STE_MAP3K14 (Mitogen-activated protein kinase kinase kinase 14)

Total number of chains: 24
Active chains: 2
Uniprot: M3K14_HUMAN
Kinase Domain Residues: 399 - 653
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 23 95.8% AF-Q99558-K1A
DFGin ABAminus 1 4.2% 4IDTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K14 AF-Q99558-K1A Q99558 391 661 947.0 No_ligand No_ligand Active DFGin 6.1012 13.6263 BLAminus -138.29, 178.68 59.98, 74.77 -87.98, 19.62 295.41, 87.19 -59.59, -22.27 in-in in 9.209 Saltbr-in 2.7159 HRD-in -71.47, -45.35 78.87, 0.75 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -73.82, 147.5 APE9-dihe-na 83.77, -172.11 APE8-dihe-in -93.94, 129.23 APE8-rot-in 304.43 APE67-dihe-in -69.87, 0.67 -51.55, -43.89 APE12-dist-in 9.5738 APE11-dist-in 10.3668 APE10-dist-in 4.8531 APE9-dist-in 3.3651 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 33 33 0 [[399, 652]] 1.0 AF-Q99558-K1 STE_MAP3K14_HUMAN STE 4.6e-63 218.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 AF-Q99558-K3A Q99558 391 661 947.0 No_ligand No_ligand Active DFGin 5.8508 13.8887 BLAminus -142.91, -179.29 55.92, 79.68 -89.36, 22.43 293.27, 83.39 -60.16, -16.03 in-in in 9.0889 Saltbr-in 2.7086 HRD-in -78.32, -42.35 75.87, -1.43 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -73.66, 150.14 APE9-dihe-na 90.55, -170.07 APE8-dihe-in -96.46, 124.51 APE8-rot-in 302.24 APE67-dihe-in -70.01, -8.32 -51.63, -40.34 APE12-dist-in 10.3858 APE11-dist-in 10.7747 APE10-dist-in 5.033 APE9-dist-in 3.5385 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 33 33 0 [[399, 652]] 1.0 AF-Q99558-K3 STE_MAP3K14_HUMAN STE 4.6e-63 218.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4IDTA Q99558 333 675 947.0 T28:701 Type1 Inactive DFGin 4.8758 13.8166 ABAminus -117.12, -43.35 -121.41, 109.43 -99.77, 25.52 290.46, 73.92 -61.38, -16.41 in-in in 8.4798 Saltbr-in 2.3797 HRD-in -72.78, -55.15 91.97, -2.23 in-in-out SNCiio in-out ActLoopNT-in 3.0247 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -68.28, 142.29 APE9-dihe-na -90.08, -132.43 APE8-dihe-in -78.86, 127.33 APE8-rot-in 308.12 APE67-dihe-in -68.25, -18.35 -55.63, -34.44 APE12-dist-in 7.7836 APE11-dist-out 5.3341 APE10-dist-out 8.7145 APE9-dist-in 4.2553 None None None XRAY 2.4 0.193 0.228 A 356.0 334.0 9 33 24 9 [[399, 652]] 1.0 4idt STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4DN5A Q99558 332 675 947.0 AGS:1008 ATPlike Inactive DFGin 5.2878 13.1112 BLAminus -131.59, 179.35 60.95, 82.45 -103.29, 32.07 306.31, 92.27 -67.11, -18.8 in-in in 8.6853 Saltbr-in 2.9369 HRD-in -77.9, -57.1 103.31, -30.91 in-in-out SNCiio in-out ActLoopNT-in 2.9712 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_noii APE10-dihe-na -78.44, 154.35 APE9-dihe-na -81.04, -47.74 APE8-dihe-in -132.59, 129.65 APE8-rot-in 312.19 APE67-dihe-in -58.65, -18.81 -60.26, -49.52 APE12-dist-none 999.0 APE11-dist-out 6.5883 APE10-dist-in 7.8559 APE9-dist-in 4.0634 S549D None None XRAY 2.5 0.184 0.222 A 356.0 331.0 13 33 20 13 [[399, 652]] 1.0 4dn5 STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4DN5B Q99558 333 675 947.0 AGS:1003 ATPlike Inactive DFGin 5.1759 13.4557 BLAminus -145.78, -179.59 62.32, 78.55 -101.18, 33.37 302.78, 88.88 -68.82, -20.54 in-in in 8.7257 Saltbr-in 2.793 HRD-in -71.67, -53.16 96.85, -25.39 in-in-out SNCiio in-out ActLoopNT-in 3.0601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_noii APE10-dihe-na -71.53, 164.6 APE9-dihe-na -90.39, -50.68 APE8-dihe-in -119.09, 127.96 APE8-rot-in 316.48 APE67-dihe-in -61.89, -23.89 -60.44, -46.4 APE12-dist-none 999.0 APE11-dist-out 7.2725 APE10-dist-in 7.9015 APE9-dist-in 4.3975 S549D None None XRAY 2.5 0.184 0.222 B 356.0 330.0 13 33 20 13 [[399, 652]] 1.0 4dn5 STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 8YHWA Q99558 334 675 947.0 AGS:701 ATPlike Inactive DFGin 5.2236 13.5714 BLAminus -131.51, 179.88 71.5, 78.13 -98.25, 28.21 291.83, 89.59 -66.77, -22.24 in-in in 8.7223 Saltbr-in 2.7921 HRD-in -71.07, -53.99 98.86, -11.92 in-in-out SNCiio in-out ActLoopNT-in 3.0735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -75.92, 156.14 APE9-dihe-na -80.02, -42.5 APE8-dihe-in -134.73, 129.92 APE8-rot-in 297.24 APE67-dihe-in -59.65, -28.29 -63.54, -48.42 APE12-dist-in 7.9565 APE11-dist-out 7.1447 APE10-dist-in 7.9576 APE9-dist-in 3.9323 None None None XRAY 2.9 0.196 0.241 A 351.0 336.0 6 33 27 6 [[399, 652]] 1.0 8yhw STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 8YHWB Q99558 334 675 947.0 AGS:701 ATPlike Inactive DFGin 5.1974 13.554 BLAminus -130.79, 179.54 70.72, 77.54 -98.72, 28.4 292.26, 88.42 -69.38, -19.05 in-in in 8.709 Saltbr-in 2.7911 HRD-in -71.33, -54.32 99.41, -13.31 in-in-out SNCiio in-out ActLoopNT-in 3.0664 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -76.24, 156.09 APE9-dihe-na -79.79, -42.6 APE8-dihe-in -135.45, 130.6 APE8-rot-in 297.54 APE67-dihe-in -59.47, -28.17 -62.63, -49.6 APE12-dist-in 7.9156 APE11-dist-out 7.1095 APE10-dist-in 7.9837 APE9-dist-in 3.9653 None None None XRAY 2.9 0.196 0.241 B 351.0 335.0 7 33 26 7 [[399, 652]] 1.0 8yhw STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 8YHWC Q99558 334 675 947.0 AGS:701 ATPlike Inactive DFGin 5.2254 13.4003 BLAminus -132.02, 179.38 71.36, 77.79 -98.56, 28.33 292.74, 88.36 -67.25, -21.3 in-in in 8.6175 Saltbr-in 2.7835 HRD-in -71.64, -54.39 97.78, -10.79 in-in-out SNCiio in-out ActLoopNT-in 3.0563 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -76.71, 156.45 APE9-dihe-na -80.42, -42.16 APE8-dihe-in -135.43, 129.92 APE8-rot-in 298.13 APE67-dihe-in -59.95, -27.85 -61.25, -50.21 APE12-dist-in 7.8829 APE11-dist-out 7.1158 APE10-dist-in 7.9268 APE9-dist-in 3.9552 None None None XRAY 2.9 0.196 0.241 C 351.0 335.0 7 33 26 7 [[399, 652]] 1.0 8yhw STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 8YHWD Q99558 334 675 947.0 AGS:701,PE8:703 ATPlike,Allosteric Inactive DFGin 5.2071 13.52 BLAminus -132.04, 179.74 71.06, 78.01 -98.25, 28.04 291.93, 89.49 -68.38, -20.37 in-in in 8.7112 Saltbr-in 2.7954 HRD-in -71.1, -54.2 99.37, -12.6 in-in-out SNCiio in-out ActLoopNT-in 3.0757 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -75.74, 155.59 APE9-dihe-na -80.11, -42.03 APE8-dihe-in -135.61, 130.31 APE8-rot-in 298.0 APE67-dihe-in -60.15, -27.6 -63.0, -48.69 APE12-dist-in 7.8856 APE11-dist-out 7.0875 APE10-dist-in 7.9923 APE9-dist-in 3.9502 None None None XRAY 2.9 0.196 0.241 D 351.0 329.0 13 33 20 13 [[399, 652]] 1.0 8yhw STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4G3DA Q99558 332 672 947.0 No_ligand No_ligand Inactive DFGin 5.2856 12.811 BLAminus -151.02, -166.16 43.2, 85.96 -99.62, 24.03 301.71, 84.96 -59.77, -25.28 in-out in 8.1934 Saltbr-out 3.8895 HRD-in -67.53, -49.6 95.04, -23.57 out-in-out SNCoio in-out ActLoopNT-in 3.0771 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -77.22, 168.19 APE9-dihe-na -104.37, -48.42 APE8-dihe-in -131.3, 118.34 APE8-rot-in 300.56 APE67-dihe-in -62.84, -28.69 -53.71, -49.48 APE12-dist-in 7.7443 APE11-dist-out 6.5533 APE10-dist-in 7.5974 APE9-dist-in 4.4932 None None None XRAY 2.9 0.206 0.266 A 371.0 324.0 4 33 33 0 [[399, 652]] 1.0 4g3d STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4G3DB Q99558 332 666 947.0 No_ligand No_ligand Inactive DFGin 5.3296 13.0471 BLAminus -145.15, -173.06 59.52, 87.75 -105.19, 27.96 295.78, 80.92 -59.8, -35.35 in-in in 8.4346 Saltbr-in 3.1394 HRD-in -68.68, -48.64 93.6, -11.39 in-in-out SNCiio in-out ActLoopNT-in 2.9674 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.8, 141.8 APE9-dihe-na -82.47, -20.88 APE8-dihe-in -150.75, 108.38 APE8-rot-in 298.53 APE67-dihe-in -57.3, -29.32 -43.58, -54.46 APE12-dist-in 7.5169 APE11-dist-out 6.5115 APE10-dist-out 8.0755 APE9-dist-in 4.1882 None None None XRAY 2.9 0.206 0.266 B 371.0 318.0 4 33 33 0 [[399, 652]] 1.0 4g3d STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 6WPPA Q99558 344 674 947.0 PZ4:701 Type1 Inactive DFGin 5.1457 13.1917 BLAminus -127.63, 178.76 64.02, 87.47 -103.35, 28.31 296.88, 94.84 -69.93, -25.22 in-in in 8.2781 Saltbr-in 3.2744 HRD-in -65.3, -52.36 86.52, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.8795 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.82, 131.48 APE9-dihe-na -83.07, -153.42 APE8-dihe-in -74.13, 126.04 APE8-rot-in 316.29 APE67-dihe-in -61.63, -22.88 -56.2, -44.91 APE12-dist-in 8.0638 APE11-dist-out 4.6425 APE10-dist-out 8.5804 APE9-dist-in 3.8791 None None None XRAY 2.55 0.207 0.256 A 347.0 312.0 7 33 26 7 [[399, 652]] 1.0 6wpp STE_MAP3K14_HUMAN STE 4.4e-62 215.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 6WPPB Q99558 343 674 947.0 PZ4:701 Type1 Inactive DFGin 4.9844 13.4264 BLAminus -137.45, -179.1 64.52, 83.15 -100.22, 29.53 297.21, 85.83 -60.38, -35.87 in-in in 8.4885 Saltbr-in 3.4926 HRD-in -73.1, -55.18 98.35, -24.22 in-in-out SNCiio in-out ActLoopNT-in 2.8729 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -70.03, 133.02 APE9-dihe-na -85.21, -134.96 APE8-dihe-in -67.2, 137.61 APE8-rot-in 303.8 APE67-dihe-in -62.66, -28.82 -67.79, -43.29 APE12-dist-in 7.9987 APE11-dist-out 4.9195 APE10-dist-out 8.8066 APE9-dist-in 4.148 None None None XRAY 2.55 0.207 0.256 B 347.0 315.0 5 33 28 5 [[399, 652]] 1.0 6wpp STE_MAP3K14_HUMAN STE 4.4e-62 215.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 6Z1QAAA Q99558 332 676 947.0 Q58:701 Type1 Inactive DFGin 5.0824 13.7498 BLAminus -139.32, -179.5 56.97, 85.54 -97.08, 22.28 294.67, 82.97 -46.15, -32.01 in-in in 8.0999 Saltbr-in 2.5909 HRD-in -65.24, -60.05 97.04, -3.62 in-in-out SNCiio in-out ActLoopNT-in 3.0779 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -69.69, 143.11 APE9-dihe-na -81.51, -110.47 APE8-dihe-in -81.03, 122.14 APE8-rot-in 317.22 APE67-dihe-in -72.27, -18.46 -58.14, -31.16 APE12-dist-in 7.775 APE11-dist-out 5.262 APE10-dist-out 8.4954 APE9-dist-in 4.2773 None None None XRAY 2.42 0.193 0.246 AAA 351.0 336.0 9 33 24 9 [[399, 652]] 1.0 6z1q STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 6Z1QBBB Q99558 332 677 947.0 Q58:701 Type1 Inactive DFGin 5.111 14.0891 BLAminus -139.08, 175.76 56.39, 83.25 -90.97, 32.3 291.01, 77.81 -60.97, -27.91 in-in in 8.0738 Saltbr-in 2.555 HRD-in -58.96, -56.36 93.57, -2.64 in-in-out SNCiio in-out ActLoopNT-in 3.1321 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -64.24, 155.91 APE9-dihe-na -86.67, -51.11 APE8-dihe-in -128.77, 119.14 APE8-rot-in 312.61 APE67-dihe-in -73.78, -18.87 -44.75, -48.16 APE12-dist-in 7.6567 APE11-dist-out 6.6998 APE10-dist-out 8.0966 APE9-dist-in 4.249 None None None XRAY 2.42 0.193 0.246 BBB 351.0 337.0 9 33 24 9 [[399, 652]] 1.0 6z1q STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 6Z1TAAA Q99558 334 676 947.0 Q55:701 Type1 Inactive DFGin 4.8796 13.8098 BLAminus -134.2, 172.83 65.46, 91.76 -102.71, 27.83 286.61, 85.9 -55.24, -34.29 in-in in 8.1622 Saltbr-in 2.6152 HRD-in -68.67, -55.26 95.9, -8.8 in-in-out SNCiio in-out ActLoopNT-in 3.0622 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -69.52, 145.36 APE9-dihe-na -84.11, -124.99 APE8-dihe-in -76.77, 125.85 APE8-rot-in 313.62 APE67-dihe-in -65.91, -24.55 -57.09, -31.27 APE12-dist-in 7.5524 APE11-dist-out 5.367 APE10-dist-out 8.6106 APE9-dist-in 4.4094 None None None XRAY 2.31 0.2 0.256 AAA 351.0 331.0 12 33 21 12 [[399, 652]] 1.0 6z1t STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 6Z1TBBB Q99558 332 677 947.0 Q55:701 Type1 Inactive DFGin 4.8811 13.8603 BLAminus -137.32, 166.84 70.68, 88.26 -97.1, 31.94 291.33, 81.76 -64.88, -25.85 in-in in 8.2638 Saltbr-in 2.7395 HRD-in -65.05, -50.15 89.82, -3.2 in-in-out SNCiio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.29, 141.05 APE9-dihe-na -85.74, -51.2 APE8-dihe-in -144.91, 116.77 APE8-rot-in 320.77 APE67-dihe-in -71.03, -21.25 -42.99, -50.04 APE12-dist-in 7.6765 APE11-dist-out 5.4681 APE10-dist-out 8.4343 APE9-dist-in 3.9838 None None None XRAY 2.31 0.2 0.256 BBB 351.0 334.0 12 33 21 12 [[399, 652]] 1.0 6z1t STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4IDTB Q99558 334 677 947.0 T28:701 Type1 Inactive DFGin 4.8332 14.0244 BLAminus -130.33, -176.63 40.62, 101.96 -102.91, 26.72 284.53, 73.19 -60.62, -17.23 in-in in 8.4331 Saltbr-in 2.3709 HRD-in -69.31, -53.69 93.06, -2.54 in-in-out SNCiio in-out ActLoopNT-in 3.1012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -68.62, 143.95 APE9-dihe-na -89.97, -131.32 APE8-dihe-in -78.44, 127.75 APE8-rot-in 306.61 APE67-dihe-in -67.78, -16.44 -55.0, -35.16 APE12-dist-in 7.8153 APE11-dist-out 5.2852 APE10-dist-out 8.6647 APE9-dist-in 4.3785 None None None XRAY 2.4 0.193 0.228 B 356.0 335.0 9 33 24 9 [[399, 652]] 1.0 4idt STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4IDVA Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.3826 12.8267 BLAminus -129.24, -176.42 63.44, 58.15 -81.16, 17.96 306.54, 94.36 -59.21, -22.9 in-in in 8.4362 Saltbr-in 2.9471 HRD-in -82.63, -42.79 91.65, -16.87 in-in-out SNCiio in-out ActLoopNT-in 2.8436 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -75.39, 160.43 APE9-dihe-na -73.6, -165.29 APE8-dihe-in -77.32, 130.17 APE8-rot-in 300.0 APE67-dihe-in -67.56, -25.78 -66.04, -38.01 APE12-dist-in 7.3323 APE11-dist-out 6.4353 APE10-dist-out 8.1656 APE9-dist-in 3.4691 None None None XRAY 2.9 0.207 0.269 A 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4IDVB Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.1392 12.6653 BLAminus -149.7, -174.94 52.79, 65.59 -88.41, 31.08 304.98, 100.79 -68.49, -23.25 in-in in 8.6905 Saltbr-in 2.7704 HRD-in -74.16, -58.51 108.87, -27.86 in-in-out SNCiio in-out ActLoopNT-in 2.7856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -76.23, 178.57 APE9-dihe-na -89.78, -149.85 APE8-dihe-in -74.1, 114.75 APE8-rot-in 292.01 APE67-dihe-in -40.71, -50.09 -40.47, -58.1 APE12-dist-in 7.4252 APE11-dist-out 6.7293 APE10-dist-out 8.0905 APE9-dist-in 3.9061 None None None XRAY 2.9 0.207 0.269 B 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4IDVC Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.4018 12.8215 BLAminus -145.01, -173.65 43.07, 81.6 -93.72, 20.71 302.58, 100.01 -64.62, -22.64 in-in in 8.6307 Saltbr-in 2.7132 HRD-in -70.49, -53.9 97.36, -13.74 in-in-out SNCiio in-out ActLoopNT-in 2.8891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -92.14, 174.93 APE9-dihe-na -72.95, -157.13 APE8-dihe-in -83.12, 122.22 APE8-rot-in 316.45 APE67-dihe-in -56.53, -35.42 -46.97, -50.29 APE12-dist-in 7.9617 APE11-dist-out 6.4618 APE10-dist-in 7.7853 APE9-dist-in 3.4663 None None None XRAY 2.9 0.207 0.269 C 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4IDVD Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.1851 12.7509 BLAminus -141.26, -170.3 49.15, 75.91 -94.03, 28.92 301.47, 99.94 -74.54, -18.37 in-in in 8.6093 Saltbr-in 2.5469 HRD-in -75.81, -46.16 90.12, -33.57 in-in-out SNCiio in-out ActLoopNT-in 3.0049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -91.45, -178.53 APE9-dihe-na -88.49, -158.57 APE8-dihe-in -71.6, 115.17 APE8-rot-in 304.36 APE67-dihe-in -51.02, -34.46 -45.71, -54.05 APE12-dist-in 7.3677 APE11-dist-out 7.1788 APE10-dist-in 7.8197 APE9-dist-in 4.0411 None None None XRAY 2.9 0.207 0.269 D 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4G3DD Q99558 338 657 947.0 No_ligand No_ligand None DFGin 5.2473 13.1968 BLAminus -139.97, -172.27 56.52, 77.31 -95.91, 22.53 297.92, 87.23 -51.62, -29.6 in-in in 8.4466 Saltbr-in 3.5129 HRD-in -79.01, -53.56 97.41, -27.23 in-in-none SNCiin in-none ActLoopNT-in 2.8898 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 88.51 APE9-dihe-na -78.1, -164.4 APE8-dihe-in -58.77, 132.43 APE8-rot-in 301.85 APE67-dihe-in -63.25, -43.05 -56.52, -49.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.4087 APE9-dist-in 3.602 None None None XRAY 2.9 0.206 0.266 D 371.0 290.0 17 33 20 13 [[399, 652]] 1.0 4g3d STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 4G3DE Q99558 332 663 947.0 No_ligand No_ligand None DFGin 5.2833 12.9982 BLAminus -137.41, -171.56 53.74, 79.67 -98.49, 16.37 295.95, 82.21 -51.27, -29.34 in-in in 8.0882 Saltbr-in 3.2752 HRD-in -56.22, -43.54 79.99, -16.43 in-in-none SNCiin in-none ActLoopNT-in 3.0578 ActLoopCT-none nonTYR APEdihe_aanin APEdist_nnii APE10-dihe-na 999.0, 175.31 APE9-dihe-na -160.21, -138.78 APE8-dihe-none -77.0, 999.0 APE8-rot-in 301.74 APE67-dihe-none 999.0, -37.88 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.6017 APE9-dist-in 4.0793 None None None XRAY 2.9 0.206 0.266 E 371.0 283.0 36 33 18 15 [[399, 652]] 1.0 4g3d STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14

STE_MAP3K14 (Mitogen-activated protein kinase kinase kinase 14)

Total number of chains: 44
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 43 97.7% AF-Q99558-K1A
DFGin ABAminus 1 2.3% 4IDTA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K14 M3K14_HUMAN AF-Q99558-K1A Q99558 391 661 947.0 No_ligand No_ligand Active DFGin 6.1012 13.6263 BLAminus -138.29, 178.68 59.98, 74.77 -87.98, 19.62 295.41, 87.19 -59.59, -22.27 in-in in 9.209 Saltbr-in 2.7159 HRD-in -71.47, -45.35 78.87, 0.75 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -73.82, 147.5 APE9-dihe-na 83.77, -172.11 APE8-dihe-in -93.94, 129.23 APE8-rot-in 304.43 APE67-dihe-in -69.87, 0.67 -51.55, -43.89 APE12-dist-in 9.5738 APE11-dist-in 10.3668 APE10-dist-in 4.8531 APE9-dist-in 3.3651 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 33 33 0 [[399, 652]] 1.0 AF-Q99558-K1 Homo sapiens STE_MAP3K14_HUMAN STE 4.6e-63 218.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN AF-Q99558-K3A Q99558 391 661 947.0 No_ligand No_ligand Active DFGin 5.8508 13.8887 BLAminus -142.91, -179.29 55.92, 79.68 -89.36, 22.43 293.27, 83.39 -60.16, -16.03 in-in in 9.0889 Saltbr-in 2.7086 HRD-in -78.32, -42.35 75.87, -1.43 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -73.66, 150.14 APE9-dihe-na 90.55, -170.07 APE8-dihe-in -96.46, 124.51 APE8-rot-in 302.24 APE67-dihe-in -70.01, -8.32 -51.63, -40.34 APE12-dist-in 10.3858 APE11-dist-in 10.7747 APE10-dist-in 5.033 APE9-dist-in 3.5385 None None None AF2 -1.0 1.0 1.0 A 271.0 271.0 0 33 33 0 [[399, 652]] 1.0 AF-Q99558-K3 Homo sapiens STE_MAP3K14_HUMAN STE 4.6e-63 218.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4IDTA Q99558 333 675 947.0 T28:701 Type1 Inactive DFGin 4.8758 13.8166 ABAminus -117.12, -43.35 -121.41, 109.43 -99.77, 25.52 290.46, 73.92 -61.38, -16.41 in-in in 8.4798 Saltbr-in 2.3797 HRD-in -72.78, -55.15 91.97, -2.23 in-in-out SNCiio in-out ActLoopNT-in 3.0247 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -68.28, 142.29 APE9-dihe-na -90.08, -132.43 APE8-dihe-in -78.86, 127.33 APE8-rot-in 308.12 APE67-dihe-in -68.25, -18.35 -55.63, -34.44 APE12-dist-in 7.7836 APE11-dist-out 5.3341 APE10-dist-out 8.7145 APE9-dist-in 4.2553 None None None XRAY 2.4 0.193 0.228 A 356.0 334.0 9 33 24 9 [[399, 652]] 1.0 4idt Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4DN5A Q99558 332 675 947.0 AGS:1008 ATPlike Inactive DFGin 5.2878 13.1112 BLAminus -131.59, 179.35 60.95, 82.45 -103.29, 32.07 306.31, 92.27 -67.11, -18.8 in-in in 8.6853 Saltbr-in 2.9369 HRD-in -77.9, -57.1 103.31, -30.91 in-in-out SNCiio in-out ActLoopNT-in 2.9712 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_noii APE10-dihe-na -78.44, 154.35 APE9-dihe-na -81.04, -47.74 APE8-dihe-in -132.59, 129.65 APE8-rot-in 312.19 APE67-dihe-in -58.65, -18.81 -60.26, -49.52 APE12-dist-none 999.0 APE11-dist-out 6.5883 APE10-dist-in 7.8559 APE9-dist-in 4.0634 S549D None None XRAY 2.5 0.184 0.222 A 356.0 331.0 13 33 20 13 [[399, 652]] 1.0 4dn5 Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4DN5B Q99558 333 675 947.0 AGS:1003 ATPlike Inactive DFGin 5.1759 13.4557 BLAminus -145.78, -179.59 62.32, 78.55 -101.18, 33.37 302.78, 88.88 -68.82, -20.54 in-in in 8.7257 Saltbr-in 2.793 HRD-in -71.67, -53.16 96.85, -25.39 in-in-out SNCiio in-out ActLoopNT-in 3.0601 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_noii APE10-dihe-na -71.53, 164.6 APE9-dihe-na -90.39, -50.68 APE8-dihe-in -119.09, 127.96 APE8-rot-in 316.48 APE67-dihe-in -61.89, -23.89 -60.44, -46.4 APE12-dist-none 999.0 APE11-dist-out 7.2725 APE10-dist-in 7.9015 APE9-dist-in 4.3975 S549D None None XRAY 2.5 0.184 0.222 B 356.0 330.0 13 33 20 13 [[399, 652]] 1.0 4dn5 Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 8YHWA Q99558 334 675 947.0 AGS:701 ATPlike Inactive DFGin 5.2236 13.5714 BLAminus -131.51, 179.88 71.5, 78.13 -98.25, 28.21 291.83, 89.59 -66.77, -22.24 in-in in 8.7223 Saltbr-in 2.7921 HRD-in -71.07, -53.99 98.86, -11.92 in-in-out SNCiio in-out ActLoopNT-in 3.0735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -75.92, 156.14 APE9-dihe-na -80.02, -42.5 APE8-dihe-in -134.73, 129.92 APE8-rot-in 297.24 APE67-dihe-in -59.65, -28.29 -63.54, -48.42 APE12-dist-in 7.9565 APE11-dist-out 7.1447 APE10-dist-in 7.9576 APE9-dist-in 3.9323 None None None XRAY 2.9 0.196 0.241 A 351.0 336.0 6 33 27 6 [[399, 652]] 1.0 8yhw Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 8YHWB Q99558 334 675 947.0 AGS:701 ATPlike Inactive DFGin 5.1974 13.554 BLAminus -130.79, 179.54 70.72, 77.54 -98.72, 28.4 292.26, 88.42 -69.38, -19.05 in-in in 8.709 Saltbr-in 2.7911 HRD-in -71.33, -54.32 99.41, -13.31 in-in-out SNCiio in-out ActLoopNT-in 3.0664 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -76.24, 156.09 APE9-dihe-na -79.79, -42.6 APE8-dihe-in -135.45, 130.6 APE8-rot-in 297.54 APE67-dihe-in -59.47, -28.17 -62.63, -49.6 APE12-dist-in 7.9156 APE11-dist-out 7.1095 APE10-dist-in 7.9837 APE9-dist-in 3.9653 None None None XRAY 2.9 0.196 0.241 B 351.0 335.0 7 33 26 7 [[399, 652]] 1.0 8yhw Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 8YHWC Q99558 334 675 947.0 AGS:701 ATPlike Inactive DFGin 5.2254 13.4003 BLAminus -132.02, 179.38 71.36, 77.79 -98.56, 28.33 292.74, 88.36 -67.25, -21.3 in-in in 8.6175 Saltbr-in 2.7835 HRD-in -71.64, -54.39 97.78, -10.79 in-in-out SNCiio in-out ActLoopNT-in 3.0563 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -76.71, 156.45 APE9-dihe-na -80.42, -42.16 APE8-dihe-in -135.43, 129.92 APE8-rot-in 298.13 APE67-dihe-in -59.95, -27.85 -61.25, -50.21 APE12-dist-in 7.8829 APE11-dist-out 7.1158 APE10-dist-in 7.9268 APE9-dist-in 3.9552 None None None XRAY 2.9 0.196 0.241 C 351.0 335.0 7 33 26 7 [[399, 652]] 1.0 8yhw Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 8YHWD Q99558 334 675 947.0 AGS:701,PE8:703 ATPlike,Allosteric Inactive DFGin 5.2071 13.52 BLAminus -132.04, 179.74 71.06, 78.01 -98.25, 28.04 291.93, 89.49 -68.38, -20.37 in-in in 8.7112 Saltbr-in 2.7954 HRD-in -71.1, -54.2 99.37, -12.6 in-in-out SNCiio in-out ActLoopNT-in 3.0757 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -75.74, 155.59 APE9-dihe-na -80.11, -42.03 APE8-dihe-in -135.61, 130.31 APE8-rot-in 298.0 APE67-dihe-in -60.15, -27.6 -63.0, -48.69 APE12-dist-in 7.8856 APE11-dist-out 7.0875 APE10-dist-in 7.9923 APE9-dist-in 3.9502 None None None XRAY 2.9 0.196 0.241 D 351.0 329.0 13 33 20 13 [[399, 652]] 1.0 8yhw Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4G3DA Q99558 332 672 947.0 No_ligand No_ligand Inactive DFGin 5.2856 12.811 BLAminus -151.02, -166.16 43.2, 85.96 -99.62, 24.03 301.71, 84.96 -59.77, -25.28 in-out in 8.1934 Saltbr-out 3.8895 HRD-in -67.53, -49.6 95.04, -23.57 out-in-out SNCoio in-out ActLoopNT-in 3.0771 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -77.22, 168.19 APE9-dihe-na -104.37, -48.42 APE8-dihe-in -131.3, 118.34 APE8-rot-in 300.56 APE67-dihe-in -62.84, -28.69 -53.71, -49.48 APE12-dist-in 7.7443 APE11-dist-out 6.5533 APE10-dist-in 7.5974 APE9-dist-in 4.4932 None None None XRAY 2.9 0.206 0.266 A 371.0 324.0 4 33 33 0 [[399, 652]] 1.0 4g3d Homo sapiens STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4G3DB Q99558 332 666 947.0 No_ligand No_ligand Inactive DFGin 5.3296 13.0471 BLAminus -145.15, -173.06 59.52, 87.75 -105.19, 27.96 295.78, 80.92 -59.8, -35.35 in-in in 8.4346 Saltbr-in 3.1394 HRD-in -68.68, -48.64 93.6, -11.39 in-in-out SNCiio in-out ActLoopNT-in 2.9674 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.8, 141.8 APE9-dihe-na -82.47, -20.88 APE8-dihe-in -150.75, 108.38 APE8-rot-in 298.53 APE67-dihe-in -57.3, -29.32 -43.58, -54.46 APE12-dist-in 7.5169 APE11-dist-out 6.5115 APE10-dist-out 8.0755 APE9-dist-in 4.1882 None None None XRAY 2.9 0.206 0.266 B 371.0 318.0 4 33 33 0 [[399, 652]] 1.0 4g3d Homo sapiens STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 6WPPA Q99558 344 674 947.0 PZ4:701 Type1 Inactive DFGin 5.1457 13.1917 BLAminus -127.63, 178.76 64.02, 87.47 -103.35, 28.31 296.88, 94.84 -69.93, -25.22 in-in in 8.2781 Saltbr-in 3.2744 HRD-in -65.3, -52.36 86.52, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.8795 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.82, 131.48 APE9-dihe-na -83.07, -153.42 APE8-dihe-in -74.13, 126.04 APE8-rot-in 316.29 APE67-dihe-in -61.63, -22.88 -56.2, -44.91 APE12-dist-in 8.0638 APE11-dist-out 4.6425 APE10-dist-out 8.5804 APE9-dist-in 3.8791 None None None XRAY 2.55 0.207 0.256 A 347.0 312.0 7 33 26 7 [[399, 652]] 1.0 6wpp Homo sapiens STE_MAP3K14_HUMAN STE 4.4e-62 215.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 6WPPB Q99558 343 674 947.0 PZ4:701 Type1 Inactive DFGin 4.9844 13.4264 BLAminus -137.45, -179.1 64.52, 83.15 -100.22, 29.53 297.21, 85.83 -60.38, -35.87 in-in in 8.4885 Saltbr-in 3.4926 HRD-in -73.1, -55.18 98.35, -24.22 in-in-out SNCiio in-out ActLoopNT-in 2.8729 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -70.03, 133.02 APE9-dihe-na -85.21, -134.96 APE8-dihe-in -67.2, 137.61 APE8-rot-in 303.8 APE67-dihe-in -62.66, -28.82 -67.79, -43.29 APE12-dist-in 7.9987 APE11-dist-out 4.9195 APE10-dist-out 8.8066 APE9-dist-in 4.148 None None None XRAY 2.55 0.207 0.256 B 347.0 315.0 5 33 28 5 [[399, 652]] 1.0 6wpp Homo sapiens STE_MAP3K14_HUMAN STE 4.4e-62 215.9 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 6Z1QAAA Q99558 332 676 947.0 Q58:701 Type1 Inactive DFGin 5.0824 13.7498 BLAminus -139.32, -179.5 56.97, 85.54 -97.08, 22.28 294.67, 82.97 -46.15, -32.01 in-in in 8.0999 Saltbr-in 2.5909 HRD-in -65.24, -60.05 97.04, -3.62 in-in-out SNCiio in-out ActLoopNT-in 3.0779 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -69.69, 143.11 APE9-dihe-na -81.51, -110.47 APE8-dihe-in -81.03, 122.14 APE8-rot-in 317.22 APE67-dihe-in -72.27, -18.46 -58.14, -31.16 APE12-dist-in 7.775 APE11-dist-out 5.262 APE10-dist-out 8.4954 APE9-dist-in 4.2773 None None None XRAY 2.42 0.193 0.246 AAA 351.0 336.0 9 33 24 9 [[399, 652]] 1.0 6z1q Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 6Z1QBBB Q99558 332 677 947.0 Q58:701 Type1 Inactive DFGin 5.111 14.0891 BLAminus -139.08, 175.76 56.39, 83.25 -90.97, 32.3 291.01, 77.81 -60.97, -27.91 in-in in 8.0738 Saltbr-in 2.555 HRD-in -58.96, -56.36 93.57, -2.64 in-in-out SNCiio in-out ActLoopNT-in 3.1321 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -64.24, 155.91 APE9-dihe-na -86.67, -51.11 APE8-dihe-in -128.77, 119.14 APE8-rot-in 312.61 APE67-dihe-in -73.78, -18.87 -44.75, -48.16 APE12-dist-in 7.6567 APE11-dist-out 6.6998 APE10-dist-out 8.0966 APE9-dist-in 4.249 None None None XRAY 2.42 0.193 0.246 BBB 351.0 337.0 9 33 24 9 [[399, 652]] 1.0 6z1q Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 6Z1TAAA Q99558 334 676 947.0 Q55:701 Type1 Inactive DFGin 4.8796 13.8098 BLAminus -134.2, 172.83 65.46, 91.76 -102.71, 27.83 286.61, 85.9 -55.24, -34.29 in-in in 8.1622 Saltbr-in 2.6152 HRD-in -68.67, -55.26 95.9, -8.8 in-in-out SNCiio in-out ActLoopNT-in 3.0622 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -69.52, 145.36 APE9-dihe-na -84.11, -124.99 APE8-dihe-in -76.77, 125.85 APE8-rot-in 313.62 APE67-dihe-in -65.91, -24.55 -57.09, -31.27 APE12-dist-in 7.5524 APE11-dist-out 5.367 APE10-dist-out 8.6106 APE9-dist-in 4.4094 None None None XRAY 2.31 0.2 0.256 AAA 351.0 331.0 12 33 21 12 [[399, 652]] 1.0 6z1t Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 6Z1TBBB Q99558 332 677 947.0 Q55:701 Type1 Inactive DFGin 4.8811 13.8603 BLAminus -137.32, 166.84 70.68, 88.26 -97.1, 31.94 291.33, 81.76 -64.88, -25.85 in-in in 8.2638 Saltbr-in 2.7395 HRD-in -65.05, -50.15 89.82, -3.2 in-in-out SNCiio in-out ActLoopNT-in 2.969 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -65.29, 141.05 APE9-dihe-na -85.74, -51.2 APE8-dihe-in -144.91, 116.77 APE8-rot-in 320.77 APE67-dihe-in -71.03, -21.25 -42.99, -50.04 APE12-dist-in 7.6765 APE11-dist-out 5.4681 APE10-dist-out 8.4343 APE9-dist-in 3.9838 None None None XRAY 2.31 0.2 0.256 BBB 351.0 334.0 12 33 21 12 [[399, 652]] 1.0 6z1t Homo sapiens STE_MAP3K14_HUMAN STE 1.1e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4IDTB Q99558 334 677 947.0 T28:701 Type1 Inactive DFGin 4.8332 14.0244 BLAminus -130.33, -176.63 40.62, 101.96 -102.91, 26.72 284.53, 73.19 -60.62, -17.23 in-in in 8.4331 Saltbr-in 2.3709 HRD-in -69.31, -53.69 93.06, -2.54 in-in-out SNCiio in-out ActLoopNT-in 3.1012 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -68.62, 143.95 APE9-dihe-na -89.97, -131.32 APE8-dihe-in -78.44, 127.75 APE8-rot-in 306.61 APE67-dihe-in -67.78, -16.44 -55.0, -35.16 APE12-dist-in 7.8153 APE11-dist-out 5.2852 APE10-dist-out 8.6647 APE9-dist-in 4.3785 None None None XRAY 2.4 0.193 0.228 B 356.0 335.0 9 33 24 9 [[399, 652]] 1.0 4idt Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4IDVA Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.3826 12.8267 BLAminus -129.24, -176.42 63.44, 58.15 -81.16, 17.96 306.54, 94.36 -59.21, -22.9 in-in in 8.4362 Saltbr-in 2.9471 HRD-in -82.63, -42.79 91.65, -16.87 in-in-out SNCiio in-out ActLoopNT-in 2.8436 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -75.39, 160.43 APE9-dihe-na -73.6, -165.29 APE8-dihe-in -77.32, 130.17 APE8-rot-in 300.0 APE67-dihe-in -67.56, -25.78 -66.04, -38.01 APE12-dist-in 7.3323 APE11-dist-out 6.4353 APE10-dist-out 8.1656 APE9-dist-in 3.4691 None None None XRAY 2.9 0.207 0.269 A 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4IDVB Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.1392 12.6653 BLAminus -149.7, -174.94 52.79, 65.59 -88.41, 31.08 304.98, 100.79 -68.49, -23.25 in-in in 8.6905 Saltbr-in 2.7704 HRD-in -74.16, -58.51 108.87, -27.86 in-in-out SNCiio in-out ActLoopNT-in 2.7856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -76.23, 178.57 APE9-dihe-na -89.78, -149.85 APE8-dihe-in -74.1, 114.75 APE8-rot-in 292.01 APE67-dihe-in -40.71, -50.09 -40.47, -58.1 APE12-dist-in 7.4252 APE11-dist-out 6.7293 APE10-dist-out 8.0905 APE9-dist-in 3.9061 None None None XRAY 2.9 0.207 0.269 B 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4IDVC Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.4018 12.8215 BLAminus -145.01, -173.65 43.07, 81.6 -93.72, 20.71 302.58, 100.01 -64.62, -22.64 in-in in 8.6307 Saltbr-in 2.7132 HRD-in -70.49, -53.9 97.36, -13.74 in-in-out SNCiio in-out ActLoopNT-in 2.8891 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -92.14, 174.93 APE9-dihe-na -72.95, -157.13 APE8-dihe-in -83.12, 122.22 APE8-rot-in 316.45 APE67-dihe-in -56.53, -35.42 -46.97, -50.29 APE12-dist-in 7.9617 APE11-dist-out 6.4618 APE10-dist-in 7.7853 APE9-dist-in 3.4663 None None None XRAY 2.9 0.207 0.269 C 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4IDVD Q99558 331 675 947.0 13V:701 Type1.5_Back Inactive DFGin 5.1851 12.7509 BLAminus -141.26, -170.3 49.15, 75.91 -94.03, 28.92 301.47, 99.94 -74.54, -18.37 in-in in 8.6093 Saltbr-in 2.5469 HRD-in -75.81, -46.16 90.12, -33.57 in-in-out SNCiio in-out ActLoopNT-in 3.0049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -91.45, -178.53 APE9-dihe-na -88.49, -158.57 APE8-dihe-in -71.6, 115.17 APE8-rot-in 304.36 APE67-dihe-in -51.02, -34.46 -45.71, -54.05 APE12-dist-in 7.3677 APE11-dist-out 7.1788 APE10-dist-in 7.8197 APE9-dist-in 4.0411 None None None XRAY 2.9 0.207 0.269 D 356.0 335.0 0 33 33 0 [[399, 652]] 1.0 4idv Homo sapiens STE_MAP3K14_HUMAN STE 1.2e-62 217.7 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4G3DD Q99558 338 657 947.0 No_ligand No_ligand None DFGin 5.2473 13.1968 BLAminus -139.97, -172.27 56.52, 77.31 -95.91, 22.53 297.92, 87.23 -51.62, -29.6 in-in in 8.4466 Saltbr-in 3.5129 HRD-in -79.01, -53.56 97.41, -27.23 in-in-none SNCiin in-none ActLoopNT-in 2.8898 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 88.51 APE9-dihe-na -78.1, -164.4 APE8-dihe-in -58.77, 132.43 APE8-rot-in 301.85 APE67-dihe-in -63.25, -43.05 -56.52, -49.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.4087 APE9-dist-in 3.602 None None None XRAY 2.9 0.206 0.266 D 371.0 290.0 17 33 20 13 [[399, 652]] 1.0 4g3d Homo sapiens STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_HUMAN 4G3DE Q99558 332 663 947.0 No_ligand No_ligand None DFGin 5.2833 12.9982 BLAminus -137.41, -171.56 53.74, 79.67 -98.49, 16.37 295.95, 82.21 -51.27, -29.34 in-in in 8.0882 Saltbr-in 3.2752 HRD-in -56.22, -43.54 79.99, -16.43 in-in-none SNCiin in-none ActLoopNT-in 3.0578 ActLoopCT-none nonTYR APEdihe_aanin APEdist_nnii APE10-dihe-na 999.0, 175.31 APE9-dihe-na -160.21, -138.78 APE8-dihe-none -77.0, 999.0 APE8-rot-in 301.74 APE67-dihe-none 999.0, -37.88 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.6017 APE9-dist-in 4.0793 None None None XRAY 2.9 0.206 0.266 E 371.0 283.0 36 33 18 15 [[399, 652]] 1.0 4g3d Homo sapiens STE_MAP3K14_HUMAN STE 1.3e-62 217.5 4.0 252.0 249.0 533 534 535 537 539 429 440 444 512 514 513 515.0 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3CA Q9WUL6 334 675 942.0 No_ligand No_ligand Inactive DFGin 5.0894 13.864 BLAminus -140.15, 168.19 68.68, 97.29 -102.08, 21.93 283.63, 73.63 -53.77, -27.47 in-in in 