AGC_RPS6KA1-1 (Ribosomal protein S6 kinase alpha-1)

Total number of chains: 6
Active chains: 2
Uniprot: KS6A1_HUMAN
Kinase Domain Residues: 62 - 321
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 50.0% 2Z7RA
DFGin BLAminus 2 33.3% AF-Q15418-K1A
DFGin BLAplus 1 16.7% 8XOVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RPS6KA1-1 AF-Q15418-K1A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.6211 14.3552 BLAminus -124.04, -166.26 40.15, 63.05 -75.14, 13.01 287.46, 77.73 -62.04, -17.57 in-in in 8.9956 Saltbr-in 2.6553 HRD-in -82.17, -49.64 65.88, 6.04 in-in-in SNCiii in-in ActLoopNT-in 2.9042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.23, 164.1 APE9-dihe-na 113.31, 168.76 APE8-dihe-in -68.46, 130.82 APE8-rot-in 292.77 APE67-dihe-in -60.62, -26.43 -61.01, -40.77 APE12-dist-in 8.4157 APE11-dist-in 11.4063 APE10-dist-in 5.6955 APE9-dist-in 3.4929 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 28 28 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K1 AGC_RPS6KA1-1_HUMAN AGC 8.9e-96 325.9 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 AF-Q15418-K3A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.4457 14.3519 BLAminus -131.09, -177.74 50.28, 63.61 -71.56, 10.34 294.57, 83.15 -62.78, -13.6 in-in in 8.88 Saltbr-in 2.6627 HRD-in -82.73, -46.46 67.14, 11.23 in-in-in SNCiii in-in ActLoopNT-in 2.8525 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.19, 164.66 APE9-dihe-na 112.66, 172.32 APE8-dihe-in -74.19, 134.18 APE8-rot-in 293.08 APE67-dihe-in -61.38, -26.34 -64.42, -40.72 APE12-dist-in 8.366 APE11-dist-in 11.4324 APE10-dist-in 5.6764 APE9-dist-in 3.3874 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 28 28 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K3 AGC_RPS6KA1-1_HUMAN AGC 8.9e-96 325.9 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 8XOVA Q15418 56 340 735.0 ANP:401 ATPlike Inactive DFGin 9.5319 13.1202 BLAplus -128.25, 170.81 61.53, 44.51 -100.37, -14.37 34.15, 82.03 -83.22, -24.55 out-out out 11.1338 Saltbr-out 8.8974 HRD-in -75.5, -43.57 69.32, -59.52 out-out-out SNCooo out-out ActLoopNT-out 9.5095 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -98.67, 154.58 APE9-dihe-na -175.48, 178.84 APE8-dihe-in -87.06, 119.03 APE8-rot-in 310.44 APE67-dihe-in -48.48, -27.39 -73.46, -38.49 APE12-dist-none 999.0 APE11-dist-in 10.4198 APE10-dist-out 11.5117 APE9-dist-out 7.6388 None None None XRAY 2.55 0.206 0.252 A 321.0 261.0 24 28 19 9 [[62, 321], [418, 675]] 2.0 8xov AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 2Z7QA Q15418 56 340 735.0 ACP:500 ATPlike Inactive DFGin 8.0284 12.3687 BLBplus -135.49, 158.95 63.12, 60.24 -125.42, -165.59 47.01, 74.46 107.04, -8.15 none-none none 999.0 Saltbr-none 999.0 HRD-out -82.53, 70.19 -54.28, -43.87 none-out-out SNCnoo out-out ActLoopNT-out 7.0527 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.36 APE8-dihe-in -67.18, 106.47 APE8-rot-in 305.06 APE67-dihe-in -59.78, -23.27 -56.13, -39.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7913 None None None XRAY 2.0 0.264 0.283 A 321.0 255.0 30 28 16 12 [[62, 321], [418, 675]] 2.0 2z7q AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 2Z7RA Q15418 53 340 735.0 STU:1 Type1 Inactive DFGin 6.9283 12.3219 BLBplus -135.18, 169.76 58.7, 61.01 -129.8, -169.31 56.27, 83.01 123.62, -72.1 none-none none 999.0 Saltbr-none 999.0 HRD-out -70.75, 75.42 -55.39, -34.53 none-out-out SNCnoo out-out ActLoopNT-out 7.3785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.4 APE8-dihe-in -65.4, 109.6 APE8-rot-in 309.27 APE67-dihe-in -55.68, -21.45 -56.7, -41.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7538 None None None XRAY 2.0 0.255 0.286 A 321.0 265.0 23 28 16 12 [[62, 321], [418, 675]] 2.0 2z7r AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 2Z7SA Q15418 56 340 735.0 P01:1 Type1 Inactive DFGin 7.2187 12.6354 BLBplus -132.64, 170.38 54.15, 50.71 -114.94, -156.75 52.84, 81.1 107.65, -49.27 none-none none 999.0 Saltbr-none 999.0 HRD-out -71.6, 70.9 -56.92, -36.92 none-out-out SNCnoo out-out ActLoopNT-out 7.0904 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.47 APE8-dihe-in -68.64, 105.29 APE8-rot-in 308.32 APE67-dihe-in -56.06, -20.75 -56.93, -41.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7344 None None None XRAY 2.1 0.279 999.0 A 321.0 256.0 29 28 16 12 [[62, 321], [418, 675]] 2.0 2z7s AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1

AGC_RPS6KA1-1 (Ribosomal protein S6 kinase alpha-1)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 3 50.0% 2Z7RA
DFGin BLAminus 2 33.3% AF-Q15418-K1A
DFGin BLAplus 1 16.7% 8XOVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
RPS6KA1-1 KS6A1_HUMAN AF-Q15418-K1A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.6211 14.3552 BLAminus -124.04, -166.26 40.15, 63.05 -75.14, 13.01 287.46, 77.73 -62.04, -17.57 in-in in 8.9956 Saltbr-in 2.6553 HRD-in -82.17, -49.64 65.88, 6.04 in-in-in SNCiii in-in ActLoopNT-in 2.9042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.23, 164.1 APE9-dihe-na 113.31, 168.76 APE8-dihe-in -68.46, 130.82 APE8-rot-in 292.77 APE67-dihe-in -60.62, -26.43 -61.01, -40.77 APE12-dist-in 8.4157 APE11-dist-in 11.4063 APE10-dist-in 5.6955 APE9-dist-in 3.4929 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 28 28 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K1 Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 8.9e-96 325.9 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 KS6A1_HUMAN AF-Q15418-K3A Q15418 54 329 735.0 No_ligand No_ligand Active DFGin 6.4457 14.3519 BLAminus -131.09, -177.74 50.28, 63.61 -71.56, 10.34 294.57, 83.15 -62.78, -13.6 in-in in 8.88 Saltbr-in 2.6627 HRD-in -82.73, -46.46 67.14, 11.23 in-in-in SNCiii in-in ActLoopNT-in 2.8525 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.19, 164.66 APE9-dihe-na 112.66, 172.32 APE8-dihe-in -74.19, 134.18 APE8-rot-in 293.08 APE67-dihe-in -61.38, -26.34 -64.42, -40.72 APE12-dist-in 8.366 APE11-dist-in 11.4324 APE10-dist-in 5.6764 APE9-dist-in 3.3874 None None None AF2 -1.0 1.0 1.0 A 276.0 276.0 0 28 28 0 [[62, 321], [418, 675]] 2.0 AF-Q15418-K3 Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 8.9e-96 325.9 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 KS6A1_HUMAN 8XOVA Q15418 56 340 735.0 ANP:401 ATPlike Inactive DFGin 9.5319 13.1202 BLAplus -128.25, 170.81 61.53, 44.51 -100.37, -14.37 34.15, 82.03 -83.22, -24.55 out-out out 11.1338 Saltbr-out 8.8974 HRD-in -75.5, -43.57 69.32, -59.52 out-out-out SNCooo out-out ActLoopNT-out 9.5095 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -98.67, 154.58 APE9-dihe-na -175.48, 178.84 APE8-dihe-in -87.06, 119.03 APE8-rot-in 310.44 APE67-dihe-in -48.48, -27.39 -73.46, -38.49 APE12-dist-none 999.0 APE11-dist-in 10.4198 APE10-dist-out 11.5117 APE9-dist-out 7.6388 None None None XRAY 2.55 0.206 0.252 A 321.0 261.0 24 28 19 9 [[62, 321], [418, 675]] 2.0 8xov Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 KS6A1_HUMAN 2Z7QA Q15418 56 340 735.0 ACP:500 ATPlike Inactive DFGin 8.0284 12.3687 BLBplus -135.49, 158.95 63.12, 60.24 -125.42, -165.59 47.01, 74.46 107.04, -8.15 none-none none 999.0 Saltbr-none 999.0 HRD-out -82.53, 70.19 -54.28, -43.87 none-out-out SNCnoo out-out ActLoopNT-out 7.0527 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -165.36 APE8-dihe-in -67.18, 106.47 APE8-rot-in 305.06 APE67-dihe-in -59.78, -23.27 -56.13, -39.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7913 None None None XRAY 2.0 0.264 0.283 A 321.0 255.0 30 28 16 12 [[62, 321], [418, 675]] 2.0 2z7q Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 KS6A1_HUMAN 2Z7RA Q15418 53 340 735.0 STU:1 Type1 Inactive DFGin 6.9283 12.3219 BLBplus -135.18, 169.76 58.7, 61.01 -129.8, -169.31 56.27, 83.01 123.62, -72.1 none-none none 999.0 Saltbr-none 999.0 HRD-out -70.75, 75.42 -55.39, -34.53 none-out-out SNCnoo out-out ActLoopNT-out 7.3785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.4 APE8-dihe-in -65.4, 109.6 APE8-rot-in 309.27 APE67-dihe-in -55.68, -21.45 -56.7, -41.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7538 None None None XRAY 2.0 0.255 0.286 A 321.0 265.0 23 28 16 12 [[62, 321], [418, 675]] 2.0 2z7r Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
RPS6KA1-1 KS6A1_HUMAN 2Z7SA Q15418 56 340 735.0 P01:1 Type1 Inactive DFGin 7.2187 12.6354 BLBplus -132.64, 170.38 54.15, 50.71 -114.94, -156.75 52.84, 81.1 107.65, -49.27 none-none none 999.0 Saltbr-none 999.0 HRD-out -71.6, 70.9 -56.92, -36.92 none-out-out SNCnoo out-out ActLoopNT-out 7.0904 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.47 APE8-dihe-in -68.64, 105.29 APE8-rot-in 308.32 APE67-dihe-in -56.06, -20.75 -56.93, -41.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.7344 None None None XRAY 2.1 0.279 999.0 A 321.0 256.0 29 28 16 12 [[62, 321], [418, 675]] 2.0 2z7s Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1

AGC_RPS6KA1-1 (Ribosomal protein S6 kinase alpha-1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name