STE_TNIK (TRAF2 and NCK-interacting protein kinase)

Total number of chains: 27
Active chains: 10
Family: STE
Uniprot: TNIK_HUMAN
Kinase Domain Residues: 25 - 289
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 18 66.7% AF-Q9UKE5-K1A
DFGin BLBplus 6 22.2% 5D7AA
DFGinter None 2 7.4% 8X88A
DFGin None 1 3.7% 2X7FE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
7XZRB 12 312 1360.0 ANP:1401 ATPlike Active DFGin 6.439 15.163 BLAminus -131.61, 176.54 70.33, 83.31 -101.27, 21.61 286.01, 77.74 -67.8, -30.96 in-in in 9.126 Saltbr-in 2.582 HRD-in -64.36, -58.64 76.74, 3.35 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.27, 150.43 APE9-dihe-na 126.35, -168.16 APE8-dihe-in -105.07, 123.33 APE8-rot-in 308.43 APE67-dihe-in -61.4, -25.19 -44.62, -54.45 APE12-dist-in 8.7 APE11-dist-in 11.705 APE10-dist-in 6.078 APE9-dist-in 3.705 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 B 306 301 0 0 0 0 [[25, 289]] 1.0 7xzr STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
AF-Q9UKE5-K1A 17 297 1360.0 No_ligand No_ligand Active DFGin 6.272 14.793 BLAminus -137.23, 178.74 65.21, 64.97 -89.8, 7.75 289.43, 84.49 -57.97, -35.65 in-in in 8.443 Saltbr-in 2.707 HRD-in -71.9, -42.57 66.07, 2.86 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.9, 152.72 APE9-dihe-na 120.75, 174.87 APE8-dihe-in -79.85, 124.11 APE8-rot-in 304.72 APE67-dihe-in -72.68, -20.0 -45.61, -46.23 APE12-dist-in 8.683 APE11-dist-in 11.811 APE10-dist-in 6.116 APE9-dist-in 3.477 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[25, 289]] 1.0 AF-Q9UKE5-K1 STE_TNIK_HUMAN STE 2.2e-105 357.6 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
AF-Q9UKE5-K3A 17 297 1360.0 No_ligand No_ligand Active DFGin 6.388 14.223 BLAminus -141.6, 176.36 60.86, 72.2 -88.68, 7.5 288.47, 84.53 -58.49, -25.46 in-in in 8.892 Saltbr-in 2.788 HRD-in -77.26, -40.23 67.24, -1.36 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 145.31 APE9-dihe-na 136.27, 177.83 APE8-dihe-in -83.59, 124.87 APE8-rot-in 301.67 APE67-dihe-in -71.33, -21.7 -42.63, -50.46 APE12-dist-in 9.204 APE11-dist-in 11.847 APE10-dist-in 6.131 APE9-dist-in 3.32 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[25, 289]] 1.0 AF-Q9UKE5-K3 STE_TNIK_HUMAN STE 2.2e-105 357.6 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
7XZQA 11 310 1360.0 No_ligand No_ligand Active DFGin 6.588 15.456 BLAminus -133.95, 170.11 78.02, 81.98 -102.58, 17.13 281.66, 76.67 -70.01, -30.29 in-in in 9.289 Saltbr-in 3.356 HRD-in -68.09, -54.91 78.44, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.34, 149.19 APE9-dihe-na 143.87, -170.72 APE8-dihe-in -111.07, 121.11 APE8-rot-in 302.45 APE67-dihe-in -63.82, -21.96 -43.56, -56.51 APE12-dist-in 8.622 APE11-dist-in 11.891 APE10-dist-in 6.338 APE9-dist-in 3.801 None TPO181,TPO187 TPO181,TPO187 XRAY 2.09 0.201 0.255 A 306 300 0 0 0 0 [[25, 289]] 1.0 7xzq STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
8ZMLB 10 310 1360.0 A1D8H:401 Type1 Active DFGin 6.341 14.681 BLAminus -137.68, 170.11 66.37, 91.63 -101.51, 26.8 289.02, 87.32 -60.41, -41.21 in-in in 9.089 Saltbr-in 2.708 HRD-in -65.54, -56.99 83.62, -6.79 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.62, 146.65 APE9-dihe-na 135.32, -165.11 APE8-dihe-in -104.54, 114.88 APE8-rot-in 314.82 APE67-dihe-in -65.12, -32.28 -36.82, -49.34 APE12-dist-in 8.591 APE11-dist-in 11.536 APE10-dist-in 5.805 APE9-dist-in 3.597 None TPO181,TPO187 TPO181,TPO187 XRAY 2.489 0.259 0.326 B 303 300 0 0 0 0 [[25, 289]] 1.0 8zml STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
6RA5A 12 309 1360.0 JWE:401 Type1 Active DFGin 5.658 14.348 BLAminus -134.84, 172.38 63.99, 94.93 -100.12, 7.63 275.89, 88.52 -57.52, -20.22 in-in in 8.483 Saltbr-in 2.723 HRD-in -67.89, -47.63 73.52, 2.34 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.07, 142.79 APE9-dihe-na 150.42, -157.87 APE8-dihe-in -112.27, 116.62 APE8-rot-in 316.05 APE67-dihe-in -58.73, -24.17 -29.52, -62.76 APE12-dist-in 8.507 APE11-dist-in 11.339 APE10-dist-in 5.621 APE9-dist-in 3.435 None TPO181,TPO187 TPO181,TPO187 XRAY 2.9 999.0 999.0 A 306 295 3 0 0 0 [[25, 289]] 1.0 6ra5 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
6RA7A 13 314 1360.0 JWK:403 Type1 Active DFGin 5.836 13.927 BLAminus -128.61, 168.63 74.01, 90.24 -94.51, 13.35 287.25, 104.01 -60.56, -24.08 in-in in 8.539 Saltbr-in 2.735 HRD-in -68.51, -50.67 74.81, 4.3 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.21, 157.06 APE9-dihe-na 123.33, -168.94 APE8-dihe-in -110.18, 118.73 APE8-rot-in 305.78 APE67-dihe-in -64.59, -21.76 -41.05, -52.56 APE12-dist-in 8.44 APE11-dist-in 11.636 APE10-dist-in 6.041 APE9-dist-in 3.567 None TPO181,TPO187 TPO181,TPO187 XRAY 1.2 999.0 999.0 A 306 302 0 0 0 0 [[25, 289]] 1.0 6ra7 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
8WM0A 12 310 1360.0 ADN:401 Type1 Active DFGin 6.684 14.428 BLAminus -137.99, 169.89 73.28, 84.67 -101.61, 23.01 291.08, 82.33 -60.26, -43.27 in-in in 9.699 Saltbr-in 3.566 HRD-in -74.37, -47.31 76.19, -3.3 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.58, 162.14 APE9-dihe-na 103.93, -165.27 APE8-dihe-in -107.19, 120.81 APE8-rot-in 307.37 APE67-dihe-in -60.27, -41.62 -35.76, -53.6 APE12-dist-in 8.707 APE11-dist-in 11.767 APE10-dist-in 6.12 APE9-dist-in 3.42 None TPO181,TPO187 TPO181,TPO187 XRAY 2.8 0.233 0.285 A 306 299 0 0 0 0 [[25, 289]] 1.0 8wm0 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
8ZMLA 11 312 1360.0 A1D8H:401 Type1.5_Back Active DFGin 6.474 14.565 BLAminus -139.61, 165.9 70.83, 90.89 -103.46, 28.11 290.64, 88.46 -72.56, -24.37 in-in in 8.975 Saltbr-in 2.705 HRD-in -67.56, -52.68 74.08, 10.21 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.53, 157.64 APE9-dihe-na 122.71, -174.5 APE8-dihe-in -96.82, 116.31 APE8-rot-in 313.0 APE67-dihe-in -60.49, -29.81 -40.39, -49.28 APE12-dist-in 8.415 APE11-dist-in 11.596 APE10-dist-in 5.843 APE9-dist-in 3.373 None TPO181,TPO187 TPO181,TPO187 XRAY 2.489 0.259 0.326 A 303 301 0 0 0 0 [[25, 289]] 1.0 8zml STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
7XZRA 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.274 14.193 BLAminus -134.39, 177.59 74.52, 87.23 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.591 Saltbr-in 2.844 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.595 APE11-dist-in 12.046 APE10-dist-in 6.44 APE9-dist-in 4.307 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306 299 0 0 0 0 [[25, 289]] 1.0 7xzr STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5AX9A 12 307 1360.0 4KT:401 Type1 Inactive DFGin 5.23 13.55 BLAminus -130.68, -179.5 62.88, 86.0 -93.54, 16.39 289.32, 99.28 -65.74, -27.24 in-in in 8.408 Saltbr-in 2.555 HRD-in -75.14, -52.41 79.64, -13.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -97.2 APE8-dihe-in -70.62, 123.86 APE8-rot-out 63.22 APE67-dihe-in -60.45, -29.94 -93.62, -15.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.005 None None None XRAY 2.4 0.208 0.271 A 308 282 14 0 0 14 [[25, 289]] 1.0 5ax9 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5AX9B 13 307 1360.0 4KT:401 Type1 Inactive DFGin 5.489 13.781 BLAminus -131.21, 168.2 66.99, 91.56 -89.13, 13.94 288.06, 96.49 -49.82, -38.56 in-in in 8.883 Saltbr-in 2.705 HRD-in -65.8, -49.95 70.08, 2.2 in-in-out SNCiio in-out ActLoopNT-in 2.729 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -43.89 APE9-dihe-na 120.72, -165.13 APE8-dihe-in -104.0, 119.33 APE8-rot-in 309.81 APE67-dihe-in -62.24, -16.96 -34.16, -64.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.063 APE9-dist-in 3.782 None None None XRAY 2.4 0.208 0.271 B 308 274 21 0 0 12 [[25, 289]] 1.0 5ax9 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5AX9C 12 309 1360.0 4KT:401 Type1 Inactive DFGin 4.855 13.747 BLAminus -133.31, 178.42 62.61, 91.57 -88.21, 15.43 284.15, 96.84 -57.06, -35.29 in-in in 8.848 Saltbr-in 2.627 HRD-in -65.76, -41.24 68.55, -5.67 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.67 APE8-dihe-out 50.85, 74.45 APE8-rot-in 323.44 APE67-dihe-in -64.1, -22.96 -92.89, 2.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.099 None None None XRAY 2.4 0.208 0.271 C 308 282 16 0 0 12 [[25, 289]] 1.0 5ax9 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
2X7FA 15 313 1360.0 824:500 Type1 Inactive DFGin 6.788 14.643 BLAminus -125.93, 176.2 60.97, 100.67 -114.36, 23.27 288.61, 85.46 -68.11, -48.66 in-none in 9.204 Saltbr-none 999.0 HRD-in -65.92, -41.18 69.14, -4.02 none-out-out SNCnoo out-out ActLoopNT-out 6.167 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -150.84 APE8-dihe-in -101.28, 96.29 APE8-rot-none 999.0 APE67-dihe-in -52.7, -32.64 -83.9, 2.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.921 None None None XRAY 2.8 0.21 0.229 A 326 276 23 0 0 13 [[25, 289]] 1.0 2x7f STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
2X7FB 13 313 1360.0 824:500 Type1 Inactive DFGin 6.759 14.616 BLAminus -125.8, 175.96 61.22, 100.42 -113.19, 24.28 288.37, 86.39 -68.54, -48.18 in-none in 9.107 Saltbr-none 999.0 HRD-in -67.06, -42.58 70.38, -4.99 none-out-out SNCnoo out-out ActLoopNT-out 6.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.09 APE8-dihe-in -121.12, 111.62 APE8-rot-out 48.12 APE67-dihe-in -53.26, -31.37 -96.48, 3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.514 None None None XRAY 2.8 0.21 0.229 B 326 288 13 0 0 12 [[25, 289]] 1.0 2x7f STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
2X7FC 14 313 1360.0 824:500 Type1 Inactive DFGin 6.764 14.765 BLAminus -124.84, 175.84 60.69, 100.51 -112.75, 22.89 287.95, 85.81 -67.51, -48.09 in-none in 9.141 Saltbr-none 999.0 HRD-in -67.07, -40.49 68.23, -3.68 none-out-none SNCnon out-none ActLoopNT-out 6.17 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.77 APE8-rot-none 999.0 APE67-dihe-in -54.15, -31.45 -96.1, 4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 C 326 285 15 0 0 14 [[25, 289]] 1.0 2x7f STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5CWZA 11 307 1360.0 No_ligand No_ligand Inactive DFGin 4.297 13.027 BLBplus -131.93, 171.39 52.81, 50.01 -93.78, 159.27 56.53, 92.13 73.7, -18.06 in-out in 9.735 Saltbr-out 5.033 HRD-in -66.69, -49.97 81.58, -13.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -103.92, -173.6 APE9-dihe-na -147.95, -142.69 APE8-dihe-in -80.43, 117.21 APE8-rot-out 64.06 APE67-dihe-in -55.24, -35.12 -86.57, -14.76 APE12-dist-out 16.904 APE11-dist-in 13.947 APE10-dist-out 15.408 APE9-dist-out 10.221 None None None XRAY 2.9 0.212 0.281 A 308 284 13 0 0 11 [[25, 289]] 1.0 5cwz STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5CWZB 11 307 1360.0 No_ligand No_ligand Inactive DFGin 4.242 13.058 BLBplus -127.34, 168.87 49.84, 48.4 -92.81, 156.83 61.46, 92.74 77.66, -28.77 in-out in 9.958 Saltbr-out 5.381 HRD-in -70.33, -45.7 76.86, 11.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -132.33, 127.61 APE9-dihe-na -72.86, -149.09 APE8-dihe-in -89.35, 128.31 APE8-rot-out 81.47 APE67-dihe-in -55.03, -25.43 -80.73, -20.88 APE12-dist-out 16.688 APE11-dist-out 14.126 APE10-dist-out 15.934 APE9-dist-out 9.321 None None None XRAY 2.9 0.212 0.281 B 308 284 13 0 0 11 [[25, 289]] 1.0 5cwz STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5CWZC 15 308 1360.0 No_ligand No_ligand Inactive DFGin 4.656 13.24 BLBplus -127.63, 168.75 47.28, 57.4 -101.13, 171.79 53.59, 90.46 67.6, -60.94 in-in in 9.179 Saltbr-in 3.576 HRD-in -65.47, -36.96 66.37, 3.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -108.04 APE8-dihe-in -110.03, 122.67 APE8-rot-out 53.24 APE67-dihe-in -62.79, -15.37 -94.77, 17.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.447 None None None XRAY 2.9 0.212 0.281 C 308 271 23 0 0 15 [[25, 289]] 1.0 5cwz STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5D7AA 11 310 1360.0 58C:401 Type1 Inactive DFGin 5.198 13.489 BLBplus -137.96, 163.33 59.53, 46.85 -103.51, 159.44 54.57, 86.23 54.51, 36.58 in-out in 9.372 Saltbr-out 3.96 HRD-in -64.59, -47.43 75.38, -15.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -124.34, 121.2 APE9-dihe-na -67.99, -164.34 APE8-dihe-in -75.83, 133.18 APE8-rot-out 68.8 APE67-dihe-in -60.87, -21.38 -81.62, -20.63 APE12-dist-out 16.852 APE11-dist-in 13.934 APE10-dist-out 15.977 APE9-dist-out 9.365 None None None XRAY 2.9 0.187 0.239 A 308 289 11 0 0 11 [[25, 289]] 1.0 5d7a STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5D7AB 11 307 1360.0 58C:401 Type1 Inactive DFGin 5.188 13.432 BLBplus -135.25, 165.9 56.77, 52.67 -104.96, 159.52 52.19, 87.71 62.53, 15.1 in-out in 9.956 Saltbr-out 4.589 HRD-in -70.46, -42.65 73.98, -4.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -138.03, 115.46 APE9-dihe-na -65.6, -158.9 APE8-dihe-in -75.74, 134.36 APE8-rot-out 83.48 APE67-dihe-in -58.55, -43.32 -87.11, -13.26 APE12-dist-out 16.491 APE11-dist-in 13.963 APE10-dist-out 15.938 APE9-dist-out 9.397 None None None XRAY 2.9 0.187 0.239 B 308 286 11 0 0 11 [[25, 289]] 1.0 5d7a STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
