD-in -75.05, -56.53 78.97, -9.5 in-out-in SNCioi out-in ActLoopNT-out 15.7357 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.77, 121.63 APE9-dihe-in -123.35, 140.69 APE8-dihe-in -84.02, 84.76 APE8-rot-na 23.95 APE67-dihe-in -76.42, -6.93 -49.4, -44.5 APE12-dist-na 16.5922 APE11-dist-na 12.7878 APE10-dist-na 8.7525 APE9-dist-in 7.8443 None None None XRAY 2.15 0.187 0.212 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npe TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPEB P00519 233 511 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.8401 11.1015 BBAminus -129.89, -169.38 -152.66, 105.04 -92.73, -27.9 303.95, 134.44 82.3, 999.0 in-in in 8.2217 Saltbr-in 2.6842 HRD-in -80.48, -54.98 79.49, -7.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.9 APE8-dihe-in -75.88, 86.79 APE8-rot-na 23.52 APE67-dihe-in -70.62, -18.32 -51.39, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6859 None None None XRAY 2.15 0.187 0.212 B 298.0 256.0 23 29 12 17 [[242, 495]] 1.0 6npe TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPUA P00519 232 500 1130.0 STI:60601,KWV:60602 Type2,Allosteric Inactive DFGout 13.7239 11.3407 BBAminus -131.32, -177.82 -147.63, 103.5 -91.61, -2.68 302.6, 133.1 64.49, 56.03 in-in in 8.1753 Saltbr-in 2.6429 HRD-in -76.28, -58.38 85.82, -8.07 in-out-in SNCioi out-in ActLoopNT-out 15.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 129.98 APE9-dihe-in -123.79, 139.52 APE8-dihe-in -78.9, 90.13 APE8-rot-na 28.21 APE67-dihe-in -75.75, -3.63 -52.56, -44.81 APE12-dist-na 16.3124 APE11-dist-na 12.5979 APE10-dist-na 8.715 APE9-dist-in 7.8012 None None None XRAY 2.33 0.196 0.234 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npu TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPUB P00519 233 510 1130.0 STI:60602,KWV:60605 Type2,Allosteric Inactive DFGout 13.7158 11.1215 BBAminus -136.03, -173.76 -148.73, 104.54 -94.68, -39.85 309.09, 136.14 93.88, 999.0 in-in in 8.0462 Saltbr-in 2.6551 HRD-in -88.42, -57.18 82.99, -10.02 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.51, 88.48 APE9-dihe-in -97.46, 155.87 APE8-dihe-in -87.38, 82.63 APE8-rot-na 29.77 APE67-dihe-in -64.85, -22.06 -45.68, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8546 None None None XRAY 2.33 0.196 0.234 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npu TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPVA P00519 232 500 1130.0 STI:60602,KWP:60603 Type2,Allosteric Inactive DFGout 13.575 11.2109 BBAminus -133.43, -176.32 -147.26, 102.27 -88.44, -2.86 301.02, 133.29 64.03, 50.03 in-in in 8.1581 Saltbr-in 2.9685 HRD-in -74.61, -59.03 88.55, -10.34 in-out-in SNCioi out-in ActLoopNT-out 15.7382 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.7, 120.65 APE9-dihe-in -115.73, 140.1 APE8-dihe-in -81.63, 87.3 APE8-rot-na 30.14 APE67-dihe-in -75.75, -5.01 -52.83, -44.97 APE12-dist-na 16.3027 APE11-dist-na 12.2839 APE10-dist-na 8.7127 APE9-dist-in 7.7824 None None None XRAY 1.86 0.183 0.207 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npv TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPVB P00519 233 510 1130.0 STI:60603,KWP:60607 Type2,Allosteric Inactive DFGout 13.5449 11.0623 BBAminus -135.7, -168.07 -155.88, 101.76 -93.13, -7.53 306.52, 136.97 78.01, 999.0 in-in in 8.2003 Saltbr-in 2.7509 HRD-in -76.84, -57.95 84.26, -8.39 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.75, 102.42 APE9-dihe-in -114.18, 151.63 APE8-dihe-in -86.78, 85.36 APE8-rot-na 20.0 APE67-dihe-in -75.22, -6.58 -51.86, -43.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9656 None None None XRAY 1.86 0.183 0.207 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npv TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL2 ABL2_HUMAN 3GVUA P42684 279 546 1182.0 STI:61001,STI:61002 Type2,Allosteric Inactive DFGout 14.2058 10.9847 BBAminus -129.16, -178.93 -150.61, 104.02 -86.08, -7.91 307.76, 136.33 64.98, 42.87 in-in in 8.1525 Saltbr-in 2.5576 HRD-in -78.06, -56.85 84.44, -8.66 in-out-none SNCion out-none ActLoopNT-out 16.2997 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 108.72 APE9-dihe-in -120.18, 140.1 APE8-dihe-in -84.77, 90.02 APE8-rot-na 31.34 APE67-dihe-in -70.3, -17.18 -52.1, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1959 APE9-dist-in 7.6056 None None None XRAY 2.05 0.191 0.226 A 292.0 261.0 7 29 22 7 [[288, 541]] 1.0 3gvu TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR CSF1R CSF1R_HUMAN 4R7IA P07333 567 914 972.0 STI:1001 Type2 Inactive DFGout 16.3338 10.4908 BBAminus -135.43, -165.69 -154.33, 113.23 -65.43, -32.31 273.23, 63.99 51.24, -116.49 in-in in 7.877 Saltbr-in 2.8524 HRD-in -76.35, -49.6 69.77, 4.78 in-out-in SNCioi out-in ActLoopNT-out 16.2403 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.49, 117.23 APE9-dihe-in -119.6, 145.64 APE8-dihe-in -75.5, 67.23 APE8-rot-na 28.71 APE67-dihe-in -66.69, -12.1 -54.21, -40.35 APE12-dist-na 17.1923 APE11-dist-na 13.4531 APE10-dist-na 12.1713 APE9-dist-in 7.5214 C667T,C830S,C907T None None XRAY 2.75 0.202 0.236 A 343.0 290.0 12 30 30 0 [[582, 912]] 1.0 4r7i TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1.0 260.0 260.0 795 796 797 799 801 616 633 637 775 777 776 778.0 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
TYR DDR1 DDR1_HUMAN 4BKJA Q08345 601 913 913.0 STI:61000 Type2 Inactive DFGout 13.0408 10.8687 BBAminus -135.57, -177.41 -150.26, 104.38 -97.26, -19.55 309.91, 132.36 76.19, -179.07 in-in in 8.0556 Saltbr-in 2.7811 HRD-in -73.25, -56.55 82.61, -12.77 in-out-in SNCioi out-in ActLoopNT-out 18.4277 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.84, 113.6 APE9-dihe-in -132.17, 138.55 APE8-dihe-in -81.73, 66.81 APE8-rot-na 30.65 APE67-dihe-in -70.94, -16.71 -56.41, -32.35 APE12-dist-na 999.0 APE11-dist-na 10.4301 APE10-dist-na 6.399 APE9-dist-in 7.2525 None None None XRAY 1.7 0.157 0.176 A 315.0 294.0 19 30 26 4 [[610, 907]] 1.0 4bkj TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 4BKJB Q08345 601 913 913.0 STI:61000 Type2 Inactive DFGout 12.9422 10.6959 BBAminus -134.88, -177.2 -150.26, 104.51 -98.15, -18.24 308.85, 133.85 76.2, -180.0 in-in in 8.078 Saltbr-in 2.7814 HRD-in -71.4, -58.01 82.61, -12.4 in-out-in SNCioi out-in ActLoopNT-out 18.4302 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.57, 113.98 APE9-dihe-in -133.47, 139.44 APE8-dihe-in -81.51, 65.72 APE8-rot-na 30.98 APE67-dihe-in -69.17, -18.25 -55.39, -33.59 APE12-dist-na 999.0 APE11-dist-na 10.7543 APE10-dist-na 6.4124 APE9-dist-in 7.2132 None None None XRAY 1.7 0.157 0.176 B 315.0 296.0 17 30 26 4 [[610, 907]] 1.0 4bkj TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR KIT KIT_HUMAN 8S16A P10721 566 932 976.0 STI:61001 Type2 Inactive DFGout 16.1561 10.6327 BBAminus -135.66, -175.47 -146.5, 109.21 -66.07, -39.1 278.01, 69.44 60.83, -124.1 in-in in 7.9119 Saltbr-in 2.9645 HRD-in -69.14, -53.88 78.27, -9.6 in-out-in SNCioi out-in ActLoopNT-out 16.0214 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.16, 109.76 APE9-dihe-in -124.4, 150.42 APE8-dihe-in -79.68, 69.89 APE8-rot-na 33.56 APE67-dihe-in -69.51, -13.06 -61.98, -37.06 APE12-dist-na 16.4365 APE11-dist-na 13.1795 APE10-dist-na 11.1209 APE9-dist-in 7.7908 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 A 327.0 289.0 0 30 30 0 [[589, 926]] 1.0 8s16 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S16B P10721 578 931 976.0 STI:61001 Type2 Inactive DFGout 15.8879 10.5227 BBAminus -137.35, -173.79 -154.74, 102.74 -60.21, -39.63 280.81, 66.69 55.03, -114.07 in-in in 7.8423 Saltbr-in 2.8528 HRD-in -70.27, -58.28 86.53, -13.22 in-out-in SNCioi out-in ActLoopNT-out 16.1216 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.71, 104.25 APE9-dihe-in -123.97, 149.57 APE8-dihe-in -79.76, 65.91 APE8-rot-na 34.81 APE67-dihe-in -69.88, -14.71 -57.96, -38.02 APE12-dist-na 17.0837 APE11-dist-na 13.8991 APE10-dist-na 11.4361 APE9-dist-in 7.9103 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 B 327.0 276.0 0 30 30 0 [[589, 926]] 1.0 8s16 TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 1T46A P10721 565 933 976.0 STI:3 Type2 Inactive DFGout 15.6984 10.1536 BBAminus -131.86, -173.06 -155.36, 102.8 -61.56, -32.02 275.6, 68.14 52.41, -121.03 in-in in 7.7769 Saltbr-in 2.635 HRD-in -73.88, -54.0 82.13, -17.12 in-out-in SNCioi out-in ActLoopNT-out 15.9953 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.78, 112.21 APE9-dihe-in -122.06, 148.23 APE8-dihe-in -76.99, 63.4 APE8-rot-na 27.97 APE67-dihe-in -65.29, -14.58 -53.78, -42.45 APE12-dist-na 17.3581 APE11-dist-na 13.8599 APE10-dist-na 12.0624 APE9-dist-in 7.8809 None None None XRAY 1.6 0.19 0.213 A 313.0 297.0 14 30 30 0 [[589, 926]] 1.0 1t46 TYR_KIT_HUMAN TYR 3.7e-102 347.0 1.0 260.0 260.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 2PL0A P06239 231 498 509.0 STI:200 Type2 Inactive DFGout 13.4391 10.9797 BBAminus -123.86, 162.41 -130.4, 102.99 -85.25, -1.39 299.47, 139.85 60.55, 49.25 in-in in 8.1088 Saltbr-in 2.891 HRD-in -103.3, -55.77 88.99, -24.94 in-out-in SNCioi out-in ActLoopNT-out 14.6912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.65, 127.24 APE9-dihe-in -162.32, 149.69 APE8-dihe-in -67.62, 110.43 APE8-rot-na 341.58 APE67-dihe-in -77.58, -4.79 -53.82, -46.7 APE12-dist-na 16.3279 APE11-dist-na 13.4942 APE10-dist-na 8.8097 APE9-dist-in 5.8879 None None None XRAY 2.8 0.215 0.261 A 289.0 268.0 0 29 29 0 [[245, 496]] 1.0 2pl0 TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR PDGFRA PGFRA_HUMAN 6JOLA P16234 583 957 1089.0 STI:1001 Type2 Inactive DFGout 16.377 10.1801 BBAminus -142.0, 174.77 -141.65, 105.94 -59.47, -37.67 274.19, 66.43 59.87, -122.37 in-in in 7.9131 Saltbr-in 2.7813 HRD-in -68.97, -54.53 78.87, -11.97 in-out-in SNCioi out-in ActLoopNT-out 15.9266 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.21, 134.53 APE9-dihe-in -124.89, 147.83 APE8-dihe-in -86.42, 79.14 APE8-rot-na 35.14 APE67-dihe-in -66.62, -11.35 -62.29, -37.28 APE12-dist-na 16.0066 APE11-dist-na 12.1566 APE10-dist-na 11.9857 APE9-dist-in 7.6302 None None None XRAY 1.9 0.215 0.236 A 356.0 279.0 24 30 30 0 [[593, 952]] 1.0 6jol TYR_PDGFRA_HUMAN TYR 9.2e-107 362.5 1.0 260.0 260.0 835 836 837 839 841 627 644 648 815 817 816 818.0 877 865 860 859 858 857 856 855 854 675 Platelet-derived growth factor receptor alpha
TYR SYK KSYK_HUMAN 1XBBA P43405 363 635 635.0 STI:60001 Type1 None DFGin 6.6637 14.623 BLAminus -128.05, 176.75 68.38, 79.08 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.2357 Saltbr-in 3.0323 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.8779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1255 APE9-dist-in 7.1998 None None None XRAY 1.57 0.191 0.221 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 1xbb TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: STI (Imatinib)

Total number of chains: 45
Active chains: 1
Total number of genes: 10
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 40 88.9% 1OPJA
DFGin BLAminus 2 4.4% 7N9GB
DFGinter None 2 4.4% 7N9GA
DFGout None 1 2.2% 3HECA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3OEZA P00523 257 533 533.0 STI:601 Type2 Inactive DFGout 14.0341 10.6614 BBAminus -136.96, 173.53 -139.3, 104.55 -85.53, 7.35 306.4, 134.51 56.26, 26.93 in-in in 8.2891 Saltbr-in 2.7272 HRD-in -93.59, -56.64 88.79, -19.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.11 APE8-dihe-in -78.8, 65.19 APE8-rot-na 28.94 APE67-dihe-in -63.83, -22.59 -45.23, -43.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5714 L317I None None XRAY 2.4 0.196 0.24 A 286.0 261.0 16 29 13 16 [[267, 518]] 1.0 3oez Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3OEZB P00523 256 533 533.0 STI:601 Type2 Inactive DFGout 13.9931 10.2851 BBAminus -131.62, 176.09 -143.36, 103.12 -83.83, 10.03 307.32, 147.35 62.78, 999.0 in-out in 9.1652 Saltbr-out 4.9123 HRD-in -87.69, -56.67 89.86, -25.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 157.24 APE8-dihe-out -75.65, 48.95 APE8-rot-na 353.29 APE67-dihe-in -71.09, -28.09 -52.22, -31.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2351 L317I None None XRAY 2.4 0.196 0.24 B 286.0 261.0 17 29 12 17 [[267, 518]] 1.0 3oez Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2OIQA P00523 256 533 533.0 STI:1001 Type2 Inactive DFGout 14.2433 11.019 BBAminus -139.93, -179.15 -152.95, 92.82 -76.29, 12.5 313.47, 139.45 51.63, 22.18 in-in in 8.3791 Saltbr-in 2.8955 HRD-in -90.91, -60.46 88.42, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -52.71, 128.16 APE9-dihe-in -125.2, 112.33 APE8-dihe-in -76.46, 64.34 APE8-rot-na 34.26 APE67-dihe-in -63.77, -22.13 -45.85, -40.51 APE12-dist-na 14.1876 APE11-dist-na 9.9046 APE10-dist-na 7.2219 APE9-dist-out 8.0385 None None None XRAY 2.07 0.232 0.263 A 286.0 265.0 13 29 16 13 [[267, 518]] 1.0 2oiq Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CMGC MAPK14 MK14_HUMAN 3HECA Q16539 5 352 360.0 STI:1 Type2 Inactive DFGout 15.7975 11.0354 None -130.2, -167.81 -152.58, 126.29 -77.67, 999.0 267.8, 49.04 999.0, 999.0 in-in in 8.8977 Saltbr-in 3.2136 HRD-in -65.98, -59.44 85.44, -17.29 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 131.24 APE8-dihe-out -59.5, -40.66 APE8-rot-in 292.4 APE67-dihe-in -54.55, -30.33 -64.97, -31.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.9353 None None None XRAY 2.5 0.222 0.3 A 348.0 329.0 19 25 11 14 [[24, 308]] 1.0 3hec Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.2e-85 291.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TYR ABL1 ABL1_HUMAN 7N9GB P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.7541 13.4449 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.8072 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.0408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.9514 APE11-dist-na 10.1213 APE10-dist-na 12.2789 APE9-dist-in 7.1369 None None None XRAY 2.2 0.219 0.251 B 271.0 264.0 2 29 29 0 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.4212 8.1868 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.8784 Saltbr-out 9.7861 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.5443 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.8503 None None None XRAY 2.2 0.219 0.251 A 271.0 250.0 16 29 16 13 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.7618 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.4392 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.4779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.8914 None None None XRAY 2.2 0.219 0.251 C 271.0 233.0 33 29 24 5 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYA P00519 235 498 1130.0 STI:600 Type2 Inactive DFGout 13.4478 10.9363 BBAminus -136.71, -169.54 -156.86, 107.67 -99.35, 1.46 307.94, 127.18 66.47, 52.08 in-in in 8.2395 Saltbr-in 3.0042 HRD-in -68.42, -63.13 91.16, -9.54 in-out-in SNCioi out-in ActLoopNT-out 16.0994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.4, 131.38 APE9-dihe-in -122.46, 141.0 APE8-dihe-in -82.09, 92.82 APE8-rot-na 22.51 APE67-dihe-in -74.51, -8.92 -44.66, -47.4 APE12-dist-na 14.4582 APE11-dist-na 11.9011 APE10-dist-na 8.4151 APE9-dist-in 7.3935 None None None XRAY 2.4 0.208 0.267 A 273.0 263.0 1 29 29 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYB P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6073 10.8376 BBAminus -140.46, -179.87 -145.37, 104.9 -88.0, -4.17 302.17, 134.32 68.19, 47.44 in-in in 8.468 Saltbr-in 2.9739 HRD-in -72.33, -53.74 81.02, -14.85 in-out-in SNCioi out-in ActLoopNT-out 15.7155 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.08, 127.85 APE9-dihe-in -116.06, 145.63 APE8-dihe-in -88.84, 91.14 APE8-rot-na 22.78 APE67-dihe-in -77.2, -5.94 -46.52, -42.21 APE12-dist-na 14.4786 APE11-dist-na 11.9487 APE10-dist-na 8.4213 APE9-dist-in 7.4165 None None None XRAY 2.4 0.208 0.267 B 273.0 265.0 1 29 29 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYC P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.817 11.1447 BBAminus -136.58, -170.43 -156.15, 102.72 -91.16, -2.19 306.71, 138.1 61.3, 49.16 in-in in 8.2912 Saltbr-in 3.4095 HRD-in -75.29, -48.77 83.65, -17.42 in-out-in SNCioi out-in ActLoopNT-out 15.6362 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.7, 128.89 APE9-dihe-in -132.69, 141.39 APE8-dihe-in -86.44, 89.34 APE8-rot-na 30.23 APE67-dihe-in -75.71, -10.45 -48.99, -40.28 APE12-dist-na 15.6276 APE11-dist-na 13.5323 APE10-dist-na 8.7762 APE9-dist-in 7.5146 None None None XRAY 2.4 0.208 0.267 C 273.0 262.0 4 29 26 3 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HYYD P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6269 11.0079 BBAminus -135.11, -170.82 -155.12, 109.43 -96.64, 9.5 309.68, 132.23 60.03, 43.1 in-in in 8.0089 Saltbr-in 2.7581 HRD-in -69.95, -55.57 86.15, -21.95 in-out-in SNCioi out-in ActLoopNT-out 15.3354 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 121.23 APE9-dihe-in -126.0, 140.68 APE8-dihe-in -79.93, 90.29 APE8-rot-na 35.26 APE67-dihe-in -80.44, -14.01 -57.15, -31.16 APE12-dist-na 15.6748 APE11-dist-na 13.4748 APE10-dist-na 8.574 APE9-dist-in 7.5548 None None None XRAY 2.4 0.208 0.267 D 273.0 264.0 2 29 29 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3PYYA P00519 232 500 1130.0 STI:60003,3YY:60538 Type2,Allosteric Inactive DFGout 13.6472 11.2623 BBAminus -130.42, -173.45 -148.82, 100.51 -87.29, -2.92 301.78, 132.98 62.26, 50.77 in-in in 8.1427 Saltbr-in 2.677 HRD-in -77.84, -60.13 91.69, -13.02 in-out-in SNCioi out-in ActLoopNT-out 15.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.57, 117.7 APE9-dihe-in -121.79, 141.76 APE8-dihe-in -85.05, 87.91 APE8-rot-na 30.64 APE67-dihe-in -73.12, -6.21 -47.76, -45.73 APE12-dist-na 16.5248 APE11-dist-na 12.81 APE10-dist-na 8.6957 APE9-dist-in 7.7291 None None None XRAY 1.85 0.189 0.204 A 298.0 265.0 4 29 29 0 [[242, 495]] 1.0 3pyy Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3PYYB P00519 233 510 1130.0 STI:60004,3YY:60532 Type2,Allosteric Inactive DFGout 13.9702 11.0172 BBAminus -132.59, -172.42 -152.94, 105.37 -94.38, -50.82 313.04, 135.61 93.2, 999.0 in-in in 8.1 Saltbr-in 2.5706 HRD-in -81.0, -57.03 86.3, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -127.99, 138.02 APE9-dihe-in -152.66, 146.9 APE8-dihe-in -80.16, 79.64 APE8-rot-na 29.64 APE67-dihe-in -75.32, -11.37 -49.83, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.258 None None None XRAY 1.85 0.189 0.204 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 3pyy Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPEA P00519 232 500 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.751 11.2768 BBAminus -132.09, -171.87 -150.82, 100.43 -86.72, -1.03 301.5, 131.9 61.32, 51.13 in-in in 8.1711 Saltbr-in 2.7788 HRD-in -75.05, -56.53 78.97, -9.5 in-out-in SNCioi out-in ActLoopNT-out 15.7357 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.77, 121.63 APE9-dihe-in -123.35, 140.69 APE8-dihe-in -84.02, 84.76 APE8-rot-na 23.95 APE67-dihe-in -76.42, -6.93 -49.4, -44.5 APE12-dist-na 16.5922 APE11-dist-na 12.7878 APE10-dist-na 8.7525 APE9-dist-in 7.8443 None None None XRAY 2.15 0.187 0.212 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npe Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPEB P00519 233 511 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.8401 11.1015 BBAminus -129.89, -169.38 -152.66, 105.04 -92.73, -27.9 303.95, 134.44 82.3, 999.0 in-in in 8.2217 Saltbr-in 2.6842 HRD-in -80.48, -54.98 79.49, -7.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.9 APE8-dihe-in -75.88, 86.79 APE8-rot-na 23.52 APE67-dihe-in -70.62, -18.32 -51.39, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6859 None None None XRAY 2.15 0.187 0.212 B 298.0 256.0 23 29 12 17 [[242, 495]] 1.0 6npe Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPUA P00519 232 500 1130.0 STI:60601,KWV:60602 Type2,Allosteric Inactive DFGout 13.7239 11.3407 BBAminus -131.32, -177.82 -147.63, 103.5 -91.61, -2.68 302.6, 133.1 64.49, 56.03 in-in in 8.1753 Saltbr-in 2.6429 HRD-in -76.28, -58.38 85.82, -8.07 in-out-in SNCioi out-in ActLoopNT-out 15.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 129.98 APE9-dihe-in -123.79, 139.52 APE8-dihe-in -78.9, 90.13 APE8-rot-na 28.21 APE67-dihe-in -75.75, -3.63 -52.56, -44.81 APE12-dist-na 16.3124 APE11-dist-na 12.5979 APE10-dist-na 8.715 APE9-dist-in 7.8012 None None None XRAY 2.33 0.196 0.234 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npu Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPUB P00519 233 510 1130.0 STI:60602,KWV:60605 Type2,Allosteric Inactive DFGout 13.7158 11.1215 BBAminus -136.03, -173.76 -148.73, 104.54 -94.68, -39.85 309.09, 136.14 93.88, 999.0 in-in in 8.0462 Saltbr-in 2.6551 HRD-in -88.42, -57.18 82.99, -10.02 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.51, 88.48 APE9-dihe-in -97.46, 155.87 APE8-dihe-in -87.38, 82.63 APE8-rot-na 29.77 APE67-dihe-in -64.85, -22.06 -45.68, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8546 None None None XRAY 2.33 0.196 0.234 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npu Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPVA P00519 232 500 1130.0 STI:60602,KWP:60603 Type2,Allosteric Inactive DFGout 13.575 11.2109 BBAminus -133.43, -176.32 -147.26, 102.27 -88.44, -2.86 301.02, 133.29 64.03, 50.03 in-in in 8.1581 Saltbr-in 2.9685 HRD-in -74.61, -59.03 88.55, -10.34 in-out-in SNCioi out-in ActLoopNT-out 15.7382 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.7, 120.65 APE9-dihe-in -115.73, 140.1 APE8-dihe-in -81.63, 87.3 APE8-rot-na 30.14 APE67-dihe-in -75.75, -5.01 -52.83, -44.97 APE12-dist-na 16.3027 APE11-dist-na 12.2839 APE10-dist-na 8.7127 APE9-dist-in 7.7824 None None None XRAY 1.86 0.183 0.207 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npv Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6NPVB P00519 233 510 1130.0 STI:60603,KWP:60607 Type2,Allosteric Inactive DFGout 13.5449 11.0623 BBAminus -135.7, -168.07 -155.88, 101.76 -93.13, -7.53 306.52, 136.97 78.01, 999.0 in-in in 8.2003 Saltbr-in 2.7509 HRD-in -76.84, -57.95 84.26, -8.39 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.75, 102.42 APE9-dihe-in -114.18, 151.63 APE8-dihe-in -86.78, 85.36 APE8-rot-na 20.0 APE67-dihe-in -75.22, -6.58 -51.86, -43.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9656 None None None XRAY 1.86 0.183 0.207 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npv Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL2 ABL2_HUMAN 3GVUA P42684 279 546 1182.0 STI:61001,STI:61002 Type2,Allosteric Inactive DFGout 14.2058 10.9847 BBAminus -129.16, -178.93 -150.61, 104.02 -86.08, -7.91 307.76, 136.33 64.98, 42.87 in-in in 8.1525 Saltbr-in 2.5576 HRD-in -78.06, -56.85 84.44, -8.66 in-out-none SNCion out-none ActLoopNT-out 16.2997 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 108.72 APE9-dihe-in -120.18, 140.1 APE8-dihe-in -84.77, 90.02 APE8-rot-na 31.34 APE67-dihe-in -70.3, -17.18 -52.1, -40.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1959 APE9-dist-in 7.6056 None None None XRAY 2.05 0.191 0.226 A 292.0 261.0 7 29 22 7 [[288, 541]] 1.0 3gvu Homo sapiens TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1.0 260.0 260.0 426 427 428 430 432 317 332 336 406 408 407 409.0 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR CSF1R CSF1R_HUMAN 4R7IA P07333 567 914 972.0 STI:1001 Type2 Inactive DFGout 16.3338 10.4908 BBAminus -135.43, -165.69 -154.33, 113.23 -65.43, -32.31 273.23, 63.99 51.24, -116.49 in-in in 7.877 Saltbr-in 2.8524 HRD-in -76.35, -49.6 69.77, 4.78 in-out-in SNCioi out-in ActLoopNT-out 16.2403 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.49, 117.23 APE9-dihe-in -119.6, 145.64 APE8-dihe-in -75.5, 67.23 APE8-rot-na 28.71 APE67-dihe-in -66.69, -12.1 -54.21, -40.35 APE12-dist-na 17.1923 APE11-dist-na 13.4531 APE10-dist-na 12.1713 APE9-dist-in 7.5214 C667T,C830S,C907T None None XRAY 2.75 0.202 0.236 A 343.0 290.0 12 30 30 0 [[582, 912]] 1.0 4r7i Homo sapiens TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1.0 260.0 260.0 795 796 797 799 801 616 633 637 775 777 776 778.0 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
TYR DDR1 DDR1_HUMAN 4BKJA Q08345 601 913 913.0 STI:61000 Type2 Inactive DFGout 13.0408 10.8687 BBAminus -135.57, -177.41 -150.26, 104.38 -97.26, -19.55 309.91, 132.36 76.19, -179.07 in-in in 8.0556 Saltbr-in 2.7811 HRD-in -73.25, -56.55 82.61, -12.77 in-out-in SNCioi out-in ActLoopNT-out 18.4277 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.84, 113.6 APE9-dihe-in -132.17, 138.55 APE8-dihe-in -81.73, 66.81 APE8-rot-na 30.65 APE67-dihe-in -70.94, -16.71 -56.41, -32.35 APE12-dist-na 999.0 APE11-dist-na 10.4301 APE10-dist-na 6.399 APE9-dist-in 7.2525 None None None XRAY 1.7 0.157 0.176 A 315.0 294.0 19 30 26 4 [[610, 907]] 1.0 4bkj Homo sapiens TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 4BKJB Q08345 601 913 913.0 STI:61000 Type2 Inactive DFGout 12.9422 10.6959 BBAminus -134.88, -177.2 -150.26, 104.51 -98.15, -18.24 308.85, 133.85 76.2, -180.0 in-in in 8.078 Saltbr-in 2.7814 HRD-in -71.4, -58.01 82.61, -12.4 in-out-in SNCioi out-in ActLoopNT-out 18.4302 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.57, 113.98 APE9-dihe-in -133.47, 139.44 APE8-dihe-in -81.51, 65.72 APE8-rot-na 30.98 APE67-dihe-in -69.17, -18.25 -55.39, -33.59 APE12-dist-na 999.0 APE11-dist-na 10.7543 APE10-dist-na 6.4124 APE9-dist-in 7.2132 None None None XRAY 1.7 0.157 0.176 B 315.0 296.0 17 30 26 4 [[610, 907]] 1.0 4bkj Homo sapiens TYR_DDR1_HUMAN TYR 1.5e-92 315.5 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR KIT KIT_HUMAN 8S16A P10721 566 932 976.0 STI:61001 Type2 Inactive DFGout 16.1561 10.6327 BBAminus -135.66, -175.47 -146.5, 109.21 -66.07, -39.1 278.01, 69.44 60.83, -124.1 in-in in 7.9119 Saltbr-in 2.9645 HRD-in -69.14, -53.88 78.27, -9.6 in-out-in SNCioi out-in ActLoopNT-out 16.0214 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.16, 109.76 APE9-dihe-in -124.4, 150.42 APE8-dihe-in -79.68, 69.89 APE8-rot-na 33.56 APE67-dihe-in -69.51, -13.06 -61.98, -37.06 APE12-dist-na 16.4365 APE11-dist-na 13.1795 APE10-dist-na 11.1209 APE9-dist-in 7.7908 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 A 327.0 289.0 0 30 30 0 [[589, 926]] 1.0 8s16 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S16B P10721 578 931 976.0 STI:61001 Type2 Inactive DFGout 15.8879 10.5227 BBAminus -137.35, -173.79 -154.74, 102.74 -60.21, -39.63 280.81, 66.69 55.03, -114.07 in-in in 7.8423 Saltbr-in 2.8528 HRD-in -70.27, -58.28 86.53, -13.22 in-out-in SNCioi out-in ActLoopNT-out 16.1216 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.71, 104.25 APE9-dihe-in -123.97, 149.57 APE8-dihe-in -79.76, 65.91 APE8-rot-na 34.81 APE67-dihe-in -69.88, -14.71 -57.96, -38.02 APE12-dist-na 17.0837 APE11-dist-na 13.8991 APE10-dist-na 11.4361 APE9-dist-in 7.9103 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.85 0.177 0.207 B 327.0 276.0 0 30 30 0 [[589, 926]] 1.0 8s16 Homo sapiens TYR_KIT_HUMAN TYR 2.3e-104 354.3 1.0 261.0 261.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 1T46A P10721 565 933 976.0 STI:3 Type2 Inactive DFGout 15.6984 10.1536 BBAminus -131.86, -173.06 -155.36, 102.8 -61.56, -32.02 275.6, 68.14 52.41, -121.03 in-in in 7.7769 Saltbr-in 2.635 HRD-in -73.88, -54.0 82.13, -17.12 in-out-in SNCioi out-in ActLoopNT-out 15.9953 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.78, 112.21 APE9-dihe-in -122.06, 148.23 APE8-dihe-in -76.99, 63.4 APE8-rot-na 27.97 APE67-dihe-in -65.29, -14.58 -53.78, -42.45 APE12-dist-na 17.3581 APE11-dist-na 13.8599 APE10-dist-na 12.0624 APE9-dist-in 7.8809 None None None XRAY 1.6 0.19 0.213 A 313.0 297.0 14 30 30 0 [[589, 926]] 1.0 1t46 Homo sapiens TYR_KIT_HUMAN TYR 3.7e-102 347.0 1.0 260.0 260.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 2PL0A P06239 231 498 509.0 STI:200 Type2 Inactive DFGout 13.4391 10.9797 BBAminus -123.86, 162.41 -130.4, 102.99 -85.25, -1.39 299.47, 139.85 60.55, 49.25 in-in in 8.1088 Saltbr-in 2.891 HRD-in -103.3, -55.77 88.99, -24.94 in-out-in SNCioi out-in ActLoopNT-out 14.6912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.65, 127.24 APE9-dihe-in -162.32, 149.69 APE8-dihe-in -67.62, 110.43 APE8-rot-na 341.58 APE67-dihe-in -77.58, -4.79 -53.82, -46.7 APE12-dist-na 16.3279 APE11-dist-na 13.4942 APE10-dist-na 8.8097 APE9-dist-in 5.8879 None None None XRAY 2.8 0.215 0.261 A 289.0 268.0 0 29 29 0 [[245, 496]] 1.0 2pl0 Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR PDGFRA PGFRA_HUMAN 6JOLA P16234 583 957 1089.0 STI:1001 Type2 Inactive DFGout 16.377 10.1801 BBAminus -142.0, 174.77 -141.65, 105.94 -59.47, -37.67 274.19, 66.43 59.87, -122.37 in-in in 7.9131 Saltbr-in 2.7813 HRD-in -68.97, -54.53 78.87, -11.97 in-out-in SNCioi out-in ActLoopNT-out 15.9266 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.21, 134.53 APE9-dihe-in -124.89, 147.83 APE8-dihe-in -86.42, 79.14 APE8-rot-na 35.14 APE67-dihe-in -66.62, -11.35 -62.29, -37.28 APE12-dist-na 16.0066 APE11-dist-na 12.1566 APE10-dist-na 11.9857 APE9-dist-in 7.6302 None None None XRAY 1.9 0.215 0.236 A 356.0 279.0 24 30 30 0 [[593, 952]] 1.0 6jol Homo sapiens TYR_PDGFRA_HUMAN TYR 9.2e-107 362.5 1.0 260.0 260.0 835 836 837 839 841 627 644 648 815 817 816 818.0 877 865 860 859 858 857 856 855 854 675 Platelet-derived growth factor receptor alpha
TYR SYK KSYK_HUMAN 1XBBA P43405 363 635 635.0 STI:60001 Type1 None DFGin 6.6637 14.623 BLAminus -128.05, 176.75 68.38, 79.08 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.2357 Saltbr-in 3.0323 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.8779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1255 APE9-dist-in 7.1998 None None None XRAY 1.57 0.191 0.221 A 291.0 264.0 9 31 27 4 [[370, 628]] 1.0 1xbb Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ABL1 ABL1_MOUSE 3K5VA P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.8272 11.0249 BBAminus -129.03, -178.81 -148.62, 103.08 -90.49, -4.28 302.25, 133.06 63.11, 53.01 in-in in 8.2222 Saltbr-in 2.8352 HRD-in -81.75, -55.21 87.7, -18.23 in-out-in SNCioi out-in ActLoopNT-out 16.3689 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.52, 121.82 APE9-dihe-in -113.18, 143.79 APE8-dihe-in -83.6, 88.45 APE8-rot-na 28.73 APE67-dihe-in -74.9, -7.51 -50.51, -43.0 APE12-dist-na 15.7887 APE11-dist-na 11.6924 APE10-dist-na 8.4451 APE9-dist-in 7.7803 None None None XRAY 1.74 0.201 0.231 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3K5VB P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.7649 11.0764 BBAminus -130.59, 178.94 -144.92, 105.3 -91.47, 1.18 305.46, 130.21 51.7, 50.11 in-in in 8.2219 Saltbr-in 2.8668 HRD-in -85.29, -53.14 86.12, -16.51 in-out-in SNCioi out-in ActLoopNT-out 16.4024 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.28, 125.5 APE9-dihe-in -111.48, 141.99 APE8-dihe-in -82.96, 81.2 APE8-rot-na 29.67 APE67-dihe-in -69.06, -10.18 -42.49, -48.14 APE12-dist-na 15.5836 APE11-dist-na 11.5044 APE10-dist-na 8.5983 APE9-dist-in 7.7555 None None None XRAY 1.74 0.201 0.231 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD4A P00520 229 510 1123.0 FYW:60603,STI:60604 Allosteric,Type2 Inactive DFGout 13.7764 10.9351 BBAminus -130.79, -174.69 -153.04, 100.11 -89.33, 0.88 308.19, 134.35 53.16, 51.61 in-in in 8.1144 Saltbr-in 2.8706 HRD-in -79.72, -53.57 88.06, -19.16 in-out-in SNCioi out-in ActLoopNT-out 16.4097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.86, 116.72 APE9-dihe-in -109.35, 142.84 APE8-dihe-in -86.21, 87.25 APE8-rot-na 23.52 APE67-dihe-in -69.15, -11.0 -46.61, -47.58 APE12-dist-na 15.7751 APE11-dist-na 11.7898 APE10-dist-na 8.3351 APE9-dist-in 7.8592 None None None XRAY 2.03 0.183 0.223 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD4B P00520 229 510 1123.0 FYW:60601,STI:60602 Allosteric,Type2 Inactive DFGout 13.8473 11.0365 BBAminus -132.33, -177.63 -150.45, 101.55 -90.95, -0.99 307.99, 135.01 52.91, 55.37 in-in in 8.1545 Saltbr-in 2.9282 HRD-in -79.19, -55.7 86.14, -16.91 in-out-in SNCioi out-in ActLoopNT-out 16.5243 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.49, 127.44 APE9-dihe-in -117.65, 140.28 APE8-dihe-in -83.09, 79.07 APE8-rot-na 27.61 APE67-dihe-in -65.5, -15.42 -38.27, -50.77 APE12-dist-na 15.5651 APE11-dist-na 11.2452 APE10-dist-na 8.3706 APE9-dist-in 7.8777 None None None XRAY 2.03 0.183 0.223 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD6A P00520 229 510 1123.0 FYH:60602,STI:60603 Allosteric,Type2 Inactive DFGout 13.7876 10.8987 BBAminus -118.54, -176.91 -146.68, 104.9 -90.05, -6.03 304.11, 138.72 66.96, 55.15 in-in in 8.2952 Saltbr-in 2.8153 HRD-in -88.34, -54.67 91.97, -25.73 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.42, 121.54 APE9-dihe-in -110.97, 144.39 APE8-dihe-in -82.04, 86.81 APE8-rot-na 32.54 APE67-dihe-in -76.73, -9.19 -49.14, -40.38 APE12-dist-na 15.6429 APE11-dist-na 11.6814 APE10-dist-na 8.157 APE9-dist-in 7.7625 None None None XRAY 2.3 0.178 0.238 A 293.0 280.0 2 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1IEPA P00520 229 498 1123.0 STI:60201 Type2 Inactive DFGout 13.5616 10.8609 BBAminus -137.03, -172.54 -153.96, 97.64 -87.18, 3.68 308.79, 136.8 52.65, 57.65 in-in in 8.3113 Saltbr-in 3.1021 HRD-in -76.11, -58.44 87.76, -16.49 in-out-in SNCioi out-in ActLoopNT-out 16.3209 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.61, 141.98 APE9-dihe-in -135.62, 143.41 APE8-dihe-in -82.32, 86.58 APE8-rot-na 35.1 APE67-dihe-in -73.95, -4.51 -43.85, -43.13 APE12-dist-na 14.642 APE11-dist-na 11.7988 APE10-dist-na 8.4893 APE9-dist-in 7.3405 None None None XRAY 2.1 0.231 0.262 A 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1IEPB P00520 229 498 1123.0 STI:60202 Type2 Inactive DFGout 13.5287 10.801 BBAminus -143.94, -178.65 -148.11, 93.74 -82.6, -2.47 307.48, 137.57 62.07, 48.88 in-out in 8.1853 Saltbr-out 4.3676 HRD-in -84.56, -56.22 87.89, -19.72 out-out-in SNCooi out-in ActLoopNT-out 14.9721 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.54, 140.59 APE9-dihe-in -139.53, 149.49 APE8-dihe-in -85.03, 86.81 APE8-rot-na 36.13 APE67-dihe-in -68.22, -7.81 -42.13, -46.9 APE12-dist-na 15.6933 APE11-dist-na 11.543 APE10-dist-na 8.6711 APE9-dist-in 7.1993 None None None XRAY 2.1 0.231 0.262 B 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1OPJA P00520 229 510 1123.0 STI:60003 Type2 Inactive DFGout 13.7798 10.8261 BBAminus -128.07, -174.54 -152.92, 98.6 -89.13, 6.29 307.36, 137.21 49.4, 56.53 in-in in 8.2618 Saltbr-in 2.6832 HRD-in -85.47, -54.47 85.47, -15.74 in-out-out SNCioo out-out ActLoopNT-out 16.1376 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -110.59, 111.76 APE9-dihe-in -105.57, 139.7 APE8-dihe-in -87.32, 84.08 APE8-rot-na 31.83 APE67-dihe-in -67.58, -10.57 -46.59, -43.84 APE12-dist-na 15.8128 APE11-dist-na 11.6321 APE10-dist-na 8.4599 APE9-dist-out 8.0909 None None None XRAY 1.75 0.21 0.242 A 293.0 282.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1OPJB P00520 229 512 1123.0 STI:60004 Type2 Inactive DFGout 13.9109 11.3214 BBAminus -132.18, -179.0 -150.37, 98.45 -86.36, 2.32 310.86, 130.49 52.69, 56.75 in-in in 8.0553 Saltbr-in 2.8815 HRD-in -79.51, -55.82 87.48, -17.62 in-out-in SNCioi out-in ActLoopNT-out 16.1636 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.86, 121.43 APE9-dihe-in -116.41, 142.51 APE8-dihe-in -88.15, 80.96 APE8-rot-na 32.33 APE67-dihe-in -69.25, -7.13 -40.7, -49.19 APE12-dist-na 15.7903 APE11-dist-na 11.8331 APE10-dist-na 8.395 APE9-dist-in 7.8063 None None None XRAY 1.75 0.21 0.242 B 293.0 284.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD6B P00520 229 510 1123.0 STI:60601 Type2 Inactive DFGout 13.8292 11.1791 BBAminus -125.12, -175.5 -154.19, 103.09 -91.96, 21.1 310.97, 128.7 31.22, 64.2 in-in in 8.3943 Saltbr-in 3.0721 HRD-in -85.22, -51.46 85.37, -17.4 in-out-in SNCioi out-in ActLoopNT-out 16.3685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.94, 122.32 APE9-dihe-in -101.91, 149.19 APE8-dihe-in -81.38, 82.15 APE8-rot-na 19.67 APE67-dihe-in -78.93, -7.66 -49.97, -39.1 APE12-dist-na 15.412 APE11-dist-na 11.1785 APE10-dist-na 8.7641 APE9-dist-in 7.7824 None None None XRAY 2.3 0.178 0.238 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MS9A P00520 230 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6604 10.9917 BBAminus -129.69, -177.84 -146.05, 100.92 -85.37, -0.41 305.07, 135.33 63.76, 47.34 in-in in 8.3409 Saltbr-in 3.1533 HRD-in -79.52, -52.27 83.07, -15.37 in-out-in SNCioi out-in ActLoopNT-out 16.086 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.38, 129.78 APE9-dihe-in -118.07, 145.91 APE8-dihe-in -88.08, 91.81 APE8-rot-na 29.01 APE67-dihe-in -75.19, -6.62 -50.02, -40.18 APE12-dist-na 14.3629 APE11-dist-na 12.2197 APE10-dist-na 8.6387 APE9-dist-in 7.5316 None None None XRAY 1.8 0.188 0.234 A 293.0 261.0 8 29 27 2 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MS9B P00520 229 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6482 10.9444 BBAminus -132.64, -179.46 -143.9, 102.88 -90.37, 5.1 303.67, 135.83 60.73, 51.4 in-in in 8.2919 Saltbr-in 2.7815 HRD-in -83.7, -52.15 86.58, -11.15 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.02, 135.09 APE9-dihe-in -128.33, 142.16 APE8-dihe-in -86.14, 87.78 APE8-rot-na 36.31 APE67-dihe-in -76.28, -2.93 -48.89, -43.33 APE12-dist-na 15.5909 APE11-dist-na 13.452 APE10-dist-na 8.8559 APE9-dist-in 7.6276 None None None XRAY 1.8 0.188 0.234 B 293.0 267.0 3 29 29 0 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSA P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.6024 10.9266 BBAminus -140.22, -178.36 -147.69, 104.27 -89.71, -2.47 299.0, 139.73 66.29, 43.35 in-in in 8.3889 Saltbr-in 3.0948 HRD-in -74.19, -56.0 83.94, -13.58 in-out-in SNCioi out-in ActLoopNT-out 16.2188 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.21, 134.82 APE9-dihe-in -123.76, 144.56 APE8-dihe-in -89.25, 91.24 APE8-rot-na 26.73 APE67-dihe-in -76.81, -6.98 -52.23, -37.7 APE12-dist-na 14.4457 APE11-dist-na 11.9742 APE10-dist-na 8.5807 APE9-dist-in 7.4405 None None None XRAY 1.95 0.172 0.22 A 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSB P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5999 10.8202 BBAminus -134.26, 179.26 -142.74, 100.94 -88.95, 3.79 301.55, 135.44 59.27, 50.16 in-in in 8.1878 Saltbr-in 2.7291 HRD-in -84.32, -52.44 85.34, -18.42 in-out-in SNCioi out-in ActLoopNT-out 15.3256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.6, 137.91 APE9-dihe-in -132.77, 140.13 APE8-dihe-in -80.01, 89.25 APE8-rot-na 23.44 APE67-dihe-in -77.65, -10.14 -50.83, -40.78 APE12-dist-na 15.5761 APE11-dist-na 13.4863 APE10-dist-na 8.8 APE9-dist-in 7.4545 None None None XRAY 1.95 0.172 0.22 B 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSC P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5909 10.9626 BBAminus -138.8, 179.7 -144.18, 103.21 -86.54, 1.5 302.89, 134.71 58.1, 46.5 in-in in 8.0875 Saltbr-in 3.0475 HRD-in -78.89, -57.09 86.43, -17.08 in-out-in SNCioi out-in ActLoopNT-out 16.1082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.32, 131.91 APE9-dihe-in -126.48, 145.59 APE8-dihe-in -89.99, 90.94 APE8-rot-na 26.3 APE67-dihe-in -77.37, -6.31 -51.14, -38.56 APE12-dist-na 14.5938 APE11-dist-na 11.8497 APE10-dist-na 8.4632 APE9-dist-in 7.442 None None None XRAY 1.95 0.172 0.22 C 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSD P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5469 10.7877 BBAminus -134.13, -175.99 -148.24, 101.28 -89.17, 5.19 302.32, 137.83 56.24, 49.56 in-in in 8.1921 Saltbr-in 2.7895 HRD-in -83.98, -55.12 89.03, -15.39 in-out-in SNCioi out-in ActLoopNT-out 15.5394 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.05, 133.37 APE9-dihe-in -131.92, 141.87 APE8-dihe-in -80.66, 89.72 APE8-rot-na 31.84 APE67-dihe-in -74.69, -8.69 -52.73, -42.14 APE12-dist-na 15.622 APE11-dist-na 13.6062 APE10-dist-na 8.7829 APE9-dist-in 7.554 None None None XRAY 1.95 0.172 0.22 D 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

Ligand: STI (Imatinib)

Total number of chains: 19
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 19 100.0% 1OPJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3OEZA P00523 257 533 533.0 STI:601 Type2 Inactive DFGout 14.0341 10.6614 BBAminus -136.96, 173.53 -139.3, 104.55 -85.53, 7.35 306.4, 134.51 56.26, 26.93 in-in in 8.2891 Saltbr-in 2.7272 HRD-in -93.59, -56.64 88.79, -19.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.11 APE8-dihe-in -78.8, 65.19 APE8-rot-na 28.94 APE67-dihe-in -63.83, -22.59 -45.23, -43.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.5714 L317I None None XRAY 2.4 0.196 0.24 A 286.0 261.0 16 29 13 16 [[267, 518]] 1.0 3oez Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3OEZB P00523 256 533 533.0 STI:601 Type2 Inactive DFGout 13.9931 10.2851 BBAminus -131.62, 176.09 -143.36, 103.12 -83.83, 10.03 307.32, 147.35 62.78, 999.0 in-out in 9.1652 Saltbr-out 4.9123 HRD-in -87.69, -56.67 89.86, -25.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 157.24 APE8-dihe-out -75.65, 48.95 APE8-rot-na 353.29 APE67-dihe-in -71.09, -28.09 -52.22, -31.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.2351 L317I None None XRAY 2.4 0.196 0.24 B 286.0 261.0 17 29 12 17 [[267, 518]] 1.0 3oez Gallus gallus TYR_SRC_CHICK TYR 7e-94 319.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 2OIQA P00523 256 533 533.0 STI:1001 Type2 Inactive DFGout 14.2433 11.019 BBAminus -139.93, -179.15 -152.95, 92.82 -76.29, 12.5 313.47, 139.45 51.63, 22.18 in-in in 8.3791 Saltbr-in 2.8955 HRD-in -90.91, -60.46 88.42, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -52.71, 128.16 APE9-dihe-in -125.2, 112.33 APE8-dihe-in -76.46, 64.34 APE8-rot-na 34.26 APE67-dihe-in -63.77, -22.13 -45.85, -40.51 APE12-dist-na 14.1876 APE11-dist-na 9.9046 APE10-dist-na 7.2219 APE9-dist-out 8.0385 None None None XRAY 2.07 0.232 0.263 A 286.0 265.0 13 29 16 13 [[267, 518]] 1.0 2oiq Gallus gallus TYR_SRC_CHICK TYR 3.4e-94 320.9 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR ABL1 ABL1_MOUSE 3K5VA P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.8272 11.0249 BBAminus -129.03, -178.81 -148.62, 103.08 -90.49, -4.28 302.25, 133.06 63.11, 53.01 in-in in 8.2222 Saltbr-in 2.8352 HRD-in -81.75, -55.21 87.7, -18.23 in-out-in SNCioi out-in ActLoopNT-out 16.3689 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.52, 121.82 APE9-dihe-in -113.18, 143.79 APE8-dihe-in -83.6, 88.45 APE8-rot-na 28.73 APE67-dihe-in -74.9, -7.51 -50.51, -43.0 APE12-dist-na 15.7887 APE11-dist-na 11.6924 APE10-dist-na 8.4451 APE9-dist-in 7.7803 None None None XRAY 1.74 0.201 0.231 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3K5VB P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.7649 11.0764 BBAminus -130.59, 178.94 -144.92, 105.3 -91.47, 1.18 305.46, 130.21 51.7, 50.11 in-in in 8.2219 Saltbr-in 2.8668 HRD-in -85.29, -53.14 86.12, -16.51 in-out-in SNCioi out-in ActLoopNT-out 16.4024 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.28, 125.5 APE9-dihe-in -111.48, 141.99 APE8-dihe-in -82.96, 81.2 APE8-rot-na 29.67 APE67-dihe-in -69.06, -10.18 -42.49, -48.14 APE12-dist-na 15.5836 APE11-dist-na 11.5044 APE10-dist-na 8.5983 APE9-dist-in 7.7555 None None None XRAY 1.74 0.201 0.231 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD4A P00520 229 510 1123.0 FYW:60603,STI:60604 Allosteric,Type2 Inactive DFGout 13.7764 10.9351 BBAminus -130.79, -174.69 -153.04, 100.11 -89.33, 0.88 308.19, 134.35 53.16, 51.61 in-in in 8.1144 Saltbr-in 2.8706 HRD-in -79.72, -53.57 88.06, -19.16 in-out-in SNCioi out-in ActLoopNT-out 16.4097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.86, 116.72 APE9-dihe-in -109.35, 142.84 APE8-dihe-in -86.21, 87.25 APE8-rot-na 23.52 APE67-dihe-in -69.15, -11.0 -46.61, -47.58 APE12-dist-na 15.7751 APE11-dist-na 11.7898 APE10-dist-na 8.3351 APE9-dist-in 7.8592 None None None XRAY 2.03 0.183 0.223 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD4B P00520 229 510 1123.0 FYW:60601,STI:60602 Allosteric,Type2 Inactive DFGout 13.8473 11.0365 BBAminus -132.33, -177.63 -150.45, 101.55 -90.95, -0.99 307.99, 135.01 52.91, 55.37 in-in in 8.1545 Saltbr-in 2.9282 HRD-in -79.19, -55.7 86.14, -16.91 in-out-in SNCioi out-in ActLoopNT-out 16.5243 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.49, 127.44 APE9-dihe-in -117.65, 140.28 APE8-dihe-in -83.09, 79.07 APE8-rot-na 27.61 APE67-dihe-in -65.5, -15.42 -38.27, -50.77 APE12-dist-na 15.5651 APE11-dist-na 11.2452 APE10-dist-na 8.3706 APE9-dist-in 7.8777 None None None XRAY 2.03 0.183 0.223 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD6A P00520 229 510 1123.0 FYH:60602,STI:60603 Allosteric,Type2 Inactive DFGout 13.7876 10.8987 BBAminus -118.54, -176.91 -146.68, 104.9 -90.05, -6.03 304.11, 138.72 66.96, 55.15 in-in in 8.2952 Saltbr-in 2.8153 HRD-in -88.34, -54.67 91.97, -25.73 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.42, 121.54 APE9-dihe-in -110.97, 144.39 APE8-dihe-in -82.04, 86.81 APE8-rot-na 32.54 APE67-dihe-in -76.73, -9.19 -49.14, -40.38 APE12-dist-na 15.6429 APE11-dist-na 11.6814 APE10-dist-na 8.157 APE9-dist-in 7.7625 None None None XRAY 2.3 0.178 0.238 A 293.0 280.0 2 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1IEPA P00520 229 498 1123.0 STI:60201 Type2 Inactive DFGout 13.5616 10.8609 BBAminus -137.03, -172.54 -153.96, 97.64 -87.18, 3.68 308.79, 136.8 52.65, 57.65 in-in in 8.3113 Saltbr-in 3.1021 HRD-in -76.11, -58.44 87.76, -16.49 in-out-in SNCioi out-in ActLoopNT-out 16.3209 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.61, 141.98 APE9-dihe-in -135.62, 143.41 APE8-dihe-in -82.32, 86.58 APE8-rot-na 35.1 APE67-dihe-in -73.95, -4.51 -43.85, -43.13 APE12-dist-na 14.642 APE11-dist-na 11.7988 APE10-dist-na 8.4893 APE9-dist-in 7.3405 None None None XRAY 2.1 0.231 0.262 A 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1IEPB P00520 229 498 1123.0 STI:60202 Type2 Inactive DFGout 13.5287 10.801 BBAminus -143.94, -178.65 -148.11, 93.74 -82.6, -2.47 307.48, 137.57 62.07, 48.88 in-out in 8.1853 Saltbr-out 4.3676 HRD-in -84.56, -56.22 87.89, -19.72 out-out-in SNCooi out-in ActLoopNT-out 14.9721 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.54, 140.59 APE9-dihe-in -139.53, 149.49 APE8-dihe-in -85.03, 86.81 APE8-rot-na 36.13 APE67-dihe-in -68.22, -7.81 -42.13, -46.9 APE12-dist-na 15.6933 APE11-dist-na 11.543 APE10-dist-na 8.6711 APE9-dist-in 7.1993 None None None XRAY 2.1 0.231 0.262 B 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1OPJA P00520 229 510 1123.0 STI:60003 Type2 Inactive DFGout 13.7798 10.8261 BBAminus -128.07, -174.54 -152.92, 98.6 -89.13, 6.29 307.36, 137.21 49.4, 56.53 in-in in 8.2618 Saltbr-in 2.6832 HRD-in -85.47, -54.47 85.47, -15.74 in-out-out SNCioo out-out ActLoopNT-out 16.1376 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -110.59, 111.76 APE9-dihe-in -105.57, 139.7 APE8-dihe-in -87.32, 84.08 APE8-rot-na 31.83 APE67-dihe-in -67.58, -10.57 -46.59, -43.84 APE12-dist-na 15.8128 APE11-dist-na 11.6321 APE10-dist-na 8.4599 APE9-dist-out 8.0909 None None None XRAY 1.75 0.21 0.242 A 293.0 282.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 1OPJB P00520 229 512 1123.0 STI:60004 Type2 Inactive DFGout 13.9109 11.3214 BBAminus -132.18, -179.0 -150.37, 98.45 -86.36, 2.32 310.86, 130.49 52.69, 56.75 in-in in 8.0553 Saltbr-in 2.8815 HRD-in -79.51, -55.82 87.48, -17.62 in-out-in SNCioi out-in ActLoopNT-out 16.1636 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.86, 121.43 APE9-dihe-in -116.41, 142.51 APE8-dihe-in -88.15, 80.96 APE8-rot-na 32.33 APE67-dihe-in -69.25, -7.13 -40.7, -49.19 APE12-dist-na 15.7903 APE11-dist-na 11.8331 APE10-dist-na 8.395 APE9-dist-in 7.8063 None None None XRAY 1.75 0.21 0.242 B 293.0 284.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 6HD6B P00520 229 510 1123.0 STI:60601 Type2 Inactive DFGout 13.8292 11.1791 BBAminus -125.12, -175.5 -154.19, 103.09 -91.96, 21.1 310.97, 128.7 31.22, 64.2 in-in in 8.3943 Saltbr-in 3.0721 HRD-in -85.22, -51.46 85.37, -17.4 in-out-in SNCioi out-in ActLoopNT-out 16.3685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.94, 122.32 APE9-dihe-in -101.91, 149.19 APE8-dihe-in -81.38, 82.15 APE8-rot-na 19.67 APE67-dihe-in -78.93, -7.66 -49.97, -39.1 APE12-dist-na 15.412 APE11-dist-na 11.1785 APE10-dist-na 8.7641 APE9-dist-in 7.7824 None None None XRAY 2.3 0.178 0.238 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MS9A P00520 230 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6604 10.9917 BBAminus -129.69, -177.84 -146.05, 100.92 -85.37, -0.41 305.07, 135.33 63.76, 47.34 in-in in 8.3409 Saltbr-in 3.1533 HRD-in -79.52, -52.27 83.07, -15.37 in-out-in SNCioi out-in ActLoopNT-out 16.086 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.38, 129.78 APE9-dihe-in -118.07, 145.91 APE8-dihe-in -88.08, 91.81 APE8-rot-na 29.01 APE67-dihe-in -75.19, -6.62 -50.02, -40.18 APE12-dist-na 14.3629 APE11-dist-na 12.2197 APE10-dist-na 8.6387 APE9-dist-in 7.5316 None None None XRAY 1.8 0.188 0.234 A 293.0 261.0 8 29 27 2 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MS9B P00520 229 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6482 10.9444 BBAminus -132.64, -179.46 -143.9, 102.88 -90.37, 5.1 303.67, 135.83 60.73, 51.4 in-in in 8.2919 Saltbr-in 2.7815 HRD-in -83.7, -52.15 86.58, -11.15 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.02, 135.09 APE9-dihe-in -128.33, 142.16 APE8-dihe-in -86.14, 87.78 APE8-rot-na 36.31 APE67-dihe-in -76.28, -2.93 -48.89, -43.33 APE12-dist-na 15.5909 APE11-dist-na 13.452 APE10-dist-na 8.8559 APE9-dist-in 7.6276 None None None XRAY 1.8 0.188 0.234 B 293.0 267.0 3 29 29 0 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSA P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.6024 10.9266 BBAminus -140.22, -178.36 -147.69, 104.27 -89.71, -2.47 299.0, 139.73 66.29, 43.35 in-in in 8.3889 Saltbr-in 3.0948 HRD-in -74.19, -56.0 83.94, -13.58 in-out-in SNCioi out-in ActLoopNT-out 16.2188 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.21, 134.82 APE9-dihe-in -123.76, 144.56 APE8-dihe-in -89.25, 91.24 APE8-rot-na 26.73 APE67-dihe-in -76.81, -6.98 -52.23, -37.7 APE12-dist-na 14.4457 APE11-dist-na 11.9742 APE10-dist-na 8.5807 APE9-dist-in 7.4405 None None None XRAY 1.95 0.172 0.22 A 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSB P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5999 10.8202 BBAminus -134.26, 179.26 -142.74, 100.94 -88.95, 3.79 301.55, 135.44 59.27, 50.16 in-in in 8.1878 Saltbr-in 2.7291 HRD-in -84.32, -52.44 85.34, -18.42 in-out-in SNCioi out-in ActLoopNT-out 15.3256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.6, 137.91 APE9-dihe-in -132.77, 140.13 APE8-dihe-in -80.01, 89.25 APE8-rot-na 23.44 APE67-dihe-in -77.65, -10.14 -50.83, -40.78 APE12-dist-na 15.5761 APE11-dist-na 13.4863 APE10-dist-na 8.8 APE9-dist-in 7.4545 None None None XRAY 1.95 0.172 0.22 B 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSC P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5909 10.9626 BBAminus -138.8, 179.7 -144.18, 103.21 -86.54, 1.5 302.89, 134.71 58.1, 46.5 in-in in 8.0875 Saltbr-in 3.0475 HRD-in -78.89, -57.09 86.43, -17.08 in-out-in SNCioi out-in ActLoopNT-out 16.1082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.32, 131.91 APE9-dihe-in -126.48, 145.59 APE8-dihe-in -89.99, 90.94 APE8-rot-na 26.3 APE67-dihe-in -77.37, -6.31 -51.14, -38.56 APE12-dist-na 14.5938 APE11-dist-na 11.8497 APE10-dist-na 8.4632 APE9-dist-in 7.442 None None None XRAY 1.95 0.172 0.22 C 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3MSSD P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5469 10.7877 BBAminus -134.13, -175.99 -148.24, 101.28 -89.17, 5.19 302.32, 137.83 56.24, 49.56 in-in in 8.1921 Saltbr-in 2.7895 HRD-in -83.98, -55.12 89.03, -15.39 in-out-in SNCioi out-in ActLoopNT-out 15.5394 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.05, 133.37 APE9-dihe-in -131.92, 141.87 APE8-dihe-in -80.66, 89.72 APE8-rot-na 31.84 APE67-dihe-in -74.69, -8.69 -52.73, -42.14 APE12-dist-na 15.622 APE11-dist-na 13.6062 APE10-dist-na 8.7829 APE9-dist-in 7.554 None None None XRAY 1.95 0.172 0.22 D 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1