Ligand: R28 (Mobocertinib, Exkivity)

Total number of chains: 9
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 55.6% 7T4IA
DFGin BLBtrans 4 44.4% 7A6KA
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page

Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 7T4IA 2.61 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R28 Type1 697 - 1017 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8F1XA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R28 Type1 696 - 1018 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7B85A 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai R28 Type1 697 - 1020 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7T4JA 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai R28 Type1 701 - 984 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7T4JB 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R28 Type1 701 - 984 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6KA 2.0 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao R28 Type1 700 - 984 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6KB 2.0 Inactive DFGin‑BLBtrans out-none none-out TYR APEdihe_niiai APEdist_aaao R28 Type1 700 - 982 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6KC 2.0 Inactive DFGin‑BLBtrans out-none none-out TYR APEdihe_niiai APEdist_aaao R28 Type1 700 - 984 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7A6KD 2.0 Inactive DFGin‑BLBtrans out-out none-out TYR APEdihe_nniai APEdist_aaao R28 Type1 702 - 984 0 None T790M,V948R Epidermal growth factor receptor

Ligand: R28 (Mobocertinib, Exkivity)

Total number of chains: 9
Active chains: 3
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 55.6% 7T4IA
DFGin BLBtrans 4 44.4% 7A6KA
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page

Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 7T4IA 2.61 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R28 Type1 697 - 1017 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8F1XA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R28 Type1 696 - 1018 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7B85A 2.5 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai R28 Type1 697 - 1020 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7T4JA 2.2 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai R28 Type1 701 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7T4JB 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R28 Type1 701 - 984 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7A6KA 2.0 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao R28 Type1 700 - 984 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7A6KB 2.0 Inactive DFGin‑BLBtrans out-none none-out TYR APEdihe_niiai APEdist_aaao R28 Type1 700 - 982 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7A6KC 2.0 Inactive DFGin‑BLBtrans out-none none-out TYR APEdihe_niiai APEdist_aaao R28 Type1 700 - 984 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7A6KD 2.0 Inactive DFGin‑BLBtrans out-out none-out TYR APEdihe_nniai APEdist_aaao R28 Type1 702 - 984 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens

Ligand: R28 (Mobocertinib, Exkivity)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page

Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism