Ligand: 8QW (Empesertib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 5N9SA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
OTHER TTK TTK_HUMAN 6TNBA 2.65 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnno 8QW Type1.5_Front 517 - 794 0 TPO686 None Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 5N9SA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_oooo 8QW Type1.5_Front 519 - 794 0 TPO686 None Dual specificity protein kinase TTK

Ligand: 8QW (Empesertib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 100.0% 5N9SA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER TTK TTK_HUMAN 6TNBA 2.65 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_nnno 8QW Type1.5_Front 517 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens
OTHER TTK TTK_HUMAN 5N9SA 2.3 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaini APEdist_oooo 8QW Type1.5_Front 519 - 794 0 TPO686 None Dual specificity protein kinase TTK Homo sapiens

Ligand: 8QW (Empesertib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism