Ligand: IZA

Total number of chains: 8
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 62.5% 3LXLA
DFGin ABAminus 3 37.5% 3EYHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK DAPK3 DAPK3_HUMAN 2J90A O43293 5 278 454.0 IZA:60300 Type1 Inactive DFGin 6.842 14.0554 BLAminus -125.3, 179.27 61.44, 82.34 -98.36, 26.77 287.5, 77.69 -60.38, -28.86 in-in in 9.482 Saltbr-in 2.724 HRD-in -74.15, -47.48 72.53, -6.38 in-in-out SNCiio in-out ActLoopNT-in 2.9328 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.29 APE8-dihe-in -60.3, 135.25 APE8-rot-out 187.21 APE67-dihe-in -56.76, -23.02 -90.5, 3.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.5456 None SEP50,TPO265 SEP50,TPO265 XRAY 2.0 0.187 0.222 A 304.0 265.0 9 27 18 9 [[13, 275]] 1.0 2j90 CAMK_DAPK3_HUMAN CAMK 1.2e-96 329.0 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 2J90B O43293 12 280 454.0 IZA:60300 Type1 Inactive DFGin 6.9718 14.048 BLAminus -120.27, 179.29 63.28, 79.45 -98.26, 31.78 290.61, 80.97 -66.96, -24.76 in-in in 9.2766 Saltbr-in 2.5215 HRD-in -71.79, -47.75 74.41, -3.27 in-in-out SNCiio in-out ActLoopNT-in 2.9897 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.89, 0.08 APE9-dihe-na -126.75, -177.65 APE8-dihe-in -67.18, 141.61 APE8-rot-out 176.86 APE67-dihe-in -59.93, -28.41 -88.21, 6.8 APE12-dist-out 27.2143 APE11-dist-out 26.973 APE10-dist-out 30.7004 APE9-dist-out 33.6659 None SEP50,TPO265 SEP50,TPO265 XRAY 2.0 0.187 0.222 B 304.0 264.0 5 27 27 0 [[13, 275]] 1.0 2j90 CAMK_DAPK3_HUMAN CAMK 1.2e-96 329.0 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
TYR JAK1-2 JAK1_HUMAN 3EYHA P23458 865 1154 1154.0 IZA:2001 Type1 Inactive DFGin 6.7108 13.7777 ABAminus -123.79, 5.59 -151.26, 147.61 -137.78, 30.19 296.78, 89.6 -63.64, -28.15 in-in in 7.7407 Saltbr-in 2.8801 HRD-in -74.82, -42.99 68.23, 5.73 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -136.22, 60.46 APE9-dihe-in -76.43, 138.22 APE8-dihe-in -79.32, 79.81 APE8-rot-na 29.32 APE67-dihe-in -73.68, -7.92 -57.92, -30.28 APE12-dist-na 10.347 APE11-dist-na 10.9945 APE10-dist-na 9.0512 APE9-dist-in 5.5722 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.178 0.237 A 290.0 287.0 3 31 31 0 [[583, 847], [875, 1151]] 2.0 3eyh TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK2-2 JAK2_HUMAN 2B7AA O60674 843 1132 1132.0 IZA:2001 Type1 Inactive DFGin 6.0912 13.6248 ABAminus -114.38, -2.16 -148.17, 146.16 -136.98, 30.75 299.01, 90.79 -59.91, -29.0 in-in in 8.5694 Saltbr-in 2.7064 HRD-in -66.9, -48.29 72.12, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.7921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.58, 136.09 APE9-dihe-in -109.08, 151.35 APE8-dihe-in -75.49, 67.84 APE8-rot-na 28.43 APE67-dihe-in -82.12, -0.33 -57.73, -26.93 APE12-dist-na 12.8376 APE11-dist-na 12.7835 APE10-dist-na 13.0283 APE9-dist-in 7.774 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 A 293.0 286.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 2b7a TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 2B7AB O60674 840 1132 1132.0 IZA:2002 Type1 Inactive DFGin 6.3444 13.9965 ABAminus -119.31, 4.3 -151.2, 143.13 -134.49, 30.64 293.9, 87.84 -61.34, -27.31 in-in in 8.5535 Saltbr-in 2.6987 HRD-in -66.93, -45.51 70.91, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.7529 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.16, 133.69 APE9-dihe-in -107.45, 143.93 APE8-dihe-in -73.92, 74.12 APE8-rot-na 26.37 APE67-dihe-in -82.73, -2.12 -60.01, -26.2 APE12-dist-na 12.4548 APE11-dist-na 10.8183 APE10-dist-na 12.4433 APE9-dist-in 7.5838 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 B 293.0 289.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 2b7a TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK3-2 JAK3_HUMAN 3LXLA P52333 814 1098 1124.0 IZA:1 Type1 Inactive DFGin 6.3563 13.9832 BLAminus -131.21, -163.1 63.94, 61.73 -90.52, 13.42 287.27, 88.72 -63.24, -20.77 in-in in 7.8734 Saltbr-in 2.759 HRD-in -76.94, -49.02 80.12, -11.64 in-in-out SNCiio in-out ActLoopNT-in 2.8049 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -131.67, 15.09 APE9-dihe-in -90.67, 156.23 APE8-dihe-in -48.41, 132.69 APE8-rot-na 328.44 APE67-dihe-in -80.87, -3.57 -71.39, -11.92 APE12-dist-na 13.8943 APE11-dist-na 9.8069 APE10-dist-na 10.408 APE9-dist-in 7.3708 C1048S None None XRAY 1.74 0.195 0.227 A 327.0 281.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 3lxl TYR_JAK3-2_HUMAN TYR 3.2e-81 278.4 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR TYK2-2 TYK2_HUMAN 3LXPA P29597 888 1178 1187.0 IZA:1183 Type1 Active DFGin 6.5159 14.0684 BLAminus -125.49, -162.27 32.56, 69.7 -75.76, 18.49 286.14, 89.4 -52.16, -34.42 in-in in 8.3529 Saltbr-in 2.5765 HRD-in -85.74, -50.8 74.46, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.9329 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.42, 114.17 APE9-dihe-in -102.81, 153.1 APE8-dihe-in -78.99, 64.19 APE8-rot-na 29.2 APE67-dihe-in -72.53, -2.22 -56.28, -30.53 APE12-dist-na 999.0 APE11-dist-na 10.9265 APE10-dist-na 11.2807 APE9-dist-in 6.7781 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 1.65 0.194 0.229 A 318.0 286.0 5 31 28 3 [[589, 868], [897, 1171]] 2.0 3lxp TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 3NZ0A P29597 888 1176 1187.0 IZA:60001 Type1 Inactive DFGin 6.1535 14.0011 BLAminus -133.5, -159.47 28.32, 83.24 -90.11, 26.57 286.27, 82.9 -67.92, -23.72 in-in in 8.3836 Saltbr-in 2.6639 HRD-in -88.61, -49.58 69.51, 9.87 in-in-out SNCiio in-out ActLoopNT-in 2.8411 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaai APE10-dihe-in -125.47, 159.63 APE9-dihe-out -77.1, -98.73 APE8-dihe-in -90.61, 111.37 APE8-rot-na 32.83 APE67-dihe-in -76.56, -4.71 -63.35, -29.86 APE12-dist-na 9.0182 APE11-dist-na 9.4876 APE10-dist-na 8.8848 APE9-dist-in 6.6533 D1023N None None XRAY 2.0 0.212 0.253 A 302.0 283.0 6 31 31 0 [[589, 868], [897, 1171]] 2.0 3nz0 TYR_TYK2-2_HUMAN TYR 4.9e-81 277.8 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: IZA

Total number of chains: 14
Active chains: 2
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 64.3% 3LXLA
DFGin ABAminus 5 35.7% 3EYHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK DAPK3 DAPK3_HUMAN 2J90A O43293 5 278 454.0 IZA:60300 Type1 Inactive DFGin 6.842 14.0554 BLAminus -125.3, 179.27 61.44, 82.34 -98.36, 26.77 287.5, 77.69 -60.38, -28.86 in-in in 9.482 Saltbr-in 2.724 HRD-in -74.15, -47.48 72.53, -6.38 in-in-out SNCiio in-out ActLoopNT-in 2.9328 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.29 APE8-dihe-in -60.3, 135.25 APE8-rot-out 187.21 APE67-dihe-in -56.76, -23.02 -90.5, 3.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 33.5456 None SEP50,TPO265 SEP50,TPO265 XRAY 2.0 0.187 0.222 A 304.0 265.0 9 27 18 9 [[13, 275]] 1.0 2j90 Homo sapiens CAMK_DAPK3_HUMAN CAMK 1.2e-96 329.0 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
CAMK DAPK3 DAPK3_HUMAN 2J90B O43293 12 280 454.0 IZA:60300 Type1 Inactive DFGin 6.9718 14.048 BLAminus -120.27, 179.29 63.28, 79.45 -98.26, 31.78 290.61, 80.97 -66.96, -24.76 in-in in 9.2766 Saltbr-in 2.5215 HRD-in -71.79, -47.75 74.41, -3.27 in-in-out SNCiio in-out ActLoopNT-in 2.9897 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.89, 0.08 APE9-dihe-na -126.75, -177.65 APE8-dihe-in -67.18, 141.61 APE8-rot-out 176.86 APE67-dihe-in -59.93, -28.41 -88.21, 6.8 APE12-dist-out 27.2143 APE11-dist-out 26.973 APE10-dist-out 30.7004 APE9-dist-out 33.6659 None SEP50,TPO265 SEP50,TPO265 XRAY 2.0 0.187 0.222 B 304.0 264.0 5 27 27 0 [[13, 275]] 1.0 2j90 Homo sapiens CAMK_DAPK3_HUMAN CAMK 1.2e-96 329.0 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 3
TYR JAK1-2 JAK1_HUMAN 3EYHA P23458 865 1154 1154.0 IZA:2001 Type1 Inactive DFGin 6.7108 13.7777 ABAminus -123.79, 5.59 -151.26, 147.61 -137.78, 30.19 296.78, 89.6 -63.64, -28.15 in-in in 7.7407 Saltbr-in 2.8801 HRD-in -74.82, -42.99 68.23, 5.73 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -136.22, 60.46 APE9-dihe-in -76.43, 138.22 APE8-dihe-in -79.32, 79.81 APE8-rot-na 29.32 APE67-dihe-in -73.68, -7.92 -57.92, -30.28 APE12-dist-na 10.347 APE11-dist-na 10.9945 APE10-dist-na 9.0512 APE9-dist-in 5.5722 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.178 0.237 A 290.0 287.0 3 31 31 0 [[583, 847], [875, 1151]] 2.0 3eyh Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK2-2 JAK2_HUMAN 2B7AA O60674 843 1132 1132.0 IZA:2001 Type1 Inactive DFGin 6.0912 13.6248 ABAminus -114.38, -2.16 -148.17, 146.16 -136.98, 30.75 299.01, 90.79 -59.91, -29.0 in-in in 8.5694 Saltbr-in 2.7064 HRD-in -66.9, -48.29 72.12, 2.52 in-in-in SNCiii in-in ActLoopNT-in 2.7921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.58, 136.09 APE9-dihe-in -109.08, 151.35 APE8-dihe-in -75.49, 67.84 APE8-rot-na 28.43 APE67-dihe-in -82.12, -0.33 -57.73, -26.93 APE12-dist-na 12.8376 APE11-dist-na 12.7835 APE10-dist-na 13.0283 APE9-dist-in 7.774 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 A 293.0 286.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 2b7a Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 2B7AB O60674 840 1132 1132.0 IZA:2002 Type1 Inactive DFGin 6.3444 13.9965 ABAminus -119.31, 4.3 -151.2, 143.13 -134.49, 30.64 293.9, 87.84 -61.34, -27.31 in-in in 8.5535 Saltbr-in 2.6987 HRD-in -66.93, -45.51 70.91, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.7529 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.16, 133.69 APE9-dihe-in -107.45, 143.93 APE8-dihe-in -73.92, 74.12 APE8-rot-na 26.37 APE67-dihe-in -82.73, -2.12 -60.01, -26.2 APE12-dist-na 12.4548 APE11-dist-na 10.8183 APE10-dist-na 12.4433 APE9-dist-in 7.5838 N1129Q PTR1007,PTR1008 PTR1007,PTR1008 XRAY 2.0 0.211 0.249 B 293.0 289.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 2b7a Homo sapiens TYR_JAK2-2_HUMAN TYR 2.4e-87 298.5 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK3-2 JAK3_HUMAN 3LXLA P52333 814 1098 1124.0 IZA:1 Type1 Inactive DFGin 6.3563 13.9832 BLAminus -131.21, -163.1 63.94, 61.73 -90.52, 13.42 287.27, 88.72 -63.24, -20.77 in-in in 7.8734 Saltbr-in 2.759 HRD-in -76.94, -49.02 80.12, -11.64 in-in-out SNCiio in-out ActLoopNT-in 2.8049 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -131.67, 15.09 APE9-dihe-in -90.67, 156.23 APE8-dihe-in -48.41, 132.69 APE8-rot-na 328.44 APE67-dihe-in -80.87, -3.57 -71.39, -11.92 APE12-dist-na 13.8943 APE11-dist-na 9.8069 APE10-dist-na 10.408 APE9-dist-in 7.3708 C1048S None None XRAY 1.74 0.195 0.227 A 327.0 281.0 4 31 31 0 [[521, 779], [822, 1097]] 2.0 3lxl Homo sapiens TYR_JAK3-2_HUMAN TYR 3.2e-81 278.4 1.0 260.0 260.0 966 967 968 970 972 855 871 875 946 948 947 949.0 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR TYK2-2 TYK2_HUMAN 3LXPA P29597 888 1178 1187.0 IZA:1183 Type1 Active DFGin 6.5159 14.0684 BLAminus -125.49, -162.27 32.56, 69.7 -75.76, 18.49 286.14, 89.4 -52.16, -34.42 in-in in 8.3529 Saltbr-in 2.5765 HRD-in -85.74, -50.8 74.46, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.9329 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.42, 114.17 APE9-dihe-in -102.81, 153.1 APE8-dihe-in -78.99, 64.19 APE8-rot-na 29.2 APE67-dihe-in -72.53, -2.22 -56.28, -30.53 APE12-dist-na 999.0 APE11-dist-na 10.9265 APE10-dist-na 11.2807 APE9-dist-in 6.7781 C936A,Q969A,E971A,K972A,C1142A PTR1054 PTR1054 XRAY 1.65 0.194 0.229 A 318.0 286.0 5 31 28 3 [[589, 868], [897, 1171]] 2.0 3lxp Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 3NZ0A P29597 888 1176 1187.0 IZA:60001 Type1 Inactive DFGin 6.1535 14.0011 BLAminus -133.5, -159.47 28.32, 83.24 -90.11, 26.57 286.27, 82.9 -67.92, -23.72 in-in in 8.3836 Saltbr-in 2.6639 HRD-in -88.61, -49.58 69.51, 9.87 in-in-out SNCiio in-out ActLoopNT-in 2.8411 ActLoopCT-out TYR APEdihe_ioiai APEdist_aaai APE10-dihe-in -125.47, 159.63 APE9-dihe-out -77.1, -98.73 APE8-dihe-in -90.61, 111.37 APE8-rot-na 32.83 APE67-dihe-in -76.56, -4.71 -63.35, -29.86 APE12-dist-na 9.0182 APE11-dist-na 9.4876 APE10-dist-na 8.8848 APE9-dist-in 6.6533 D1023N None None XRAY 2.0 0.212 0.253 A 302.0 283.0 6 31 31 0 [[589, 868], [897, 1171]] 2.0 3nz0 Homo sapiens TYR_TYK2-2_HUMAN TYR 4.9e-81 277.8 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR JAK2-2 JAK2_MOUSE 4GL9A Q62120 843 1130 1132.0 IZA:62001 Type1 Inactive DFGin 5.7577 14.5353 BLAminus -131.1, 175.47 54.64, 81.14 -92.19, 32.98 300.1, 95.95 -58.27, -44.01 in-in in 9.0349 Saltbr-in 3.3604 HRD-in -73.72, -44.47 64.56, -43.96 in-in-out SNCiio in-out ActLoopNT-in 3.1066 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.67, 134.18 APE9-dihe-in -146.45, 151.12 APE8-dihe-in -74.76, 79.94 APE8-rot-na 27.08 APE67-dihe-in -82.75, -26.09 -66.14, -14.69 APE12-dist-na 11.8979 APE11-dist-na 11.3463 APE10-dist-na 12.1263 APE9-dist-out 8.4949 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 A 297.0 284.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_MOUSE 4GL9B Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 5.9255 13.9565 BLAminus -131.65, 175.34 54.28, 82.24 -93.18, 32.79 301.63, 90.67 -58.15, -43.04 in-in in 8.7836 Saltbr-in 2.7775 HRD-in -75.15, -44.99 64.86, -43.48 in-in-out SNCiio in-out ActLoopNT-in 3.1731 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.23, 133.88 APE9-dihe-in -145.62, 151.28 APE8-dihe-in -74.33, 80.39 APE8-rot-na 26.93 APE67-dihe-in -82.22, -25.66 -66.02, -15.3 APE12-dist-na 10.8545 APE11-dist-na 10.5463 APE10-dist-na 11.5765 APE9-dist-out 8.1552 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 B 297.0 282.0 6 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_MOUSE 4GL9C Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 6.0667 14.3386 BLAminus -130.77, 175.48 54.57, 81.25 -92.89, 33.32 299.53, 89.15 -58.8, -44.7 in-in in 9.076 Saltbr-in 2.9964 HRD-in -74.67, -44.19 64.59, -44.72 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -53.52, 135.21 APE9-dihe-in -144.8, 151.59 APE8-dihe-in -74.44, 79.48 APE8-rot-na 27.41 APE67-dihe-in -84.46, -26.89 -66.72, -16.8 APE12-dist-na 11.515 APE11-dist-na 11.1772 APE10-dist-na 11.8564 APE9-dist-out 8.4803 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 C 297.0 284.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_MOUSE 4GL9D Q62120 843 1130 1132.0 IZA:61201 Type1 Active DFGin 6.1126 14.1044 BLAminus -130.51, 174.55 54.31, 81.77 -91.69, 33.32 299.7, 91.33 -57.81, -43.55 in-in in 9.0369 Saltbr-in 3.3257 HRD-in -75.42, -43.64 65.18, -41.08 in-in-in SNCiii in-in ActLoopNT-in 3.1093 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.34, 133.7 APE9-dihe-in -146.39, 149.67 APE8-dihe-in -76.13, 80.18 APE8-rot-na 27.12 APE67-dihe-in -82.31, -26.02 -65.86, -16.39 APE12-dist-na 11.4611 APE11-dist-na 10.3143 APE10-dist-na 10.7895 APE9-dist-in 7.989 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 D 297.0 284.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
OTHER IRE1 IRE1_YEAST 3LJ2A P32361 665 1115 1115.0 IZA:1 Type1 Inactive DFGin 5.9463 14.1047 ABAminus -134.11, -29.21 -103.96, 101.1 -105.66, 14.03 294.34, 66.42 -66.28, -46.88 in-in in 9.1819 Saltbr-in 3.4434 HRD-out -66.97, 141.77 -110.32, -6.86 in-in-none SNCiin in-none ActLoopNT-in 2.8057 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.36 APE8-rot-none 999.0 APE67-dihe-in -68.73, -29.06 -119.26, 28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.256 0.293 A 434.0 407.0 20 32 25 7 [[672, 977]] 1.0 3lj2 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ2B P32361 665 1115 1115.0 IZA:1 Type1 Inactive DFGin 5.9268 14.0513 ABAminus -135.45, -27.25 -103.53, 103.68 -105.95, 11.89 293.73, 66.79 -67.41, -44.42 in-in in 9.1852 Saltbr-in 3.3472 HRD-out -74.66, 131.68 -106.03, -3.68 in-in-none SNCiin in-none ActLoopNT-in 2.7942 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.63 APE8-rot-none 999.0 APE67-dihe-in -74.43, -20.72 -115.58, 29.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.256 0.293 B 434.0 407.0 20 32 25 7 [[672, 977]] 1.0 3lj2 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1

Ligand: IZA

Total number of chains: 6
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 66.7% 4GL9A
DFGin ABAminus 2 33.3% 3LJ2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR JAK2-2 JAK2_MOUSE 4GL9A Q62120 843 1130 1132.0 IZA:62001 Type1 Inactive DFGin 5.7577 14.5353 BLAminus -131.1, 175.47 54.64, 81.14 -92.19, 32.98 300.1, 95.95 -58.27, -44.01 in-in in 9.0349 Saltbr-in 3.3604 HRD-in -73.72, -44.47 64.56, -43.96 in-in-out SNCiio in-out ActLoopNT-in 3.1066 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.67, 134.18 APE9-dihe-in -146.45, 151.12 APE8-dihe-in -74.76, 79.94 APE8-rot-na 27.08 APE67-dihe-in -82.75, -26.09 -66.14, -14.69 APE12-dist-na 11.8979 APE11-dist-na 11.3463 APE10-dist-na 12.1263 APE9-dist-out 8.4949 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 A 297.0 284.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_MOUSE 4GL9B Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 5.9255 13.9565 BLAminus -131.65, 175.34 54.28, 82.24 -93.18, 32.79 301.63, 90.67 -58.15, -43.04 in-in in 8.7836 Saltbr-in 2.7775 HRD-in -75.15, -44.99 64.86, -43.48 in-in-out SNCiio in-out ActLoopNT-in 3.1731 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -55.23, 133.88 APE9-dihe-in -145.62, 151.28 APE8-dihe-in -74.33, 80.39 APE8-rot-na 26.93 APE67-dihe-in -82.22, -25.66 -66.02, -15.3 APE12-dist-na 10.8545 APE11-dist-na 10.5463 APE10-dist-na 11.5765 APE9-dist-out 8.1552 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 B 297.0 282.0 6 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_MOUSE 4GL9C Q62120 843 1130 1132.0 IZA:61201 Type1 Inactive DFGin 6.0667 14.3386 BLAminus -130.77, 175.48 54.57, 81.25 -92.89, 33.32 299.53, 89.15 -58.8, -44.7 in-in in 9.076 Saltbr-in 2.9964 HRD-in -74.67, -44.19 64.59, -44.72 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -53.52, 135.21 APE9-dihe-in -144.8, 151.59 APE8-dihe-in -74.44, 79.48 APE8-rot-na 27.41 APE67-dihe-in -84.46, -26.89 -66.72, -16.8 APE12-dist-na 11.515 APE11-dist-na 11.1772 APE10-dist-na 11.8564 APE9-dist-out 8.4803 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 C 297.0 284.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_MOUSE 4GL9D Q62120 843 1130 1132.0 IZA:61201 Type1 Active DFGin 6.1126 14.1044 BLAminus -130.51, 174.55 54.31, 81.77 -91.69, 33.32 299.7, 91.33 -57.81, -43.55 in-in in 9.0369 Saltbr-in 3.3257 HRD-in -75.42, -43.64 65.18, -41.08 in-in-in SNCiii in-in ActLoopNT-in 3.1093 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.34, 133.7 APE9-dihe-in -146.39, 149.67 APE8-dihe-in -76.13, 80.18 APE8-rot-na 27.12 APE67-dihe-in -82.31, -26.02 -65.86, -16.39 APE12-dist-na 11.4611 APE11-dist-na 10.3143 APE10-dist-na 10.7895 APE9-dist-in 7.989 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 3.9 0.254 0.281 D 297.0 284.0 4 31 31 0 [[545, 807], [849, 1125]] 2.0 4gl9 Mus musculus TYR_JAK2-2_MOUSE TYR 7.3e-87 296.9 1.0 260.0 260.0 993 994 995 997 999 882 898 902 973 975 974 976.0 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
OTHER IRE1 IRE1_YEAST 3LJ2A P32361 665 1115 1115.0 IZA:1 Type1 Inactive DFGin 5.9463 14.1047 ABAminus -134.11, -29.21 -103.96, 101.1 -105.66, 14.03 294.34, 66.42 -66.28, -46.88 in-in in 9.1819 Saltbr-in 3.4434 HRD-out -66.97, 141.77 -110.32, -6.86 in-in-none SNCiin in-none ActLoopNT-in 2.8057 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -31.36 APE8-rot-none 999.0 APE67-dihe-in -68.73, -29.06 -119.26, 28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.256 0.293 A 434.0 407.0 20 32 25 7 [[672, 977]] 1.0 3lj2 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ2B P32361 665 1115 1115.0 IZA:1 Type1 Inactive DFGin 5.9268 14.0513 ABAminus -135.45, -27.25 -103.53, 103.68 -105.95, 11.89 293.73, 66.79 -67.41, -44.42 in-in in 9.1852 Saltbr-in 3.3472 HRD-out -74.66, 131.68 -106.03, -3.68 in-in-none SNCiin in-none ActLoopNT-in 2.7942 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.63 APE8-rot-none 999.0 APE67-dihe-in -74.43, -20.72 -115.58, 29.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.256 0.293 B 434.0 407.0 20 32 25 7 [[672, 977]] 1.0 3lj2 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1