5D7AC 13 310 1360.0 58C:401 Type1 Inactive DFGin 5.249 13.606 BLBplus -145.0, 158.47 58.46, 71.57 -125.2, 156.39 52.4, 82.94 72.26, 999.0 in-in in 9.982 Saltbr-in 3.216 HRD-in -68.67, -45.95 72.07, -1.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -137.04, 108.78 APE9-dihe-na -65.87, -168.4 APE8-dihe-in -72.16, 134.73 APE8-rot-out 88.32 APE67-dihe-in -62.28, -23.28 -89.29, -9.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.184 None None None XRAY 2.9 0.187 0.239 C 308 286 12 0 0 12 [[25, 289]] 1.0 5d7a STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
2X7FE 14 309 1360.0 824:500 Type1 Inactive DFGin 6.66 14.794 None -124.38, 176.52 58.71, 103.53 -115.64, 999.0 286.98, 84.26 999.0, 999.0 in-none in 9.525 Saltbr-none 999.0 HRD-in -65.29, -41.79 67.65, -3.62 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.45 APE8-rot-none 999.0 APE67-dihe-in -51.92, -33.29 -95.18, 3.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 E 326 251 45 0 0 18 [[25, 289]] 1.0 2x7f STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
8X88A 15 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.725 9.945 None -92.61, 126.66 78.57, 160.72 -147.84, 30.92 39.89, 92.66 114.91, -1.91 out-out out 13.653 Saltbr-out 13.772 HRD-in -94.03, -60.42 72.05, 9.07 out-out-out SNCooo out-out ActLoopNT-out 5.487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.41 APE9-dihe-na -127.93, -146.37 APE8-dihe-in -61.41, 141.34 APE8-rot-out 49.25 APE67-dihe-in -64.12, -24.22 -101.87, 9.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.573 APE9-dist-out 10.143 None None None XRAY 2.7 0.201 0.256 A 304 294 3 0 0 3 [[25, 289]] 1.0 8x88 STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
8X88B 17 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.705 9.985 None -90.48, 120.54 88.19, 158.07 -146.13, 29.2 40.03, 97.67 115.62, 0.39 out-out out 14.512 Saltbr-out 13.634 HRD-in -79.11, -58.67 70.41, 12.41 out-out-out SNCooo out-out ActLoopNT-out 5.012 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -66.52, 155.13 APE9-dihe-na -65.68, 177.97 APE8-dihe-out 49.97, 73.81 APE8-rot-out 69.45 APE67-dihe-in -68.36, -20.09 -87.33, 12.07 APE12-dist-out 17.505 APE11-dist-out 17.455 APE10-dist-out 12.947 APE9-dist-out 10.863 None None None XRAY 2.7 0.201 0.256 B 304 291 4 0 0 0 [[25, 289]] 1.0 8x88 STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
6RA5B 14 310 1360.0 No_ligand No_ligand None DFGin 5.788 14.265 BLAminus -136.76, 172.1 63.28, 95.48 -100.13, 6.47 275.29, 87.87 -57.63, -20.13 in-none in 8.566 Saltbr-none 999.0 HRD-in -68.06, -48.15 74.67, 0.64 none-in-in SNCnii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.41, 141.46 APE9-dihe-na 147.76, -160.31 APE8-dihe-in -111.74, 117.5 APE8-rot-in 316.28 APE67-dihe-in -47.73, -42.39 -30.97, -64.12 APE12-dist-in 8.838 APE11-dist-in 11.283 APE10-dist-in 5.559 APE9-dist-in 3.461 None TPO181,TPO187 TPO181,TPO187 XRAY 2.9 999.0 999.0 B 306 283 14 0 0 7 [[25, 289]] 1.0 6ra5 STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
2X7FD 17 306 1360.0 824:500 Type1 None DFGin 6.647 15.046 BLAminus -124.52, 178.85 56.71, 102.04 -114.11, 22.87 287.2, 83.98 -65.42, -48.91 in-none in 9.444 Saltbr-none 999.0 HRD-in -66.67, -40.26 66.21, -2.06 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 119.49 APE8-rot-none 999.0 APE67-dihe-in -52.92, -32.7 -93.58, 2.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 D 326 236 51 0 0 15 [[25, 289]] 1.0 2x7f STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase

STE_TNIK (TRAF2 and NCK-interacting protein kinase)

Total number of chains: 27
Active chains: 10
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 18 66.7% AF-Q9UKE5-K1A
DFGin BLBplus 6 22.2% 5D7AA
DFGinter None 2 7.4% 8X88A
DFGin None 1 3.7% 2X7FE
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TNIK_HUMAN 7XZRB Q9UKE5 12 312 1360.0 ANP:1401 ATPlike Active DFGin 6.439 15.163 BLAminus -131.61, 176.54 70.33, 83.31 -101.27, 21.61 286.01, 77.74 -67.8, -30.96 in-in in 9.126 Saltbr-in 2.582 HRD-in -64.36, -58.64 76.74, 3.35 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.27, 150.43 APE9-dihe-na 126.35, -168.16 APE8-dihe-in -105.07, 123.33 APE8-rot-in 308.43 APE67-dihe-in -61.4, -25.19 -44.62, -54.45 APE12-dist-in 8.7 APE11-dist-in 11.705 APE10-dist-in 6.078 APE9-dist-in 3.705 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 B 306 301 0 0 0 0 [[25, 289]] 1.0 7xzr Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN AF-Q9UKE5-K1A Q9UKE5 17 297 1360.0 No_ligand No_ligand Active DFGin 6.272 14.793 BLAminus -137.23, 178.74 65.21, 64.97 -89.8, 7.75 289.43, 84.49 -57.97, -35.65 in-in in 8.443 Saltbr-in 2.707 HRD-in -71.9, -42.57 66.07, 2.86 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.9, 152.72 APE9-dihe-na 120.75, 174.87 APE8-dihe-in -79.85, 124.11 APE8-rot-in 304.72 APE67-dihe-in -72.68, -20.0 -45.61, -46.23 APE12-dist-in 8.683 APE11-dist-in 11.811 APE10-dist-in 6.116 APE9-dist-in 3.477 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[25, 289]] 1.0 AF-Q9UKE5-K1 Homo sapiens STE_TNIK_HUMAN STE 2.2e-105 357.6 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN AF-Q9UKE5-K3A Q9UKE5 17 297 1360.0 No_ligand No_ligand Active DFGin 6.388 14.223 BLAminus -141.6, 176.36 60.86, 72.2 -88.68, 7.5 288.47, 84.53 -58.49, -25.46 in-in in 8.892 Saltbr-in 2.788 HRD-in -77.26, -40.23 67.24, -1.36 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 145.31 APE9-dihe-na 136.27, 177.83 APE8-dihe-in -83.59, 124.87 APE8-rot-in 301.67 APE67-dihe-in -71.33, -21.7 -42.63, -50.46 APE12-dist-in 9.204 APE11-dist-in 11.847 APE10-dist-in 6.131 APE9-dist-in 3.32 None None None AF2 -1.0 1.0 1.0 A 281 281 0 0 0 0 [[25, 289]] 1.0 AF-Q9UKE5-K3 Homo sapiens STE_TNIK_HUMAN STE 2.2e-105 357.6 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 7XZQA Q9UKE5 11 310 1360.0 No_ligand No_ligand Active DFGin 6.588 15.456 BLAminus -133.95, 170.11 78.02, 81.98 -102.58, 17.13 281.66, 76.67 -70.01, -30.29 in-in in 9.289 Saltbr-in 3.356 HRD-in -68.09, -54.91 78.44, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.34, 149.19 APE9-dihe-na 143.87, -170.72 APE8-dihe-in -111.07, 121.11 APE8-rot-in 302.45 APE67-dihe-in -63.82, -21.96 -43.56, -56.51 APE12-dist-in 8.622 APE11-dist-in 11.891 APE10-dist-in 6.338 APE9-dist-in 3.801 None TPO181,TPO187 TPO181,TPO187 XRAY 2.09 0.201 0.255 A 306 300 0 0 0 0 [[25, 289]] 1.0 7xzq Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 8ZMLB Q9UKE5 10 310 1360.0 A1D8H:401 Type1 Active DFGin 6.341 14.681 BLAminus -137.68, 170.11 66.37, 91.63 -101.51, 26.8 289.02, 87.32 -60.41, -41.21 in-in in 9.089 Saltbr-in 2.708 HRD-in -65.54, -56.99 83.62, -6.79 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.62, 146.65 APE9-dihe-na 135.32, -165.11 APE8-dihe-in -104.54, 114.88 APE8-rot-in 314.82 APE67-dihe-in -65.12, -32.28 -36.82, -49.34 APE12-dist-in 8.591 APE11-dist-in 11.536 APE10-dist-in 5.805 APE9-dist-in 3.597 None TPO181,TPO187 TPO181,TPO187 XRAY 2.489 0.259 0.326 B 303 300 0 0 0 0 [[25, 289]] 1.0 8zml Homo sapiens STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 6RA5A Q9UKE5 12 309 1360.0 JWE:401 Type1 Active DFGin 5.658 14.348 BLAminus -134.84, 172.38 63.99, 94.93 -100.12, 7.63 275.89, 88.52 -57.52, -20.22 in-in in 8.483 Saltbr-in 2.723 HRD-in -67.89, -47.63 73.52, 2.34 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.07, 142.79 APE9-dihe-na 150.42, -157.87 APE8-dihe-in -112.27, 116.62 APE8-rot-in 316.05 APE67-dihe-in -58.73, -24.17 -29.52, -62.76 APE12-dist-in 8.507 APE11-dist-in 11.339 APE10-dist-in 5.621 APE9-dist-in 3.435 None TPO181,TPO187 TPO181,TPO187 XRAY 2.9 999.0 999.0 A 306 295 3 0 0 0 [[25, 289]] 1.0 6ra5 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 6RA7A Q9UKE5 13 314 1360.0 JWK:403 Type1 Active DFGin 5.836 13.927 BLAminus -128.61, 168.63 74.01, 90.24 -94.51, 13.35 287.25, 104.01 -60.56, -24.08 in-in in 8.539 Saltbr-in 2.735 HRD-in -68.51, -50.67 74.81, 4.3 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.21, 157.06 APE9-dihe-na 123.33, -168.94 APE8-dihe-in -110.18, 118.73 APE8-rot-in 305.78 APE67-dihe-in -64.59, -21.76 -41.05, -52.56 APE12-dist-in 8.44 APE11-dist-in 11.636 APE10-dist-in 6.041 APE9-dist-in 3.567 None TPO181,TPO187 TPO181,TPO187 XRAY 1.2 999.0 999.0 A 306 302 0 0 0 0 [[25, 289]] 1.0 6ra7 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 8WM0A Q9UKE5 12 310 1360.0 ADN:401 Type1 Active DFGin 6.684 14.428 BLAminus -137.99, 169.89 73.28, 84.67 -101.61, 23.01 291.08, 82.33 -60.26, -43.27 in-in in 9.699 Saltbr-in 3.566 HRD-in -74.37, -47.31 76.19, -3.3 in-in-in SNCiii in-in ActLoopNT-in 2.94 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.58, 162.14 APE9-dihe-na 103.93, -165.27 APE8-dihe-in -107.19, 120.81 APE8-rot-in 307.37 APE67-dihe-in -60.27, -41.62 -35.76, -53.6 APE12-dist-in 8.707 APE11-dist-in 11.767 APE10-dist-in 6.12 APE9-dist-in 3.42 None TPO181,TPO187 TPO181,TPO187 XRAY 2.8 0.233 0.285 A 306 299 0 0 0 0 [[25, 289]] 1.0 8wm0 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 8ZMLA Q9UKE5 11 312 1360.0 A1D8H:401 Type1.5_Back Active DFGin 6.474 14.565 BLAminus -139.61, 165.9 70.83, 90.89 -103.46, 28.11 290.64, 88.46 -72.56, -24.37 in-in in 8.975 Saltbr-in 2.705 HRD-in -67.56, -52.68 74.08, 10.21 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.53, 157.64 APE9-dihe-na 122.71, -174.5 APE8-dihe-in -96.82, 116.31 APE8-rot-in 313.0 APE67-dihe-in -60.49, -29.81 -40.39, -49.28 APE12-dist-in 8.415 APE11-dist-in 11.596 APE10-dist-in 5.843 APE9-dist-in 3.373 None TPO181,TPO187 TPO181,TPO187 XRAY 2.489 0.259 0.326 A 303 301 0 0 0 0 [[25, 289]] 1.0 8zml Homo sapiens STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 7XZRA Q9UKE5 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.274 14.193 BLAminus -134.39, 177.59 74.52, 87.23 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.591 Saltbr-in 2.844 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.595 APE11-dist-in 12.046 APE10-dist-in 6.44 APE9-dist-in 4.307 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306 299 0 0 0 0 [[25, 289]] 1.0 7xzr Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5AX9A Q9UKE5 12 307 1360.0 4KT:401 Type1 Inactive DFGin 5.23 13.55 BLAminus -130.68, -179.5 62.88, 86.0 -93.54, 16.39 289.32, 99.28 -65.74, -27.24 in-in in 8.408 Saltbr-in 2.555 HRD-in -75.14, -52.41 79.64, -13.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -97.2 APE8-dihe-in -70.62, 123.86 APE8-rot-out 63.22 APE67-dihe-in -60.45, -29.94 -93.62, -15.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.005 None None None XRAY 2.4 0.208 0.271 A 308 282 14 0 0 14 [[25, 289]] 1.0 5ax9 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5AX9B Q9UKE5 13 307 1360.0 4KT:401 Type1 Inactive DFGin 5.489 13.781 BLAminus -131.21, 168.2 66.99, 91.56 -89.13, 13.94 288.06, 96.49 -49.82, -38.56 in-in in 8.883 Saltbr-in 2.705 HRD-in -65.8, -49.95 70.08, 2.2 in-in-out SNCiio in-out ActLoopNT-in 2.729 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -43.89 APE9-dihe-na 120.72, -165.13 APE8-dihe-in -104.0, 119.33 APE8-rot-in 309.81 APE67-dihe-in -62.24, -16.96 -34.16, -64.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.063 APE9-dist-in 3.782 None None None XRAY 2.4 0.208 0.271 B 308 274 21 0 0 12 [[25, 289]] 1.0 5ax9 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5AX9C Q9UKE5 12 309 1360.0 4KT:401 Type1 Inactive DFGin 4.855 13.747 BLAminus -133.31, 178.42 62.61, 91.57 -88.21, 15.43 284.15, 96.84 -57.06, -35.29 in-in in 8.848 Saltbr-in 2.627 HRD-in -65.76, -41.24 68.55, -5.67 in-in-out SNCiio in-out ActLoopNT-in 2.939 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 149.67 APE8-dihe-out 50.85, 74.45 APE8-rot-in 323.44 APE67-dihe-in -64.1, -22.96 -92.89, 2.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.099 None None None XRAY 2.4 0.208 0.271 C 308 282 16 0 0 12 [[25, 289]] 1.0 5ax9 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 2X7FA Q9UKE5 15 313 1360.0 824:500 Type1 Inactive DFGin 6.788 14.643 BLAminus -125.93, 176.2 60.97, 100.67 -114.36, 23.27 288.61, 85.46 -68.11, -48.66 in-none in 9.204 Saltbr-none 999.0 HRD-in -65.92, -41.18 69.14, -4.02 none-out-out SNCnoo out-out ActLoopNT-out 6.167 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -150.84 APE8-dihe-in -101.28, 96.29 APE8-rot-none 999.0 APE67-dihe-in -52.7, -32.64 -83.9, 2.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.921 None None None XRAY 2.8 0.21 0.229 A 326 276 23 0 0 13 [[25, 289]] 1.0 2x7f Homo sapiens STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 2X7FB Q9UKE5 13 313 1360.0 824:500 Type1 Inactive DFGin 6.759 14.616 BLAminus -125.8, 175.96 61.22, 100.42 -113.19, 24.28 288.37, 86.39 -68.54, -48.18 in-none in 9.107 Saltbr-none 999.0 HRD-in -67.06, -42.58 70.38, -4.99 none-out-out SNCnoo out-out ActLoopNT-out 6.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.09 APE8-dihe-in -121.12, 111.62 APE8-rot-out 48.12 APE67-dihe-in -53.26, -31.37 -96.48, 3.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.514 None None None XRAY 2.8 0.21 0.229 B 326 288 13 0 0 12 [[25, 289]] 1.0 2x7f Homo sapiens STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 2X7FC Q9UKE5 14 313 1360.0 824:500 Type1 Inactive DFGin 6.764 14.765 BLAminus -124.84, 175.84 60.69, 100.51 -112.75, 22.89 287.95, 85.81 -67.51, -48.09 in-none in 9.141 Saltbr-none 999.0 HRD-in -67.07, -40.49 68.23, -3.68 none-out-none SNCnon out-none ActLoopNT-out 6.17 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.77 APE8-rot-none 999.0 APE67-dihe-in -54.15, -31.45 -96.1, 4.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 C 326 285 15 0 0 14 [[25, 289]] 1.0 2x7f Homo sapiens STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5CWZA Q9UKE5 11 307 1360.0 No_ligand No_ligand Inactive DFGin 4.297 13.027 BLBplus -131.93, 171.39 52.81, 50.01 -93.78, 159.27 56.53, 92.13 73.7, -18.06 in-out in 9.735 Saltbr-out 5.033 HRD-in -66.69, -49.97 81.58, -13.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -103.92, -173.6 APE9-dihe-na -147.95, -142.69 APE8-dihe-in -80.43, 117.21 APE8-rot-out 64.06 APE67-dihe-in -55.24, -35.12 -86.57, -14.76 APE12-dist-out 16.904 APE11-dist-in 13.947 APE10-dist-out 15.408 APE9-dist-out 10.221 None None None XRAY 2.9 0.212 0.281 A 308 284 13 0 0 11 [[25, 289]] 1.0 5cwz Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5CWZB Q9UKE5 11 307 1360.0 No_ligand No_ligand Inactive DFGin 4.242 13.058 BLBplus -127.34, 168.87 49.84, 48.4 -92.81, 156.83 61.46, 92.74 77.66, -28.77 in-out in 9.958 Saltbr-out 5.381 HRD-in -70.33, -45.7 76.86, 11.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -132.33, 127.61 APE9-dihe-na -72.86, -149.09 APE8-dihe-in -89.35, 128.31 APE8-rot-out 81.47 APE67-dihe-in -55.03, -25.43 -80.73, -20.88 APE12-dist-out 16.688 APE11-dist-out 14.126 APE10-dist-out 15.934 APE9-dist-out 9.321 None None None XRAY 2.9 0.212 0.281 B 308 284 13 0 0 11 [[25, 289]] 1.0 5cwz Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5CWZC Q9UKE5 15 308 1360.0 No_ligand No_ligand Inactive DFGin 4.656 13.24 BLBplus -127.63, 168.75 47.28, 57.4 -101.13, 171.79 53.59, 90.46 67.6, -60.94 in-in in 9.179 Saltbr-in 3.576 HRD-in -65.47, -36.96 66.37, 3.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -108.04 APE8-dihe-in -110.03, 122.67 APE8-rot-out 53.24 APE67-dihe-in -62.79, -15.37 -94.77, 17.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.447 None None None XRAY 2.9 0.212 0.281 C 308 271 23 0 0 15 [[25, 289]] 1.0 5cwz Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5D7AA Q9UKE5 11 310 1360.0 58C:401 Type1 Inactive DFGin 5.198 13.489 BLBplus -137.96, 163.33 59.53, 46.85 -103.51, 159.44 54.57, 86.23 54.51, 36.58 in-out in 9.372 Saltbr-out 3.96 HRD-in -64.59, -47.43 75.38, -15.16 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -124.34, 121.2 APE9-dihe-na -67.99, -164.34 APE8-dihe-in -75.83, 133.18 APE8-rot-out 68.8 APE67-dihe-in -60.87, -21.38 -81.62, -20.63 APE12-dist-out 16.852 APE11-dist-in 13.934 APE10-dist-out 15.977 APE9-dist-out 9.365 None None None XRAY 2.9 0.187 0.239 A 308 289 11 0 0 11 [[25, 289]] 1.0 5d7a Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5D7AB Q9UKE5 11 307 1360.0 58C:401 Type1 Inactive DFGin 5.188 13.432 BLBplus -135.25, 165.9 56.77, 52.67 -104.96, 159.52 52.19, 87.71 62.53, 15.1 in-out in 9.956 Saltbr-out 4.589 HRD-in -70.46, -42.65 73.98, -4.