Ligand: 35R

Total number of chains: 8
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 4 50.0% 5UT0A
DFGin BLAminus 2 25.0% 4QMMA
DFGinter None 2 25.0% 6CPGD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_HUMAN 5N23A P17612 9 351 351.0 35R:60401 Type1 Active DFGin 5.4212 13.8637 BLAminus -109.83, 165.02 72.7, 94.27 -97.78, 24.01 286.85, 71.32 -58.73, -25.18 in-in in 9.4998 Saltbr-in 2.9266 HRD-in -90.99, -49.74 71.93, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.8779 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.89, 153.96 APE9-dihe-na 137.51, -163.29 APE8-dihe-in -116.51, 133.79 APE8-rot-in 303.7 APE67-dihe-in -56.98, -24.74 -46.64, -52.33 APE12-dist-in 8.0559 APE11-dist-in 11.5849 APE10-dist-in 5.9451 APE9-dist-in 3.6536 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.088 0.192 0.239 A 352.0 337.0 0 25 25 0 [[44, 298]] 1.0 5n23 AGC_PRKACA_HUMAN AGC 5.3e-93 316.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK AURKA AURKA_HUMAN 6CPGA O14965 127 387 403.0 35R:501 Type1 Inactive DFGinter 6.711 9.4851 None -140.02, 96.03 -108.44, 103.16 -141.15, -67.9 302.74, 112.44 175.19, -125.6 out-out out 12.4294 Saltbr-out 10.9407 HRD-out 55.39, 71.59 -104.21, 123.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -80.02 APE9-dihe-na 97.77, -146.55 APE8-dihe-out -62.97, -12.48 APE8-rot-none 999.0 APE67-dihe-in -58.41, -29.26 -54.85, -41.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0413 APE9-dist-out 13.6566 None None None XRAY 2.8 0.285 0.335 A 285.0 249.0 12 26 14 12 [[133, 383]] 1.0 6cpg CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGD O14965 127 388 403.0 35R:501 Type1 Inactive DFGinter 6.4037 9.7723 None -125.89, 77.36 -98.94, 84.58 -127.68, 52.17 302.92, 103.94 97.64, -149.27 out-out out 11.6201 Saltbr-out 12.7753 HRD-out 61.84, 98.64 -116.43, 122.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -115.97, 178.85 APE9-dihe-na -115.52, -132.49 APE8-dihe-out -76.59, 1.28 APE8-rot-out 68.27 APE67-dihe-in -65.85, -12.72 -75.15, -27.74 APE12-dist-none 999.0 APE11-dist-out 19.3876 APE10-dist-out 16.4598 APE9-dist-out 14.8298 None None None XRAY 2.8 0.285 0.335 D 285.0 252.0 10 26 16 10 [[133, 383]] 1.0 6cpg CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
STE STK24 STK24_HUMAN 4QMMA Q9Y6E0 18 309 443.0 35R:60401 Type1 Active DFGin 6.4563 14.8686 BLAminus -136.1, 172.57 56.6, 85.7 -97.18, 29.33 287.89, 78.12 -60.54, -24.23 in-in in 9.0347 Saltbr-in 2.7262 HRD-in -73.78, -49.7 70.31, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.8063 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.74, 158.6 APE9-dihe-na 131.64, -167.88 APE8-dihe-in -113.08, 118.53 APE8-rot-in 307.24 APE67-dihe-in -61.4, -26.15 -38.81, -50.43 APE12-dist-in 8.458 APE11-dist-in 10.8934 APE10-dist-in 5.0773 APE9-dist-in 3.2961 None TPO190 TPO190 XRAY 1.852 0.141 0.198 A 310.0 289.0 0 28 28 0 [[36, 286]] 1.0 4qmm STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR JAK2-1 JAK2_HUMAN 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.5522 13.6514 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.6393 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7002 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.5196 APE11-dist-na 11.5137 APE10-dist-na 16.3152 APE9-dist-out 13.0189 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.7449 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.4363 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.4489 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.5863 APE11-dist-na 11.8904 APE10-dist-na 16.6501 APE9-dist-out 12.8955 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.7523 13.5845 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.5675 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.8496 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.8326 APE11-dist-na 11.5419 APE10-dist-na 15.898 APE9-dist-out 12.8889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wim TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.5715 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.9387 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.9661 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.0051 APE11-dist-na 11.4779 APE10-dist-na 16.1348 APE9-dist-out 12.9322 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut0 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

Ligand: 35R

Total number of chains: 8
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 4 50.0% 5UT0A
DFGin BLAminus 2 25.0% 4QMMA
DFGinter None 2 25.0% 6CPGD
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_HUMAN 5N23A P17612 9 351 351.0 35R:60401 Type1 Active DFGin 5.4212 13.8637 BLAminus -109.83, 165.02 72.7, 94.27 -97.78, 24.01 286.85, 71.32 -58.73, -25.18 in-in in 9.4998 Saltbr-in 2.9266 HRD-in -90.99, -49.74 71.93, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.8779 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.89, 153.96 APE9-dihe-na 137.51, -163.29 APE8-dihe-in -116.51, 133.79 APE8-rot-in 303.7 APE67-dihe-in -56.98, -24.74 -46.64, -52.33 APE12-dist-in 8.0559 APE11-dist-in 11.5849 APE10-dist-in 5.9451 APE9-dist-in 3.6536 K48R,L96Q,M121L,V124A,Q182K,T184A SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.088 0.192 0.239 A 352.0 337.0 0 25 25 0 [[44, 298]] 1.0 5n23 Homo sapiens AGC_PRKACA_HUMAN AGC 5.3e-93 316.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK AURKA AURKA_HUMAN 6CPGA O14965 127 387 403.0 35R:501 Type1 Inactive DFGinter 6.711 9.4851 None -140.02, 96.03 -108.44, 103.16 -141.15, -67.9 302.74, 112.44 175.19, -125.6 out-out out 12.4294 Saltbr-out 10.9407 HRD-out 55.39, 71.59 -104.21, 123.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -80.02 APE9-dihe-na 97.77, -146.55 APE8-dihe-out -62.97, -12.48 APE8-rot-none 999.0 APE67-dihe-in -58.41, -29.26 -54.85, -41.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.0413 APE9-dist-out 13.6566 None None None XRAY 2.8 0.285 0.335 A 285.0 249.0 12 26 14 12 [[133, 383]] 1.0 6cpg Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGD O14965 127 388 403.0 35R:501 Type1 Inactive DFGinter 6.4037 9.7723 None -125.89, 77.36 -98.94, 84.58 -127.68, 52.17 302.92, 103.94 97.64, -149.27 out-out out 11.6201 Saltbr-out 12.7753 HRD-out 61.84, 98.64 -116.43, 122.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -115.97, 178.85 APE9-dihe-na -115.52, -132.49 APE8-dihe-out -76.59, 1.28 APE8-rot-out 68.27 APE67-dihe-in -65.85, -12.72 -75.15, -27.74 APE12-dist-none 999.0 APE11-dist-out 19.3876 APE10-dist-out 16.4598 APE9-dist-out 14.8298 None None None XRAY 2.8 0.285 0.335 D 285.0 252.0 10 26 16 10 [[133, 383]] 1.0 6cpg Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
STE STK24 STK24_HUMAN 4QMMA Q9Y6E0 18 309 443.0 35R:60401 Type1 Active DFGin 6.4563 14.8686 BLAminus -136.1, 172.57 56.6, 85.7 -97.18, 29.33 287.89, 78.12 -60.54, -24.23 in-in in 9.0347 Saltbr-in 2.7262 HRD-in -73.78, -49.7 70.31, 2.64 in-in-in SNCiii in-in ActLoopNT-in 2.8063 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.74, 158.6 APE9-dihe-na 131.64, -167.88 APE8-dihe-in -113.08, 118.53 APE8-rot-in 307.24 APE67-dihe-in -61.4, -26.15 -38.81, -50.43 APE12-dist-in 8.458 APE11-dist-in 10.8934 APE10-dist-in 5.0773 APE9-dist-in 3.2961 None TPO190 TPO190 XRAY 1.852 0.141 0.198 A 310.0 289.0 0 28 28 0 [[36, 286]] 1.0 4qmm Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
TYR JAK2-1 JAK2_HUMAN 6D2IA O60674 536 808 1132.0 35R:901 Type1 Pseudo DFGin 6.5522 13.6514 None -85.6, -168.64 -71.02, 159.25 -67.8, -19.61 341.93, 32.5 72.61, -145.53 in-na in 9.6393 Saltbr-na 999.0 HRD-in -88.15, -70.56 100.36, -8.76 na-out-out SNCaoo out-out ActLoopNT-out 9.7002 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -69.19, -30.63 APE9-dihe-out -73.76, -13.56 APE8-dihe-out -89.52, 2.58 APE8-rot-na 300.29 APE67-dihe-out -99.98, 28.53 -66.76, 135.82 APE12-dist-na 10.5196 APE11-dist-na 11.5137 APE10-dist-na 16.3152 APE9-dist-out 13.0189 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 A 273.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 6D2IB O60674 537 808 1132.0 35R:901 Type1 Pseudo DFGin 6.7449 13.508 None -83.97, -172.62 -69.78, 158.02 -65.46, -20.62 341.26, 32.34 71.79, -145.54 in-na in 9.4363 Saltbr-na 999.0 HRD-in -84.58, -69.97 97.0, -6.55 na-out-out SNCaoo out-out ActLoopNT-out 9.4489 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.97, -30.79 APE9-dihe-out -72.59, -17.09 APE8-dihe-out -89.77, 2.61 APE8-rot-na 301.92 APE67-dihe-out -99.31, 27.86 -67.19, 135.78 APE12-dist-na 10.5863 APE11-dist-na 11.8904 APE10-dist-na 16.6501 APE9-dist-out 12.8955 W659A,W777A,F794H None None XRAY 3.192 0.272 0.29 B 273.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 6d2i Homo sapiens TYR_JAK2-1_HUMAN TYR 2.9e-64 222.8 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5WIMA O60674 536 809 1132.0 35R:901 Type1 Pseudo DFGin 7.7523 13.5845 None -93.28, 176.5 -38.24, 151.14 -78.63, -21.68 29.2, 149.11 81.15, -169.97 out-na out 10.5675 Saltbr-na 999.0 HRD-in -83.09, -66.39 96.8, 0.86 na-out-out SNCaoo out-out ActLoopNT-out 9.8496 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -105.18, -10.47 APE9-dihe-out -83.98, -20.52 APE8-dihe-out -80.31, 9.26 APE8-rot-na 299.8 APE67-dihe-out -97.29, 28.98 -67.31, 132.23 APE12-dist-na 9.8326 APE11-dist-na 11.5419 APE10-dist-na 15.898 APE9-dist-out 12.8889 W659A,W777A,F794H None None XRAY 2.55 0.211 0.258 A 277.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5wim Homo sapiens TYR_JAK2-1_HUMAN TYR 1.6e-64 223.6 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 5UT0A O60674 537 808 1132.0 35R:903 Type1 Pseudo DFGin 7.594 13.5715 None -93.9, 174.39 -69.93, 155.11 -74.3, -13.06 28.06, 143.5 77.21, -173.63 in-na in 9.9387 Saltbr-na 999.0 HRD-in -83.57, -61.23 99.02, -12.98 na-out-out SNCaoo out-out ActLoopNT-out 9.9661 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -63.47, -40.74 APE9-dihe-out -59.34, -26.03 APE8-dihe-out -86.35, 4.34 APE8-rot-na 287.5 APE67-dihe-out -101.06, 28.12 -64.23, 136.97 APE12-dist-na 10.0051 APE11-dist-na 11.4779 APE10-dist-na 16.1348 APE9-dist-out 12.9322 W659A,W777A,F794H None None XRAY 2.102 0.171 0.226 A 289.0 272.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5ut0 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2

Ligand: 35R

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name