Ligand: 919 (Rebastinib)

Total number of chains: 11
Active chains: 0
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 9 81.8% 3QRJB
DFGout None 2 18.2% 5G6VB

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK16 CDK16_HUMAN 5G6VA Q00536 163 474 496.0 919:61475 Type2 Inactive DFGout 14.197 9.592 BBAminus -121.31, 168.89 -135.99, 99.11 -71.7, -18.89 281.11, 104.22 81.3, -120.31 in-in in 8.6104 Saltbr-in 2.6336 HRD-in -70.2, -56.21 78.25, -5.64 in-out-out SNCioo out-out ActLoopNT-out 18.4004 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -97.04, 112.11 APE9-dihe-na -121.65, 12.66 APE8-dihe-out -41.77, -45.44 APE8-rot-in 308.9 APE67-dihe-in -49.91, -30.99 -101.95, -17.17 APE12-dist-in 12.5547 APE11-dist-out 14.3176 APE10-dist-out 12.8314 APE9-dist-out 11.3069 S319D None None XRAY 2.2 0.211 0.271 A 324.0 307.0 5 28 23 5 [[165, 446]] 1.0 5g6v CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC CDK16 CDK16_HUMAN 5G6VB Q00536 163 475 496.0 919:61475 Type2 Inactive DFGout 14.7022 10.3484 None -133.8, 175.0 -147.55, 99.49 -161.85, 159.42 69.16, 120.87 -118.14, 117.72 in-in in 8.8188 Saltbr-in 2.7269 HRD-in -62.7, -57.87 75.37, 3.15 in-out-out SNCioo out-out ActLoopNT-out 23.3281 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.32 APE8-dihe-out -33.08, -72.64 APE8-rot-in 304.04 APE67-dihe-in -60.88, -29.71 -104.87, 15.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.511 S319D None None XRAY 2.2 0.211 0.271 B 324.0 301.0 12 28 16 12 [[165, 446]] 1.0 5g6v CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC PRP4K PRP4K_HUMAN 6CNHA Q13523 657 1005 1007.0 919:61101 Type2 Inactive DFGout 13.8726 9.6874 None -146.22, 178.88 -148.9, 133.4 -113.52, 999.0 289.34, 105.17 999.0, 999.0 in-in in 8.7431 Saltbr-in 2.7285 HRD-in -76.45, -58.34 75.69, 1.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -69.49 APE9-dihe-na -64.24, -27.34 APE8-dihe-out -53.85, -35.73 APE8-rot-in 287.32 APE67-dihe-in -65.75, -22.29 -59.96, -34.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7999 None None None XRAY 2.0 0.183 0.206 A 351.0 319.0 21 26 12 14 [[687, 1003]] 1.0 6cnh CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
TKL LRRK2 LRRK2_HUMAN 8U8BA Q5S007 558 2527 2527.0 919:2602 Type2 Inactive DFGout 14.9848 10.7673 BBAminus -149.25, 136.17 -99.76, 91.29 -52.15, -10.61 276.36, 113.64 76.74, 3.44 in-out in 9.1775 Saltbr-out 4.7045 HRD-out -74.73, -14.63 57.07, -112.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -110.86 APE8-dihe-in -64.22, 146.58 APE8-rot-out 61.38 APE67-dihe-in -67.91, -38.53 -58.15, -35.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.1562 None None None EM 3.7 999.0 999.0 A 2527.0 1712.0 29 26 13 13 [[1875, 2134]] 1.0 8u8b TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8U8BB Q5S007 558 2527 2527.0 919:2602 Type2 Inactive DFGout 15.1337 10.7613 BBAminus -149.27, 136.01 -99.86, 91.22 -52.2, -10.44 276.32, 113.8 76.86, 3.6 in-out in 9.1521 Saltbr-out 4.659 HRD-out -74.69, -14.68 57.08, -112.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -110.92 APE8-dihe-in -64.16, 146.68 APE8-rot-out 61.4 APE67-dihe-in -67.92, -38.48 -58.09, -35.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.1489 None None None EM 3.7 999.0 999.0 B 2527.0 1712.0 29 26 13 13 [[1875, 2134]] 1.0 8u8b TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TYR ABL1 ABL1_HUMAN 3QRJA P00519 234 496 1130.0 919:2 Type2 Inactive DFGout 13.1495 8.9896 BBAminus -140.1, 177.46 -140.75, 104.13 -86.94, 4.73 283.88, 85.78 63.32, 48.64 in-in in 7.6735 Saltbr-in 2.7754 HRD-in -79.02, -49.06 80.26, -14.09 in-out-in SNCioi out-in ActLoopNT-out 14.9879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.38, 130.47 APE9-dihe-in -139.16, 150.69 APE8-dihe-in -78.39, 79.63 APE8-rot-na 34.62 APE67-dihe-in -72.48, -9.29 -46.12, -53.19 APE12-dist-na 18.622 APE11-dist-na 15.6447 APE10-dist-na 10.8448 APE9-dist-in 7.3579 T315I None None XRAY 1.82 0.232 0.286 A 277.0 258.0 5 29 29 0 [[242, 495]] 1.0 3qrj TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3QRJB P00519 233 497 1130.0 919:1 Type2 Inactive DFGout 13.1286 9.0788 BBAminus -139.41, 169.11 -133.48, 106.22 -82.14, 0.45 283.14, 89.48 61.09, 48.15 in-in in 7.9313 Saltbr-in 2.7953 HRD-in -78.78, -56.83 82.44, -6.52 in-out-in SNCioi out-in ActLoopNT-out 15.1049 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.29, 121.26 APE9-dihe-in -134.93, 153.91 APE8-dihe-in -77.7, 85.51 APE8-rot-na 33.76 APE67-dihe-in -63.53, -18.09 -55.44, -46.47 APE12-dist-na 18.6564 APE11-dist-na 15.3761 APE10-dist-na 10.8226 APE9-dist-in 7.7219 T315I None None XRAY 1.82 0.232 0.286 B 277.0 265.0 0 29 29 0 [[242, 495]] 1.0 3qrj TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3QRIA P00519 229 498 1130.0 919:60500 Type2 Inactive DFGout 13.4048 9.244 BBAminus -140.23, -177.67 -143.73, 111.06 -85.62, -1.21 285.71, 95.83 64.84, 45.13 in-in in 7.938 Saltbr-in 2.6713 HRD-in -68.59, -54.98 84.86, -16.08 in-out-in SNCioi out-in ActLoopNT-out 15.3297 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.68, 128.64 APE9-dihe-in -141.86, 154.54 APE8-dihe-in -79.64, 85.81 APE8-rot-na 26.51 APE67-dihe-in -72.47, -7.02 -44.71, -48.72 APE12-dist-na 18.4987 APE11-dist-na 15.5857 APE10-dist-na 10.7258 APE9-dist-in 7.4255 None None None XRAY 2.1 0.216 0.272 A 277.0 270.0 0 29 29 0 [[242, 495]] 1.0 3qri TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3QRIB P00519 232 498 1130.0 919:60002 Type2 Inactive DFGout 13.3944 9.3548 BBAminus -137.99, -177.06 -143.59, 113.56 -88.43, -2.03 287.13, 98.7 64.72, 47.42 in-in in 7.8509 Saltbr-in 2.8565 HRD-in -75.25, -51.53 85.01, -17.97 in-out-in SNCioi out-in ActLoopNT-out 15.3271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.54, 128.19 APE9-dihe-in -140.43, 156.29 APE8-dihe-in -80.95, 78.25 APE8-rot-na 29.21 APE67-dihe-in -73.74, -7.02 -42.67, -45.53 APE12-dist-na 18.487 APE11-dist-na 15.5621 APE10-dist-na 10.7895 APE9-dist-in 7.4803 None None None XRAY 2.1 0.216 0.272 B 277.0 262.0 5 29 29 0 [[242, 495]] 1.0 3qri TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR TEK TIE2_HUMAN 6MWEA Q02763 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.3535 10.6059 BBAminus -139.56, 179.54 -155.41, 121.99 -100.36, 10.81 282.44, 103.03 91.89, 0.35 in-in in 7.5591 Saltbr-in 2.4825 HRD-in -71.19, -54.67 81.44, -10.36 in-out-out SNCioo out-out ActLoopNT-out 10.5425 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.4, -5.72 APE9-dihe-out -57.22, -41.43 APE8-dihe-out -59.21, -21.01 APE8-rot-na 337.82 APE67-dihe-in -71.75, -11.24 -48.45, -35.17 APE12-dist-na 11.3805 APE11-dist-na 8.608 APE10-dist-na 12.5606 APE9-dist-out 10.785 None None None XRAY 2.05 0.149 0.166 A 317.0 292.0 15 27 25 2 [[824, 1094]] 1.0 6mwe TYR_TEK_HUMAN TYR 7.5e-91 310.0 1.0 260.0 260.0 981 982 983 985 987 855 872 876 961 963 962 964.0 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 6MWEB Q02763 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.3959 10.5044 BBAminus -136.71, -178.85 -151.95, 121.17 -94.08, 7.28 284.75, 97.66 92.39, -1.76 in-in in 7.559 Saltbr-in 2.5849 HRD-in -68.95, -51.62 79.52, -11.84 in-out-out SNCioo out-out ActLoopNT-out 10.4156 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.44, -0.78 APE9-dihe-out -58.14, -40.06 APE8-dihe-out -58.25, -21.33 APE8-rot-na 337.67 APE67-dihe-in -69.06, -11.94 -47.55, -40.23 APE12-dist-na 10.9599 APE11-dist-na 7.9391 APE10-dist-na 11.8184 APE9-dist-out 10.9023 None None None XRAY 2.05 0.149 0.166 B 317.0 290.0 17 27 24 3 [[824, 1094]] 1.0 6mwe TYR_TEK_HUMAN TYR 7.5e-91 310.0 1.0 260.0 260.0 981 982 983 985 987 855 872 876 961 963 962 964.0 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor

Ligand: 919 (Rebastinib)

Total number of chains: 11
Active chains: 0
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 9 81.8% 3QRJB
DFGout None 2 18.2% 5G6VB

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK16 CDK16_HUMAN 5G6VA Q00536 163 474 496.0 919:61475 Type2 Inactive DFGout 14.197 9.592 BBAminus -121.31, 168.89 -135.99, 99.11 -71.7, -18.89 281.11, 104.22 81.3, -120.31 in-in in 8.6104 Saltbr-in 2.6336 HRD-in -70.2, -56.21 78.25, -5.64 in-out-out SNCioo out-out ActLoopNT-out 18.4004 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -97.04, 112.11 APE9-dihe-na -121.65, 12.66 APE8-dihe-out -41.77, -45.44 APE8-rot-in 308.9 APE67-dihe-in -49.91, -30.99 -101.95, -17.17 APE12-dist-in 12.5547 APE11-dist-out 14.3176 APE10-dist-out 12.8314 APE9-dist-out 11.3069 S319D None None XRAY 2.2 0.211 0.271 A 324.0 307.0 5 28 23 5 [[165, 446]] 1.0 5g6v Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC CDK16 CDK16_HUMAN 5G6VB Q00536 163 475 496.0 919:61475 Type2 Inactive DFGout 14.7022 10.3484 None -133.8, 175.0 -147.55, 99.49 -161.85, 159.42 69.16, 120.87 -118.14, 117.72 in-in in 8.8188 Saltbr-in 2.7269 HRD-in -62.7, -57.87 75.37, 3.15 in-out-out SNCioo out-out ActLoopNT-out 23.3281 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -26.32 APE8-dihe-out -33.08, -72.64 APE8-rot-in 304.04 APE67-dihe-in -60.88, -29.71 -104.87, 15.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.511 S319D None None XRAY 2.2 0.211 0.271 B 324.0 301.0 12 28 16 12 [[165, 446]] 1.0 5g6v Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC PRP4K PRP4K_HUMAN 6CNHA Q13523 657 1005 1007.0 919:61101 Type2 Inactive DFGout 13.8726 9.6874 None -146.22, 178.88 -148.9, 133.4 -113.52, 999.0 289.34, 105.17 999.0, 999.0 in-in in 8.7431 Saltbr-in 2.7285 HRD-in -76.45, -58.34 75.69, 1.93 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -69.49 APE9-dihe-na -64.24, -27.34 APE8-dihe-out -53.85, -35.73 APE8-rot-in 287.32 APE67-dihe-in -65.75, -22.29 -59.96, -34.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7999 None None None XRAY 2.0 0.183 0.206 A 351.0 319.0 21 26 12 14 [[687, 1003]] 1.0 6cnh Homo sapiens CMGC_PRP4K_HUMAN CMGC 4.2e-82 281.6 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
TKL LRRK2 LRRK2_HUMAN 8U8BA Q5S007 558 2527 2527.0 919:2602 Type2 Inactive DFGout 14.9848 10.7673 BBAminus -149.25, 136.17 -99.76, 91.29 -52.15, -10.61 276.36, 113.64 76.74, 3.44 in-out in 9.1775 Saltbr-out 4.7045 HRD-out -74.73, -14.63 57.07, -112.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -110.86 APE8-dihe-in -64.22, 146.58 APE8-rot-out 61.38 APE67-dihe-in -67.91, -38.53 -58.15, -35.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.1562 None None None EM 3.7 999.0 999.0 A 2527.0 1712.0 29 26 13 13 [[1875, 2134]] 1.0 8u8b Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8U8BB Q5S007 558 2527 2527.0 919:2602 Type2 Inactive DFGout 15.1337 10.7613 BBAminus -149.27, 136.01 -99.86, 91.22 -52.2, -10.44 276.32, 113.8 76.86, 3.6 in-out in 9.1521 Saltbr-out 4.659 HRD-out -74.69, -14.68 57.08, -112.62 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -110.92 APE8-dihe-in -64.16, 146.68 APE8-rot-out 61.4 APE67-dihe-in -67.92, -38.48 -58.09, -35.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.1489 None None None EM 3.7 999.0 999.0 B 2527.0 1712.0 29 26 13 13 [[1875, 2134]] 1.0 8u8b Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TYR ABL1 ABL1_HUMAN 3QRJA P00519 234 496 1130.0 919:2 Type2 Inactive DFGout 13.1495 8.9896 BBAminus -140.1, 177.46 -140.75, 104.13 -86.94, 4.73 283.88, 85.78 63.32, 48.64 in-in in 7.6735 Saltbr-in 2.7754 HRD-in -79.02, -49.06 80.26, -14.09 in-out-in SNCioi out-in ActLoopNT-out 14.9879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.38, 130.47 APE9-dihe-in -139.16, 150.69 APE8-dihe-in -78.39, 79.63 APE8-rot-na 34.62 APE67-dihe-in -72.48, -9.29 -46.12, -53.19 APE12-dist-na 18.622 APE11-dist-na 15.6447 APE10-dist-na 10.8448 APE9-dist-in 7.3579 T315I None None XRAY 1.82 0.232 0.286 A 277.0 258.0 5 29 29 0 [[242, 495]] 1.0 3qrj Homo sapiens TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3QRJB P00519 233 497 1130.0 919:1 Type2 Inactive DFGout 13.1286 9.0788 BBAminus -139.41, 169.11 -133.48, 106.22 -82.14, 0.45 283.14, 89.48 61.09, 48.15 in-in in 7.9313 Saltbr-in 2.7953 HRD-in -78.78, -56.83 82.44, -6.52 in-out-in SNCioi out-in ActLoopNT-out 15.1049 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.29, 121.26 APE9-dihe-in -134.93, 153.91 APE8-dihe-in -77.7, 85.51 APE8-rot-na 33.76 APE67-dihe-in -63.53, -18.09 -55.44, -46.47 APE12-dist-na 18.6564 APE11-dist-na 15.3761 APE10-dist-na 10.8226 APE9-dist-in 7.7219 T315I None None XRAY 1.82 0.232 0.286 B 277.0 265.0 0 29 29 0 [[242, 495]] 1.0 3qrj Homo sapiens TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3QRIA P00519 229 498 1130.0 919:60500 Type2 Inactive DFGout 13.4048 9.244 BBAminus -140.23, -177.67 -143.73, 111.06 -85.62, -1.21 285.71, 95.83 64.84, 45.13 in-in in 7.938 Saltbr-in 2.6713 HRD-in -68.59, -54.98 84.86, -16.08 in-out-in SNCioi out-in ActLoopNT-out 15.3297 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.68, 128.64 APE9-dihe-in -141.86, 154.54 APE8-dihe-in -79.64, 85.81 APE8-rot-na 26.51 APE67-dihe-in -72.47, -7.02 -44.71, -48.72 APE12-dist-na 18.4987 APE11-dist-na 15.5857 APE10-dist-na 10.7258 APE9-dist-in 7.4255 None None None XRAY 2.1 0.216 0.272 A 277.0 270.0 0 29 29 0 [[242, 495]] 1.0 3qri Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3QRIB P00519 232 498 1130.0 919:60002 Type2 Inactive DFGout 13.3944 9.3548 BBAminus -137.99, -177.06 -143.59, 113.56 -88.43, -2.03 287.13, 98.7 64.72, 47.42 in-in in 7.8509 Saltbr-in 2.8565 HRD-in -75.25, -51.53 85.01, -17.97 in-out-in SNCioi out-in ActLoopNT-out 15.3271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.54, 128.19 APE9-dihe-in -140.43, 156.29 APE8-dihe-in -80.95, 78.25 APE8-rot-na 29.21 APE67-dihe-in -73.74, -7.02 -42.67, -45.53 APE12-dist-na 18.487 APE11-dist-na 15.5621 APE10-dist-na 10.7895 APE9-dist-in 7.4803 None None None XRAY 2.1 0.216 0.272 B 277.0 262.0 5 29 29 0 [[242, 495]] 1.0 3qri Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR TEK TIE2_HUMAN 6MWEA Q02763 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.3535 10.6059 BBAminus -139.56, 179.54 -155.41, 121.99 -100.36, 10.81 282.44, 103.03 91.89, 0.35 in-in in 7.5591 Saltbr-in 2.4825 HRD-in -71.19, -54.67 81.44, -10.36 in-out-out SNCioo out-out ActLoopNT-out 10.5425 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.4, -5.72 APE9-dihe-out -57.22, -41.43 APE8-dihe-out -59.21, -21.01 APE8-rot-na 337.82 APE67-dihe-in -71.75, -11.24 -48.45, -35.17 APE12-dist-na 11.3805 APE11-dist-na 8.608 APE10-dist-na 12.5606 APE9-dist-out 10.785 None None None XRAY 2.05 0.149 0.166 A 317.0 292.0 15 27 25 2 [[824, 1094]] 1.0 6mwe Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1.0 260.0 260.0 981 982 983 985 987 855 872 876 961 963 962 964.0 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 6MWEB Q02763 816 1122 1124.0 919:1203 Type2 Inactive DFGout 13.3959 10.5044 BBAminus -136.71, -178.85 -151.95, 121.17 -94.08, 7.28 284.75, 97.66 92.39, -1.76 in-in in 7.559 Saltbr-in 2.5849 HRD-in -68.95, -51.62 79.52, -11.84 in-out-out SNCioo out-out ActLoopNT-out 10.4156 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -91.44, -0.78 APE9-dihe-out -58.14, -40.06 APE8-dihe-out -58.25, -21.33 APE8-rot-na 337.67 APE67-dihe-in -69.06, -11.94 -47.55, -40.23 APE12-dist-na 10.9599 APE11-dist-na 7.9391 APE10-dist-na 11.8184 APE9-dist-out 10.9023 None None None XRAY 2.05 0.149 0.166 B 317.0 290.0 17 27 24 3 [[824, 1094]] 1.0 6mwe Homo sapiens TYR_TEK_HUMAN TYR 7.5e-91 310.0 1.0 260.0 260.0 981 982 983 985 987 855 872 876 961 963 962 964.0 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor

Ligand: 919 (Rebastinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name