Ligand: FEF

Total number of chains: 6
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 3 50.0% 4C57A
DFGin BLAminus 2 33.3% 2VZ6B
DFGout None 1 16.7% 3MTLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMK2A KCC2A_HUMAN 2VZ6A Q9UQM7 9 299 478.0 FEF:60600 Type1 Active DFGin 7.1238 13.9304 BLAminus -130.3, 144.9 77.59, 104.3 -118.45, 37.91 281.19, 70.53 -60.86, -31.43 in-in in 9.0324 Saltbr-in 2.6227 HRD-in -71.43, -45.76 75.34, -9.9 in-in-in SNCiii in-in ActLoopNT-in 2.8051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.76, 148.02 APE9-dihe-na 132.07, -168.34 APE8-dihe-in -120.79, 126.49 APE8-rot-in 299.71 APE67-dihe-in -63.07, -18.83 -35.01, -58.7 APE12-dist-in 10.327 APE11-dist-in 11.8194 APE10-dist-in 5.9929 APE9-dist-in 3.8322 None None None XRAY 2.3 0.165 0.203 A 313.0 289.0 2 28 28 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B Q9UQM7 9 300 478.0 FEF:60600 Type1 Active DFGin 6.8653 14.0317 BLAminus -131.92, 139.26 77.54, 110.88 -122.08, 32.95 286.68, 71.96 -61.55, -26.54 in-in in 9.3105 Saltbr-in 2.9307 HRD-in -73.12, -44.65 73.93, -20.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 149.78 APE9-dihe-na 143.11, -171.05 APE8-dihe-in -118.3, 128.44 APE8-rot-in 303.95 APE67-dihe-in -66.72, -18.78 -39.97, -52.82 APE12-dist-in 10.2519 APE11-dist-in 11.7563 APE10-dist-in 5.9962 APE9-dist-in 3.963 None None None XRAY 2.3 0.165 0.203 B 313.0 292.0 0 28 28 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CMGC CDK16 CDK16_HUMAN 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.3993 7.4716 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.3848 Saltbr-in 2.6411 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.1638 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324.0 293.0 18 28 16 12 [[165, 446]] 1.0 3mtl CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.7541 14.1406 ABAminus -112.53, -37.31 -102.07, 134.52 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.9935 Saltbr-out 4.0566 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.7793 APE11-dist-in 8.5735 APE10-dist-in 4.3301 APE9-dist-in 4.0704 None None None XRAY 2.55 0.18 0.228 A 340.0 310.0 0 40 40 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.7695 14.2334 ABAminus -105.07, -37.59 -101.51, 133.86 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.0646 Saltbr-out 4.0563 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.8914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.9284 APE11-dist-in 8.6579 APE10-dist-in 4.358 APE9-dist-in 4.0859 None None None XRAY 2.55 0.18 0.228 B 340.0 308.0 0 40 40 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.8147 13.6797 ABAminus -134.62, -10.32 -105.18, 88.43 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.0927 Saltbr-in 2.8554 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.8383 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340.0 266.0 41 40 13 27 [[40, 313]] 1.0 4c59 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase

Ligand: FEF

Total number of chains: 6
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 3 50.0% 4C57A
DFGin BLAminus 2 33.3% 2VZ6B
DFGout None 1 16.7% 3MTLA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK CAMK2A KCC2A_HUMAN 2VZ6A Q9UQM7 9 299 478.0 FEF:60600 Type1 Active DFGin 7.1238 13.9304 BLAminus -130.3, 144.9 77.59, 104.3 -118.45, 37.91 281.19, 70.53 -60.86, -31.43 in-in in 9.0324 Saltbr-in 2.6227 HRD-in -71.43, -45.76 75.34, -9.9 in-in-in SNCiii in-in ActLoopNT-in 2.8051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.76, 148.02 APE9-dihe-na 132.07, -168.34 APE8-dihe-in -120.79, 126.49 APE8-rot-in 299.71 APE67-dihe-in -63.07, -18.83 -35.01, -58.7 APE12-dist-in 10.327 APE11-dist-in 11.8194 APE10-dist-in 5.9929 APE9-dist-in 3.8322 None None None XRAY 2.3 0.165 0.203 A 313.0 289.0 2 28 28 0 [[13, 271]] 1.0 2vz6 Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B Q9UQM7 9 300 478.0 FEF:60600 Type1 Active DFGin 6.8653 14.0317 BLAminus -131.92, 139.26 77.54, 110.88 -122.08, 32.95 286.68, 71.96 -61.55, -26.54 in-in in 9.3105 Saltbr-in 2.9307 HRD-in -73.12, -44.65 73.93, -20.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 149.78 APE9-dihe-na 143.11, -171.05 APE8-dihe-in -118.3, 128.44 APE8-rot-in 303.95 APE67-dihe-in -66.72, -18.78 -39.97, -52.82 APE12-dist-in 10.2519 APE11-dist-in 11.7563 APE10-dist-in 5.9962 APE9-dist-in 3.963 None None None XRAY 2.3 0.165 0.203 B 313.0 292.0 0 28 28 0 [[13, 271]] 1.0 2vz6 Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CMGC CDK16 CDK16_HUMAN 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.3993 7.4716 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.3848 Saltbr-in 2.6411 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.1638 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324.0 293.0 18 28 16 12 [[165, 446]] 1.0 3mtl Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.7541 14.1406 ABAminus -112.53, -37.31 -102.07, 134.52 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.9935 Saltbr-out 4.0566 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.7793 APE11-dist-in 8.5735 APE10-dist-in 4.3301 APE9-dist-in 4.0704 None None None XRAY 2.55 0.18 0.228 A 340.0 310.0 0 40 40 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.7695 14.2334 ABAminus -105.07, -37.59 -101.51, 133.86 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.0646 Saltbr-out 4.0563 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.8914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.9284 APE11-dist-in 8.6579 APE10-dist-in 4.358 APE9-dist-in 4.0859 None None None XRAY 2.55 0.18 0.228 B 340.0 308.0 0 40 40 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.8147 13.6797 ABAminus -134.62, -10.32 -105.18, 88.43 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.0927 Saltbr-in 2.8554 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.8383 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340.0 266.0 41 40 13 27 [[40, 313]] 1.0 4c59 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase

Ligand: FEF

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name