STE_STK4 (Serine/threonine-protein kinase 4)

Total number of chains: 14
Active chains: 5
Uniprot: STK4_HUMAN
Kinase Domain Residues: 30 - 281
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 78.6% AF-Q13043-K1A
DFGin BLBminus 2 14.3% 9IICA
None None 1 7.1% 8A5JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK4 6YATA Q13043 18 308 487.0 3FX:401,OJ5:409 Allosteric,Type1 Active DFGin 6.2669 14.6304 BLAminus -123.05, 161.34 79.45, 79.28 -95.94, 25.78 291.09, 82.71 -60.89, -35.67 in-in in 8.8476 Saltbr-in 2.3985 HRD-in -72.0, -55.62 83.05, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7705 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.81, 160.17 APE9-dihe-na 133.44, -167.08 APE8-dihe-in -110.68, 117.33 APE8-rot-in 312.01 APE67-dihe-in -56.0, -30.43 -38.16, -54.69 APE12-dist-in 8.5183 APE11-dist-in 11.6437 APE10-dist-in 5.9657 APE9-dist-in 3.3089 None TPO177,TPO183 TPO177,TPO183 XRAY 2.58 0.227 0.259 A 314.0 291.0 0 28 28 0 [[30, 281]] 1.0 6yat STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 AF-Q13043-K1A Q13043 22 289 487.0 No_ligand No_ligand Active DFGin 6.3313 14.4935 BLAminus -134.56, 174.27 58.92, 72.46 -86.05, 14.37 290.43, 88.1 -51.84, -37.05 in-in in 9.0902 Saltbr-in 2.7724 HRD-in -74.3, -42.81 65.61, 6.43 in-in-in SNCiii in-in ActLoopNT-in 2.7763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.17, 156.13 APE9-dihe-na 115.64, 171.88 APE8-dihe-in -76.33, 124.22 APE8-rot-in 307.06 APE67-dihe-in -73.26, -20.73 -46.88, -41.68 APE12-dist-in 8.7653 APE11-dist-in 11.5751 APE10-dist-in 5.8416 APE9-dist-in 3.4024 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 28 28 0 [[30, 281]] 1.0 AF-Q13043-K1 STE_STK4_HUMAN STE 2.4e-102 347.6 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 AF-Q13043-K3A Q13043 22 289 487.0 No_ligand No_ligand Active DFGin 6.0563 14.2938 BLAminus -137.4, 172.64 58.37, 77.35 -88.69, 12.68 290.82, 88.8 -53.52, -33.99 in-in in 9.0751 Saltbr-in 2.7868 HRD-in -76.45, -40.44 66.37, 2.78 in-in-in SNCiii in-in ActLoopNT-in 2.8167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.32, 146.0 APE9-dihe-na 127.33, 176.15 APE8-dihe-in -83.95, 124.75 APE8-rot-in 306.08 APE67-dihe-in -72.48, -20.3 -45.46, -43.36 APE12-dist-in 8.9882 APE11-dist-in 11.5721 APE10-dist-in 5.8121 APE9-dist-in 3.2257 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 28 28 0 [[30, 281]] 1.0 AF-Q13043-K3 STE_STK4_HUMAN STE 2.4e-102 347.6 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 8A5JA Q13043 28 309 487.0 5BS:60501 Type1 Active DFGin 6.1115 14.4237 BLAminus -137.01, 164.18 68.22, 83.42 -95.37, 24.9 295.6, 83.78 -58.89, -29.18 in-in in 9.5782 Saltbr-in 2.6601 HRD-in -62.52, -46.35 71.81, -5.19 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.87, 157.76 APE9-dihe-na 133.26, -159.59 APE8-dihe-in -112.62, 116.79 APE8-rot-in 307.48 APE67-dihe-in -60.45, -27.7 -37.29, -52.56 APE12-dist-in 8.4002 APE11-dist-in 11.5567 APE10-dist-in 5.8785 APE9-dist-in 3.3033 None TPO177,TPO183 TPO177,TPO183 XRAY 2.123 0.243 0.248 A 282.0 279.0 3 28 28 0 [[30, 281]] 1.0 8a5j STE_STK4_HUMAN STE 2.9e-102 347.4 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 8PAVA Q13043 23 298 487.0 XOZ:1001 Type1 Active DFGin 6.1585 15.989 BLAminus -133.3, 175.14 52.11, 83.27 -92.36, 20.05 285.81, 94.02 -64.88, -17.71 in-in in 9.5782 Saltbr-in 2.8541 HRD-in -59.17, -52.16 71.25, -2.23 in-in-in SNCiii in-in ActLoopNT-in 2.7682 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 151.27 APE9-dihe-na 137.39, -156.9 APE8-dihe-in -117.81, 117.32 APE8-rot-in 305.25 APE67-dihe-in -59.0, -25.32 -38.56, -53.39 APE12-dist-in 8.503 APE11-dist-in 11.6077 APE10-dist-in 5.9178 APE9-dist-in 3.2244 None TPO177,TPO183 TPO177,TPO183 XRAY 1.9 0.177 0.212 A 312.0 273.0 3 28 28 0 [[30, 281]] 1.0 8pav STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 3COMA Q13043 29 298 487.0 No_ligand No_ligand Inactive DFGin 6.286 16.0739 BLAminus -125.36, 176.71 66.24, 69.76 -88.93, 18.58 291.27, 83.94 -65.53, -12.38 in-out in 9.5768 Saltbr-out 3.7913 HRD-in -65.3, -48.8 78.48, -9.1 out-in-in SNCoii in-in ActLoopNT-in 2.7615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.25, 151.38 APE9-dihe-na 139.51, -156.96 APE8-dihe-in -114.6, 124.74 APE8-rot-in 304.66 APE67-dihe-in -65.13, -24.96 -35.15, -56.5 APE12-dist-in 8.5972 APE11-dist-in 11.7065 APE10-dist-in 6.1151 APE9-dist-in 3.3214 None TPO177,TPO183 TPO177,TPO183 XRAY 2.2 0.208 0.244 A 314.0 266.0 4 28 28 0 [[30, 281]] 1.0 3com STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 8PAVB Q13043 14 299 487.0 XOZ:1001 Type1 Inactive DFGin 6.0984 16.1081 BLAminus -132.92, 167.6 65.27, 88.73 -94.87, 25.08 287.66, 84.1 -65.32, -22.38 out-out out 10.2524 Saltbr-out 4.5788 HRD-in -60.82, -50.96 71.74, -0.45 out-in-in SNCoii in-in ActLoopNT-in 2.7554 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.53, 155.3 APE9-dihe-na 137.74, -159.61 APE8-dihe-in -114.72, 114.19 APE8-rot-in 308.5 APE67-dihe-in -57.84, -24.43 -37.29, -54.62 APE12-dist-in 8.3636 APE11-dist-in 11.5526 APE10-dist-in 5.8624 APE9-dist-in 3.3687 None TPO177,TPO183 TPO177,TPO183 XRAY 1.9 0.177 0.212 B 312.0 283.0 3 28 28 0 [[30, 281]] 1.0 8pav STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 8PAWA Q13043 23 298 487.0 XQL:402 Type1 Inactive DFGin 6.1277 15.9513 BLAminus -132.89, 169.15 64.34, 80.6 -92.47, 21.59 289.33, 87.55 -63.36, -23.01 in-out in 9.5601 Saltbr-out 6.3895 HRD-in -61.61, -52.12 76.78, -6.44 out-in-in SNCoii in-in ActLoopNT-in 2.8217 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.75, 155.95 APE9-dihe-na 130.96, -163.99 APE8-dihe-in -113.43, 120.76 APE8-rot-in 308.82 APE67-dihe-in -63.93, -24.08 -38.54, -50.4 APE12-dist-in 8.4532 APE11-dist-in 11.5934 APE10-dist-in 5.8892 APE9-dist-in 3.2303 None TPO177,TPO183 TPO177,TPO183 XRAY 2.14 0.196 0.226 A 312.0 272.0 4 28 28 0 [[30, 281]] 1.0 8paw STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 8PAWB Q13043 14 299 487.0 XQL:1001 Type1 Inactive DFGin 6.0996 16.0525 BLAminus -133.09, 165.97 68.44, 85.21 -93.54, 27.55 289.93, 83.76 -58.28, -28.45 in-out in 9.9607 Saltbr-out 6.7309 HRD-in -63.01, -50.43 74.36, -2.79 out-in-in SNCoii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.49, 153.86 APE9-dihe-na 139.8, -162.94 APE8-dihe-in -110.25, 117.0 APE8-rot-in 311.46 APE67-dihe-in -65.88, -22.98 -34.81, -50.8 APE12-dist-in 8.3614 APE11-dist-in 11.5719 APE10-dist-in 5.8687 APE9-dist-in 3.2992 None TPO177,TPO183 TPO177,TPO183 XRAY 2.14 0.196 0.226 B 312.0 285.0 1 28 28 0 [[30, 281]] 1.0 8paw STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 9IICA Q13043 11 308 487.0 No_ligand No_ligand Inactive DFGin 5.6435 16.5994 BLBminus -134.06, 173.38 52.3, 65.08 -56.98, 120.61 286.96, 83.01 -62.14, 111.02 out-none out 10.6299 Saltbr-none 999.0 HRD-in -70.0, -47.61 78.26, -3.42 none-out-out SNCnoo out-out ActLoopNT-out 10.309 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -111.21 APE8-dihe-in -88.77, 118.71 APE8-rot-out 84.26 APE67-dihe-in -62.54, -32.6 -95.3, 9.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6344 K59R None None XRAY 2.78 0.239 0.28 A 302.0 287.0 11 28 17 11 [[30, 281]] 1.0 9iic STE_STK4_HUMAN STE 1.3e-101 345.2 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 9IICB Q13043 11 311 487.0 No_ligand No_ligand Inactive DFGin 5.4437 16.0122 BLBminus -143.15, 164.12 57.93, 65.86 -58.88, 137.24 292.46, 83.89 -63.86, 138.05 out-none out 10.0991 Saltbr-none 999.0 HRD-in -67.75, -47.0 77.13, -5.46 none-out-out SNCnoo out-out ActLoopNT-out 10.374 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -125.79 APE8-dihe-in -76.78, 127.52 APE8-rot-out 51.31 APE67-dihe-in -61.47, -24.11 -92.04, -1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0726 K59R None None XRAY 2.78 0.239 0.28 B 302.0 289.0 12 28 16 12 [[30, 281]] 1.0 9iic STE_STK4_HUMAN STE 1.3e-101 345.2 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 8A5JB Q13043 32 309 487.0 5BS:60501 Type1 Inactive None 6.1832 999.0 None -136.98, 164.64 68.65, 82.94 -95.0, 23.57 294.73, 84.74 -56.91, -33.47 none-none none 999.0 Saltbr-none 999.0 HRD-in -61.94, -46.75 72.95, -3.57 none-in-in SNCnii in-in ActLoopNT-in 2.7991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.28, 156.86 APE9-dihe-na 133.22, -159.66 APE8-dihe-in -113.06, 118.47 APE8-rot-in 300.84 APE67-dihe-in -66.93, -24.0 -39.55, -46.8 APE12-dist-in 8.294 APE11-dist-in 11.5278 APE10-dist-in 5.8585 APE9-dist-in 3.2972 None TPO177,TPO183 TPO177,TPO183 XRAY 2.123 0.243 0.248 B 282.0 249.0 31 28 28 0 [[30, 281]] 1.0 8a5j STE_STK4_HUMAN STE 2.9e-102 347.4 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 3COMB Q13043 16 300 487.0 No_ligand No_ligand None DFGin 6.1366 16.6005 BLAminus -134.01, 172.5 67.0, 78.39 -93.14, 23.87 292.75, 86.25 -56.92, -29.06 out-none out 11.0565 Saltbr-none 999.0 HRD-in -66.76, -48.0 70.25, -1.11 none-in-in SNCnii in-in ActLoopNT-in 2.7456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 159.2 APE9-dihe-na 132.23, -164.97 APE8-dihe-in -110.63, 116.4 APE8-rot-in 300.96 APE67-dihe-in -64.28, -22.43 -30.15, -57.75 APE12-dist-in 8.506 APE11-dist-in 11.5383 APE10-dist-in 5.9492 APE9-dist-in 3.4023 None TPO177,TPO183 TPO177,TPO183 XRAY 2.2 0.208 0.244 B 314.0 281.0 4 28 28 0 [[30, 281]] 1.0 3com STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 6YATB Q13043 29 307 487.0 OJ5:401 Type1 None DFGin 6.4664 13.8541 BLAminus -122.05, 162.57 77.71, 80.56 -97.31, 25.12 292.31, 85.07 -58.76, -37.95 in-none in 8.6838 Saltbr-none 999.0 HRD-in -73.27, -56.52 82.91, -0.91 none-in-in SNCnii in-in ActLoopNT-in 2.7507 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.95, 157.18 APE9-dihe-na 132.69, -166.17 APE8-dihe-in -108.9, 116.74 APE8-rot-in 312.41 APE67-dihe-in -55.33, -29.29 -39.0, -55.77 APE12-dist-in 8.4324 APE11-dist-in 11.4918 APE10-dist-in 5.7891 APE9-dist-in 3.2856 None TPO177,TPO183 TPO177,TPO183 XRAY 2.58 0.227 0.259 B 314.0 276.0 3 28 28 0 [[30, 281]] 1.0 6yat STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4

STE_STK4 (Serine/threonine-protein kinase 4)

Total number of chains: 14
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 78.6% AF-Q13043-K1A
DFGin BLBminus 2 14.3% 9IICA
None None 1 7.1% 8A5JB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STK4 STK4_HUMAN 6YATA Q13043 18 308 487.0 3FX:401,OJ5:409 Allosteric,Type1 Active DFGin 6.2669 14.6304 BLAminus -123.05, 161.34 79.45, 79.28 -95.94, 25.78 291.09, 82.71 -60.89, -35.67 in-in in 8.8476 Saltbr-in 2.3985 HRD-in -72.0, -55.62 83.05, -4.12 in-in-in SNCiii in-in ActLoopNT-in 2.7705 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.81, 160.17 APE9-dihe-na 133.44, -167.08 APE8-dihe-in -110.68, 117.33 APE8-rot-in 312.01 APE67-dihe-in -56.0, -30.43 -38.16, -54.69 APE12-dist-in 8.5183 APE11-dist-in 11.6437 APE10-dist-in 5.9657 APE9-dist-in 3.3089 None TPO177,TPO183 TPO177,TPO183 XRAY 2.58 0.227 0.259 A 314.0 291.0 0 28 28 0 [[30, 281]] 1.0 6yat Homo sapiens STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN AF-Q13043-K1A Q13043 22 289 487.0 No_ligand No_ligand Active DFGin 6.3313 14.4935 BLAminus -134.56, 174.27 58.92, 72.46 -86.05, 14.37 290.43, 88.1 -51.84, -37.05 in-in in 9.0902 Saltbr-in 2.7724 HRD-in -74.3, -42.81 65.61, 6.43 in-in-in SNCiii in-in ActLoopNT-in 2.7763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.17, 156.13 APE9-dihe-na 115.64, 171.88 APE8-dihe-in -76.33, 124.22 APE8-rot-in 307.06 APE67-dihe-in -73.26, -20.73 -46.88, -41.68 APE12-dist-in 8.7653 APE11-dist-in 11.5751 APE10-dist-in 5.8416 APE9-dist-in 3.4024 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 28 28 0 [[30, 281]] 1.0 AF-Q13043-K1 Homo sapiens STE_STK4_HUMAN STE 2.4e-102 347.6 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN AF-Q13043-K3A Q13043 22 289 487.0 No_ligand No_ligand Active DFGin 6.0563 14.2938 BLAminus -137.4, 172.64 58.37, 77.35 -88.69, 12.68 290.82, 88.8 -53.52, -33.99 in-in in 9.0751 Saltbr-in 2.7868 HRD-in -76.45, -40.44 66.37, 2.78 in-in-in SNCiii in-in ActLoopNT-in 2.8167 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.32, 146.0 APE9-dihe-na 127.33, 176.15 APE8-dihe-in -83.95, 124.75 APE8-rot-in 306.08 APE67-dihe-in -72.48, -20.3 -45.46, -43.36 APE12-dist-in 8.9882 APE11-dist-in 11.5721 APE10-dist-in 5.8121 APE9-dist-in 3.2257 None None None AF2 -1.0 1.0 1.0 A 268.0 268.0 0 28 28 0 [[30, 281]] 1.0 AF-Q13043-K3 Homo sapiens STE_STK4_HUMAN STE 2.4e-102 347.6 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 8A5JA Q13043 28 309 487.0 5BS:60501 Type1 Active DFGin 6.1115 14.4237 BLAminus -137.01, 164.18 68.22, 83.42 -95.37, 24.9 295.6, 83.78 -58.89, -29.18 in-in in 9.5782 Saltbr-in 2.6601 HRD-in -62.52, -46.35 71.81, -5.19 in-in-in SNCiii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.87, 157.76 APE9-dihe-na 133.26, -159.59 APE8-dihe-in -112.62, 116.79 APE8-rot-in 307.48 APE67-dihe-in -60.45, -27.7 -37.29, -52.56 APE12-dist-in 8.4002 APE11-dist-in 11.5567 APE10-dist-in 5.8785 APE9-dist-in 3.3033 None TPO177,TPO183 TPO177,TPO183 XRAY 2.123 0.243 0.248 A 282.0 279.0 3 28 28 0 [[30, 281]] 1.0 8a5j Homo sapiens STE_STK4_HUMAN STE 2.9e-102 347.4 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 8PAVA Q13043 23 298 487.0 XOZ:1001 Type1 Active DFGin 6.1585 15.989 BLAminus -133.3, 175.14 52.11, 83.27 -92.36, 20.05 285.81, 94.02 -64.88, -17.71 in-in in 9.5782 Saltbr-in 2.8541 HRD-in -59.17, -52.16 71.25, -2.23 in-in-in SNCiii in-in ActLoopNT-in 2.7682 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 151.27 APE9-dihe-na 137.39, -156.9 APE8-dihe-in -117.81, 117.32 APE8-rot-in 305.25 APE67-dihe-in -59.0, -25.32 -38.56, -53.39 APE12-dist-in 8.503 APE11-dist-in 11.6077 APE10-dist-in 5.9178 APE9-dist-in 3.2244 None TPO177,TPO183 TPO177,TPO183 XRAY 1.9 0.177 0.212 A 312.0 273.0 3 28 28 0 [[30, 281]] 1.0 8pav Homo sapiens STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 3COMA Q13043 29 298 487.0 No_ligand No_ligand Inactive DFGin 6.286 16.0739 BLAminus -125.36, 176.71 66.24, 69.76 -88.93, 18.58 291.27, 83.94 -65.53, -12.38 in-out in 9.5768 Saltbr-out 3.7913 HRD-in -65.3, -48.8 78.48, -9.1 out-in-in SNCoii in-in ActLoopNT-in 2.7615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.25, 151.38 APE9-dihe-na 139.51, -156.96 APE8-dihe-in -114.6, 124.74 APE8-rot-in 304.66 APE67-dihe-in -65.13, -24.96 -35.15, -56.5 APE12-dist-in 8.5972 APE11-dist-in 11.7065 APE10-dist-in 6.1151 APE9-dist-in 3.3214 None TPO177,TPO183 TPO177,TPO183 XRAY 2.2 0.208 0.244 A 314.0 266.0 4 28 28 0 [[30, 281]] 1.0 3com Homo sapiens STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 8PAVB Q13043 14 299 487.0 XOZ:1001 Type1 Inactive DFGin 6.0984 16.1081 BLAminus -132.92, 167.6 65.27, 88.73 -94.87, 25.08 287.66, 84.1 -65.32, -22.38 out-out out 10.2524 Saltbr-out 4.5788 HRD-in -60.82, -50.96 71.74, -0.45 out-in-in SNCoii in-in ActLoopNT-in 2.7554 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.53, 155.3 APE9-dihe-na 137.74, -159.61 APE8-dihe-in -114.72, 114.19 APE8-rot-in 308.5 APE67-dihe-in -57.84, -24.43 -37.29, -54.62 APE12-dist-in 8.3636 APE11-dist-in 11.5526 APE10-dist-in 5.8624 APE9-dist-in 3.3687 None TPO177,TPO183 TPO177,TPO183 XRAY 1.9 0.177 0.212 B 312.0 283.0 3 28 28 0 [[30, 281]] 1.0 8pav Homo sapiens STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 8PAWA Q13043 23 298 487.0 XQL:402 Type1 Inactive DFGin 6.1277 15.9513 BLAminus -132.89, 169.15 64.34, 80.6 -92.47, 21.59 289.33, 87.55 -63.36, -23.01 in-out in 9.5601 Saltbr-out 6.3895 HRD-in -61.61, -52.12 76.78, -6.44 out-in-in SNCoii in-in ActLoopNT-in 2.8217 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.75, 155.95 APE9-dihe-na 130.96, -163.99 APE8-dihe-in -113.43, 120.76 APE8-rot-in 308.82 APE67-dihe-in -63.93, -24.08 -38.54, -50.4 APE12-dist-in 8.4532 APE11-dist-in 11.5934 APE10-dist-in 5.8892 APE9-dist-in 3.2303 None TPO177,TPO183 TPO177,TPO183 XRAY 2.14 0.196 0.226 A 312.0 272.0 4 28 28 0 [[30, 281]] 1.0 8paw Homo sapiens STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 8PAWB Q13043 14 299 487.0 XQL:1001 Type1 Inactive DFGin 6.0996 16.0525 BLAminus -133.09, 165.97 68.44, 85.21 -93.54, 27.55 289.93, 83.76 -58.28, -28.45 in-out in 9.9607 Saltbr-out 6.7309 HRD-in -63.01, -50.43 74.36, -2.79 out-in-in SNCoii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.49, 153.86 APE9-dihe-na 139.8, -162.94 APE8-dihe-in -110.25, 117.0 APE8-rot-in 311.46 APE67-dihe-in -65.88, -22.98 -34.81, -50.8 APE12-dist-in 8.3614 APE11-dist-in 11.5719 APE10-dist-in 5.8687 APE9-dist-in 3.2992 None TPO177,TPO183 TPO177,TPO183 XRAY 2.14 0.196 0.226 B 312.0 285.0 1 28 28 0 [[30, 281]] 1.0 8paw Homo sapiens STE_STK4_HUMAN STE 4.1e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 9IICA Q13043 11 308 487.0 No_ligand No_ligand Inactive DFGin 5.6435 16.5994 BLBminus -134.06, 173.38 52.3, 65.08 -56.98, 120.61 286.96, 83.01 -62.14, 111.02 out-none out 10.6299 Saltbr-none 999.0 HRD-in -70.0, -47.61 78.26, -3.42 none-out-out SNCnoo out-out ActLoopNT-out 10.309 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -111.21 APE8-dihe-in -88.77, 118.71 APE8-rot-out 84.26 APE67-dihe-in -62.54, -32.6 -95.3, 9.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6344 K59R None None XRAY 2.78 0.239 0.28 A 302.0 287.0 11 28 17 11 [[30, 281]] 1.0 9iic Homo sapiens STE_STK4_HUMAN STE 1.3e-101 345.2 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 9IICB Q13043 11 311 487.0 No_ligand No_ligand Inactive DFGin 5.4437 16.0122 BLBminus -143.15, 164.12 57.93, 65.86 -58.88, 137.24 292.46, 83.89 -63.86, 138.05 out-none out 10.0991 Saltbr-none 999.0 HRD-in -67.75, -47.0 77.13, -5.46 none-out-out SNCnoo out-out ActLoopNT-out 10.374 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -125.79 APE8-dihe-in -76.78, 127.52 APE8-rot-out 51.31 APE67-dihe-in -61.47, -24.11 -92.04, -1.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.0726 K59R None None XRAY 2.78 0.239 0.28 B 302.0 289.0 12 28 16 12 [[30, 281]] 1.0 9iic Homo sapiens STE_STK4_HUMAN STE 1.3e-101 345.2 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 8A5JB Q13043 32 309 487.0 5BS:60501 Type1 Inactive None 6.1832 999.0 None -136.98, 164.64 68.65, 82.94 -95.0, 23.57 294.73, 84.74 -56.91, -33.47 none-none none 999.0 Saltbr-none 999.0 HRD-in -61.94, -46.75 72.95, -3.57 none-in-in SNCnii in-in ActLoopNT-in 2.7991 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.28, 156.86 APE9-dihe-na 133.22, -159.66 APE8-dihe-in -113.06, 118.47 APE8-rot-in 300.84 APE67-dihe-in -66.93, -24.0 -39.55, -46.8 APE12-dist-in 8.294 APE11-dist-in 11.5278 APE10-dist-in 5.8585 APE9-dist-in 3.2972 None TPO177,TPO183 TPO177,TPO183 XRAY 2.123 0.243 0.248 B 282.0 249.0 31 28 28 0 [[30, 281]] 1.0 8a5j Homo sapiens STE_STK4_HUMAN STE 2.9e-102 347.4 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 3COMB Q13043 16 300 487.0 No_ligand No_ligand None DFGin 6.1366 16.6005 BLAminus -134.01, 172.5 67.0, 78.39 -93.14, 23.87 292.75, 86.25 -56.92, -29.06 out-none out 11.0565 Saltbr-none 999.0 HRD-in -66.76, -48.0 70.25, -1.11 none-in-in SNCnii in-in ActLoopNT-in 2.7456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 159.2 APE9-dihe-na 132.23, -164.97 APE8-dihe-in -110.63, 116.4 APE8-rot-in 300.96 APE67-dihe-in -64.28, -22.43 -30.15, -57.75 APE12-dist-in 8.506 APE11-dist-in 11.5383 APE10-dist-in 5.9492 APE9-dist-in 3.4023 None TPO177,TPO183 TPO177,TPO183 XRAY 2.2 0.208 0.244 B 314.0 281.0 4 28 28 0 [[30, 281]] 1.0 3com Homo sapiens STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STK4 STK4_HUMAN 6YATB Q13043 29 307 487.0 OJ5:401 Type1 None DFGin 6.4664 13.8541 BLAminus -122.05, 162.57 77.71, 80.56 -97.31, 25.12 292.31, 85.07 -58.76, -37.95 in-none in 8.6838 Saltbr-none 999.0 HRD-in -73.27, -56.52 82.91, -0.91 none-in-in SNCnii in-in ActLoopNT-in 2.7507 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.95, 157.18 APE9-dihe-na 132.69, -166.17 APE8-dihe-in -108.9, 116.74 APE8-rot-in 312.41 APE67-dihe-in -55.33, -29.29 -39.0, -55.77 APE12-dist-in 8.4324 APE11-dist-in 11.4918 APE10-dist-in 5.7891 APE9-dist-in 3.2856 None TPO177,TPO183 TPO177,TPO183 XRAY 2.58 0.227 0.259 B 314.0 276.0 3 28 28 0 [[30, 281]] 1.0 6yat Homo sapiens STE_STK4_HUMAN STE 4.2e-102 346.9 2.0 257.0 256.0 166 167 168 170 172 59 73 77 146 148 147 149.0 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4

STE_STK4 (Serine/threonine-protein kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name