STE_STK4 (Serine/threonine-protein kinase 4)

Total number of chains: 14
Active chains: 5
Uniprot: STK4_HUMAN
Kinase Domain Residues: 30 - 281
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 78.6% AF-Q13043-K1A
DFGin BLBminus 2 14.3% 9IICA
None None 1 7.1% 8A5JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
6YATA 2.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3FX, OJ5 Allosteric, Type1 18 - 308 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
AF-Q13043-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4
AF-Q13043-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4
8A5JA 2.123 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 28 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
8PAVA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
3COMA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
8PAVB 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
8PAWA 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
8PAWB 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
9IICA 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 308 0 None K59R Serine/threonine-protein kinase 4
9IICB 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 311 0 None K59R Serine/threonine-protein kinase 4
8A5JB 2.123 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 32 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
3COMB 2.2 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 300 0 TPO177,TPO183 None Serine/threonine-protein kinase 4
6YATB 2.58 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii OJ5 Type1 29 - 307 0 TPO177,TPO183 None Serine/threonine-protein kinase 4

STE_STK4 (Serine/threonine-protein kinase 4)

Total number of chains: 14
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 78.6% AF-Q13043-K1A
DFGin BLBminus 2 14.3% 9IICA
None None 1 7.1% 8A5JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STK4_HUMAN 6YATA 2.58 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3FX, OJ5 Allosteric, Type1 18 - 308 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN AF-Q13043-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN AF-Q13043-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 22 - 289 0 None None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 8A5JA 2.123 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 28 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 8PAVA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 3COMA 2.2 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 8PAVB 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii XOZ Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 8PAWA 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 23 - 298 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 8PAWB 2.14 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii XQL Type1 14 - 299 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 9IICA 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 308 0 None K59R Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 9IICB 2.78 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 11 - 311 0 None K59R Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 8A5JB 2.123 Inactive None‑None none-none in-in nonTYR APEdihe_aaiii APEdist_iiii 5BS Type1 32 - 309 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 3COMB 2.2 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 16 - 300 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens
STK4_HUMAN 6YATB 2.58 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii OJ5 Type1 29 - 307 0 TPO177,TPO183 None Serine/threonine-protein kinase 4 Homo sapiens

STE_STK4 (Serine/threonine-protein kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism