CAMK_RPS6KA3-2 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 8
Active chains: 2
Uniprot: KS6A3_HUMAN
Kinase Domain Residues: 422 - 679
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 75.0% AF-P51812-K2A
DFGin ABAminus 2 25.0% 4D9TA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RPS6KA3-2 AF-P51812-K2A P51812 414 687 740.0 No_ligand No_ligand Active DFGin 6.7298 14.1683 BLAminus -125.79, -177.39 55.82, 66.57 -75.99, 24.17 288.05, 79.68 -59.14, -33.85 in-in in 8.8374 Saltbr-in 2.7385 HRD-in -74.61, -43.89 70.54, -1.34 in-in-in SNCiii in-in ActLoopNT-in 2.9872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 128.02 APE9-dihe-na -170.43, 160.5 APE8-dihe-in -95.56, 132.02 APE8-rot-in 299.76 APE67-dihe-in -73.03, -14.52 -50.87, -42.54 APE12-dist-in 8.8657 APE11-dist-in 10.8421 APE10-dist-in 4.9928 APE9-dist-in 4.1216 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K2 CAMK_RPS6KA3-2_HUMAN CAMK 3.1e-87 298.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 AF-P51812-K4A P51812 414 687 740.0 No_ligand No_ligand Active DFGin 6.4354 14.3644 BLAminus -132.83, -176.2 53.82, 63.58 -70.94, 24.31 287.91, 81.74 -68.64, -24.12 in-in in 8.9142 Saltbr-in 2.7514 HRD-in -78.93, -40.76 66.85, 11.06 in-in-in SNCiii in-in ActLoopNT-in 2.9108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.71, 127.25 APE9-dihe-na -171.64, 159.25 APE8-dihe-in -90.92, 129.8 APE8-rot-in 301.02 APE67-dihe-in -76.65, -14.51 -52.74, -40.79 APE12-dist-in 8.6566 APE11-dist-in 10.9774 APE10-dist-in 5.0713 APE9-dist-in 4.2444 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K4 CAMK_RPS6KA3-2_HUMAN CAMK 3.1e-87 298.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 4D9TA P51812 415 713 740.0 0JG:900 Type1 Inactive DFGin 6.976 14.4387 ABAminus -123.37, -26.43 -117.77, 107.6 -100.86, 28.87 289.79, 89.39 -60.07, -20.69 in-in in 8.7394 Saltbr-in 3.1497 HRD-in -72.84, -46.9 81.48, -16.03 in-in-out SNCiio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -61.28, -50.0 APE9-dihe-na -81.45, 77.98 APE8-dihe-out -88.71, -7.89 APE8-rot-out 49.36 APE67-dihe-out -110.14, 134.16 -72.29, 2.31 APE12-dist-out 19.167 APE11-dist-out 18.9183 APE10-dist-out 23.0797 APE9-dist-out 23.8455 None None None XRAY 2.4 0.221 0.267 A 342.0 299.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4d9t CAMK_RPS6KA3-2_HUMAN CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 4D9UA P51812 408 714 740.0 0JH:900 Type1 Inactive DFGin 7.045 14.3564 ABAminus -122.72, -19.83 -127.14, 120.2 -114.81, 31.53 288.04, 82.42 -70.73, -13.66 in-in in 8.6409 Saltbr-in 3.1357 HRD-in -84.15, -40.15 69.87, 5.17 in-in-out SNCiio in-out ActLoopNT-in 2.8022 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -82.29, -44.29 APE9-dihe-na -85.78, 92.06 APE8-dihe-out -106.5, 23.16 APE8-rot-out 51.26 APE67-dihe-out -48.2, 167.35 -68.75, -64.98 APE12-dist-out 19.1319 APE11-dist-out 18.4603 APE10-dist-out 22.8566 APE9-dist-out 23.8817 K591E None None XRAY 2.4 0.211 0.276 A 342.0 307.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4d9u CAMK_RPS6KA3-2_HUMAN CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 8XEYA P51812 403 714 740.0 No_ligand No_ligand Inactive DFGin 7.2927 14.93 BLAminus -128.88, 178.02 41.7, 89.43 -94.22, 36.81 277.9, 75.18 -84.15, -18.19 in-in in 8.9184 Saltbr-in 3.1488 HRD-in -82.41, -53.52 71.38, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.9555 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -95.24, -27.76 APE9-dihe-na -119.9, 106.6 APE8-dihe-in -136.38, 62.2 APE8-rot-out 49.06 APE67-dihe-out -72.26, 74.08 -68.67, -17.16 APE12-dist-out 19.517 APE11-dist-out 18.1292 APE10-dist-out 22.9444 APE9-dist-out 23.6532 None None None XRAY 2.65 0.206 0.28 A 341.0 312.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 8xey CAMK_RPS6KA3-2_HUMAN CAMK 6.8e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 4JG8A P51812 415 714 740.0 1LE:801 Type1 Inactive DFGin 6.8677 13.8736 BLAminus -129.01, -179.28 48.24, 84.45 -98.51, 34.17 293.09, 82.14 -68.73, -8.82 in-in in 8.75 Saltbr-in 2.8892 HRD-in -70.44, -45.96 64.59, 14.32 in-in-out SNCiio in-out ActLoopNT-in 3.0346 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -100.34, -59.82 APE9-dihe-na -68.45, 104.5 APE8-dihe-out -119.26, 6.56 APE8-rot-in 317.81 APE67-dihe-out -95.71, 170.52 -65.78, -12.7 APE12-dist-out 19.3271 APE11-dist-out 18.5906 APE10-dist-out 23.3231 APE9-dist-out 24.1508 T493M None None XRAY 3.1 0.239 0.298 A 355.0 300.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4jg8 CAMK_RPS6KA3-2_HUMAN CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 4JG6A P51812 406 712 740.0 1LB:801 Type1 Inactive DFGin 7.0521 14.0988 BLAminus -133.66, 169.33 59.04, 73.34 -88.06, 9.76 286.04, 75.68 -46.67, -30.97 in-in in 8.8603 Saltbr-in 2.9256 HRD-in -71.74, -45.47 70.87, -14.77 in-in-out SNCiio in-out ActLoopNT-in 3.0526 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -80.02, -37.23 APE9-dihe-na -93.52, 105.96 APE8-dihe-out -102.75, 1.4 APE8-rot-out 180.67 APE67-dihe-out -110.48, 150.73 -67.93, -7.72 APE12-dist-out 19.4734 APE11-dist-out 18.658 APE10-dist-out 23.2864 APE9-dist-out 23.9427 None None None XRAY 2.6 0.254 0.299 A 355.0 302.0 5 28 28 0 [[68, 327], [422, 679]] 2.0 4jg6 CAMK_RPS6KA3-2_HUMAN CAMK 7.8e-87 296.9 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 4JG7A P51812 405 713 740.0 1LC:801 Type1 Inactive DFGin 6.709 13.9322 BLAminus -127.74, 178.59 48.13, 83.89 -95.46, 34.87 291.92, 77.05 -61.15, -41.68 in-in in 8.8003 Saltbr-in 2.9906 HRD-in -88.43, -51.93 64.25, 30.01 in-in-out SNCiio in-out ActLoopNT-in 3.2205 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -84.97, -56.89 APE9-dihe-na -58.97, 113.84 APE8-dihe-out -115.99, -12.38 APE8-rot-out 181.22 APE67-dihe-out -66.23, 165.95 -46.5, -41.56 APE12-dist-out 19.3828 APE11-dist-out 18.0965 APE10-dist-out 22.9831 APE9-dist-out 23.9596 None None None XRAY 3.0 0.263 0.298 A 355.0 307.0 2 28 28 0 [[68, 327], [422, 679]] 2.0 4jg7 CAMK_RPS6KA3-2_HUMAN CAMK 7.8e-87 296.9 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3

CAMK_RPS6KA3-2 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 13
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 76.9% AF-P51812-K2A
DFGin ABAminus 2 15.4% 4D9TA
DFGin None 1 7.7% 4MAOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RPS6KA3-2 KS6A3_HUMAN AF-P51812-K2A P51812 414 687 740.0 No_ligand No_ligand Active DFGin 6.7298 14.1683 BLAminus -125.79, -177.39 55.82, 66.57 -75.99, 24.17 288.05, 79.68 -59.14, -33.85 in-in in 8.8374 Saltbr-in 2.7385 HRD-in -74.61, -43.89 70.54, -1.34 in-in-in SNCiii in-in ActLoopNT-in 2.9872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 128.02 APE9-dihe-na -170.43, 160.5 APE8-dihe-in -95.56, 132.02 APE8-rot-in 299.76 APE67-dihe-in -73.03, -14.52 -50.87, -42.54 APE12-dist-in 8.8657 APE11-dist-in 10.8421 APE10-dist-in 4.9928 APE9-dist-in 4.1216 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K2 Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 3.1e-87 298.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_HUMAN AF-P51812-K4A P51812 414 687 740.0 No_ligand No_ligand Active DFGin 6.4354 14.3644 BLAminus -132.83, -176.2 53.82, 63.58 -70.94, 24.31 287.91, 81.74 -68.64, -24.12 in-in in 8.9142 Saltbr-in 2.7514 HRD-in -78.93, -40.76 66.85, 11.06 in-in-in SNCiii in-in ActLoopNT-in 2.9108 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.71, 127.25 APE9-dihe-na -171.64, 159.25 APE8-dihe-in -90.92, 129.8 APE8-rot-in 301.02 APE67-dihe-in -76.65, -14.51 -52.74, -40.79 APE12-dist-in 8.6566 APE11-dist-in 10.9774 APE10-dist-in 5.0713 APE9-dist-in 4.2444 None None None AF2 -1.0 1.0 1.0 A 274.0 274.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 AF-P51812-K4 Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 3.1e-87 298.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_HUMAN 4D9TA P51812 415 713 740.0 0JG:900 Type1 Inactive DFGin 6.976 14.4387 ABAminus -123.37, -26.43 -117.77, 107.6 -100.86, 28.87 289.79, 89.39 -60.07, -20.69 in-in in 8.7394 Saltbr-in 3.1497 HRD-in -72.84, -46.9 81.48, -16.03 in-in-out SNCiio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -61.28, -50.0 APE9-dihe-na -81.45, 77.98 APE8-dihe-out -88.71, -7.89 APE8-rot-out 49.36 APE67-dihe-out -110.14, 134.16 -72.29, 2.31 APE12-dist-out 19.167 APE11-dist-out 18.9183 APE10-dist-out 23.0797 APE9-dist-out 23.8455 None None None XRAY 2.4 0.221 0.267 A 342.0 299.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4d9t Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_HUMAN 4D9UA P51812 408 714 740.0 0JH:900 Type1 Inactive DFGin 7.045 14.3564 ABAminus -122.72, -19.83 -127.14, 120.2 -114.81, 31.53 288.04, 82.42 -70.73, -13.66 in-in in 8.6409 Saltbr-in 3.1357 HRD-in -84.15, -40.15 69.87, 5.17 in-in-out SNCiio in-out ActLoopNT-in 2.8022 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -82.29, -44.29 APE9-dihe-na -85.78, 92.06 APE8-dihe-out -106.5, 23.16 APE8-rot-out 51.26 APE67-dihe-out -48.2, 167.35 -68.75, -64.98 APE12-dist-out 19.1319 APE11-dist-out 18.4603 APE10-dist-out 22.8566 APE9-dist-out 23.8817 K591E None None XRAY 2.4 0.211 0.276 A 342.0 307.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4d9u Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_HUMAN 8XEYA P51812 403 714 740.0 No_ligand No_ligand Inactive DFGin 7.2927 14.93 BLAminus -128.88, 178.02 41.7, 89.43 -94.22, 36.81 277.9, 75.18 -84.15, -18.19 in-in in 8.9184 Saltbr-in 3.1488 HRD-in -82.41, -53.52 71.38, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.9555 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -95.24, -27.76 APE9-dihe-na -119.9, 106.6 APE8-dihe-in -136.38, 62.2 APE8-rot-out 49.06 APE67-dihe-out -72.26, 74.08 -68.67, -17.16 APE12-dist-out 19.517 APE11-dist-out 18.1292 APE10-dist-out 22.9444 APE9-dist-out 23.6532 None None None XRAY 2.65 0.206 0.28 A 341.0 312.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 8xey Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 6.8e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_HUMAN 4JG8A P51812 415 714 740.0 1LE:801 Type1 Inactive DFGin 6.8677 13.8736 BLAminus -129.01, -179.28 48.24, 84.45 -98.51, 34.17 293.09, 82.14 -68.73, -8.82 in-in in 8.75 Saltbr-in 2.8892 HRD-in -70.44, -45.96 64.59, 14.32 in-in-out SNCiio in-out ActLoopNT-in 3.0346 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -100.34, -59.82 APE9-dihe-na -68.45, 104.5 APE8-dihe-out -119.26, 6.56 APE8-rot-in 317.81 APE67-dihe-out -95.71, 170.52 -65.78, -12.7 APE12-dist-out 19.3271 APE11-dist-out 18.5906 APE10-dist-out 23.3231 APE9-dist-out 24.1508 T493M None None XRAY 3.1 0.239 0.298 A 355.0 300.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4jg8 Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_HUMAN 4JG6A P51812 406 712 740.0 1LB:801 Type1 Inactive DFGin 7.0521 14.0988 BLAminus -133.66, 169.33 59.04, 73.34 -88.06, 9.76 286.04, 75.68 -46.67, -30.97 in-in in 8.8603 Saltbr-in 2.9256 HRD-in -71.74, -45.47 70.87, -14.77 in-in-out SNCiio in-out ActLoopNT-in 3.0526 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -80.02, -37.23 APE9-dihe-na -93.52, 105.96 APE8-dihe-out -102.75, 1.4 APE8-rot-out 180.67 APE67-dihe-out -110.48, 150.73 -67.93, -7.72 APE12-dist-out 19.4734 APE11-dist-out 18.658 APE10-dist-out 23.2864 APE9-dist-out 23.9427 None None None XRAY 2.6 0.254 0.299 A 355.0 302.0 5 28 28 0 [[68, 327], [422, 679]] 2.0 4jg6 Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 7.8e-87 296.9 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_HUMAN 4JG7A P51812 405 713 740.0 1LC:801 Type1 Inactive DFGin 6.709 13.9322 BLAminus -127.74, 178.59 48.13, 83.89 -95.46, 34.87 291.92, 77.05 -61.15, -41.68 in-in in 8.8003 Saltbr-in 2.9906 HRD-in -88.43, -51.93 64.25, 30.01 in-in-out SNCiio in-out ActLoopNT-in 3.2205 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -84.97, -56.89 APE9-dihe-na -58.97, 113.84 APE8-dihe-out -115.99, -12.38 APE8-rot-out 181.22 APE67-dihe-out -66.23, 165.95 -46.5, -41.56 APE12-dist-out 19.3828 APE11-dist-out 18.0965 APE10-dist-out 22.9831 APE9-dist-out 23.9596 None None None XRAY 3.0 0.263 0.298 A 355.0 307.0 2 28 28 0 [[68, 327], [422, 679]] 2.0 4jg7 Homo sapiens CAMK_RPS6KA3-2_HUMAN CAMK 7.8e-87 296.9 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 5O1SA P18654 415 712 740.0 9HB:802,9HB:803 Allosteric,Type1 Inactive DFGin 6.9597 14.3377 BLAminus -123.09, 179.41 48.53, 81.77 -90.66, 18.51 296.23, 58.17 -59.0, -20.36 in-in in 8.7072 Saltbr-in 2.6863 HRD-in -79.13, -49.77 77.14, -16.1 in-in-out SNCiio in-out ActLoopNT-in 3.0126 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ooon APE10-dihe-na -95.95, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -151.49 999.0, 999.0 APE12-dist-out 18.9964 APE11-dist-out 18.2505 APE10-dist-out 22.8101 APE9-dist-none 999.0 None None None XRAY 1.9 0.209 0.241 A 364.0 290.0 8 28 25 3 [[68, 327], [422, 679]] 2.0 5o1s Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 8.4e-87 296.8 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 2QR7A P18654 417 714 740.0 No_ligand No_ligand Inactive DFGin 6.9513 14.6633 BLAminus -123.24, 178.76 52.1, 79.11 -95.31, 22.65 285.29, 74.87 -65.4, -11.34 in-in in 8.8154 Saltbr-in 2.6082 HRD-in -86.49, -45.76 71.29, 4.47 in-in-out SNCiio in-out ActLoopNT-in 3.0817 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -87.96, -48.95 APE9-dihe-na -64.96, 88.41 APE8-dihe-out -103.98, 11.41 APE8-rot-in 320.25 APE67-dihe-out -107.15, 146.83 -83.94, 0.71 APE12-dist-out 18.9296 APE11-dist-out 18.3782 APE10-dist-out 23.1502 APE9-dist-out 24.0984 K591E None MSE399,MSE446,MSE496,MSE576,MSE611,MSE659,MSE703 XRAY 2.0 0.204 0.238 A 342.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 2qr7 Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 2QR8A P18654 417 714 740.0 No_ligand No_ligand Inactive DFGin 7.0308 14.3235 BLAminus -121.84, 177.44 50.88, 79.27 -88.94, 24.21 285.33, 72.08 -73.42, -11.98 in-in in 8.5258 Saltbr-in 2.7016 HRD-in -83.49, -44.23 73.8, -3.47 in-in-out SNCiio in-out ActLoopNT-in 3.1535 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -75.44, -47.57 APE9-dihe-na -92.74, 111.78 APE8-dihe-out -120.22, 21.33 APE8-rot-in 305.45 APE67-dihe-out -132.68, 145.2 -85.56, 16.58 APE12-dist-out 18.9993 APE11-dist-out 18.6446 APE10-dist-out 23.2584 APE9-dist-out 24.2544 K591E None None XRAY 2.0 0.218 0.259 A 342.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 2qr8 Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 4M8TA P18654 410 712 740.0 RMM:801 Type1 Inactive DFGin 7.0054 13.7871 BLAminus -138.7, 179.98 44.92, 72.15 -88.21, 10.84 283.87, 83.69 -47.78, -36.02 in-in in 8.7318 Saltbr-in 3.0815 HRD-in -75.65, -46.91 58.17, 13.3 in-in-out SNCiio in-out ActLoopNT-in 2.8109 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.37, -66.86 APE9-dihe-na -55.68, 143.05 APE8-dihe-out -124.9, -58.97 APE8-rot-out 57.51 APE67-dihe-out -49.19, 132.58 -42.27, -63.12 APE12-dist-out 20.043 APE11-dist-out 18.9454 APE10-dist-out 23.453 APE9-dist-out 24.0578 T493M None None XRAY 3.0 0.255 0.311 A 355.0 303.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4m8t Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 4MAOA P18654 415 712 740.0 28D:801 Type1 Inactive DFGin 6.9498 13.9692 None -122.16, -3.09 -110.62, -87.21 89.06, 8.42 296.98, 89.53 -66.42, 0.71 in-in in 8.7172 Saltbr-in 3.0464 HRD-in -80.58, -55.21 74.16, -0.39 in-in-out SNCiio in-out ActLoopNT-in 2.9492 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -78.96, -40.3 APE9-dihe-na -99.2, 112.48 APE8-dihe-out -111.75, -5.25 APE8-rot-out 40.44 APE67-dihe-out -98.05, 166.61 -67.15, -3.4 APE12-dist-out 18.9517 APE11-dist-out 18.4684 APE10-dist-out 22.8607 APE9-dist-out 24.2627 T493M,K591E None None XRAY 2.6 0.238 0.292 A 355.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4mao Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3

CAMK_RPS6KA3-2 (Ribosomal protein S6 kinase alpha-3)

Total number of chains: 5
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 2QR7A
DFGin None 1 20.0% 4MAOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RPS6KA3-2 KS6A3_MOUSE 5O1SA P18654 415 712 740.0 9HB:802,9HB:803 Allosteric,Type1 Inactive DFGin 6.9597 14.3377 BLAminus -123.09, 179.41 48.53, 81.77 -90.66, 18.51 296.23, 58.17 -59.0, -20.36 in-in in 8.7072 Saltbr-in 2.6863 HRD-in -79.13, -49.77 77.14, -16.1 in-in-out SNCiio in-out ActLoopNT-in 3.0126 ActLoopCT-out nonTYR APEdihe_aannn APEdist_ooon APE10-dihe-na -95.95, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -151.49 999.0, 999.0 APE12-dist-out 18.9964 APE11-dist-out 18.2505 APE10-dist-out 22.8101 APE9-dist-none 999.0 None None None XRAY 1.9 0.209 0.241 A 364.0 290.0 8 28 25 3 [[68, 327], [422, 679]] 2.0 5o1s Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 8.4e-87 296.8 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 2QR7A P18654 417 714 740.0 No_ligand No_ligand Inactive DFGin 6.9513 14.6633 BLAminus -123.24, 178.76 52.1, 79.11 -95.31, 22.65 285.29, 74.87 -65.4, -11.34 in-in in 8.8154 Saltbr-in 2.6082 HRD-in -86.49, -45.76 71.29, 4.47 in-in-out SNCiio in-out ActLoopNT-in 3.0817 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -87.96, -48.95 APE9-dihe-na -64.96, 88.41 APE8-dihe-out -103.98, 11.41 APE8-rot-in 320.25 APE67-dihe-out -107.15, 146.83 -83.94, 0.71 APE12-dist-out 18.9296 APE11-dist-out 18.3782 APE10-dist-out 23.1502 APE9-dist-out 24.0984 K591E None MSE399,MSE446,MSE496,MSE576,MSE611,MSE659,MSE703 XRAY 2.0 0.204 0.238 A 342.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 2qr7 Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 2QR8A P18654 417 714 740.0 No_ligand No_ligand Inactive DFGin 7.0308 14.3235 BLAminus -121.84, 177.44 50.88, 79.27 -88.94, 24.21 285.33, 72.08 -73.42, -11.98 in-in in 8.5258 Saltbr-in 2.7016 HRD-in -83.49, -44.23 73.8, -3.47 in-in-out SNCiio in-out ActLoopNT-in 3.1535 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -75.44, -47.57 APE9-dihe-na -92.74, 111.78 APE8-dihe-out -120.22, 21.33 APE8-rot-in 305.45 APE67-dihe-out -132.68, 145.2 -85.56, 16.58 APE12-dist-out 18.9993 APE11-dist-out 18.6446 APE10-dist-out 23.2584 APE9-dist-out 24.2544 K591E None None XRAY 2.0 0.218 0.259 A 342.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 2qr8 Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 6.9e-87 297.1 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 4M8TA P18654 410 712 740.0 RMM:801 Type1 Inactive DFGin 7.0054 13.7871 BLAminus -138.7, 179.98 44.92, 72.15 -88.21, 10.84 283.87, 83.69 -47.78, -36.02 in-in in 8.7318 Saltbr-in 3.0815 HRD-in -75.65, -46.91 58.17, 13.3 in-in-out SNCiio in-out ActLoopNT-in 2.8109 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.37, -66.86 APE9-dihe-na -55.68, 143.05 APE8-dihe-out -124.9, -58.97 APE8-rot-out 57.51 APE67-dihe-out -49.19, 132.58 -42.27, -63.12 APE12-dist-out 20.043 APE11-dist-out 18.9454 APE10-dist-out 23.453 APE9-dist-out 24.0578 T493M None None XRAY 3.0 0.255 0.311 A 355.0 303.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4m8t Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3
RPS6KA3-2 KS6A3_MOUSE 4MAOA P18654 415 712 740.0 28D:801 Type1 Inactive DFGin 6.9498 13.9692 None -122.16, -3.09 -110.62, -87.21 89.06, 8.42 296.98, 89.53 -66.42, 0.71 in-in in 8.7172 Saltbr-in 3.0464 HRD-in -80.58, -55.21 74.16, -0.39 in-in-out SNCiio in-out ActLoopNT-in 2.9492 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -78.96, -40.3 APE9-dihe-na -99.2, 112.48 APE8-dihe-out -111.75, -5.25 APE8-rot-out 40.44 APE67-dihe-out -98.05, 166.61 -67.15, -3.4 APE12-dist-out 18.9517 APE11-dist-out 18.4684 APE10-dist-out 22.8607 APE9-dist-out 24.2627 T493M,K591E None None XRAY 2.6 0.238 0.292 A 355.0 298.0 0 28 28 0 [[68, 327], [422, 679]] 2.0 4mao Mus musculus CAMK_RPS6KA3-2_MOUSE CAMK 1.1e-87 299.7 1.0 256.0 256.0 560 561 562 564 566 451 463 467 536 538 537 539.0 600 588 583 582 581 580 579 578 577 494 Ribosomal protein S6 kinase alpha-3