Ligand: 8BS

Total number of chains: 11
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 5 45.5% 6Z4DB
DFGin BLBtrans 3 27.3% 6Z4DA
DFGin BLBminus 1 9.1% 7JXIC
DFGin None 1 9.1% 7JXIB
DFGout BBAminus 1 9.1% 5UGCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 7JXIC P00533 700 1007 1210.0 8BS:1101 Type1 Inactive DFGin 7.1768 14.4109 BLBminus -132.91, 172.84 59.41, 71.0 -110.11, -162.74 349.91, 78.05 63.69, 999.0 out-out out 13.5132 Saltbr-out 12.4902 HRD-in -66.45, -56.15 77.12, -7.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.52 APE8-dihe-in -79.96, 70.34 APE8-rot-na 30.69 APE67-dihe-in -73.05, -5.2 -53.29, -45.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5326 T790M,V948R None None XRAY 3.0 0.278 0.312 C 331.0 283.0 21 30 12 18 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKA P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.8625 14.8244 BLBplus -134.12, 169.24 58.43, 39.5 -93.7, 161.51 49.25, 87.25 75.0, 16.23 out-out out 13.7778 Saltbr-out 10.4611 HRD-in -66.55, -57.53 81.35, -6.11 out-out-none SNCoon out-none ActLoopNT-out 8.8163 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.68 APE8-dihe-in -81.09, 70.58 APE8-rot-na 30.58 APE67-dihe-in -73.21, -4.24 -54.1, -46.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4886 T790M,V948R None None XRAY 3.1 0.223 0.261 A 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKC P00533 701 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.5028 14.594 BLBplus -134.13, 170.52 59.34, 39.88 -92.58, 159.61 51.08, 87.14 75.55, 20.71 out-out out 13.6078 Saltbr-out 11.9254 HRD-in -66.31, -58.5 79.98, -6.68 out-out-none SNCoon out-none ActLoopNT-out 8.4402 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.55 APE8-dihe-in -81.28, 70.99 APE8-rot-na 30.58 APE67-dihe-in -73.05, -5.14 -53.98, -44.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4444 T790M,V948R None None XRAY 3.1 0.223 0.261 C 331.0 292.0 15 30 15 15 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKE P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.8927 14.4875 BLBplus -134.7, 170.02 59.73, 38.84 -95.72, 161.23 49.85, 87.39 75.41, 21.47 out-out out 13.5094 Saltbr-out 11.7833 HRD-in -66.69, -59.11 80.54, -6.15 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.43 APE8-dihe-in -79.83, 71.88 APE8-rot-na 29.74 APE67-dihe-in -73.96, -4.52 -53.36, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5344 T790M,V948R None None XRAY 3.1 0.223 0.261 E 331.0 287.0 16 30 14 16 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKF P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.8717 14.3868 BLBplus -134.77, 169.91 59.08, 39.36 -94.94, 160.87 49.89, 87.34 75.14, 17.06 out-out out 13.5278 Saltbr-out 12.787 HRD-in -66.88, -58.5 80.33, -5.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.79 APE8-dihe-in -81.39, 71.1 APE8-rot-na 29.52 APE67-dihe-in -73.84, -5.2 -54.64, -45.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4784 T790M,V948R None None XRAY 3.1 0.223 0.261 F 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6Z4DB P00533 700 984 1210.0 8BS:1101,57N:1102 Type1,Type3 Inactive DFGin 5.2156 14.7595 BLBplus -130.83, 169.9 60.42, 43.34 -92.85, 149.61 47.56, 91.66 72.77, 15.07 out-none out 13.4584 Saltbr-none 999.0 HRD-in -75.42, -54.52 82.84, -20.67 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 176.11 APE9-dihe-in -119.54, 129.26 APE8-dihe-in -76.04, 63.14 APE8-rot-na 30.86 APE67-dihe-in -72.75, -5.66 -53.62, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.6746 APE9-dist-out 8.425 T790M,V948R None None XRAY 2.0 0.195 0.221 B 333.0 270.0 15 30 15 15 [[712, 970]] 1.0 6z4d TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXIA P00533 700 1006 1210.0 8BS:1101 Type1 Inactive DFGin 6.0024 16.5386 BLBtrans -128.56, -179.35 55.18, 20.34 -72.14, 105.08 161.03, 82.24 -164.24, -136.24 out-out out 13.3568 Saltbr-out 11.3801 HRD-in -66.93, -56.02 77.07, -6.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.19 APE8-dihe-in -80.02, 70.1 APE8-rot-na 30.7 APE67-dihe-in -73.23, -5.24 -53.52, -45.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4787 T790M,V948R None None XRAY 3.0 0.278 0.312 A 331.0 290.0 17 30 13 17 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXID P00533 702 1006 1210.0 8BS:1101 Type1 Inactive DFGin 5.4069 16.2574 BLBtrans -129.42, 179.04 50.18, 64.39 -110.41, 142.47 148.26, 80.05 85.73, -1.43 out-out out 13.403 Saltbr-out 12.5958 HRD-in -71.0, -57.45 77.99, -6.63 out-out-none SNCoon out-none ActLoopNT-out 9.2227 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.12 APE8-dihe-in -80.19, 70.22 APE8-rot-na 30.77 APE67-dihe-in -72.81, -5.27 -53.35, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3831 T790M,V948R None None XRAY 3.0 0.278 0.312 D 331.0 289.0 16 30 17 13 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6Z4DA P00533 701 984 1210.0 8BS:1101 Type1 Inactive DFGin 5.582 16.9114 BLBtrans -114.92, 175.53 65.11, 24.14 -66.3, 140.38 162.98, 75.92 74.11, -7.31 out-out out 14.2152 Saltbr-out 12.8265 HRD-in -79.35, -52.49 82.58, -13.07 out-out-out SNCooo out-out ActLoopNT-out 7.154 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.13 APE8-dihe-in -73.43, 66.21 APE8-rot-na 29.65 APE67-dihe-in -74.75, -4.91 -55.02, -43.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3163 T790M,V948R None None XRAY 2.0 0.195 0.221 A 333.0 269.0 15 30 17 13 [[712, 970]] 1.0 6z4d TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXIB P00533 702 1004 1210.0 8BS:1101 Type1 Inactive DFGin 4.6415 14.267 None -127.65, -24.47 -127.47, 108.69 -144.39, 139.56 46.55, 108.56 -178.57, -134.7 out-out out 13.4169 Saltbr-out 12.2007 HRD-in -66.29, -55.89 76.11, -7.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.37 APE8-dihe-in -80.39, 70.42 APE8-rot-na 30.87 APE67-dihe-in -73.29, -5.7 -53.51, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5111 T790M,V948R None None XRAY 3.0 0.278 0.312 B 331.0 274.0 25 30 13 17 [[712, 970]] 1.0 7jxi TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5UGCA P00533 702 985 1210.0 8BS:9001 Type1 Inactive DFGout 14.396 8.2625 BBAminus -131.19, 172.02 -138.19, 139.68 -122.92, 19.28 287.71, 102.44 122.8, -6.46 out-out out 13.4183 Saltbr-out 10.8291 HRD-in -75.41, -48.99 67.88, 4.79 out-in-in SNCoii in-in ActLoopNT-in 2.8112 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.27, 140.43 APE9-dihe-in -121.9, 140.0 APE8-dihe-in -80.12, 76.64 APE8-rot-na 31.38 APE67-dihe-in -74.2, -5.62 -50.31, -42.01 APE12-dist-na 12.0069 APE11-dist-na 8.9048 APE10-dist-na 10.2302 APE9-dist-in 6.8809 T790M,L858R,V948R None None XRAY 1.58 0.201 0.223 A 329.0 280.0 4 30 30 0 [[712, 970]] 1.0 5ugc TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 8BS

Total number of chains: 11
