Ligand: IED

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 9FPDA
DFGout None 1 50.0% 8PYMAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL MAP3K7 M3K7_HUMAN 9FPDA O43318 31 496 606.0 A1IED:60601 Type1 None DFGin 6.676 14.4767 BLAminus -130.28, -171.82 55.25, 77.32 -97.54, 29.58 293.23, 81.36 -74.32, -25.41 in-in in 8.0496 Saltbr-in 3.0776 HRD-in -74.6, -42.17 67.8, -12.87 in-in-none SNCiin in-none ActLoopNT-in 2.9968 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -117.84, 110.58 APE9-dihe-na 124.51, -160.03 APE8-dihe-in -112.48, 132.82 APE8-rot-none 999.0 APE67-dihe-in -69.76, -34.93 -42.07, -38.63 APE12-dist-in 12.6106 APE11-dist-in 11.2233 APE10-dist-in 5.9913 APE9-dist-in 3.7642 None TPO187,SEP192 TPO187,SEP192 XRAY 2.402 0.209 0.222 A 316.0 270.0 3 25 22 3 [[36, 286]] 1.0 9fpd TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR IGF1R IGF1R_HUMAN 8PYMAAA P08069 984 1270 1367.0 IED:1301 Type2 Inactive DFGout 17.3876 8.0662 None -140.29, -174.19 -150.41, 118.32 -112.85, 8.25 208.87, 151.48 70.27, -164.18 out-out out 10.1033 Saltbr-out 5.0897 HRD-in -64.19, -38.83 54.72, 11.98 out-out-in SNCooi out-in ActLoopNT-out 18.3194 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.12, 139.29 APE9-dihe-in -129.72, 131.76 APE8-dihe-in -83.92, 64.41 APE8-rot-na 36.05 APE67-dihe-in -67.04, -15.79 -60.07, -31.92 APE12-dist-na 13.8357 APE11-dist-na 9.654 APE10-dist-na 5.5654 APE9-dist-in 7.5601 None None None XRAY 2.652 0.24 0.309 AAA 321.0 278.0 9 30 30 0 [[999, 1268]] 1.0 8pym TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor

Ligand: IED

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 9FPDA
DFGout None 1 50.0% 8PYMAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL MAP3K7 M3K7_HUMAN 9FPDA O43318 31 496 606.0 A1IED:60601 Type1 None DFGin 6.676 14.4767 BLAminus -130.28, -171.82 55.25, 77.32 -97.54, 29.58 293.23, 81.36 -74.32, -25.41 in-in in 8.0496 Saltbr-in 3.0776 HRD-in -74.6, -42.17 67.8, -12.87 in-in-none SNCiin in-none ActLoopNT-in 2.9968 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -117.84, 110.58 APE9-dihe-na 124.51, -160.03 APE8-dihe-in -112.48, 132.82 APE8-rot-none 999.0 APE67-dihe-in -69.76, -34.93 -42.07, -38.63 APE12-dist-in 12.6106 APE11-dist-in 11.2233 APE10-dist-in 5.9913 APE9-dist-in 3.7642 None TPO187,SEP192 TPO187,SEP192 XRAY 2.402 0.209 0.222 A 316.0 270.0 3 25 22 3 [[36, 286]] 1.0 9fpd Homo sapiens TKL_MAP3K7_HUMAN TKL 4.1e-74 255.4 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR IGF1R IGF1R_HUMAN 8PYMAAA P08069 984 1270 1367.0 IED:1301 Type2 Inactive DFGout 17.3876 8.0662 None -140.29, -174.19 -150.41, 118.32 -112.85, 8.25 208.87, 151.48 70.27, -164.18 out-out out 10.1033 Saltbr-out 5.0897 HRD-in -64.19, -38.83 54.72, 11.98 out-out-in SNCooi out-in ActLoopNT-out 18.3194 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.12, 139.29 APE9-dihe-in -129.72, 131.76 APE8-dihe-in -83.92, 64.41 APE8-rot-na 36.05 APE67-dihe-in -67.04, -15.79 -60.07, -31.92 APE12-dist-na 13.8357 APE11-dist-na 9.654 APE10-dist-na 5.5654 APE9-dist-in 7.5601 None None None XRAY 2.652 0.24 0.309 AAA 321.0 278.0 9 30 30 0 [[999, 1268]] 1.0 8pym Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor

Ligand: IED

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name