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -138.03, 115.46 APE9-dihe-na -65.6, -158.9 APE8-dihe-in -75.74, 134.36 APE8-rot-out 83.48 APE67-dihe-in -58.55, -43.32 -87.11, -13.26 APE12-dist-out 16.491 APE11-dist-in 13.963 APE10-dist-out 15.938 APE9-dist-out 9.397 None None None XRAY 2.9 0.187 0.239 B 308 286 11 0 0 11 [[25, 289]] 1.0 5d7a Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 5D7AC Q9UKE5 13 310 1360.0 58C:401 Type1 Inactive DFGin 5.249 13.606 BLBplus -145.0, 158.47 58.46, 71.57 -125.2, 156.39 52.4, 82.94 72.26, 999.0 in-in in 9.982 Saltbr-in 3.216 HRD-in -68.67, -45.95 72.07, -1.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -137.04, 108.78 APE9-dihe-na -65.87, -168.4 APE8-dihe-in -72.16, 134.73 APE8-rot-out 88.32 APE67-dihe-in -62.28, -23.28 -89.29, -9.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.184 None None None XRAY 2.9 0.187 0.239 C 308 286 12 0 0 12 [[25, 289]] 1.0 5d7a Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 2X7FE Q9UKE5 14 309 1360.0 824:500 Type1 Inactive DFGin 6.66 14.794 None -124.38, 176.52 58.71, 103.53 -115.64, 999.0 286.98, 84.26 999.0, 999.0 in-none in 9.525 Saltbr-none 999.0 HRD-in -65.29, -41.79 67.65, -3.62 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 128.45 APE8-rot-none 999.0 APE67-dihe-in -51.92, -33.29 -95.18, 3.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 E 326 251 45 0 0 18 [[25, 289]] 1.0 2x7f Homo sapiens STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 8X88A Q9UKE5 15 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.725 9.945 None -92.61, 126.66 78.57, 160.72 -147.84, 30.92 39.89, 92.66 114.91, -1.91 out-out out 13.653 Saltbr-out 13.772 HRD-in -94.03, -60.42 72.05, 9.07 out-out-out SNCooo out-out ActLoopNT-out 5.487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.41 APE9-dihe-na -127.93, -146.37 APE8-dihe-in -61.41, 141.34 APE8-rot-out 49.25 APE67-dihe-in -64.12, -24.22 -101.87, 9.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.573 APE9-dist-out 10.143 None None None XRAY 2.7 0.201 0.256 A 304 294 3 0 0 3 [[25, 289]] 1.0 8x88 Homo sapiens STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 8X88B Q9UKE5 17 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.705 9.985 None -90.48, 120.54 88.19, 158.07 -146.13, 29.2 40.03, 97.67 115.62, 0.39 out-out out 14.512 Saltbr-out 13.634 HRD-in -79.11, -58.67 70.41, 12.41 out-out-out SNCooo out-out ActLoopNT-out 5.012 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -66.52, 155.13 APE9-dihe-na -65.68, 177.97 APE8-dihe-out 49.97, 73.81 APE8-rot-out 69.45 APE67-dihe-in -68.36, -20.09 -87.33, 12.07 APE12-dist-out 17.505 APE11-dist-out 17.455 APE10-dist-out 12.947 APE9-dist-out 10.863 None None None XRAY 2.7 0.201 0.256 B 304 291 4 0 0 0 [[25, 289]] 1.0 8x88 Homo sapiens STE_TNIK_HUMAN STE 2.9e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 6RA5B Q9UKE5 14 310 1360.0 No_ligand No_ligand None DFGin 5.788 14.265 BLAminus -136.76, 172.1 63.28, 95.48 -100.13, 6.47 275.29, 87.87 -57.63, -20.13 in-none in 8.566 Saltbr-none 999.0 HRD-in -68.06, -48.15 74.67, 0.64 none-in-in SNCnii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.41, 141.46 APE9-dihe-na 147.76, -160.31 APE8-dihe-in -111.74, 117.5 APE8-rot-in 316.28 APE67-dihe-in -47.73, -42.39 -30.97, -64.12 APE12-dist-in 8.838 APE11-dist-in 11.283 APE10-dist-in 5.559 APE9-dist-in 3.461 None TPO181,TPO187 TPO181,TPO187 XRAY 2.9 999.0 999.0 B 306 283 14 0 0 7 [[25, 289]] 1.0 6ra5 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TNIK_HUMAN 2X7FD Q9UKE5 17 306 1360.0 824:500 Type1 None DFGin 6.647 15.046 BLAminus -124.52, 178.85 56.71, 102.04 -114.11, 22.87 287.2, 83.98 -65.42, -48.91 in-none in 9.444 Saltbr-none 999.0 HRD-in -66.67, -40.26 66.21, -2.06 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 119.49 APE8-rot-none 999.0 APE67-dihe-in -52.92, -32.7 -93.58, 2.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 D 326 236 51 0 0 15 [[25, 289]] 1.0 2x7f Homo sapiens STE_TNIK_HUMAN STE 3.7e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase

STE_TNIK (TRAF2 and NCK-interacting protein kinase)

Total number of chains: 0
Active chains: 0
Family: STE
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name