Ligand: AEE

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2ITPA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 2JIUA P00533 696 1016 1210.0 AEE:2017 Type1 Inactive DFGin 5.634 14.082 BLAminus -145.49, 179.31 63.52, 89.73 -108.67, 24.16 309.25, 93.65 -34.66, -27.93 in-out in 9.641 Saltbr-out 4.002 HRD-in -49.5, -61.5 85.29, -11.16 out-in-in SNCoii in-in ActLoopNT-in 3.445 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.44, 148.67 APE9-dihe-in -156.98, 144.14 APE8-dihe-in -91.11, 79.49 APE8-rot-na 27.16 APE67-dihe-in -68.15, 3.02 -38.52, -39.86 APE12-dist-na 11.717 APE11-dist-na 9.516 APE10-dist-na 10.218 APE9-dist-in 6.625 T790M None None XRAY 3.05 0.214 0.277 A 328 304 0 0 0 0 [[712, 970]] 1.0 2jiu TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2J6MA P00533 697 1020 1210.0 AEE:2021 Type1 Active DFGin 5.591 14.628 BLAminus -132.01, -171.36 64.21, 86.56 -104.74, 23.26 301.97, 101.16 -61.7, -5.65 in-in in 8.642 Saltbr-in 3.021 HRD-in -66.75, -41.48 62.82, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.86, 117.91 APE9-dihe-in -126.99, 135.18 APE8-dihe-in -74.97, 82.99 APE8-rot-na 39.67 APE67-dihe-in -53.8, -21.73 -47.34, -52.41 APE12-dist-na 11.859 APE11-dist-na 10.864 APE10-dist-na 10.63 APE9-dist-in 6.911 None None None XRAY 3.1 0.202 0.249 A 327 306 0 0 0 0 [[712, 970]] 1.0 2j6m TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITPA P00533 697 1018 1210.0 AEE:2019 Type1 Active DFGin 5.862 14.646 BLAminus -129.98, -162.9 59.16, 79.47 -92.61, 9.17 298.14, 95.91 -39.72, -19.96 in-in in 8.075 Saltbr-in 2.967 HRD-in -64.35, -49.17 69.51, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.58, 125.89 APE9-dihe-in -133.11, 143.15 APE8-dihe-in -86.75, 111.19 APE8-rot-na 34.96 APE67-dihe-in -68.3, -8.64 -72.28, -40.19 APE12-dist-na 11.875 APE11-dist-na 10.343 APE10-dist-na 11.0 APE9-dist-in 6.7 G719S None None XRAY 2.74 0.2 0.255 A 327 305 0 0 0 0 [[712, 970]] 1.0 2itp TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITTA P00533 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.936 14.965 BLAminus -130.73, -162.83 54.09, 78.3 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.368 Saltbr-in 2.867 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.493 L858R None None XRAY 2.73 0.212 0.262 A 327 302 9 0 0 9 [[712, 970]] 1.0 2itt TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: AEE

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2ITPA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 2JIUA P00533 696 1016 1210.0 AEE:2017 Type1 Inactive DFGin 5.634 14.082 BLAminus -145.49, 179.31 63.52, 89.73 -108.67, 24.16 309.25, 93.65 -34.66, -27.93 in-out in 9.641 Saltbr-out 4.002 HRD-in -49.5, -61.5 85.29, -11.16 out-in-in SNCoii in-in ActLoopNT-in 3.445 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.44, 148.67 APE9-dihe-in -156.98, 144.14 APE8-dihe-in -91.11, 79.49 APE8-rot-na 27.16 APE67-dihe-in -68.15, 3.02 -38.52, -39.86 APE12-dist-na 11.717 APE11-dist-na 9.516 APE10-dist-na 10.218 APE9-dist-in 6.625 T790M None None XRAY 3.05 0.214 0.277 A 328 304 0 0 0 0 [[712, 970]] 1.0 2jiu Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2J6MA P00533 697 1020 1210.0 AEE:2021 Type1 Active DFGin 5.591 14.628 BLAminus -132.01, -171.36 64.21, 86.56 -104.74, 23.26 301.97, 101.16 -61.7, -5.65 in-in in 8.642 Saltbr-in 3.021 HRD-in -66.75, -41.48 62.82, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.789 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.86, 117.91 APE9-dihe-in -126.99, 135.18 APE8-dihe-in -74.97, 82.99 APE8-rot-na 39.67 APE67-dihe-in -53.8, -21.73 -47.34, -52.41 APE12-dist-na 11.859 APE11-dist-na 10.864 APE10-dist-na 10.63 APE9-dist-in 6.911 None None None XRAY 3.1 0.202 0.249 A 327 306 0 0 0 0 [[712, 970]] 1.0 2j6m Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITPA P00533 697 1018 1210.0 AEE:2019 Type1 Active DFGin 5.862 14.646 BLAminus -129.98, -162.9 59.16, 79.47 -92.61, 9.17 298.14, 95.91 -39.72, -19.96 in-in in 8.075 Saltbr-in 2.967 HRD-in -64.35, -49.17 69.51, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.58, 125.89 APE9-dihe-in -133.11, 143.15 APE8-dihe-in -86.75, 111.19 APE8-rot-na 34.96 APE67-dihe-in -68.3, -8.64 -72.28, -40.19 APE12-dist-na 11.875 APE11-dist-na 10.343 APE10-dist-na 11.0 APE9-dist-in 6.7 G719S None None XRAY 2.74 0.2 0.255 A 327 305 0 0 0 0 [[712, 970]] 1.0 2itp Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITTA P00533 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.936 14.965 BLAminus -130.73, -162.83 54.09, 78.3 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.368 Saltbr-in 2.867 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.493 L858R None None XRAY 2.73 0.212 0.262 A 327 302 9 0 0 9 [[712, 970]] 1.0 2itt Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: AEE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name