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 5 45.5% 6Z4DB
DFGin BLBtrans 3 27.3% 6Z4DA
DFGin BLBminus 1 9.1% 7JXIC
DFGin None 1 9.1% 7JXIB
DFGout BBAminus 1 9.1% 5UGCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 7JXIC P00533 700 1007 1210.0 8BS:1101 Type1 Inactive DFGin 7.1768 14.4109 BLBminus -132.91, 172.84 59.41, 71.0 -110.11, -162.74 349.91, 78.05 63.69, 999.0 out-out out 13.5132 Saltbr-out 12.4902 HRD-in -66.45, -56.15 77.12, -7.0 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.52 APE8-dihe-in -79.96, 70.34 APE8-rot-na 30.69 APE67-dihe-in -73.05, -5.2 -53.29, -45.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5326 T790M,V948R None None XRAY 3.0 0.278 0.312 C 331.0 283.0 21 30 12 18 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKA P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.8625 14.8244 BLBplus -134.12, 169.24 58.43, 39.5 -93.7, 161.51 49.25, 87.25 75.0, 16.23 out-out out 13.7778 Saltbr-out 10.4611 HRD-in -66.55, -57.53 81.35, -6.11 out-out-none SNCoon out-none ActLoopNT-out 8.8163 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.68 APE8-dihe-in -81.09, 70.58 APE8-rot-na 30.58 APE67-dihe-in -73.21, -4.24 -54.1, -46.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4886 T790M,V948R None None XRAY 3.1 0.223 0.261 A 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKC P00533 701 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.5028 14.594 BLBplus -134.13, 170.52 59.34, 39.88 -92.58, 159.61 51.08, 87.14 75.55, 20.71 out-out out 13.6078 Saltbr-out 11.9254 HRD-in -66.31, -58.5 79.98, -6.68 out-out-none SNCoon out-none ActLoopNT-out 8.4402 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.55 APE8-dihe-in -81.28, 70.99 APE8-rot-na 30.58 APE67-dihe-in -73.05, -5.14 -53.98, -44.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4444 T790M,V948R None None XRAY 3.1 0.223 0.261 C 331.0 292.0 15 30 15 15 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKE P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.8927 14.4875 BLBplus -134.7, 170.02 59.73, 38.84 -95.72, 161.23 49.85, 87.39 75.41, 21.47 out-out out 13.5094 Saltbr-out 11.7833 HRD-in -66.69, -59.11 80.54, -6.15 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.43 APE8-dihe-in -79.83, 71.88 APE8-rot-na 29.74 APE67-dihe-in -73.96, -4.52 -53.36, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5344 T790M,V948R None None XRAY 3.1 0.223 0.261 E 331.0 287.0 16 30 14 16 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKF P00533 700 1007 1210.0 8BS:1101,JBJ:1102 Type1,Type3 Inactive DFGin 4.8717 14.3868 BLBplus -134.77, 169.91 59.08, 39.36 -94.94, 160.87 49.89, 87.34 75.14, 17.06 out-out out 13.5278 Saltbr-out 12.787 HRD-in -66.88, -58.5 80.33, -5.79 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.79 APE8-dihe-in -81.39, 71.1 APE8-rot-na 29.52 APE67-dihe-in -73.84, -5.2 -54.64, -45.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4784 T790M,V948R None None XRAY 3.1 0.223 0.261 F 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6Z4DB P00533 700 984 1210.0 8BS:1101,57N:1102 Type1,Type3 Inactive DFGin 5.2156 14.7595 BLBplus -130.83, 169.9 60.42, 43.34 -92.85, 149.61 47.56, 91.66 72.77, 15.07 out-none out 13.4584 Saltbr-none 999.0 HRD-in -75.42, -54.52 82.84, -20.67 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 176.11 APE9-dihe-in -119.54, 129.26 APE8-dihe-in -76.04, 63.14 APE8-rot-na 30.86 APE67-dihe-in -72.75, -5.66 -53.62, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.6746 APE9-dist-out 8.425 T790M,V948R None None XRAY 2.0 0.195 0.221 B 333.0 270.0 15 30 15 15 [[712, 970]] 1.0 6z4d Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXIA P00533 700 1006 1210.0 8BS:1101 Type1 Inactive DFGin 6.0024 16.5386 BLBtrans -128.56, -179.35 55.18, 20.34 -72.14, 105.08 161.03, 82.24 -164.24, -136.24 out-out out 13.3568 Saltbr-out 11.3801 HRD-in -66.93, -56.02 77.07, -6.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.19 APE8-dihe-in -80.02, 70.1 APE8-rot-na 30.7 APE67-dihe-in -73.23, -5.24 -53.52, -45.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4787 T790M,V948R None None XRAY 3.0 0.278 0.312 A 331.0 290.0 17 30 13 17 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXID P00533 702 1006 1210.0 8BS:1101 Type1 Inactive DFGin 5.4069 16.2574 BLBtrans -129.42, 179.04 50.18, 64.39 -110.41, 142.47 148.26, 80.05 85.73, -1.43 out-out out 13.403 Saltbr-out 12.5958 HRD-in -71.0, -57.45 77.99, -6.63 out-out-none SNCoon out-none ActLoopNT-out 9.2227 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.12 APE8-dihe-in -80.19, 70.22 APE8-rot-na 30.77 APE67-dihe-in -72.81, -5.27 -53.35, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3831 T790M,V948R None None XRAY 3.0 0.278 0.312 D 331.0 289.0 16 30 17 13 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6Z4DA P00533 701 984 1210.0 8BS:1101 Type1 Inactive DFGin 5.582 16.9114 BLBtrans -114.92, 175.53 65.11, 24.14 -66.3, 140.38 162.98, 75.92 74.11, -7.31 out-out out 14.2152 Saltbr-out 12.8265 HRD-in -79.35, -52.49 82.58, -13.07 out-out-out SNCooo out-out ActLoopNT-out 7.154 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.13 APE8-dihe-in -73.43, 66.21 APE8-rot-na 29.65 APE67-dihe-in -74.75, -4.91 -55.02, -43.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3163 T790M,V948R None None XRAY 2.0 0.195 0.221 A 333.0 269.0 15 30 17 13 [[712, 970]] 1.0 6z4d Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXIB P00533 702 1004 1210.0 8BS:1101 Type1 Inactive DFGin 4.6415 14.267 None -127.65, -24.47 -127.47, 108.69 -144.39, 139.56 46.55, 108.56 -178.57, -134.7 out-out out 13.4169 Saltbr-out 12.2007 HRD-in -66.29, -55.89 76.11, -7.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.37 APE8-dihe-in -80.39, 70.42 APE8-rot-na 30.87 APE67-dihe-in -73.29, -5.7 -53.51, -46.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5111 T790M,V948R None None XRAY 3.0 0.278 0.312 B 331.0 274.0 25 30 13 17 [[712, 970]] 1.0 7jxi Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5UGCA P00533 702 985 1210.0 8BS:9001 Type1 Inactive DFGout 14.396 8.2625 BBAminus -131.19, 172.02 -138.19, 139.68 -122.92, 19.28 287.71, 102.44 122.8, -6.46 out-out out 13.4183 Saltbr-out 10.8291 HRD-in -75.41, -48.99 67.88, 4.79 out-in-in SNCoii in-in ActLoopNT-in 2.8112 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.27, 140.43 APE9-dihe-in -121.9, 140.0 APE8-dihe-in -80.12, 76.64 APE8-rot-na 31.38 APE67-dihe-in -74.2, -5.62 -50.31, -42.01 APE12-dist-na 12.0069 APE11-dist-na 8.9048 APE10-dist-na 10.2302 APE9-dist-in 6.8809 T790M,L858R,V948R None None XRAY 1.58 0.201 0.223 A 329.0 280.0 4 30 30 0 [[712, 970]] 1.0 5ugc Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-87 297.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 8BS

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name