CAMK_MKNK1 (MAP kinase-interacting serine/threonine-protein kinase 1)

Total number of chains: 6
Active chains: 2
Uniprot: MKNK1_HUMAN
Kinase Domain Residues: 48 - 374
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q9BUB5-K1A
DFGout BBAminus 2 33.3% 2HW6A
DFGout None 2 33.3% 5WVDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MKNK1 AF-Q9BUB5-K1A Q9BUB5 40 382 465.0 No_ligand No_ligand Active DFGin 6.5506 14.4479 BLAminus -139.51, 177.87 63.89, 76.2 -93.98, 21.31 285.56, 81.43 -66.18, -24.6 in-in in 8.9919 Saltbr-in 2.8097 HRD-in -72.31, -45.84 65.95, -0.63 in-in-in SNCiii in-in ActLoopNT-in 3.0592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.16, 168.03 APE9-dihe-na 111.05, 173.22 APE8-dihe-in -72.54, 133.69 APE8-rot-in 282.56 APE67-dihe-in -71.55, -19.98 -54.49, -39.36 APE12-dist-in 9.1894 APE11-dist-in 11.3492 APE10-dist-in 5.7763 APE9-dist-in 3.5009 None None None AF2 -1.0 1.0 1.0 A 343.0 343.0 0 35 35 0 [[48, 374]] 1.0 AF-Q9BUB5-K1 CAMK_MKNK1_HUMAN CAMK 3e-74 256.7 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 AF-Q9BUB5-K3A Q9BUB5 40 382 465.0 No_ligand No_ligand Active DFGin 6.4006 14.2032 BLAminus -141.0, 178.88 62.92, 73.65 -91.35, 18.98 284.34, 81.84 -65.7, -27.47 in-in in 8.8495 Saltbr-in 2.7928 HRD-in -75.5, -43.96 67.15, 1.07 in-in-in SNCiii in-in ActLoopNT-in 2.9449 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.11, 176.01 APE9-dihe-na 93.67, 177.34 APE8-dihe-in -72.69, 132.8 APE8-rot-in 289.12 APE67-dihe-in -66.83, -21.71 -56.7, -37.4 APE12-dist-in 9.2399 APE11-dist-in 11.3616 APE10-dist-in 5.9164 APE9-dist-in 3.579 None None None AF2 -1.0 1.0 1.0 A 343.0 343.0 0 35 35 0 [[48, 374]] 1.0 AF-Q9BUB5-K3 CAMK_MKNK1_HUMAN CAMK 3e-74 256.7 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 2HW6A Q9BUB5 39 376 465.0 No_ligand No_ligand Inactive DFGout 13.0472 6.8685 BBAminus -147.58, 179.67 -118.68, 97.88 -107.66, 35.68 273.28, 2.83 -82.21, 122.21 in-out in 9.9608 Saltbr-out 5.0537 HRD-in -71.04, -52.36 89.58, -4.5 out-out-none SNCoon out-none ActLoopNT-out 19.4542 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.209 0.257 A 307.0 242.0 55 35 9 26 [[48, 374]] 1.0 2hw6 CAMK_MKNK1_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 2HW6B Q9BUB5 40 375 465.0 No_ligand No_ligand Inactive DFGout 12.9352 6.6985 BBAminus -152.37, 173.84 -112.12, 89.97 -108.38, 40.51 277.91, 15.03 -86.34, 127.2 out-out out 10.3183 Saltbr-out 5.3364 HRD-in -67.62, -48.77 89.55, -16.06 out-out-none SNCoon out-none ActLoopNT-out 20.2713 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.209 0.257 B 307.0 233.0 62 35 11 24 [[48, 374]] 1.0 2hw6 CAMK_MKNK1_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 5WVDA Q9BUB5 41 375 465.0 7UX:60402 Type1 Inactive DFGout 16.817 8.8256 None -153.53, -175.02 -120.1, 91.21 -96.84, 20.27 228.47, 136.79 -82.58, 118.32 in-out in 9.9781 Saltbr-out 5.1757 HRD-in -73.05, -41.28 72.15, -15.5 out-out-none SNCoon out-none ActLoopNT-out 19.0967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.242 0.271 A 310.0 241.0 53 35 12 23 [[48, 374]] 1.0 5wvd CAMK_MKNK1_HUMAN CAMK 5.7e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 5WVDB Q9BUB5 41 374 465.0 7UX:60401 Type1 Inactive DFGout 17.1237 8.9337 None -152.62, -172.83 -117.54, 96.55 -104.25, 19.77 225.98, 148.86 -82.9, 120.08 in-out in 9.941 Saltbr-out 5.839 HRD-in -75.79, -41.74 71.59, -16.32 out-out-none SNCoon out-none ActLoopNT-out 19.082 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 79.77 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.242 0.271 B 310.0 212.0 81 35 14 21 [[48, 374]] 1.0 5wvd CAMK_MKNK1_HUMAN CAMK 5.7e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1

CAMK_MKNK1 (MAP kinase-interacting serine/threonine-protein kinase 1)

Total number of chains: 6
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 33.3% AF-Q9BUB5-K1A
DFGout BBAminus 2 33.3% 2HW6A
DFGout None 2 33.3% 5WVDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MKNK1 MKNK1_HUMAN AF-Q9BUB5-K1A Q9BUB5 40 382 465.0 No_ligand No_ligand Active DFGin 6.5506 14.4479 BLAminus -139.51, 177.87 63.89, 76.2 -93.98, 21.31 285.56, 81.43 -66.18, -24.6 in-in in 8.9919 Saltbr-in 2.8097 HRD-in -72.31, -45.84 65.95, -0.63 in-in-in SNCiii in-in ActLoopNT-in 3.0592 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.16, 168.03 APE9-dihe-na 111.05, 173.22 APE8-dihe-in -72.54, 133.69 APE8-rot-in 282.56 APE67-dihe-in -71.55, -19.98 -54.49, -39.36 APE12-dist-in 9.1894 APE11-dist-in 11.3492 APE10-dist-in 5.7763 APE9-dist-in 3.5009 None None None AF2 -1.0 1.0 1.0 A 343.0 343.0 0 35 35 0 [[48, 374]] 1.0 AF-Q9BUB5-K1 Homo sapiens CAMK_MKNK1_HUMAN CAMK 3e-74 256.7 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 MKNK1_HUMAN AF-Q9BUB5-K3A Q9BUB5 40 382 465.0 No_ligand No_ligand Active DFGin 6.4006 14.2032 BLAminus -141.0, 178.88 62.92, 73.65 -91.35, 18.98 284.34, 81.84 -65.7, -27.47 in-in in 8.8495 Saltbr-in 2.7928 HRD-in -75.5, -43.96 67.15, 1.07 in-in-in SNCiii in-in ActLoopNT-in 2.9449 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.11, 176.01 APE9-dihe-na 93.67, 177.34 APE8-dihe-in -72.69, 132.8 APE8-rot-in 289.12 APE67-dihe-in -66.83, -21.71 -56.7, -37.4 APE12-dist-in 9.2399 APE11-dist-in 11.3616 APE10-dist-in 5.9164 APE9-dist-in 3.579 None None None AF2 -1.0 1.0 1.0 A 343.0 343.0 0 35 35 0 [[48, 374]] 1.0 AF-Q9BUB5-K3 Homo sapiens CAMK_MKNK1_HUMAN CAMK 3e-74 256.7 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 MKNK1_HUMAN 2HW6A Q9BUB5 39 376 465.0 No_ligand No_ligand Inactive DFGout 13.0472 6.8685 BBAminus -147.58, 179.67 -118.68, 97.88 -107.66, 35.68 273.28, 2.83 -82.21, 122.21 in-out in 9.9608 Saltbr-out 5.0537 HRD-in -71.04, -52.36 89.58, -4.5 out-out-none SNCoon out-none ActLoopNT-out 19.4542 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.209 0.257 A 307.0 242.0 55 35 9 26 [[48, 374]] 1.0 2hw6 Homo sapiens CAMK_MKNK1_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 MKNK1_HUMAN 2HW6B Q9BUB5 40 375 465.0 No_ligand No_ligand Inactive DFGout 12.9352 6.6985 BBAminus -152.37, 173.84 -112.12, 89.97 -108.38, 40.51 277.91, 15.03 -86.34, 127.2 out-out out 10.3183 Saltbr-out 5.3364 HRD-in -67.62, -48.77 89.55, -16.06 out-out-none SNCoon out-none ActLoopNT-out 20.2713 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.209 0.257 B 307.0 233.0 62 35 11 24 [[48, 374]] 1.0 2hw6 Homo sapiens CAMK_MKNK1_HUMAN CAMK 5.5e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 MKNK1_HUMAN 5WVDA Q9BUB5 41 375 465.0 7UX:60402 Type1 Inactive DFGout 16.817 8.8256 None -153.53, -175.02 -120.1, 91.21 -96.84, 20.27 228.47, 136.79 -82.58, 118.32 in-out in 9.9781 Saltbr-out 5.1757 HRD-in -73.05, -41.28 72.15, -15.5 out-out-none SNCoon out-none ActLoopNT-out 19.0967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.242 0.271 A 310.0 241.0 53 35 12 23 [[48, 374]] 1.0 5wvd Homo sapiens CAMK_MKNK1_HUMAN CAMK 5.7e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1
MKNK1 MKNK1_HUMAN 5WVDB Q9BUB5 41 374 465.0 7UX:60401 Type1 Inactive DFGout 17.1237 8.9337 None -152.62, -172.83 -117.54, 96.55 -104.25, 19.77 225.98, 148.86 -82.9, 120.08 in-out in 9.941 Saltbr-out 5.839 HRD-in -75.79, -41.74 71.59, -16.32 out-out-none SNCoon out-none ActLoopNT-out 19.082 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 79.77 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.242 0.271 B 310.0 212.0 81 35 14 21 [[48, 374]] 1.0 5wvd Homo sapiens CAMK_MKNK1_HUMAN CAMK 5.7e-80 274.3 1.0 256.0 256.0 231 232 233 235 237 78 94 98 208 210 209 211.0 283 266 261 260 259 258 257 256 255 125 MAP kinase-interacting serine/threonine-protein kinase 1

CAMK_MKNK1 (MAP kinase-interacting serine/threonine-protein kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name