KinCore

CAMK_RPS6KA3-2 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 8

Active chains: 2

Uniprot: KS6A3_HUMAN

Kinase Domain Residues: 422 - 679

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	6	75.0%	AF-P51812-K2A
DFGin	ABAminus	2	25.0%	4D9TA

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PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
AF-P51812-K2A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	414 - 687	0	None	None	Ribosomal protein S6 kinase alpha-3
AF-P51812-K4A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	414 - 687	0	None	None	Ribosomal protein S6 kinase alpha-3
4D9TA	2.4	Inactive	DFGin‑ABAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	0JG	Type1	415 - 713	0	None	None	Ribosomal protein S6 kinase alpha-3
4D9UA	2.4	Inactive	DFGin‑ABAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	0JH	Type1	408 - 714	0	None	K591E	Ribosomal protein S6 kinase alpha-3
8XEYA	2.65	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioo	APEdist_oooo	No_ligand	No_ligand	403 - 714	0	None	None	Ribosomal protein S6 kinase alpha-3
4JG8A	3.1	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaoio	APEdist_oooo	1LE	Type1	415 - 714	0	None	T493M	Ribosomal protein S6 kinase alpha-3
4JG6A	2.6	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	1LB	Type1	406 - 712	0	None	None	Ribosomal protein S6 kinase alpha-3
4JG7A	3.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	1LC	Type1	405 - 713	0	None	None	Ribosomal protein S6 kinase alpha-3

CAMK_RPS6KA3-2 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 13

Active chains: 2

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	10	76.9%	AF-P51812-K2A
DFGin	ABAminus	2	15.4%	4D9TA
DFGin	None	1	7.7%	4MAOA

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
KS6A3_HUMAN	AF-P51812-K2A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	414 - 687	0	None	None	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_HUMAN	AF-P51812-K4A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	414 - 687	0	None	None	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_HUMAN	4D9TA	2.4	Inactive	DFGin‑ABAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	0JG	Type1	415 - 713	0	None	None	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_HUMAN	4D9UA	2.4	Inactive	DFGin‑ABAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	0JH	Type1	408 - 714	0	None	K591E	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_HUMAN	8XEYA	2.65	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioo	APEdist_oooo	No_ligand	No_ligand	403 - 714	0	None	None	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_HUMAN	4JG8A	3.1	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaoio	APEdist_oooo	1LE	Type1	415 - 714	0	None	T493M	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_HUMAN	4JG6A	2.6	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	1LB	Type1	406 - 712	0	None	None	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_HUMAN	4JG7A	3.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	1LC	Type1	405 - 713	0	None	None	Ribosomal protein S6 kinase alpha-3	Homo sapiens
KS6A3_MOUSE	5O1SA	1.9	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aannn	APEdist_ooon	9HB, 9HB	Allosteric, Type1	415 - 712	0	None	None	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	2QR7A	2.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaoio	APEdist_oooo	No_ligand	No_ligand	417 - 714	0	None	K591E	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	2QR8A	2.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaoio	APEdist_oooo	No_ligand	No_ligand	417 - 714	0	None	K591E	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	4M8TA	3.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	RMM	Type1	410 - 712	0	None	T493M	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	4MAOA	2.6	Inactive	DFGin‑None	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	28D	Type1	415 - 712	0	None	T493M,K591E	Ribosomal protein S6 kinase alpha-3	Mus musculus

CAMK_RPS6KA3-2 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 5

Active chains: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	4	80.0%	2QR7A
DFGin	None	1	20.0%	4MAOA

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
KS6A3_MOUSE	5O1SA	1.9	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aannn	APEdist_ooon	9HB, 9HB	Allosteric, Type1	415 - 712	0	None	None	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	2QR7A	2.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaoio	APEdist_oooo	No_ligand	No_ligand	417 - 714	0	None	K591E	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	2QR8A	2.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaoio	APEdist_oooo	No_ligand	No_ligand	417 - 714	0	None	K591E	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	4M8TA	3.0	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	RMM	Type1	410 - 712	0	None	T493M	Ribosomal protein S6 kinase alpha-3	Mus musculus
KS6A3_MOUSE	4MAOA	2.6	Inactive	DFGin‑None	in-in	in-out	nonTYR	APEdihe_aaooo	APEdist_oooo	28D	Type1	415 - 712	0	None	T493M,K591E	Ribosomal protein S6 kinase alpha-3	Mus musculus