Ligand: 0UN

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 7ZYNA
DFGin ABAminus 1 33.3% 3IKAA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 3IKAA 2.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0UN Type1 696 - 1020 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2KA 3.201 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0UN Type1 696 - 1020 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7ZYNA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0UN Type1 697 - 1018 0 None T790M,C797S,E865A,E866A,K867A Epidermal growth factor receptor

Ligand: 0UN

Total number of chains: 3
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 66.7% 7ZYNA
DFGin ABAminus 1 33.3% 3IKAA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 3IKAA 2.9 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0UN Type1 696 - 1020 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5X2KA 3.201 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0UN Type1 696 - 1020 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7ZYNA 2.3 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0UN Type1 697 - 1018 0 None T790M,C797S,E865A,E866A,K867A Epidermal growth factor receptor Homo sapiens

Ligand: 0UN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism