KinCore

Ligand: R28

Total number of chains: 9

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLAminus	5	7T4IA
DFGin	BLBtrans	4	7A6KA

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
TYR	EGFR	EGFR_HUMAN	7T4IA	2.61	Active	DFGin‑BLAminus	in-in	in-in	R28	Type1	697 - 1017	0	None	None	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	8F1XA	2.3	Active	DFGin‑BLAminus	in-in	in-in	R28	Type1	696 - 1018	0	None	None	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7B85A	2.5	None	DFGin‑BLAminus	in-in	in-none	R28	Type1	697 - 1020	2	None	None	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7T4JA	2.2	Inactive	DFGin‑BLAminus	in-in	in-out	R28	Type1	701 - 984	0	None	V948R	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7T4JB	2.2	Active	DFGin‑BLAminus	in-in	in-in	R28	Type1	701 - 984	0	None	V948R	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7A6KA	2.0	Inactive	DFGin‑BLBtrans	out-out	out-out	R28	Type1	700 - 984	14	None	T790M,V948R	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7A6KB	2.0	Inactive	DFGin‑BLBtrans	out-none	none-out	R28	Type1	700 - 982	17	None	T790M,V948R	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7A6KC	2.0	Inactive	DFGin‑BLBtrans	out-none	none-out	R28	Type1	700 - 984	17	None	T790M,V948R	Epidermal growth factor receptor
TYR	EGFR	EGFR_HUMAN	7A6KD	2.0	Inactive	DFGin‑BLBtrans	out-out	none-out	R28	Type1	702 - 984	18	None	T790M,V948R	Epidermal growth factor receptor

Ligand: R28

Total number of chains: 9

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLAminus	5	7T4IA
DFGin	BLBtrans	4	7A6KA

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
TYR	EGFR	EGFR_HUMAN	7T4IA	2.61	Active	DFGin‑BLAminus	in-in	in-in	R28	Type1	697 - 1017	0	None	None	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	8F1XA	2.3	Active	DFGin‑BLAminus	in-in	in-in	R28	Type1	696 - 1018	0	None	None	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7B85A	2.5	None	DFGin‑BLAminus	in-in	in-none	R28	Type1	697 - 1020	2	None	None	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7T4JA	2.2	Inactive	DFGin‑BLAminus	in-in	in-out	R28	Type1	701 - 984	0	None	V948R	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7T4JB	2.2	Active	DFGin‑BLAminus	in-in	in-in	R28	Type1	701 - 984	0	None	V948R	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7A6KA	2.0	Inactive	DFGin‑BLBtrans	out-out	out-out	R28	Type1	700 - 984	14	None	T790M,V948R	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7A6KB	2.0	Inactive	DFGin‑BLBtrans	out-none	none-out	R28	Type1	700 - 982	17	None	T790M,V948R	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7A6KC	2.0	Inactive	DFGin‑BLBtrans	out-none	none-out	R28	Type1	700 - 984	17	None	T790M,V948R	Epidermal growth factor receptor	Homo sapiens
TYR	EGFR	EGFR_HUMAN	7A6KD	2.0	Inactive	DFGin‑BLBtrans	out-out	none-out	R28	Type1	702 - 984	18	None	T790M,V948R	Epidermal growth factor receptor	Homo sapiens

Ligand: R28

Total number of chains: 0

Spatial label	Dihedral label	Number of Chains	Representative

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism