AGC_SGK1 (Serine/threonine-protein kinase Sgk1)

Total number of chains: 6
Active chains: 2
Uniprot: SGK1_HUMAN
Kinase Domain Residues: 98 - 355
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 3 50.0% 2R5TA
DFGin BLAminus 2 33.3% AF-O00141-K1A
DFGout None 1 16.7% 7PUEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SGK1 AF-O00141-K1A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.5808 13.1243 BLAminus -124.65, -166.79 42.56, 64.43 -73.44, 18.78 305.22, 97.86 -59.66, -29.15 in-in in 8.6427 Saltbr-in 2.6189 HRD-in -74.89, -49.13 66.3, -0.59 in-in-in SNCiii in-in ActLoopNT-in 2.8306 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.35, 160.2 APE9-dihe-na 121.68, 167.97 APE8-dihe-in -78.59, 129.41 APE8-rot-in 299.24 APE67-dihe-in -64.62, -22.89 -47.15, -41.83 APE12-dist-in 8.3961 APE11-dist-in 11.5978 APE10-dist-in 5.8668 APE9-dist-in 3.6645 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[98, 355]] 1.0 AF-O00141-K1 AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 AF-O00141-K3A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.3019 13.205 BLAminus -132.91, -176.65 51.85, 63.47 -69.17, 14.1 303.31, 90.06 -64.44, -24.17 in-in in 8.8737 Saltbr-in 2.6458 HRD-in -80.08, -49.64 66.81, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.31, 163.89 APE9-dihe-na 116.3, 167.63 APE8-dihe-in -77.55, 132.12 APE8-rot-in 281.34 APE67-dihe-in -64.39, -24.37 -47.8, -41.95 APE12-dist-in 8.4295 APE11-dist-in 11.5863 APE10-dist-in 5.9135 APE9-dist-in 3.4281 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[98, 355]] 1.0 AF-O00141-K3 AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.2486 5.7396 None -86.79, -16.14 -72.2, 135.26 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.2434 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.8831 APE11-dist-out 30.6496 APE10-dist-out 28.0339 APE9-dist-out 16.2479 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373.0 284.0 13 28 28 0 [[98, 355]] 1.0 2r5t AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 3HDMA O00141 81 378 431.0 MMG:500 Type1 Inactive DFGinter 9.9767 5.7434 None -83.68, -7.68 -69.69, 128.31 -122.03, 7.18 59.85, 94.45 118.71, -0.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.93, -38.18 84.66, -53.42 none-out-out SNCnoo out-out ActLoopNT-out 7.7801 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.48, 64.87 APE9-dihe-na -77.63, -170.21 APE8-dihe-in -69.51, 134.86 APE8-rot-in 310.86 APE67-dihe-out -140.61, 157.94 -65.57, 107.15 APE12-dist-out 30.439 APE11-dist-out 31.1206 APE10-dist-out 28.3853 APE9-dist-out 16.4222 S74A,S78A,S397A,S401A None None XRAY 2.6 0.22 0.262 A 373.0 285.0 13 28 28 0 [[98, 355]] 1.0 3hdm AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 3HDNA O00141 82 374 431.0 GMG:1 Type1 Inactive DFGinter 10.6836 6.0592 None -80.54, -17.07 -64.88, 127.58 -123.29, -5.01 55.66, 91.25 125.69, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.11, -29.45 73.47, -60.84 none-out-out SNCnoo out-out ActLoopNT-out 8.2837 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.04, 66.32 APE9-dihe-na -71.14, 173.43 APE8-dihe-in -68.52, 127.58 APE8-rot-in 307.02 APE67-dihe-out -159.22, 150.57 -56.04, 117.71 APE12-dist-out 30.0995 APE11-dist-out 30.8654 APE10-dist-out 28.034 APE9-dist-out 16.4823 S74A,S78A,S397A,S401A None None XRAY 3.1 0.251 0.278 A 373.0 280.0 13 28 28 0 [[98, 355]] 1.0 3hdn AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 7PUEA O00141 82 376 431.0 86H:503 Type1 Inactive DFGout 13.845 12.4563 None -128.32, 161.54 66.3, 44.42 -96.18, 38.15 38.7, 87.51 60.24, 26.6 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.9, -50.5 67.78, -47.28 none-out-out SNCnoo out-out ActLoopNT-out 10.1544 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 61.89, -99.42 APE9-dihe-na 71.22, 134.57 APE8-dihe-in -55.98, 129.77 APE8-rot-out 64.18 APE67-dihe-out -107.13, 123.21 -48.22, 142.9 APE12-dist-out 34.2812 APE11-dist-out 33.5334 APE10-dist-out 29.714 APE9-dist-out 16.8999 R192A,S422D None None XRAY 2.506 0.216 0.249 A 375.0 271.0 24 28 20 8 [[98, 355]] 1.0 7pue AGC_SGK1_HUMAN AGC 7.2e-99 336.1 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1

AGC_SGK1 (Serine/threonine-protein kinase Sgk1)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 3 50.0% 2R5TA
DFGin BLAminus 2 33.3% AF-O00141-K1A
DFGout None 1 16.7% 7PUEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
SGK1 SGK1_HUMAN AF-O00141-K1A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.5808 13.1243 BLAminus -124.65, -166.79 42.56, 64.43 -73.44, 18.78 305.22, 97.86 -59.66, -29.15 in-in in 8.6427 Saltbr-in 2.6189 HRD-in -74.89, -49.13 66.3, -0.59 in-in-in SNCiii in-in ActLoopNT-in 2.8306 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.35, 160.2 APE9-dihe-na 121.68, 167.97 APE8-dihe-in -78.59, 129.41 APE8-rot-in 299.24 APE67-dihe-in -64.62, -22.89 -47.15, -41.83 APE12-dist-in 8.3961 APE11-dist-in 11.5978 APE10-dist-in 5.8668 APE9-dist-in 3.6645 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[98, 355]] 1.0 AF-O00141-K1 Homo sapiens AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 SGK1_HUMAN AF-O00141-K3A O00141 90 363 431.0 No_ligand No_ligand Active DFGin 6.3019 13.205 BLAminus -132.91, -176.65 51.85, 63.47 -69.17, 14.1 303.31, 90.06 -64.44, -24.17 in-in in 8.8737 Saltbr-in 2.6458 HRD-in -80.08, -49.64 66.81, 9.28 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.31, 163.89 APE9-dihe-na 116.3, 167.63 APE8-dihe-in -77.55, 132.12 APE8-rot-in 281.34 APE67-dihe-in -64.39, -24.37 -47.8, -41.95 APE12-dist-in 8.4295 APE11-dist-in 11.5863 APE10-dist-in 5.9135 APE9-dist-in 3.4281 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[98, 355]] 1.0 AF-O00141-K3 Homo sapiens AGC_SGK1_HUMAN AGC 1.6e-99 338.1 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.2486 5.7396 None -86.79, -16.14 -72.2, 135.26 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.2434 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.8831 APE11-dist-out 30.6496 APE10-dist-out 28.0339 APE9-dist-out 16.2479 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373.0 284.0 13 28 28 0 [[98, 355]] 1.0 2r5t Homo sapiens AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 SGK1_HUMAN 3HDMA O00141 81 378 431.0 MMG:500 Type1 Inactive DFGinter 9.9767 5.7434 None -83.68, -7.68 -69.69, 128.31 -122.03, 7.18 59.85, 94.45 118.71, -0.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.93, -38.18 84.66, -53.42 none-out-out SNCnoo out-out ActLoopNT-out 7.7801 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.48, 64.87 APE9-dihe-na -77.63, -170.21 APE8-dihe-in -69.51, 134.86 APE8-rot-in 310.86 APE67-dihe-out -140.61, 157.94 -65.57, 107.15 APE12-dist-out 30.439 APE11-dist-out 31.1206 APE10-dist-out 28.3853 APE9-dist-out 16.4222 S74A,S78A,S397A,S401A None None XRAY 2.6 0.22 0.262 A 373.0 285.0 13 28 28 0 [[98, 355]] 1.0 3hdm Homo sapiens AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 SGK1_HUMAN 3HDNA O00141 82 374 431.0 GMG:1 Type1 Inactive DFGinter 10.6836 6.0592 None -80.54, -17.07 -64.88, 127.58 -123.29, -5.01 55.66, 91.25 125.69, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.11, -29.45 73.47, -60.84 none-out-out SNCnoo out-out ActLoopNT-out 8.2837 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.04, 66.32 APE9-dihe-na -71.14, 173.43 APE8-dihe-in -68.52, 127.58 APE8-rot-in 307.02 APE67-dihe-out -159.22, 150.57 -56.04, 117.71 APE12-dist-out 30.0995 APE11-dist-out 30.8654 APE10-dist-out 28.034 APE9-dist-out 16.4823 S74A,S78A,S397A,S401A None None XRAY 3.1 0.251 0.278 A 373.0 280.0 13 28 28 0 [[98, 355]] 1.0 3hdn Homo sapiens AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
SGK1 SGK1_HUMAN 7PUEA O00141 82 376 431.0 86H:503 Type1 Inactive DFGout 13.845 12.4563 None -128.32, 161.54 66.3, 44.42 -96.18, 38.15 38.7, 87.51 60.24, 26.6 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.9, -50.5 67.78, -47.28 none-out-out SNCnoo out-out ActLoopNT-out 10.1544 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 61.89, -99.42 APE9-dihe-na 71.22, 134.57 APE8-dihe-in -55.98, 129.77 APE8-rot-out 64.18 APE67-dihe-out -107.13, 123.21 -48.22, 142.9 APE12-dist-out 34.2812 APE11-dist-out 33.5334 APE10-dist-out 29.714 APE9-dist-out 16.8999 R192A,S422D None None XRAY 2.506 0.216 0.249 A 375.0 271.0 24 28 20 8 [[98, 355]] 1.0 7pue Homo sapiens AGC_SGK1_HUMAN AGC 7.2e-99 336.1 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1

AGC_SGK1 (Serine/threonine-protein kinase Sgk1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name