Ligand: 32

Total number of chains: 8
Active chains: 0
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 5 62.5% 4RZVB
DFGin BLBminus 1 12.5% 2BTSA
DFGin BLBplus 1 12.5% 3W32A
DFGin None 1 12.5% 3PTGA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 2BTSA P24941 1 298 298.0 U32:1299 Type1 Inactive DFGin 8.571 15.954 BLBminus -131.25, 144.03 57.41, 68.71 -62.53, 135.6 279.58, 62.82 -80.98, 150.36 out-out out 15.624 Saltbr-out 14.997 HRD-in -78.23, -53.97 79.57, -25.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 156.64 APE8-dihe-in -86.98, 135.56 APE8-rot-in 291.23 APE67-dihe-in -60.1, -28.56 -107.23, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.197 None None None XRAY 1.99 0.216 0.261 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bts CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC MAPK10 MK10_HUMAN 3PTGA P53779 46 401 464.0 932:60001 Type1 Inactive DFGin 3.713 13.158 None -76.5, -95.65 -85.65, -153.0 -174.62, 83.6 38.12, 37.79 -80.26, -75.99 in-in in 8.949 Saltbr-in 2.713 HRD-in -82.38, -47.37 67.19, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -33.68 APE8-dihe-out 167.39, -0.43 APE8-rot-out 180.66 APE67-dihe-in -48.92, -26.13 -62.89, -39.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.804 None None None XRAY 2.43 0.247 0.316 A 363 340 16 0 0 13 [[64, 359]] 1.0 3ptg CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
TKL BRAF BRAF_HUMAN 4RZVA P15056 449 721 766.0 032:801 Type1.5_Back Inactive DFGin 6.623 12.87 BLAplus -130.91, -172.9 60.6, 24.8 -98.53, -10.69 57.76, 91.05 -69.22, 172.66 out-out out 12.644 Saltbr-out 10.258 HRD-in -67.58, -51.33 73.51, -5.96 out-out-out SNCooo out-out ActLoopNT-out 7.109 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -135.17, 121.31 APE9-dihe-na -132.69, 47.25 APE8-dihe-in -116.19, 105.13 APE8-rot-in 306.78 APE67-dihe-in -65.92, -31.75 -100.96, -1.47 APE12-dist-none 999.0 APE11-dist-in 13.566 APE10-dist-out 15.169 APE9-dist-out 10.302 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 A 281 261 12 0 0 12 [[457, 716]] 1.0 4rzv TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4RZVB P15056 449 722 766.0 032:801 Type1.5_Back Inactive DFGin 6.47 12.835 BLAplus -121.2, 178.65 56.71, 36.71 -99.28, -19.01 59.27, 87.57 -68.87, 172.54 out-out out 12.328 Saltbr-out 11.67 HRD-in -71.84, -50.61 63.03, 10.44 out-out-out SNCooo out-out ActLoopNT-out 6.743 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -82.65, 28.28 APE9-dihe-na -100.48, -28.28 APE8-dihe-in -136.49, 95.01 APE8-rot-in 296.61 APE67-dihe-in -55.46, -18.41 -85.27, -21.3 APE12-dist-in 13.178 APE11-dist-in 13.816 APE10-dist-out 18.847 APE9-dist-out 11.166 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 B 281 271 3 0 0 0 [[457, 716]] 1.0 4rzv TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3OG7A P15056 449 720 766.0 032:1 Type1.5_Back Inactive DFGin 5.36 13.446 BLAplus -137.59, -179.01 76.97, 18.21 -89.25, -11.03 54.09, 93.51 -42.45, 999.0 out-out out 11.242 Saltbr-out 8.406 HRD-in -57.13, -46.63 78.91, -15.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -115.54 APE8-dihe-in -81.75, 114.02 APE8-rot-out 53.56 APE67-dihe-in -69.21, -23.46 -108.29, -5.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.262 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 A 289 247 25 0 0 18 [[457, 716]] 1.0 3og7 TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL MAP3K20 M3K20_HUMAN 5HESB Q9NYL2 7 298 800.0 032:401 Type1 Inactive DFGin 6.41 13.023 BLAplus -143.58, 177.64 72.44, 21.16 -87.16, -28.78 42.57, 80.13 -79.68, 999.0 out-out out 13.614 Saltbr-out 12.253 HRD-in -72.66, -57.27 76.35, 0.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -8.17 APE8-dihe-out -112.48, -1.68 APE8-rot-in 299.88 APE67-dihe-in -59.28, -26.85 -56.83, -32.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.611 None TPO161 TPO161 XRAY 2.14 0.18 0.226 B 307 278 14 0 0 14 [[16, 262]] 1.0 5hes TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TKL MAP3K20 M3K20_HUMAN 5HESA Q9NYL2 6 299 800.0 032:401 Type1.5_Back Inactive DFGin 6.508 12.947 BLAplus -149.3, -178.78 72.05, 18.35 -79.29, -13.47 42.54, 81.81 -105.89, 8.43 out-out out 10.327 Saltbr-out 7.91 HRD-in -63.65, -61.5 81.63, -14.81 out-out-out SNCooo out-out ActLoopNT-out 8.531 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.01 APE8-dihe-out -130.74, 34.59 APE8-rot-out 64.32 APE67-dihe-in -59.25, -25.49 -57.81, -30.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.632 None TPO161 TPO161 XRAY 2.14 0.18 0.226 A 307 288 6 0 0 6 [[16, 262]] 1.0 5hes TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TYR EGFR EGFR_HUMAN 3W32A P00533 701 1017 1210.0 W32:1101 Type1.5_Back Inactive DFGin 4.654 13.377 BLBplus -134.93, 174.75 75.62, 15.73 -74.59, 136.0 48.33, 88.42 85.13, 3.49 out-out out 14.094 Saltbr-out 13.598 HRD-in -69.8, -59.18 76.05, -4.36 out-out-in SNCooi out-in ActLoopNT-out 6.242 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.7, 158.18 APE9-dihe-in -131.47, 158.06 APE8-dihe-in -79.68, 77.14 APE8-rot-na 27.77 APE67-dihe-in -73.57, -6.08 -55.16, -38.17 APE12-dist-na 16.516 APE11-dist-na 12.808 APE10-dist-na 13.448 APE9-dist-in 7.197 None None None XRAY 1.8 0.202 0.236 A 330 317 0 0 0 0 [[712, 970]] 1.0 3w32 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 32

Total number of chains: 9
Active chains: 1
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 5 55.6% 4RZVB
DFGin BLAminus 1 11.1% 2OXDA
DFGin BLBminus 1 11.1% 2BTSA
DFGin BLBplus 1 11.1% 3W32A
DFGin None 1 11.1% 3PTGA
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CDK2 CDK2_HUMAN 2BTSA P24941 1 298 298.0 U32:1299 Type1 Inactive DFGin 8.571 15.954 BLBminus -131.25, 144.03 57.41, 68.71 -62.53, 135.6 279.58, 62.82 -80.98, 150.36 out-out out 15.624 Saltbr-out 14.997 HRD-in -78.23, -53.97 79.57, -25.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 156.64 APE8-dihe-in -86.98, 135.56 APE8-rot-in 291.23 APE67-dihe-in -60.1, -28.56 -107.23, -11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.197 None None None XRAY 1.99 0.216 0.261 A 298 274 24 0 0 15 [[4, 286]] 1.0 2bts Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC MAPK10 MK10_HUMAN 3PTGA P53779 46 401 464.0 932:60001 Type1 Inactive DFGin 3.713 13.158 None -76.5, -95.65 -85.65, -153.0 -174.62, 83.6 38.12, 37.79 -80.26, -75.99 in-in in 8.949 Saltbr-in 2.713 HRD-in -82.38, -47.37 67.19, -16.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -33.68 APE8-dihe-out 167.39, -0.43 APE8-rot-out 180.66 APE67-dihe-in -48.92, -26.13 -62.89, -39.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.804 None None None XRAY 2.43 0.247 0.316 A 363 340 16 0 0 13 [[64, 359]] 1.0 3ptg Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
TKL BRAF BRAF_HUMAN 4RZVA P15056 449 721 766.0 032:801 Type1.5_Back Inactive DFGin 6.623 12.87 BLAplus -130.91, -172.9 60.6, 24.8 -98.53, -10.69 57.76, 91.05 -69.22, 172.66 out-out out 12.644 Saltbr-out 10.258 HRD-in -67.58, -51.33 73.51, -5.96 out-out-out SNCooo out-out ActLoopNT-out 7.109 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -135.17, 121.31 APE9-dihe-na -132.69, 47.25 APE8-dihe-in -116.19, 105.13 APE8-rot-in 306.78 APE67-dihe-in -65.92, -31.75 -100.96, -1.47 APE12-dist-none 999.0 APE11-dist-in 13.566 APE10-dist-out 15.169 APE9-dist-out 10.302 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 A 281 261 12 0 0 12 [[457, 716]] 1.0 4rzv Homo sapiens TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4RZVB P15056 449 722 766.0 032:801 Type1.5_Back Inactive DFGin 6.47 12.835 BLAplus -121.2, 178.65 56.71, 36.71 -99.28, -19.01 59.27, 87.57 -68.87, 172.54 out-out out 12.328 Saltbr-out 11.67 HRD-in -71.84, -50.61 63.03, 10.44 out-out-out SNCooo out-out ActLoopNT-out 6.743 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -82.65, 28.28 APE9-dihe-na -100.48, -28.28 APE8-dihe-in -136.49, 95.01 APE8-rot-in 296.61 APE67-dihe-in -55.46, -18.41 -85.27, -21.3 APE12-dist-in 13.178 APE11-dist-in 13.816 APE10-dist-out 18.847 APE9-dist-out 11.166 R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G None None XRAY 2.994 0.207 0.267 B 281 271 3 0 0 0 [[457, 716]] 1.0 4rzv Homo sapiens TKL_BRAF_HUMAN TKL 7.2e-84 287.4 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3OG7A P15056 449 720 766.0 032:1 Type1.5_Back Inactive DFGin 5.36 13.446 BLAplus -137.59, -179.01 76.97, 18.21 -89.25, -11.03 54.09, 93.51 -42.45, 999.0 out-out out 11.242 Saltbr-out 8.406 HRD-in -57.13, -46.63 78.91, -15.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -115.54 APE8-dihe-in -81.75, 114.02 APE8-rot-out 53.56 APE67-dihe-in -69.21, -23.46 -108.29, -5.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.262 K522A,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E None None XRAY 2.45 0.214 0.258 A 289 247 25 0 0 18 [[457, 716]] 1.0 3og7 Homo sapiens TKL_BRAF_HUMAN TKL 1.2e-83 286.6 4 267 264 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL MAP3K20 M3K20_HUMAN 5HESB Q9NYL2 7 298 800.0 032:401 Type1 Inactive DFGin 6.41 13.023 BLAplus -143.58, 177.64 72.44, 21.16 -87.16, -28.78 42.57, 80.13 -79.68, 999.0 out-out out 13.614 Saltbr-out 12.253 HRD-in -72.66, -57.27 76.35, 0.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -8.17 APE8-dihe-out -112.48, -1.68 APE8-rot-in 299.88 APE67-dihe-in -59.28, -26.85 -56.83, -32.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.611 None TPO161 TPO161 XRAY 2.14 0.18 0.226 B 307 278 14 0 0 14 [[16, 262]] 1.0 5hes Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TKL MAP3K20 M3K20_HUMAN 5HESA Q9NYL2 6 299 800.0 032:401 Type1.5_Back Inactive DFGin 6.508 12.947 BLAplus -149.3, -178.78 72.05, 18.35 -79.29, -13.47 42.54, 81.81 -105.89, 8.43 out-out out 10.327 Saltbr-out 7.91 HRD-in -63.65, -61.5 81.63, -14.81 out-out-out SNCooo out-out ActLoopNT-out 8.531 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.01 APE8-dihe-out -130.74, 34.59 APE8-rot-out 64.32 APE67-dihe-in -59.25, -25.49 -57.81, -30.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.632 None TPO161 TPO161 XRAY 2.14 0.18 0.226 A 307 288 6 0 0 6 [[16, 262]] 1.0 5hes Homo sapiens TKL_MAP3K20_HUMAN TKL 1.2e-78 270.5 2 266 265 150 151 152 154 156 45 53 57 130 132 131 133 188 176 171 170 169 168 167 166 165 83 Mitogen-activated protein kinase kinase kinase 20
TYR EGFR EGFR_HUMAN 3W32A P00533 701 1017 1210.0 W32:1101 Type1.5_Back Inactive DFGin 4.654 13.377 BLBplus -134.93, 174.75 75.62, 15.73 -74.59, 136.0 48.33, 88.42 85.13, 3.49 out-out out 14.094 Saltbr-out 13.598 HRD-in -69.8, -59.18 76.05, -4.36 out-out-in SNCooi out-in ActLoopNT-out 6.242 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.7, 158.18 APE9-dihe-in -131.47, 158.06 APE8-dihe-in -79.68, 77.14 APE8-rot-na 27.77 APE67-dihe-in -73.57, -6.08 -55.16, -38.17 APE12-dist-na 16.516 APE11-dist-na 12.808 APE10-dist-na 13.448 APE9-dist-in 7.197 None None None XRAY 1.8 0.202 0.236 A 330 317 0 0 0 0 [[712, 970]] 1.0 3w32 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
CMGC ACK2 CSK2A_MAIZE 2OXDA P28523 2 326 332.0 K32:60338 Type1 Active DFGin 7.627 16.533 BLAminus -113.97, -177.91 58.49, 67.22 -84.76, 29.07 300.12, 84.53 -72.16, -27.75 in-in in 9.841 Saltbr-in 2.913 HRD-in -66.78, -41.75 57.86, 18.66 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.26, -175.9 APE9-dihe-na 55.62, 178.78 APE8-dihe-in -103.46, 153.42 APE8-rot-in 304.07 APE67-dihe-in -72.09, -2.75 -46.02, -54.8 APE12-dist-in 12.479 APE11-dist-in 10.395 APE10-dist-in 5.983 APE9-dist-in 2.906 None None None XRAY 2.3 0.223 0.273 A 332 325 0 0 0 0 [[34, 319]] 1.0 2oxd Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha

Ligand: 32

Total number of chains: 1
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 2OXDA
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC ACK2 CSK2A_MAIZE 2OXDA P28523 2 326 332.0 K32:60338 Type1 Active DFGin 7.627 16.533 BLAminus -113.97, -177.91 58.49, 67.22 -84.76, 29.07 300.12, 84.53 -72.16, -27.75 in-in in 9.841 Saltbr-in 2.913 HRD-in -66.78, -41.75 57.86, 18.66 in-in-in SNCiii in-in ActLoopNT-in 2.783 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.26, -175.9 APE9-dihe-na 55.62, 178.78 APE8-dihe-in -103.46, 153.42 APE8-rot-in 304.07 APE67-dihe-in -72.09, -2.75 -46.02, -54.8 APE12-dist-in 12.479 APE11-dist-in 10.395 APE10-dist-in 5.983 APE9-dist-in 2.906 None None None XRAY 2.3 0.223 0.273 A 332 325 0 0 0 0 [[34, 319]] 1.0 2oxd Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha