TYR_PTK2B (Protein-tyrosine kinase 2-beta)

Total number of chains: 16
Active chains: 2
Uniprot: FAK2_HUMAN
Kinase Domain Residues: 425 - 681
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 6 37.5% 4H1JA
DFGin None 5 31.2% 3CC6A
DFGin BLAminus 2 12.5% AF-Q14289-K1A
DFGout BBAminus 2 12.5% 4H1MA
None None 1 6.2% 3H3CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PTK2B AF-Q14289-K1A Q14289 417 689 1009.0 No_ligand No_ligand Active DFGin 6.5367 14.3617 BLAminus -131.72, -171.58 53.51, 75.84 -88.65, 13.62 289.79, 84.72 -60.6, -30.86 in-in in 8.0375 Saltbr-in 2.6623 HRD-in -85.79, -41.54 67.03, -0.33 in-in-in SNCiii in-in ActLoopNT-in 2.8753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.04, 122.0 APE9-dihe-in -116.02, 145.37 APE8-dihe-in -80.41, 68.29 APE8-rot-na 34.64 APE67-dihe-in -71.07, -12.92 -45.72, -40.78 APE12-dist-na 14.0761 APE11-dist-na 8.6746 APE10-dist-na 10.952 APE9-dist-in 6.9005 None None None AF2 -1.0 1.0 1.0 A 273.0 273.0 0 29 29 0 [[425, 681]] 1.0 AF-Q14289-K1 TYR_PTK2B_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B AF-Q14289-K3A Q14289 417 689 1009.0 No_ligand No_ligand Active DFGin 6.5912 13.6326 BLAminus -132.33, -167.16 54.04, 69.82 -81.16, 13.85 294.41, 87.46 -60.07, -30.95 in-in in 7.9223 Saltbr-in 2.6751 HRD-in -81.94, -43.61 63.46, 1.92 in-in-in SNCiii in-in ActLoopNT-in 2.8646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.6, 122.15 APE9-dihe-in -126.53, 149.12 APE8-dihe-in -79.44, 64.83 APE8-rot-na 35.41 APE67-dihe-in -68.84, -16.04 -45.55, -41.72 APE12-dist-na 14.1997 APE11-dist-na 8.9647 APE10-dist-na 10.3978 APE9-dist-in 6.6585 None None None AF2 -1.0 1.0 1.0 A 273.0 273.0 0 29 29 0 [[425, 681]] 1.0 AF-Q14289-K3 TYR_PTK2B_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3FZOA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.0411 16.6484 None -80.41, -161.53 -55.79, 145.03 -57.19, 149.81 278.1, 79.23 -63.36, 124.08 in-out in 8.6788 Saltbr-out 3.9901 HRD-in -88.56, -44.48 71.73, -1.23 out-out-out SNCooo out-out ActLoopNT-out 7.2159 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.21 APE8-dihe-in -78.85, 65.44 APE8-rot-na 30.29 APE67-dihe-in -67.97, -12.51 -51.67, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2021 None None None XRAY 2.2 0.207 0.265 A 277.0 262.0 10 29 19 10 [[425, 681]] 1.0 3fzo TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 8YGXA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.3395 16.9549 None -81.04, -163.09 -79.3, 167.03 -64.4, 154.66 279.14, 72.36 -77.31, 999.0 in-out in 9.6398 Saltbr-out 9.5712 HRD-in -87.71, -52.71 73.64, 6.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 156.88 APE8-dihe-in -79.69, 73.24 APE8-rot-na 32.8 APE67-dihe-in -69.65, -12.51 -56.52, -42.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1124 None None None XRAY 2.0 0.209 0.27 A 277.0 255.0 17 29 12 17 [[425, 681]] 1.0 8ygx TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3CC6A Q14289 415 692 1009.0 No_ligand No_ligand Inactive DFGin 7.0032 16.5591 None -87.76, -163.7 -58.23, 148.28 -56.0, 147.59 284.53, 73.73 -57.12, 131.04 in-in in 8.8937 Saltbr-in 3.5112 HRD-in -90.62, -51.5 76.85, -2.02 in-out-out SNCioo out-out ActLoopNT-out 7.4363 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 61.77, 49.9 APE9-dihe-in -65.83, 147.14 APE8-dihe-in -78.84, 67.36 APE8-rot-na 28.85 APE67-dihe-in -70.52, -9.23 -47.7, -42.04 APE12-dist-na 14.4486 APE11-dist-na 8.5486 APE10-dist-na 10.5072 APE9-dist-out 8.2152 None None None XRAY 1.6 0.187 0.219 A 281.0 269.0 9 29 20 9 [[425, 681]] 1.0 3cc6 TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 8XOXA Q14289 417 692 1009.0 YAM:701 Type1 Inactive DFGin 6.9505 16.4086 None -80.09, -162.96 -67.92, 153.8 -59.81, 149.69 281.78, 71.56 -67.49, 135.35 in-out in 9.5056 Saltbr-out 8.7294 HRD-in -84.67, -50.29 73.68, 0.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.93 APE8-dihe-in -79.37, 59.37 APE8-rot-na 36.03 APE67-dihe-in -77.94, -4.55 -50.42, -39.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3588 None None None XRAY 1.9 0.172 0.23 A 277.0 261.0 15 29 14 15 [[425, 681]] 1.0 8xox TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 5TOBA Q14289 420 690 1009.0 YAM:701 Type1 Inactive DFGin 6.6239 15.8925 None -80.12, -169.51 -62.87, 163.32 -68.81, 156.27 288.67, 73.8 -89.77, 999.0 in-none in 9.4038 Saltbr-none 999.0 HRD-in -91.14, -46.46 78.7, -8.23 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.94 APE8-rot-na 29.17 APE67-dihe-in -80.81, -3.79 -54.7, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.117 0.212 0.262 A 282.0 245.0 26 29 11 18 [[425, 681]] 1.0 5tob TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3FZSA Q14289 420 690 1009.0 B96:999 Type2 Inactive DFGout 12.641 12.4442 BBAminus -127.47, -169.01 -143.4, 93.19 -98.42, 0.88 314.47, 143.45 166.67, 999.0 in-in in 7.2782 Saltbr-in 2.8064 HRD-in -80.03, -52.45 81.61, -5.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.94 APE8-dihe-in -78.53, 64.45 APE8-rot-na 27.86 APE67-dihe-in -71.99, -8.0 -49.85, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6317 None None None XRAY 1.75 0.192 0.224 A 277.0 254.0 17 29 12 17 [[425, 681]] 1.0 3fzs TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 4H1MA Q14289 420 690 1009.0 0YJ:701 Type2 Inactive DFGout 12.3351 12.5671 BBAminus -135.72, -167.81 -149.06, 100.0 -111.39, 17.17 334.16, 127.27 -99.68, 166.5 in-in in 7.2163 Saltbr-in 2.6341 HRD-in -75.07, -50.15 74.3, -3.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.63 APE8-dihe-in -78.98, 62.56 APE8-rot-na 29.97 APE67-dihe-in -66.24, -7.33 -42.14, -49.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6662 None None None XRAY 1.99 0.226 0.296 A 293.0 256.0 15 29 14 15 [[425, 681]] 1.0 4h1m TYR_PTK2B_HUMAN TYR 2.9e-92 314.6 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3FZPA Q14289 419 692 1009.0 AGS:999 ATPlike Inactive DFGout 13.1422 11.9545 None -76.23, -175.2 -102.86, 78.24 -127.89, 25.71 251.37, 121.91 162.92, 999.0 in-out in 9.4326 Saltbr-out 4.27 HRD-out -102.53, 130.12 -113.62, 20.17 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -45.5, 93.87 APE9-dihe-in -76.94, 158.38 APE8-dihe-in -82.03, 71.77 APE8-rot-na 28.7 APE67-dihe-in -73.32, -11.31 -53.21, -40.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6516 None None None XRAY 2.1 0.212 0.239 A 277.0 259.0 15 29 14 15 [[425, 681]] 1.0 3fzp TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3ET7A Q14289 419 691 1009.0 349:999 Type1 Inactive DFGout 14.7056 12.4106 None 9.5, -105.84 87.78, 85.36 135.69, 112.37 158.4, 74.72 96.57, -24.26 in-in in 8.2878 Saltbr-in 3.1337 HRD-out -130.83, 127.11 -101.37, -8.15 in-out-in SNCioi out-in ActLoopNT-out 5.525 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.56, 117.5 APE9-dihe-in -133.88, 114.06 APE8-dihe-in -58.49, 68.9 APE8-rot-na 17.47 APE67-dihe-in -61.16, -23.15 -55.8, -40.79 APE12-dist-na 999.0 APE11-dist-na 14.9459 APE10-dist-na 15.0773 APE9-dist-in 7.5487 None None None XRAY 2.7 0.251 0.328 A 277.0 261.0 12 29 17 12 [[425, 681]] 1.0 3et7 TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3FZRA Q14289 419 691 1009.0 3JZ:999 Type1 Inactive DFGout 14.2642 11.962 None -7.43, -120.21 113.73, 73.46 151.46, 106.83 174.47, 70.32 106.69, -16.15 in-in in 8.1633 Saltbr-in 2.8461 HRD-out -122.47, 120.14 -93.5, 4.21 in-out-in SNCioi out-in ActLoopNT-out 5.0753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.64, 119.44 APE9-dihe-in -125.95, 120.03 APE8-dihe-in -60.02, 59.61 APE8-rot-na 29.81 APE67-dihe-in -69.21, -10.71 -49.49, -38.43 APE12-dist-na 999.0 APE11-dist-na 14.0021 APE10-dist-na 14.9922 APE9-dist-in 7.5054 None None None XRAY 2.7 0.214 0.274 A 277.0 261.0 12 29 17 12 [[425, 681]] 1.0 3fzr TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 5TO8A Q14289 420 691 1009.0 7FM:701 Type1 Inactive DFGout 14.9344 13.4875 None -71.2, 168.16 -83.49, -36.59 -55.56, 124.42 174.54, 82.75 92.61, -6.78 in-none in 9.5309 Saltbr-none 999.0 HRD-out -136.24, 118.23 -91.4, -1.6 none-out-none SNCnon out-none ActLoopNT-out 4.0669 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -76.18, 1.59 999.0, -46.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.985 0.206 0.235 A 282.0 250.0 22 29 13 16 [[425, 681]] 1.0 5to8 TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3FZTA Q14289 420 690 1009.0 4JZ:999 Type2 Inactive DFGout 14.508 12.5449 None -122.98, -178.19 -149.4, 88.08 -140.66, 17.05 57.59, 91.54 -74.77, 162.83 in-in in 7.6722 Saltbr-in 2.8852 HRD-in -86.01, -49.17 78.5, -11.43 in-out-none SNCion out-none ActLoopNT-out 10.261 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.0 APE8-dihe-in -80.03, 69.45 APE8-rot-na 31.22 APE67-dihe-in -70.47, -8.61 -48.26, -44.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4943 None None None XRAY 1.95 0.198 0.242 A 277.0 259.0 12 29 17 12 [[425, 681]] 1.0 3fzt TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 4H1JA Q14289 419 690 1009.0 0YH:701 Type2 Inactive DFGout 14.3157 12.6449 None -124.86, 177.49 -148.24, 81.73 -130.95, 20.74 51.44, 79.82 -75.76, 155.99 in-in in 7.509 Saltbr-in 2.7504 HRD-in -86.09, -50.17 68.32, 2.97 in-out-out SNCioo out-out ActLoopNT-out 10.2853 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 69.93, -50.61 APE9-dihe-in -88.32, 144.1 APE8-dihe-in -83.53, 70.17 APE8-rot-na 31.56 APE67-dihe-in -65.88, -10.37 -45.99, -46.6 APE12-dist-na 13.9933 APE11-dist-na 12.1711 APE10-dist-na 7.9236 APE9-dist-in 7.5334 None None None XRAY 2.0 0.182 0.209 A 293.0 263.0 9 29 20 9 [[425, 681]] 1.0 4h1j TYR_PTK2B_HUMAN TYR 2.9e-92 314.6 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B 3H3CA Q14289 416 692 1009.0 P1E:999 Type1 Inactive None 14.5399 14.3031 None -72.29, 173.5 -83.79, -75.33 -27.66, 138.67 168.27, 88.28 84.71, 2.13 in-out in 9.2748 Saltbr-out 4.0671 HRD-out -102.14, 121.26 -94.56, 14.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 25.0, 70.6 APE9-dihe-in -85.64, 154.22 APE8-dihe-in -82.06, 67.49 APE8-rot-na 30.84 APE67-dihe-in -69.88, -12.73 -41.52, -48.14 APE12-dist-na 999.0 APE11-dist-na 16.7821 APE10-dist-na 16.0004 APE9-dist-in 7.6667 None None None XRAY 2.0 0.225 0.273 A 277.0 263.0 14 29 15 14 [[425, 681]] 1.0 3h3c TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta

TYR_PTK2B (Protein-tyrosine kinase 2-beta)

Total number of chains: 16
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 6 37.5% 4H1JA
DFGin None 5 31.2% 3CC6A
DFGin BLAminus 2 12.5% AF-Q14289-K1A
DFGout BBAminus 2 12.5% 4H1MA
None None 1 6.2% 3H3CA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
PTK2B FAK2_HUMAN AF-Q14289-K1A Q14289 417 689 1009.0 No_ligand No_ligand Active DFGin 6.5367 14.3617 BLAminus -131.72, -171.58 53.51, 75.84 -88.65, 13.62 289.79, 84.72 -60.6, -30.86 in-in in 8.0375 Saltbr-in 2.6623 HRD-in -85.79, -41.54 67.03, -0.33 in-in-in SNCiii in-in ActLoopNT-in 2.8753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.04, 122.0 APE9-dihe-in -116.02, 145.37 APE8-dihe-in -80.41, 68.29 APE8-rot-na 34.64 APE67-dihe-in -71.07, -12.92 -45.72, -40.78 APE12-dist-na 14.0761 APE11-dist-na 8.6746 APE10-dist-na 10.952 APE9-dist-in 6.9005 None None None AF2 -1.0 1.0 1.0 A 273.0 273.0 0 29 29 0 [[425, 681]] 1.0 AF-Q14289-K1 Homo sapiens TYR_PTK2B_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN AF-Q14289-K3A Q14289 417 689 1009.0 No_ligand No_ligand Active DFGin 6.5912 13.6326 BLAminus -132.33, -167.16 54.04, 69.82 -81.16, 13.85 294.41, 87.46 -60.07, -30.95 in-in in 7.9223 Saltbr-in 2.6751 HRD-in -81.94, -43.61 63.46, 1.92 in-in-in SNCiii in-in ActLoopNT-in 2.8646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.6, 122.15 APE9-dihe-in -126.53, 149.12 APE8-dihe-in -79.44, 64.83 APE8-rot-na 35.41 APE67-dihe-in -68.84, -16.04 -45.55, -41.72 APE12-dist-na 14.1997 APE11-dist-na 8.9647 APE10-dist-na 10.3978 APE9-dist-in 6.6585 None None None AF2 -1.0 1.0 1.0 A 273.0 273.0 0 29 29 0 [[425, 681]] 1.0 AF-Q14289-K3 Homo sapiens TYR_PTK2B_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3FZOA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.0411 16.6484 None -80.41, -161.53 -55.79, 145.03 -57.19, 149.81 278.1, 79.23 -63.36, 124.08 in-out in 8.6788 Saltbr-out 3.9901 HRD-in -88.56, -44.48 71.73, -1.23 out-out-out SNCooo out-out ActLoopNT-out 7.2159 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.21 APE8-dihe-in -78.85, 65.44 APE8-rot-na 30.29 APE67-dihe-in -67.97, -12.51 -51.67, -39.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2021 None None None XRAY 2.2 0.207 0.265 A 277.0 262.0 10 29 19 10 [[425, 681]] 1.0 3fzo Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 8YGXA Q14289 420 691 1009.0 No_ligand No_ligand Inactive DFGin 7.3395 16.9549 None -81.04, -163.09 -79.3, 167.03 -64.4, 154.66 279.14, 72.36 -77.31, 999.0 in-out in 9.6398 Saltbr-out 9.5712 HRD-in -87.71, -52.71 73.64, 6.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 156.88 APE8-dihe-in -79.69, 73.24 APE8-rot-na 32.8 APE67-dihe-in -69.65, -12.51 -56.52, -42.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1124 None None None XRAY 2.0 0.209 0.27 A 277.0 255.0 17 29 12 17 [[425, 681]] 1.0 8ygx Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3CC6A Q14289 415 692 1009.0 No_ligand No_ligand Inactive DFGin 7.0032 16.5591 None -87.76, -163.7 -58.23, 148.28 -56.0, 147.59 284.53, 73.73 -57.12, 131.04 in-in in 8.8937 Saltbr-in 3.5112 HRD-in -90.62, -51.5 76.85, -2.02 in-out-out SNCioo out-out ActLoopNT-out 7.4363 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 61.77, 49.9 APE9-dihe-in -65.83, 147.14 APE8-dihe-in -78.84, 67.36 APE8-rot-na 28.85 APE67-dihe-in -70.52, -9.23 -47.7, -42.04 APE12-dist-na 14.4486 APE11-dist-na 8.5486 APE10-dist-na 10.5072 APE9-dist-out 8.2152 None None None XRAY 1.6 0.187 0.219 A 281.0 269.0 9 29 20 9 [[425, 681]] 1.0 3cc6 Homo sapiens TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 8XOXA Q14289 417 692 1009.0 YAM:701 Type1 Inactive DFGin 6.9505 16.4086 None -80.09, -162.96 -67.92, 153.8 -59.81, 149.69 281.78, 71.56 -67.49, 135.35 in-out in 9.5056 Saltbr-out 8.7294 HRD-in -84.67, -50.29 73.68, 0.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.93 APE8-dihe-in -79.37, 59.37 APE8-rot-na 36.03 APE67-dihe-in -77.94, -4.55 -50.42, -39.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3588 None None None XRAY 1.9 0.172 0.23 A 277.0 261.0 15 29 14 15 [[425, 681]] 1.0 8xox Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 5TOBA Q14289 420 690 1009.0 YAM:701 Type1 Inactive DFGin 6.6239 15.8925 None -80.12, -169.51 -62.87, 163.32 -68.81, 156.27 288.67, 73.8 -89.77, 999.0 in-none in 9.4038 Saltbr-none 999.0 HRD-in -91.14, -46.46 78.7, -8.23 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 58.94 APE8-rot-na 29.17 APE67-dihe-in -80.81, -3.79 -54.7, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.117 0.212 0.262 A 282.0 245.0 26 29 11 18 [[425, 681]] 1.0 5tob Homo sapiens TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3FZSA Q14289 420 690 1009.0 B96:999 Type2 Inactive DFGout 12.641 12.4442 BBAminus -127.47, -169.01 -143.4, 93.19 -98.42, 0.88 314.47, 143.45 166.67, 999.0 in-in in 7.2782 Saltbr-in 2.8064 HRD-in -80.03, -52.45 81.61, -5.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.94 APE8-dihe-in -78.53, 64.45 APE8-rot-na 27.86 APE67-dihe-in -71.99, -8.0 -49.85, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6317 None None None XRAY 1.75 0.192 0.224 A 277.0 254.0 17 29 12 17 [[425, 681]] 1.0 3fzs Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 4H1MA Q14289 420 690 1009.0 0YJ:701 Type2 Inactive DFGout 12.3351 12.5671 BBAminus -135.72, -167.81 -149.06, 100.0 -111.39, 17.17 334.16, 127.27 -99.68, 166.5 in-in in 7.2163 Saltbr-in 2.6341 HRD-in -75.07, -50.15 74.3, -3.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.63 APE8-dihe-in -78.98, 62.56 APE8-rot-na 29.97 APE67-dihe-in -66.24, -7.33 -42.14, -49.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6662 None None None XRAY 1.99 0.226 0.296 A 293.0 256.0 15 29 14 15 [[425, 681]] 1.0 4h1m Homo sapiens TYR_PTK2B_HUMAN TYR 2.9e-92 314.6 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3FZPA Q14289 419 692 1009.0 AGS:999 ATPlike Inactive DFGout 13.1422 11.9545 None -76.23, -175.2 -102.86, 78.24 -127.89, 25.71 251.37, 121.91 162.92, 999.0 in-out in 9.4326 Saltbr-out 4.27 HRD-out -102.53, 130.12 -113.62, 20.17 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -45.5, 93.87 APE9-dihe-in -76.94, 158.38 APE8-dihe-in -82.03, 71.77 APE8-rot-na 28.7 APE67-dihe-in -73.32, -11.31 -53.21, -40.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6516 None None None XRAY 2.1 0.212 0.239 A 277.0 259.0 15 29 14 15 [[425, 681]] 1.0 3fzp Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3ET7A Q14289 419 691 1009.0 349:999 Type1 Inactive DFGout 14.7056 12.4106 None 9.5, -105.84 87.78, 85.36 135.69, 112.37 158.4, 74.72 96.57, -24.26 in-in in 8.2878 Saltbr-in 3.1337 HRD-out -130.83, 127.11 -101.37, -8.15 in-out-in SNCioi out-in ActLoopNT-out 5.525 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.56, 117.5 APE9-dihe-in -133.88, 114.06 APE8-dihe-in -58.49, 68.9 APE8-rot-na 17.47 APE67-dihe-in -61.16, -23.15 -55.8, -40.79 APE12-dist-na 999.0 APE11-dist-na 14.9459 APE10-dist-na 15.0773 APE9-dist-in 7.5487 None None None XRAY 2.7 0.251 0.328 A 277.0 261.0 12 29 17 12 [[425, 681]] 1.0 3et7 Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3FZRA Q14289 419 691 1009.0 3JZ:999 Type1 Inactive DFGout 14.2642 11.962 None -7.43, -120.21 113.73, 73.46 151.46, 106.83 174.47, 70.32 106.69, -16.15 in-in in 8.1633 Saltbr-in 2.8461 HRD-out -122.47, 120.14 -93.5, 4.21 in-out-in SNCioi out-in ActLoopNT-out 5.0753 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.64, 119.44 APE9-dihe-in -125.95, 120.03 APE8-dihe-in -60.02, 59.61 APE8-rot-na 29.81 APE67-dihe-in -69.21, -10.71 -49.49, -38.43 APE12-dist-na 999.0 APE11-dist-na 14.0021 APE10-dist-na 14.9922 APE9-dist-in 7.5054 None None None XRAY 2.7 0.214 0.274 A 277.0 261.0 12 29 17 12 [[425, 681]] 1.0 3fzr Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 5TO8A Q14289 420 691 1009.0 7FM:701 Type1 Inactive DFGout 14.9344 13.4875 None -71.2, 168.16 -83.49, -36.59 -55.56, 124.42 174.54, 82.75 92.61, -6.78 in-none in 9.5309 Saltbr-none 999.0 HRD-out -136.24, 118.23 -91.4, -1.6 none-out-none SNCnon out-none ActLoopNT-out 4.0669 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -76.18, 1.59 999.0, -46.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.985 0.206 0.235 A 282.0 250.0 22 29 13 16 [[425, 681]] 1.0 5to8 Homo sapiens TYR_PTK2B_HUMAN TYR 2.5e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3FZTA Q14289 420 690 1009.0 4JZ:999 Type2 Inactive DFGout 14.508 12.5449 None -122.98, -178.19 -149.4, 88.08 -140.66, 17.05 57.59, 91.54 -74.77, 162.83 in-in in 7.6722 Saltbr-in 2.8852 HRD-in -86.01, -49.17 78.5, -11.43 in-out-none SNCion out-none ActLoopNT-out 10.261 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.0 APE8-dihe-in -80.03, 69.45 APE8-rot-na 31.22 APE67-dihe-in -70.47, -8.61 -48.26, -44.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4943 None None None XRAY 1.95 0.198 0.242 A 277.0 259.0 12 29 17 12 [[425, 681]] 1.0 3fzt Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 4H1JA Q14289 419 690 1009.0 0YH:701 Type2 Inactive DFGout 14.3157 12.6449 None -124.86, 177.49 -148.24, 81.73 -130.95, 20.74 51.44, 79.82 -75.76, 155.99 in-in in 7.509 Saltbr-in 2.7504 HRD-in -86.09, -50.17 68.32, 2.97 in-out-out SNCioo out-out ActLoopNT-out 10.2853 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 69.93, -50.61 APE9-dihe-in -88.32, 144.1 APE8-dihe-in -83.53, 70.17 APE8-rot-na 31.56 APE67-dihe-in -65.88, -10.37 -45.99, -46.6 APE12-dist-na 13.9933 APE11-dist-na 12.1711 APE10-dist-na 7.9236 APE9-dist-in 7.5334 None None None XRAY 2.0 0.182 0.209 A 293.0 263.0 9 29 20 9 [[425, 681]] 1.0 4h1j Homo sapiens TYR_PTK2B_HUMAN TYR 2.9e-92 314.6 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta
PTK2B FAK2_HUMAN 3H3CA Q14289 416 692 1009.0 P1E:999 Type1 Inactive None 14.5399 14.3031 None -72.29, 173.5 -83.79, -75.33 -27.66, 138.67 168.27, 88.28 84.71, 2.13 in-out in 9.2748 Saltbr-out 4.0671 HRD-out -102.14, 121.26 -94.56, 14.11 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 25.0, 70.6 APE9-dihe-in -85.64, 154.22 APE8-dihe-in -82.06, 67.49 APE8-rot-na 30.84 APE67-dihe-in -69.88, -12.73 -41.52, -48.14 APE12-dist-na 999.0 APE11-dist-na 16.7821 APE10-dist-na 16.0004 APE9-dist-in 7.6667 None None None XRAY 2.0 0.225 0.273 A 277.0 263.0 14 29 15 14 [[425, 681]] 1.0 3h3c Homo sapiens TYR_PTK2B_HUMAN TYR 2.4e-92 314.8 2.0 260.0 259.0 566 567 568 570 572 457 474 478 546 548 547 549.0 607 595 590 589 588 587 586 585 584 503 Protein-tyrosine kinase 2-beta

TYR_PTK2B (Protein-tyrosine kinase 2-beta)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name