Ligand: PP2

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 1QPEA
DFGinter BABtrans 1 50.0% 3SXSA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BMX BMX_HUMAN 3SXSA P51813 411 671 675.0 PP2:60001 Type1 Inactive DFGinter 8.876 7.889 BABtrans -95.61, 121.24 -113.83, -1.35 -56.54, 124.12 176.46, 76.51 70.61, 15.34 out-out out 10.716 Saltbr-out 10.788 HRD-out -98.32, 130.38 -82.0, -12.25 out-in-in SNCoii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.4, 107.31 APE9-dihe-in -93.49, 162.66 APE8-dihe-in -48.34, 121.12 APE8-rot-na 328.7 APE67-dihe-in -67.4, -11.35 -59.38, -25.39 APE12-dist-na 10.326 APE11-dist-na 7.505 APE10-dist-na 12.208 APE9-dist-in 5.385 Q432K,Q611M,D617T,Q620E None None XRAY 1.89 0.18 0.209 A 268 261 0 0 0 0 [[417, 668]] 1.0 3sxs TYR_BMX_HUMAN TYR 3.1e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR LCK LCK_HUMAN 1QPEA P06239 231 501 509.0 PP2:1904 Type1 Active DFGin 6.391 14.313 BLAminus -142.96, -179.55 55.35, 67.52 -84.73, 15.63 297.65, 101.73 -55.95, -34.43 in-in in 8.023 Saltbr-in 2.692 HRD-in -108.83, -49.35 72.69, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.37, 142.25 APE9-dihe-in -130.54, 154.89 APE8-dihe-in -61.74, 112.03 APE8-rot-na 337.13 APE67-dihe-in -65.74, -24.28 -52.69, -45.66 APE12-dist-na 14.926 APE11-dist-na 10.306 APE10-dist-na 13.019 APE9-dist-in 6.87 None PTR394 PTR394 XRAY 2.0 0.189 0.254 A 279 271 0 0 0 0 [[245, 496]] 1.0 1qpe TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck

Ligand: PP2

Total number of chains: 7
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 85.7% 1QPEA
DFGinter BABtrans 1 14.3% 3SXSA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3GEQA P00523 251 533 533.0 PP2:60001 Type1 None DFGin 6.498 13.318 BLAminus -136.98, 178.41 65.65, 71.66 -99.5, 24.9 312.03, 74.44 -53.59, -39.51 in-in in 7.878 Saltbr-in 3.27 HRD-in -84.4, -45.83 74.36, -12.61 in-in-none SNCiin in-none ActLoopNT-in 3.122 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 9.88 APE8-rot-na 37.33 APE67-dihe-in -72.37, -14.89 -59.72, -29.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 R388A None None XRAY 2.2 0.226 0.273 A 286 269 14 0 0 14 [[267, 518]] 1.0 3geq Gallus gallus TYR_SRC_CHICK TYR 4.2e-95 323.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3GEQB P00523 251 533 533.0 PP2:60002 Type1 None DFGin 6.81 14.098 BLAminus -136.46, -175.26 62.68, 65.52 -94.23, 33.02 296.16, 73.87 -61.98, -42.96 in-in in 7.762 Saltbr-in 3.085 HRD-in -86.14, -48.11 74.48, -14.66 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 99.99 APE8-rot-na 34.86 APE67-dihe-in -57.61, -32.22 -55.2, -29.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 R388A None None XRAY 2.2 0.226 0.273 B 286 270 13 0 0 13 [[267, 518]] 1.0 3geq Gallus gallus TYR_SRC_CHICK TYR 4.2e-95 323.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR BMX BMX_HUMAN 3SXSA P51813 411 671 675.0 PP2:60001 Type1 Inactive DFGinter 8.876 7.889 BABtrans -95.61, 121.24 -113.83, -1.35 -56.54, 124.12 176.46, 76.51 70.61, 15.34 out-out out 10.716 Saltbr-out 10.788 HRD-out -98.32, 130.38 -82.0, -12.25 out-in-in SNCoii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -91.4, 107.31 APE9-dihe-in -93.49, 162.66 APE8-dihe-in -48.34, 121.12 APE8-rot-na 328.7 APE67-dihe-in -67.4, -11.35 -59.38, -25.39 APE12-dist-na 10.326 APE11-dist-na 7.505 APE10-dist-na 12.208 APE9-dist-in 5.385 Q432K,Q611M,D617T,Q620E None None XRAY 1.89 0.18 0.209 A 268 261 0 0 0 0 [[417, 668]] 1.0 3sxs Homo sapiens TYR_BMX_HUMAN TYR 3.1e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR LCK LCK_HUMAN 1QPEA P06239 231 501 509.0 PP2:1904 Type1 Active DFGin 6.391 14.313 BLAminus -142.96, -179.55 55.35, 67.52 -84.73, 15.63 297.65, 101.73 -55.95, -34.43 in-in in 8.023 Saltbr-in 2.692 HRD-in -108.83, -49.35 72.69, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.37, 142.25 APE9-dihe-in -130.54, 154.89 APE8-dihe-in -61.74, 112.03 APE8-rot-na 337.13 APE67-dihe-in -65.74, -24.28 -52.69, -45.66 APE12-dist-na 14.926 APE11-dist-na 10.306 APE10-dist-na 13.019 APE9-dist-in 6.87 None PTR394 PTR394 XRAY 2.0 0.189 0.254 A 279 271 0 0 0 0 [[245, 496]] 1.0 1qpe Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TKL RIPK3 RIPK3_MOUSE 9IX1A Q9QZL0 15 313 486.0 PP2:60401 Type1 None DFGin 5.913 14.386 BLAminus -149.4, 179.25 53.78, 84.76 -98.68, 28.86 296.35, 93.86 -68.88, -29.86 in-in in 8.49 Saltbr-in 2.82 HRD-in -73.45, -52.59 70.92, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.862 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -23.19 999.0, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 A 325 268 31 0 0 19 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX1B Q9QZL0 15 313 486.0 PP2:60401 Type1 Inactive DFGin 6.167 14.352 BLAminus -148.46, 177.74 57.68, 87.36 -104.16, 25.73 298.93, 91.95 -67.83, -27.46 in-in in 8.157 Saltbr-in 2.678 HRD-in -72.53, -47.36 68.74, 3.0 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -77.43 APE8-rot-out 57.1 APE67-dihe-in -61.06, -23.36 -77.17, -1.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 B 325 255 44 0 0 18 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR LYN LYN_MOUSE 2ZV9A P25911 239 501 512.0 PP2:60513 Type1 Inactive DFGin 6.245 14.172 BLAminus -124.48, -167.73 52.26, 77.17 -98.78, 29.04 301.34, 92.61 -56.8, -39.49 in-in in 7.854 Saltbr-in 2.837 HRD-na-N -87.99, -47.48 77.2, -16.11 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 98.44, 84.97 APE9-dihe-in -72.58, 150.24 APE8-dihe-in -84.15, 103.4 APE8-rot-na 22.51 APE67-dihe-in -68.71, -6.51 -45.04, -53.44 APE12-dist-na 9.04 APE11-dist-na 6.263 APE10-dist-na 9.379 APE9-dist-in 4.786 None None None XRAY 2.76 0.197 0.231 A 279 255 8 0 0 8 [[247, 499]] 1.0 2zv9 Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1 260 260 384 385 386 388 390 275 290 294 364 366 365 367 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn

Ligand: PP2

Total number of chains: 5
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 2ZV9A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR SRC SRC_CHICK 3GEQA P00523 251 533 533.0 PP2:60001 Type1 None DFGin 6.498 13.318 BLAminus -136.98, 178.41 65.65, 71.66 -99.5, 24.9 312.03, 74.44 -53.59, -39.51 in-in in 7.878 Saltbr-in 3.27 HRD-in -84.4, -45.83 74.36, -12.61 in-in-none SNCiin in-none ActLoopNT-in 3.122 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 9.88 APE8-rot-na 37.33 APE67-dihe-in -72.37, -14.89 -59.72, -29.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 R388A None None XRAY 2.2 0.226 0.273 A 286 269 14 0 0 14 [[267, 518]] 1.0 3geq Gallus gallus TYR_SRC_CHICK TYR 4.2e-95 323.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3GEQB P00523 251 533 533.0 PP2:60002 Type1 None DFGin 6.81 14.098 BLAminus -136.46, -175.26 62.68, 65.52 -94.23, 33.02 296.16, 73.87 -61.98, -42.96 in-in in 7.762 Saltbr-in 3.085 HRD-in -86.14, -48.11 74.48, -14.66 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 99.99 APE8-rot-na 34.86 APE67-dihe-in -57.61, -32.22 -55.2, -29.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 R388A None None XRAY 2.2 0.226 0.273 B 286 270 13 0 0 13 [[267, 518]] 1.0 3geq Gallus gallus TYR_SRC_CHICK TYR 4.2e-95 323.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TKL RIPK3 RIPK3_MOUSE 9IX1A Q9QZL0 15 313 486.0 PP2:60401 Type1 None DFGin 5.913 14.386 BLAminus -149.4, 179.25 53.78, 84.76 -98.68, 28.86 296.35, 93.86 -68.88, -29.86 in-in in 8.49 Saltbr-in 2.82 HRD-in -73.45, -52.59 70.92, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.862 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -23.19 999.0, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 A 325 268 31 0 0 19 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX1B Q9QZL0 15 313 486.0 PP2:60401 Type1 Inactive DFGin 6.167 14.352 BLAminus -148.46, 177.74 57.68, 87.36 -104.16, 25.73 298.93, 91.95 -67.83, -27.46 in-in in 8.157 Saltbr-in 2.678 HRD-in -72.53, -47.36 68.74, 3.0 in-in-out SNCiio in-out ActLoopNT-in 2.805 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -77.43 APE8-rot-out 57.1 APE67-dihe-in -61.06, -23.36 -77.17, -1.46 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 B 325 255 44 0 0 18 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR LYN LYN_MOUSE 2ZV9A P25911 239 501 512.0 PP2:60513 Type1 Inactive DFGin 6.245 14.172 BLAminus -124.48, -167.73 52.26, 77.17 -98.78, 29.04 301.34, 92.61 -56.8, -39.49 in-in in 7.854 Saltbr-in 2.837 HRD-na-N -87.99, -47.48 77.2, -16.11 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 98.44, 84.97 APE9-dihe-in -72.58, 150.24 APE8-dihe-in -84.15, 103.4 APE8-rot-na 22.51 APE67-dihe-in -68.71, -6.51 -45.04, -53.44 APE12-dist-na 9.04 APE11-dist-na 6.263 APE10-dist-na 9.379 APE9-dist-in 4.786 None None None XRAY 2.76 0.197 0.231 A 279 255 8 0 0 8 [[247, 499]] 1.0 2zv9 Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1 260 260 384 385 386 388 390 275 290 294 364 366 365 367 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn