STE_SLK (STE20-like serine/threonine-protein kinase)

Total number of chains: 13
Active chains: 2
Uniprot: SLK_HUMAN
Kinase Domain Residues: 34 - 292
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 53.8% AF-Q9H2G2-K1A
DFGout BBAminus 4 30.8% 8BEMB
DFGinter None 2 15.4% 4USFB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SLK AF-Q9H2G2-K1A Q9H2G2 26 300 1235.0 No_ligand No_ligand Active DFGin 6.6124 14.4718 BLAminus -135.09, 172.8 59.16, 73.19 -86.98, 11.14 285.47, 79.75 -61.72, -25.19 in-in in 8.6298 Saltbr-in 2.7744 HRD-in -70.46, -43.4 65.85, -8.4 in-in-in SNCiii in-in ActLoopNT-in 2.8851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.2, 160.63 APE9-dihe-na 105.89, 171.46 APE8-dihe-in -80.35, 125.56 APE8-rot-in 307.87 APE67-dihe-in -69.13, -28.4 -49.23, -38.29 APE12-dist-in 8.6884 APE11-dist-in 11.8004 APE10-dist-in 6.066 APE9-dist-in 3.4947 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[34, 292]] 1.0 AF-Q9H2G2-K1 STE_SLK_HUMAN STE 6e-97 329.9 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK AF-Q9H2G2-K3A Q9H2G2 26 300 1235.0 No_ligand No_ligand Active DFGin 6.1785 14.8959 BLAminus -133.24, -179.3 59.69, 75.55 -92.64, 10.12 282.43, 76.96 -60.69, -19.93 in-in in 9.1262 Saltbr-in 2.9284 HRD-in -76.74, -45.0 68.92, -11.71 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.05, 136.75 APE9-dihe-na 135.26, 167.89 APE8-dihe-in -76.59, 127.05 APE8-rot-in 301.09 APE67-dihe-in -74.19, -26.31 -49.99, -38.13 APE12-dist-in 9.2458 APE11-dist-in 11.82 APE10-dist-in 6.0525 APE9-dist-in 3.3381 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[34, 292]] 1.0 AF-Q9H2G2-K3 STE_SLK_HUMAN STE 6e-97 329.9 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 2JFMA Q9H2G2 21 308 1235.0 No_ligand No_ligand Inactive DFGin 6.4295 14.7774 BLAminus -136.32, -161.29 40.72, 88.42 -104.09, 26.01 295.99, 85.45 -52.37, -40.48 in-none in 8.6802 Saltbr-none 999.0 HRD-in -63.98, -55.04 72.7, 8.28 none-in-out SNCnio in-out ActLoopNT-in 2.8876 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -134.4, 157.83 APE9-dihe-na 77.23, 165.53 APE8-dihe-in -68.7, 125.82 APE8-rot-in 313.07 APE67-dihe-out -56.99, -22.42 -93.28, 60.24 APE12-dist-out 26.0033 APE11-dist-out 30.0213 APE10-dist-out 33.6512 APE9-dist-out 38.8188 None TPO183 TPO183 XRAY 2.85 0.232 0.271 A 325.0 288.0 0 28 28 0 [[34, 292]] 1.0 2jfm STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 6HVDA Q9H2G2 19 309 1235.0 GUQ:60404 Type1 Inactive DFGin 6.7019 14.7753 BLAminus -132.62, -178.43 48.45, 81.21 -89.1, 25.63 287.8, 75.88 -64.56, -25.09 in-in in 8.3305 Saltbr-in 2.9126 HRD-in -65.71, -49.9 76.16, 2.26 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.19, -43.8 APE9-dihe-na 96.15, -176.95 APE8-dihe-in -73.29, 130.82 APE8-rot-out 58.13 APE67-dihe-in -60.81, -24.49 -95.73, -0.67 APE12-dist-out 28.1443 APE11-dist-out 32.1564 APE10-dist-out 31.7429 APE9-dist-out 36.7373 None None None XRAY 1.63 0.187 0.207 A 304.0 285.0 6 28 22 6 [[34, 292]] 1.0 6hvd STE_SLK_HUMAN STE 8.7e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 2J51A Q9H2G2 21 308 1235.0 DKI:1314 Type1 Inactive DFGin 6.5233 14.8292 BLAminus -130.32, -176.18 60.33, 78.02 -96.46, 29.37 298.21, 93.29 -66.33, -25.13 in-out in 9.3343 Saltbr-out 4.065 HRD-in -63.84, -54.01 78.76, -8.07 out-in-out SNCoio in-out ActLoopNT-in 2.8097 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -122.41, 160.73 APE9-dihe-na 70.8, 172.83 APE8-dihe-in -83.92, 118.66 APE8-rot-in 311.16 APE67-dihe-out -60.04, -26.26 -91.46, 69.72 APE12-dist-out 25.4912 APE11-dist-out 29.6303 APE10-dist-out 33.2987 APE9-dist-out 38.3911 None None None XRAY 2.1 0.202 0.233 A 325.0 288.0 0 28 28 0 [[34, 292]] 1.0 2j51 STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 2JFLA Q9H2G2 21 308 1235.0 DKI:1309 Type1 Inactive DFGin 6.5483 14.9408 BLAminus -134.74, -178.0 59.5, 81.29 -99.1, 26.08 298.0, 90.14 -61.58, -25.76 in-out in 9.462 Saltbr-out 4.3715 HRD-in -63.48, -53.98 76.6, -2.17 out-in-out SNCoio in-out ActLoopNT-in 2.8113 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -134.72, 146.95 APE9-dihe-na 74.36, 175.84 APE8-dihe-in -85.0, 123.29 APE8-rot-in 314.87 APE67-dihe-out -59.55, -27.06 -91.86, 66.94 APE12-dist-out 25.8401 APE11-dist-out 30.0028 APE10-dist-out 33.5178 APE9-dist-out 38.7571 None TPO183,SEP189 TPO183,SEP189 XRAY 2.2 0.205 0.242 A 325.0 288.0 0 28 28 0 [[34, 292]] 1.0 2jfl STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 2UV2A Q9H2G2 21 308 1235.0 GVD:1316 Type1 Inactive DFGin 6.3917 14.6683 BLAminus -137.63, 176.53 65.09, 88.86 -105.79, 29.31 299.3, 89.13 -57.8, -30.07 in-in in 9.266 Saltbr-in 3.0091 HRD-in -63.28, -54.67 77.02, -4.58 in-in-out SNCiio in-out ActLoopNT-in 2.8423 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -136.25, 151.49 APE9-dihe-na 68.24, 176.61 APE8-dihe-in -84.97, 119.74 APE8-rot-in 310.47 APE67-dihe-out -66.38, -23.85 -91.33, 75.21 APE12-dist-out 25.7456 APE11-dist-out 29.9092 APE10-dist-out 33.3833 APE9-dist-out 38.719 K25T None None XRAY 2.3 0.199 0.234 A 325.0 286.0 2 28 28 0 [[34, 292]] 1.0 2uv2 STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 4USFA Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.0421 10.058 None -117.97, -164.7 -148.31, 161.25 67.07, 10.53 308.47, 138.36 -64.12, 155.64 out-out out 12.2698 Saltbr-out 11.5207 HRD-in -81.47, -50.79 75.66, -10.69 out-out-out SNCooo out-out ActLoopNT-out 20.0813 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.78 APE8-rot-in 310.95 APE67-dihe-out -63.58, -25.56 -87.14, 59.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.198 0.228 A 304.0 275.0 17 28 15 13 [[34, 292]] 1.0 4usf STE_SLK_HUMAN STE 8.7e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 4USFB Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.3797 9.9495 None -116.24, -167.43 -147.44, 163.23 64.7, 16.11 306.44, 141.27 -69.71, 155.48 out-out out 11.908 Saltbr-out 10.4915 HRD-in -81.17, -51.97 77.33, -10.55 out-out-out SNCooo out-out ActLoopNT-out 19.9632 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -129.76, 123.16 APE9-dihe-na 56.23, 51.46 APE8-dihe-in -52.62, 128.43 APE8-rot-in 306.51 APE67-dihe-in -63.75, -23.49 -58.2, -37.55 APE12-dist-none 999.0 APE11-dist-out 7.8043 APE10-dist-out 11.9679 APE9-dist-in 3.5176 None None None XRAY 1.75 0.198 0.228 B 304.0 283.0 9 28 19 9 [[34, 292]] 1.0 4usf STE_SLK_HUMAN STE 8.7e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 8BEMD Q9H2G2 19 310 1235.0 AV9:60401 Type1 Inactive DFGout 15.609 9.9932 BBAminus -129.69, -171.85 -147.29, 95.2 -67.37, -14.53 272.02, 82.73 97.97, 999.0 out-none out 11.5707 Saltbr-none 999.0 HRD-in -73.63, -51.69 82.34, -9.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -107.2, 146.53 APE9-dihe-na -108.51, -140.02 APE8-dihe-in -73.06, 128.87 APE8-rot-out 206.21 APE67-dihe-in -57.91, -29.99 -86.03, -11.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7505 None None None XRAY 2.6 0.224 0.255 D 303.0 273.0 19 28 15 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 8BEMG Q9H2G2 19 309 1235.0 AV9:60401 Type1 Inactive DFGout 15.3561 9.9535 BBAminus -127.42, -170.65 -149.27, 90.59 -63.76, -33.71 272.3, 85.55 107.87, 999.0 out-none out 11.5692 Saltbr-none 999.0 HRD-in -73.12, -53.95 82.08, -10.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -90.9, -30.32 APE9-dihe-na 83.56, -160.87 APE8-dihe-in -88.82, 133.57 APE8-rot-out 56.86 APE67-dihe-in -57.37, -30.65 -86.38, -11.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8172 None None None XRAY 2.6 0.224 0.255 G 303.0 270.0 21 28 14 14 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 8BEMA Q9H2G2 19 309 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3204 10.3427 BBAminus -126.87, -173.24 -145.98, 95.31 -71.29, -11.44 274.39, 85.56 92.57, 999.0 out-none out 11.248 Saltbr-none 999.0 HRD-in -73.36, -54.08 82.06, -7.69 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -86.71, -31.34 APE9-dihe-na 83.07, -163.39 APE8-dihe-in -88.8, 134.74 APE8-rot-out 59.81 APE67-dihe-in -58.75, -30.61 -85.18, -13.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 None None None XRAY 2.6 0.224 0.255 A 303.0 272.0 19 28 15 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK 8BEMB Q9H2G2 19 310 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3625 10.3862 BBAminus -130.09, -171.07 -147.42, 95.57 -73.15, -8.63 276.71, 86.66 100.89, 999.0 out-out out 11.371 Saltbr-out 8.7129 HRD-in -73.46, -53.46 83.25, -10.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -84.78, -30.24 APE9-dihe-na 85.62, -163.37 APE8-dihe-in -89.09, 132.42 APE8-rot-out 195.94 APE67-dihe-in -58.26, -30.88 -85.95, -14.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4036 None None None XRAY 2.6 0.224 0.255 B 303.0 275.0 17 28 15 13 [[34, 292]] 1.0 8bem STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase

STE_SLK (STE20-like serine/threonine-protein kinase)

Total number of chains: 13
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 53.8% AF-Q9H2G2-K1A
DFGout BBAminus 4 30.8% 8BEMB
DFGinter None 2 15.4% 4USFB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SLK SLK_HUMAN AF-Q9H2G2-K1A Q9H2G2 26 300 1235.0 No_ligand No_ligand Active DFGin 6.6124 14.4718 BLAminus -135.09, 172.8 59.16, 73.19 -86.98, 11.14 285.47, 79.75 -61.72, -25.19 in-in in 8.6298 Saltbr-in 2.7744 HRD-in -70.46, -43.4 65.85, -8.4 in-in-in SNCiii in-in ActLoopNT-in 2.8851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.2, 160.63 APE9-dihe-na 105.89, 171.46 APE8-dihe-in -80.35, 125.56 APE8-rot-in 307.87 APE67-dihe-in -69.13, -28.4 -49.23, -38.29 APE12-dist-in 8.6884 APE11-dist-in 11.8004 APE10-dist-in 6.066 APE9-dist-in 3.4947 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[34, 292]] 1.0 AF-Q9H2G2-K1 Homo sapiens STE_SLK_HUMAN STE 6e-97 329.9 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN AF-Q9H2G2-K3A Q9H2G2 26 300 1235.0 No_ligand No_ligand Active DFGin 6.1785 14.8959 BLAminus -133.24, -179.3 59.69, 75.55 -92.64, 10.12 282.43, 76.96 -60.69, -19.93 in-in in 9.1262 Saltbr-in 2.9284 HRD-in -76.74, -45.0 68.92, -11.71 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.05, 136.75 APE9-dihe-na 135.26, 167.89 APE8-dihe-in -76.59, 127.05 APE8-rot-in 301.09 APE67-dihe-in -74.19, -26.31 -49.99, -38.13 APE12-dist-in 9.2458 APE11-dist-in 11.82 APE10-dist-in 6.0525 APE9-dist-in 3.3381 None None None AF2 -1.0 1.0 1.0 A 275.0 275.0 0 28 28 0 [[34, 292]] 1.0 AF-Q9H2G2-K3 Homo sapiens STE_SLK_HUMAN STE 6e-97 329.9 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 2JFMA Q9H2G2 21 308 1235.0 No_ligand No_ligand Inactive DFGin 6.4295 14.7774 BLAminus -136.32, -161.29 40.72, 88.42 -104.09, 26.01 295.99, 85.45 -52.37, -40.48 in-none in 8.6802 Saltbr-none 999.0 HRD-in -63.98, -55.04 72.7, 8.28 none-in-out SNCnio in-out ActLoopNT-in 2.8876 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -134.4, 157.83 APE9-dihe-na 77.23, 165.53 APE8-dihe-in -68.7, 125.82 APE8-rot-in 313.07 APE67-dihe-out -56.99, -22.42 -93.28, 60.24 APE12-dist-out 26.0033 APE11-dist-out 30.0213 APE10-dist-out 33.6512 APE9-dist-out 38.8188 None TPO183 TPO183 XRAY 2.85 0.232 0.271 A 325.0 288.0 0 28 28 0 [[34, 292]] 1.0 2jfm Homo sapiens STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 6HVDA Q9H2G2 19 309 1235.0 GUQ:60404 Type1 Inactive DFGin 6.7019 14.7753 BLAminus -132.62, -178.43 48.45, 81.21 -89.1, 25.63 287.8, 75.88 -64.56, -25.09 in-in in 8.3305 Saltbr-in 2.9126 HRD-in -65.71, -49.9 76.16, 2.26 in-in-out SNCiio in-out ActLoopNT-in 2.894 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.19, -43.8 APE9-dihe-na 96.15, -176.95 APE8-dihe-in -73.29, 130.82 APE8-rot-out 58.13 APE67-dihe-in -60.81, -24.49 -95.73, -0.67 APE12-dist-out 28.1443 APE11-dist-out 32.1564 APE10-dist-out 31.7429 APE9-dist-out 36.7373 None None None XRAY 1.63 0.187 0.207 A 304.0 285.0 6 28 22 6 [[34, 292]] 1.0 6hvd Homo sapiens STE_SLK_HUMAN STE 8.7e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 2J51A Q9H2G2 21 308 1235.0 DKI:1314 Type1 Inactive DFGin 6.5233 14.8292 BLAminus -130.32, -176.18 60.33, 78.02 -96.46, 29.37 298.21, 93.29 -66.33, -25.13 in-out in 9.3343 Saltbr-out 4.065 HRD-in -63.84, -54.01 78.76, -8.07 out-in-out SNCoio in-out ActLoopNT-in 2.8097 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -122.41, 160.73 APE9-dihe-na 70.8, 172.83 APE8-dihe-in -83.92, 118.66 APE8-rot-in 311.16 APE67-dihe-out -60.04, -26.26 -91.46, 69.72 APE12-dist-out 25.4912 APE11-dist-out 29.6303 APE10-dist-out 33.2987 APE9-dist-out 38.3911 None None None XRAY 2.1 0.202 0.233 A 325.0 288.0 0 28 28 0 [[34, 292]] 1.0 2j51 Homo sapiens STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 2JFLA Q9H2G2 21 308 1235.0 DKI:1309 Type1 Inactive DFGin 6.5483 14.9408 BLAminus -134.74, -178.0 59.5, 81.29 -99.1, 26.08 298.0, 90.14 -61.58, -25.76 in-out in 9.462 Saltbr-out 4.3715 HRD-in -63.48, -53.98 76.6, -2.17 out-in-out SNCoio in-out ActLoopNT-in 2.8113 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -134.72, 146.95 APE9-dihe-na 74.36, 175.84 APE8-dihe-in -85.0, 123.29 APE8-rot-in 314.87 APE67-dihe-out -59.55, -27.06 -91.86, 66.94 APE12-dist-out 25.8401 APE11-dist-out 30.0028 APE10-dist-out 33.5178 APE9-dist-out 38.7571 None TPO183,SEP189 TPO183,SEP189 XRAY 2.2 0.205 0.242 A 325.0 288.0 0 28 28 0 [[34, 292]] 1.0 2jfl Homo sapiens STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 2UV2A Q9H2G2 21 308 1235.0 GVD:1316 Type1 Inactive DFGin 6.3917 14.6683 BLAminus -137.63, 176.53 65.09, 88.86 -105.79, 29.31 299.3, 89.13 -57.8, -30.07 in-in in 9.266 Saltbr-in 3.0091 HRD-in -63.28, -54.67 77.02, -4.58 in-in-out SNCiio in-out ActLoopNT-in 2.8423 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -136.25, 151.49 APE9-dihe-na 68.24, 176.61 APE8-dihe-in -84.97, 119.74 APE8-rot-in 310.47 APE67-dihe-out -66.38, -23.85 -91.33, 75.21 APE12-dist-out 25.7456 APE11-dist-out 29.9092 APE10-dist-out 33.3833 APE9-dist-out 38.719 K25T None None XRAY 2.3 0.199 0.234 A 325.0 286.0 2 28 28 0 [[34, 292]] 1.0 2uv2 Homo sapiens STE_SLK_HUMAN STE 1.1e-96 329.1 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 4USFA Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.0421 10.058 None -117.97, -164.7 -148.31, 161.25 67.07, 10.53 308.47, 138.36 -64.12, 155.64 out-out out 12.2698 Saltbr-out 11.5207 HRD-in -81.47, -50.79 75.66, -10.69 out-out-out SNCooo out-out ActLoopNT-out 20.0813 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.78 APE8-rot-in 310.95 APE67-dihe-out -63.58, -25.56 -87.14, 59.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.198 0.228 A 304.0 275.0 17 28 15 13 [[34, 292]] 1.0 4usf Homo sapiens STE_SLK_HUMAN STE 8.7e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 4USFB Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.3797 9.9495 None -116.24, -167.43 -147.44, 163.23 64.7, 16.11 306.44, 141.27 -69.71, 155.48 out-out out 11.908 Saltbr-out 10.4915 HRD-in -81.17, -51.97 77.33, -10.55 out-out-out SNCooo out-out ActLoopNT-out 19.9632 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -129.76, 123.16 APE9-dihe-na 56.23, 51.46 APE8-dihe-in -52.62, 128.43 APE8-rot-in 306.51 APE67-dihe-in -63.75, -23.49 -58.2, -37.55 APE12-dist-none 999.0 APE11-dist-out 7.8043 APE10-dist-out 11.9679 APE9-dist-in 3.5176 None None None XRAY 1.75 0.198 0.228 B 304.0 283.0 9 28 19 9 [[34, 292]] 1.0 4usf Homo sapiens STE_SLK_HUMAN STE 8.7e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 8BEMD Q9H2G2 19 310 1235.0 AV9:60401 Type1 Inactive DFGout 15.609 9.9932 BBAminus -129.69, -171.85 -147.29, 95.2 -67.37, -14.53 272.02, 82.73 97.97, 999.0 out-none out 11.5707 Saltbr-none 999.0 HRD-in -73.63, -51.69 82.34, -9.81 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -107.2, 146.53 APE9-dihe-na -108.51, -140.02 APE8-dihe-in -73.06, 128.87 APE8-rot-out 206.21 APE67-dihe-in -57.91, -29.99 -86.03, -11.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.7505 None None None XRAY 2.6 0.224 0.255 D 303.0 273.0 19 28 15 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 8BEMG Q9H2G2 19 309 1235.0 AV9:60401 Type1 Inactive DFGout 15.3561 9.9535 BBAminus -127.42, -170.65 -149.27, 90.59 -63.76, -33.71 272.3, 85.55 107.87, 999.0 out-none out 11.5692 Saltbr-none 999.0 HRD-in -73.12, -53.95 82.08, -10.44 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -90.9, -30.32 APE9-dihe-na 83.56, -160.87 APE8-dihe-in -88.82, 133.57 APE8-rot-out 56.86 APE67-dihe-in -57.37, -30.65 -86.38, -11.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.8172 None None None XRAY 2.6 0.224 0.255 G 303.0 270.0 21 28 14 14 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 8BEMA Q9H2G2 19 309 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3204 10.3427 BBAminus -126.87, -173.24 -145.98, 95.31 -71.29, -11.44 274.39, 85.56 92.57, 999.0 out-none out 11.248 Saltbr-none 999.0 HRD-in -73.36, -54.08 82.06, -7.69 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -86.71, -31.34 APE9-dihe-na 83.07, -163.39 APE8-dihe-in -88.8, 134.74 APE8-rot-out 59.81 APE67-dihe-in -58.75, -30.61 -85.18, -13.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.336 None None None XRAY 2.6 0.224 0.255 A 303.0 272.0 19 28 15 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
SLK SLK_HUMAN 8BEMB Q9H2G2 19 310 1235.0 AV9:60401 Type1.5_Front Inactive DFGout 15.3625 10.3862 BBAminus -130.09, -171.07 -147.42, 95.57 -73.15, -8.63 276.71, 86.66 100.89, 999.0 out-out out 11.371 Saltbr-out 8.7129 HRD-in -73.46, -53.46 83.25, -10.95 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -84.78, -30.24 APE9-dihe-na 85.62, -163.37 APE8-dihe-in -89.09, 132.42 APE8-rot-out 195.94 APE67-dihe-in -58.26, -30.88 -85.95, -14.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4036 None None None XRAY 2.6 0.224 0.255 B 303.0 275.0 17 28 15 13 [[34, 292]] 1.0 8bem Homo sapiens STE_SLK_HUMAN STE 8.6e-97 329.4 1.0 257.0 257.0 172 173 174 176 178 63 79 83 152 154 153 155.0 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase

STE_SLK (STE20-like serine/threonine-protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name