Ligand: AEE

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2ITPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 2JIUA P00533 696 1016 1210.0 AEE:2017 Type1 Inactive DFGin 5.6343 14.0824 BLAminus -145.49, 179.31 63.52, 89.73 -108.67, 24.16 309.25, 93.65 -34.66, -27.93 in-out in 9.6408 Saltbr-out 4.0021 HRD-in -49.5, -61.5 85.29, -11.16 out-in-in SNCoii in-in ActLoopNT-in 3.4445 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.44, 148.67 APE9-dihe-in -156.98, 144.14 APE8-dihe-in -91.11, 79.49 APE8-rot-na 27.16 APE67-dihe-in -68.15, 3.02 -38.52, -39.86 APE12-dist-na 11.7168 APE11-dist-na 9.5164 APE10-dist-na 10.2181 APE9-dist-in 6.6245 T790M None None XRAY 3.05 0.214 0.277 A 328.0 304.0 0 30 30 0 [[712, 970]] 1.0 2jiu TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2J6MA P00533 697 1020 1210.0 AEE:2021 Type1 Active DFGin 5.5914 14.6282 BLAminus -132.01, -171.36 64.21, 86.56 -104.74, 23.26 301.97, 101.16 -61.7, -5.65 in-in in 8.6417 Saltbr-in 3.0209 HRD-in -66.75, -41.48 62.82, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.7887 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.86, 117.91 APE9-dihe-in -126.99, 135.18 APE8-dihe-in -74.97, 82.99 APE8-rot-na 39.67 APE67-dihe-in -53.8, -21.73 -47.34, -52.41 APE12-dist-na 11.8591 APE11-dist-na 10.8637 APE10-dist-na 10.6303 APE9-dist-in 6.9107 None None None XRAY 3.1 0.202 0.249 A 327.0 306.0 0 30 30 0 [[712, 970]] 1.0 2j6m TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITPA P00533 697 1018 1210.0 AEE:2019 Type1 Active DFGin 5.8623 14.6457 BLAminus -129.98, -162.9 59.16, 79.47 -92.61, 9.17 298.14, 95.91 -39.72, -19.96 in-in in 8.0749 Saltbr-in 2.9674 HRD-in -64.35, -49.17 69.51, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.9122 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.58, 125.89 APE9-dihe-in -133.11, 143.15 APE8-dihe-in -86.75, 111.19 APE8-rot-na 34.96 APE67-dihe-in -68.3, -8.64 -72.28, -40.19 APE12-dist-na 11.8748 APE11-dist-na 10.343 APE10-dist-na 11.0004 APE9-dist-in 6.7005 G719S None None XRAY 2.74 0.2 0.255 A 327.0 305.0 0 30 30 0 [[712, 970]] 1.0 2itp TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITTA P00533 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.9357 14.9648 BLAminus -130.73, -162.83 54.09, 78.3 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.3678 Saltbr-in 2.8668 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.8205 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4932 L858R None None XRAY 2.73 0.212 0.262 A 327.0 302.0 9 30 21 9 [[712, 970]] 1.0 2itt TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: AEE

Total number of chains: 4
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 2ITPA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 2JIUA P00533 696 1016 1210.0 AEE:2017 Type1 Inactive DFGin 5.6343 14.0824 BLAminus -145.49, 179.31 63.52, 89.73 -108.67, 24.16 309.25, 93.65 -34.66, -27.93 in-out in 9.6408 Saltbr-out 4.0021 HRD-in -49.5, -61.5 85.29, -11.16 out-in-in SNCoii in-in ActLoopNT-in 3.4445 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.44, 148.67 APE9-dihe-in -156.98, 144.14 APE8-dihe-in -91.11, 79.49 APE8-rot-na 27.16 APE67-dihe-in -68.15, 3.02 -38.52, -39.86 APE12-dist-na 11.7168 APE11-dist-na 9.5164 APE10-dist-na 10.2181 APE9-dist-in 6.6245 T790M None None XRAY 3.05 0.214 0.277 A 328.0 304.0 0 30 30 0 [[712, 970]] 1.0 2jiu Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2J6MA P00533 697 1020 1210.0 AEE:2021 Type1 Active DFGin 5.5914 14.6282 BLAminus -132.01, -171.36 64.21, 86.56 -104.74, 23.26 301.97, 101.16 -61.7, -5.65 in-in in 8.6417 Saltbr-in 3.0209 HRD-in -66.75, -41.48 62.82, -7.14 in-in-in SNCiii in-in ActLoopNT-in 2.7887 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.86, 117.91 APE9-dihe-in -126.99, 135.18 APE8-dihe-in -74.97, 82.99 APE8-rot-na 39.67 APE67-dihe-in -53.8, -21.73 -47.34, -52.41 APE12-dist-na 11.8591 APE11-dist-na 10.8637 APE10-dist-na 10.6303 APE9-dist-in 6.9107 None None None XRAY 3.1 0.202 0.249 A 327.0 306.0 0 30 30 0 [[712, 970]] 1.0 2j6m Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITPA P00533 697 1018 1210.0 AEE:2019 Type1 Active DFGin 5.8623 14.6457 BLAminus -129.98, -162.9 59.16, 79.47 -92.61, 9.17 298.14, 95.91 -39.72, -19.96 in-in in 8.0749 Saltbr-in 2.9674 HRD-in -64.35, -49.17 69.51, 1.0 in-in-in SNCiii in-in ActLoopNT-in 2.9122 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.58, 125.89 APE9-dihe-in -133.11, 143.15 APE8-dihe-in -86.75, 111.19 APE8-rot-na 34.96 APE67-dihe-in -68.3, -8.64 -72.28, -40.19 APE12-dist-na 11.8748 APE11-dist-na 10.343 APE10-dist-na 11.0004 APE9-dist-in 6.7005 G719S None None XRAY 2.74 0.2 0.255 A 327.0 305.0 0 30 30 0 [[712, 970]] 1.0 2itp Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITTA P00533 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.9357 14.9648 BLAminus -130.73, -162.83 54.09, 78.3 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.3678 Saltbr-in 2.8668 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.8205 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4932 L858R None None XRAY 2.73 0.212 0.262 A 327.0 302.0 9 30 21 9 [[712, 970]] 1.0 2itt Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: AEE

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name