Ligand: AEE

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2ITPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 2JIUA 3.05 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai AEE Type1 696 - 1016 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2J6MA 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AEE Type1 697 - 1020 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITPA 2.74 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AEE Type1 697 - 1018 0 None G719S Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITTA 2.73 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai AEE Type1 697 - 1019 0 None L858R Epidermal growth factor receptor

Ligand: AEE

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2ITPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 2JIUA 3.05 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai AEE Type1 696 - 1016 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2J6MA 3.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AEE Type1 697 - 1020 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2ITPA 2.74 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AEE Type1 697 - 1018 0 None G719S Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2ITTA 2.73 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai AEE Type1 697 - 1019 0 None L858R Epidermal growth factor receptor Homo sapiens

Ligand: AEE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism