TYR_NTRK2 (BDNF/NT-3 growth factors receptor)

Total number of chains: 6
Active chains: 2
Uniprot: NTRK2_HUMAN
Kinase Domain Residues: 538 - 809
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q16620-K1A
DFGout None 2 33.3% 4AT5A
DFGin None 1 16.7% 4AT3A
DFGout BBAminus 1 16.7% 4AT4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NTRK2 AF-Q16620-K1A Q16620 530 817 822.0 No_ligand No_ligand Active DFGin 7.2505 14.0814 BLAminus -129.92, -167.83 48.26, 76.15 -89.09, 12.73 295.8, 100.4 -61.26, -31.29 in-in in 9.4494 Saltbr-in 3.3967 HRD-in -68.82, -41.65 68.43, -23.34 in-in-in SNCiii in-in ActLoopNT-in 2.9625 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.01, 134.76 APE9-dihe-in -121.62, 135.62 APE8-dihe-in -78.15, 62.44 APE8-rot-na 34.24 APE67-dihe-in -72.1, -16.74 -41.5, -42.01 APE12-dist-na 14.6966 APE11-dist-na 8.5724 APE10-dist-na 10.1212 APE9-dist-in 7.1349 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 30 30 0 [[538, 809]] 1.0 AF-Q16620-K1 TYR_NTRK2_HUMAN TYR 2e-103 351.2 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 AF-Q16620-K3A Q16620 530 817 822.0 No_ligand No_ligand Active DFGin 7.1788 13.9637 BLAminus -133.49, -167.46 48.41, 73.77 -85.7, 10.59 290.87, 90.54 -61.17, -30.34 in-in in 9.3033 Saltbr-in 2.7941 HRD-in -72.82, -41.85 64.78, -16.33 in-in-in SNCiii in-in ActLoopNT-in 2.8564 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.98, 132.49 APE9-dihe-in -124.1, 152.13 APE8-dihe-in -79.67, 63.19 APE8-rot-na 36.17 APE67-dihe-in -66.1, -26.78 -41.97, -41.64 APE12-dist-na 15.1032 APE11-dist-na 8.8964 APE10-dist-na 10.8263 APE9-dist-in 6.6386 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 30 30 0 [[538, 809]] 1.0 AF-Q16620-K3 TYR_NTRK2_HUMAN TYR 2e-103 351.2 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 4AT3A Q16620 527 822 822.0 LTI:61839 Type1 Inactive DFGin 6.9991 14.7396 None -152.42, -173.22 72.78, -62.99 65.94, 17.52 310.83, 124.61 77.58, 6.11 out-out out 10.154 Saltbr-out 5.3168 HRD-in -64.12, -49.63 78.79, -14.53 out-out-in SNCooi out-in ActLoopNT-out 14.2538 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.1, 112.61 APE9-dihe-in -128.93, 146.94 APE8-dihe-in -81.25, 69.04 APE8-rot-na 31.63 APE67-dihe-in -62.22, -21.09 -43.86, -43.94 APE12-dist-na 17.2682 APE11-dist-na 12.9856 APE10-dist-na 11.6967 APE9-dist-in 6.9412 None None None XRAY 1.77 0.2 0.224 A 299.0 286.0 10 30 28 2 [[538, 809]] 1.0 4at3 TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 4AT4A Q16620 527 822 822.0 T6E:61839 Type2 Inactive DFGout 16.083 12.3173 BBAminus -138.33, -173.82 -150.65, 91.45 -46.63, -53.96 277.03, 78.64 56.91, 31.32 in-out in 9.398 Saltbr-out 5.7374 HRD-in -65.6, -50.01 78.16, -12.89 out-out-in SNCooi out-in ActLoopNT-out 19.2866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.75, 107.47 APE9-dihe-in -123.67, 142.68 APE8-dihe-in -78.17, 69.35 APE8-rot-na 30.23 APE67-dihe-in -67.52, -16.77 -45.62, -38.91 APE12-dist-na 19.7766 APE11-dist-na 16.0907 APE10-dist-na 11.9894 APE9-dist-in 7.0137 None None None XRAY 2.36 0.183 0.217 A 299.0 289.0 7 30 30 0 [[538, 809]] 1.0 4at4 TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 4ASZA Q16620 527 822 822.0 No_ligand No_ligand Inactive DFGout 12.4032 8.2584 None 169.91, 150.05 -158.04, 162.97 -111.83, 25.98 308.25, 105.01 68.75, 31.9 in-out in 9.4204 Saltbr-out 4.7367 HRD-in -71.65, -51.89 78.99, -14.9 out-out-in SNCooi out-in ActLoopNT-out 15.6089 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.24, 110.29 APE9-dihe-in -127.13, 144.64 APE8-dihe-in -80.0, 69.62 APE8-rot-na 32.89 APE67-dihe-in -63.53, -19.21 -46.87, -40.46 APE12-dist-na 20.1547 APE11-dist-na 16.3469 APE10-dist-na 11.7799 APE9-dist-in 6.9583 None None None XRAY 1.7 0.181 0.203 A 299.0 286.0 10 30 30 0 [[538, 809]] 1.0 4asz TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 4AT5A Q16620 527 822 822.0 MUJ:61839 Type2 Inactive DFGout 17.2305 8.4059 None -135.24, -156.16 -157.88, 106.42 -62.2, -33.06 188.28, 101.45 59.23, 49.63 in-out in 9.1087 Saltbr-out 5.4187 HRD-in -72.52, -54.37 79.73, -15.76 out-out-in SNCooi out-in ActLoopNT-out 16.3728 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.69, 115.31 APE9-dihe-in -131.07, 148.0 APE8-dihe-in -82.2, 69.87 APE8-rot-na 34.04 APE67-dihe-in -62.44, -22.01 -49.38, -37.73 APE12-dist-na 18.2204 APE11-dist-na 14.5007 APE10-dist-na 9.9728 APE9-dist-in 6.7379 None None None XRAY 1.71 0.158 0.186 A 299.0 291.0 5 30 30 0 [[538, 809]] 1.0 4at5 TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor

TYR_NTRK2 (BDNF/NT-3 growth factors receptor)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q16620-K1A
DFGout None 2 33.3% 4AT5A
DFGin None 1 16.7% 4AT3A
DFGout BBAminus 1 16.7% 4AT4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
NTRK2 NTRK2_HUMAN AF-Q16620-K1A Q16620 530 817 822.0 No_ligand No_ligand Active DFGin 7.2505 14.0814 BLAminus -129.92, -167.83 48.26, 76.15 -89.09, 12.73 295.8, 100.4 -61.26, -31.29 in-in in 9.4494 Saltbr-in 3.3967 HRD-in -68.82, -41.65 68.43, -23.34 in-in-in SNCiii in-in ActLoopNT-in 2.9625 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.01, 134.76 APE9-dihe-in -121.62, 135.62 APE8-dihe-in -78.15, 62.44 APE8-rot-na 34.24 APE67-dihe-in -72.1, -16.74 -41.5, -42.01 APE12-dist-na 14.6966 APE11-dist-na 8.5724 APE10-dist-na 10.1212 APE9-dist-in 7.1349 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 30 30 0 [[538, 809]] 1.0 AF-Q16620-K1 Homo sapiens TYR_NTRK2_HUMAN TYR 2e-103 351.2 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 NTRK2_HUMAN AF-Q16620-K3A Q16620 530 817 822.0 No_ligand No_ligand Active DFGin 7.1788 13.9637 BLAminus -133.49, -167.46 48.41, 73.77 -85.7, 10.59 290.87, 90.54 -61.17, -30.34 in-in in 9.3033 Saltbr-in 2.7941 HRD-in -72.82, -41.85 64.78, -16.33 in-in-in SNCiii in-in ActLoopNT-in 2.8564 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -66.98, 132.49 APE9-dihe-in -124.1, 152.13 APE8-dihe-in -79.67, 63.19 APE8-rot-na 36.17 APE67-dihe-in -66.1, -26.78 -41.97, -41.64 APE12-dist-na 15.1032 APE11-dist-na 8.8964 APE10-dist-na 10.8263 APE9-dist-in 6.6386 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 30 30 0 [[538, 809]] 1.0 AF-Q16620-K3 Homo sapiens TYR_NTRK2_HUMAN TYR 2e-103 351.2 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 NTRK2_HUMAN 4AT3A Q16620 527 822 822.0 LTI:61839 Type1 Inactive DFGin 6.9991 14.7396 None -152.42, -173.22 72.78, -62.99 65.94, 17.52 310.83, 124.61 77.58, 6.11 out-out out 10.154 Saltbr-out 5.3168 HRD-in -64.12, -49.63 78.79, -14.53 out-out-in SNCooi out-in ActLoopNT-out 14.2538 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.1, 112.61 APE9-dihe-in -128.93, 146.94 APE8-dihe-in -81.25, 69.04 APE8-rot-na 31.63 APE67-dihe-in -62.22, -21.09 -43.86, -43.94 APE12-dist-na 17.2682 APE11-dist-na 12.9856 APE10-dist-na 11.6967 APE9-dist-in 6.9412 None None None XRAY 1.77 0.2 0.224 A 299.0 286.0 10 30 28 2 [[538, 809]] 1.0 4at3 Homo sapiens TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 NTRK2_HUMAN 4AT4A Q16620 527 822 822.0 T6E:61839 Type2 Inactive DFGout 16.083 12.3173 BBAminus -138.33, -173.82 -150.65, 91.45 -46.63, -53.96 277.03, 78.64 56.91, 31.32 in-out in 9.398 Saltbr-out 5.7374 HRD-in -65.6, -50.01 78.16, -12.89 out-out-in SNCooi out-in ActLoopNT-out 19.2866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.75, 107.47 APE9-dihe-in -123.67, 142.68 APE8-dihe-in -78.17, 69.35 APE8-rot-na 30.23 APE67-dihe-in -67.52, -16.77 -45.62, -38.91 APE12-dist-na 19.7766 APE11-dist-na 16.0907 APE10-dist-na 11.9894 APE9-dist-in 7.0137 None None None XRAY 2.36 0.183 0.217 A 299.0 289.0 7 30 30 0 [[538, 809]] 1.0 4at4 Homo sapiens TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 NTRK2_HUMAN 4ASZA Q16620 527 822 822.0 No_ligand No_ligand Inactive DFGout 12.4032 8.2584 None 169.91, 150.05 -158.04, 162.97 -111.83, 25.98 308.25, 105.01 68.75, 31.9 in-out in 9.4204 Saltbr-out 4.7367 HRD-in -71.65, -51.89 78.99, -14.9 out-out-in SNCooi out-in ActLoopNT-out 15.6089 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -74.24, 110.29 APE9-dihe-in -127.13, 144.64 APE8-dihe-in -80.0, 69.62 APE8-rot-na 32.89 APE67-dihe-in -63.53, -19.21 -46.87, -40.46 APE12-dist-na 20.1547 APE11-dist-na 16.3469 APE10-dist-na 11.7799 APE9-dist-in 6.9583 None None None XRAY 1.7 0.181 0.203 A 299.0 286.0 10 30 30 0 [[538, 809]] 1.0 4asz Homo sapiens TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor
NTRK2 NTRK2_HUMAN 4AT5A Q16620 527 822 822.0 MUJ:61839 Type2 Inactive DFGout 17.2305 8.4059 None -135.24, -156.16 -157.88, 106.42 -62.2, -33.06 188.28, 101.45 59.23, 49.63 in-out in 9.1087 Saltbr-out 5.4187 HRD-in -72.52, -54.37 79.73, -15.76 out-out-in SNCooi out-in ActLoopNT-out 16.3728 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -76.69, 115.31 APE9-dihe-in -131.07, 148.0 APE8-dihe-in -82.2, 69.87 APE8-rot-na 34.04 APE67-dihe-in -62.44, -22.01 -49.38, -37.73 APE12-dist-na 18.2204 APE11-dist-na 14.5007 APE10-dist-na 9.9728 APE9-dist-in 6.7379 None None None XRAY 1.71 0.158 0.186 A 299.0 291.0 5 30 30 0 [[538, 809]] 1.0 4at5 Homo sapiens TYR_NTRK2_HUMAN TYR 2.3e-103 351.0 1.0 260.0 260.0 693 694 695 697 699 572 588 592 673 675 674 676.0 735 723 718 717 716 715 714 713 712 618 BDNF/NT-3 growth factors receptor

TYR_NTRK2 (BDNF/NT-3 growth factors receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name