8.7806 Saltbr-in 2.5233 HRD-in -64.69, -51.77 93.59, -17.71 in-in-out SNCiio in-out ActLoopNT-in 2.8351 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -57.77, 133.1 APE9-dihe-na -80.94, -159.93 APE8-dihe-in -68.53, 122.42 APE8-rot-in 308.39 APE67-dihe-in -57.63, -22.6 -55.47, -45.8 APE12-dist-none 999.0 APE11-dist-out 5.8898 APE10-dist-out 8.64 APE9-dist-in 3.9125 None None None XRAY 2.15 0.19 0.225 A 352.0 315.0 13 33 20 13 [[402, 653]] 1.0 4g3c Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3CB Q9WUL6 334 674 942.0 No_ligand No_ligand Inactive DFGin 5.205 13.7156 BLAminus -140.13, 170.16 66.8, 96.03 -98.78, 20.47 288.84, 72.74 -55.79, -27.24 in-in in 8.8516 Saltbr-in 2.5694 HRD-in -63.41, -51.56 90.19, -12.99 in-in-out SNCiio in-out ActLoopNT-in 2.8445 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -71.12, 155.95 APE9-dihe-na -82.82, -165.23 APE8-dihe-in -66.56, 124.25 APE8-rot-in 308.77 APE67-dihe-in -56.64, -26.52 -59.22, -45.11 APE12-dist-in 7.4182 APE11-dist-out 5.9438 APE10-dist-in 7.9408 APE9-dist-in 3.8266 None None None XRAY 2.15 0.19 0.225 B 352.0 327.0 0 33 33 0 [[402, 653]] 1.0 4g3c Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3GA Q9WUL6 345 675 942.0 0WA:60701 Type1 Inactive DFGin 6.1401 14.6613 BLAminus -144.18, 178.52 59.7, 98.13 -104.99, 25.09 285.83, 82.79 -56.18, -30.33 in-in in 8.6239 Saltbr-in 2.9352 HRD-in -64.61, -51.31 100.72, -19.25 in-in-out SNCiio in-out ActLoopNT-in 2.9092 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -60.09, 149.14 APE9-dihe-na -93.14, -147.96 APE8-dihe-in -58.17, 130.96 APE8-rot-in 317.12 APE67-dihe-in -54.98, -23.01 -61.63, -48.39 APE12-dist-in 7.7466 APE11-dist-out 5.4156 APE10-dist-out 8.5443 APE9-dist-in 4.0073 V408L None None XRAY 2.5 0.201 0.252 A 350.0 310.0 12 33 21 12 [[402, 653]] 1.0 4g3g Mus musculus STE_MAP3K14_MOUSE STE 1.8e-61 213.9 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3FA Q9WUL6 345 675 942.0 0WB:60701 Type1 Inactive DFGin 6.2731 14.5948 BLAminus -136.37, 175.76 68.62, 93.96 -104.2, 24.58 286.67, 80.03 -56.69, -30.64 in-in in 8.6506 Saltbr-in 2.9203 HRD-in -65.67, -50.45 97.82, -16.82 in-in-out SNCiio in-out ActLoopNT-in 2.9293 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -54.09, 143.29 APE9-dihe-na -88.45, -137.31 APE8-dihe-in -75.01, 123.85 APE8-rot-in 304.54 APE67-dihe-in -61.42, -21.03 -49.54, -48.2 APE12-dist-in 7.8748 APE11-dist-out 5.4072 APE10-dist-out 8.539 APE9-dist-in 4.0353 None None None XRAY 1.642 0.18 0.208 A 336.0 310.0 12 33 21 12 [[402, 653]] 1.0 4g3f Mus musculus STE_MAP3K14_MOUSE STE 2.4e-61 213.5 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8PA Q9WUL6 333 675 942.0 774:701 Type1 Inactive DFGin 5.1018 13.8045 BLAminus -130.87, 175.13 69.52, 94.01 -101.96, 23.87 285.11, 73.05 -59.46, -26.18 in-in in 9.006 Saltbr-in 2.7386 HRD-in -69.86, -50.42 89.41, -11.67 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -64.72, 153.21 APE9-dihe-na -72.6, -162.93 APE8-dihe-in -75.35, 131.12 APE8-rot-in 300.5 APE67-dihe-in -63.26, -20.39 -65.5, -41.36 APE12-dist-in 7.4619 APE11-dist-out 5.7575 APE10-dist-out 8.2507 APE9-dist-in 3.7106 None None None XRAY 2.32 0.183 0.232 A 349.0 327.0 2 33 31 2 [[402, 653]] 1.0 5t8p Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8PB Q9WUL6 334 675 942.0 774:703 Type1 Inactive DFGin 5.3776 13.5444 BLAminus -127.14, 177.51 72.71, 87.14 -92.81, 20.99 291.61, 75.87 -63.65, -25.7 in-in in 8.9114 Saltbr-in 2.5083 HRD-in -65.09, -50.1 85.06, -10.38 in-in-out SNCiio in-out ActLoopNT-in 2.7987 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -74.16, 162.0 APE9-dihe-na -79.09, -170.16 APE8-dihe-in -64.98, 125.11 APE8-rot-in 302.43 APE67-dihe-in -61.26, -24.69 -62.41, -39.39 APE12-dist-in 7.5025 APE11-dist-out 5.6794 APE10-dist-in 7.7557 APE9-dist-in 3.6835 None None None XRAY 2.32 0.183 0.232 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 5t8p Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8QA Q9WUL6 334 675 942.0 76Y:706 Type1 Inactive DFGin 5.1837 14.0061 BLAminus -130.74, 160.83 73.75, 94.38 -94.56, 17.14 282.45, 79.25 -53.65, -26.76 in-in in 9.089 Saltbr-in 2.8007 HRD-in -67.78, -51.7 101.68, -12.67 in-in-out SNCiio in-out ActLoopNT-in 2.8432 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -75.45, 153.73 APE9-dihe-na -75.91, -172.31 APE8-dihe-in -63.49, 125.47 APE8-rot-in 302.64 APE67-dihe-in -65.75, -24.83 -54.0, -46.19 APE12-dist-in 8.6361 APE11-dist-out 5.4008 APE10-dist-out 8.4398 APE9-dist-in 3.5743 None None None XRAY 2.63 0.203 0.25 A 349.0 323.0 5 33 28 5 [[402, 653]] 1.0 5t8q Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8QB Q9WUL6 334 675 942.0 76Y:707 Type1 Inactive DFGin 5.4082 14.1271 BLAminus -145.17, 162.25 64.87, 96.91 -100.45, 25.61 283.18, 79.59 -62.55, -21.3 in-in in 9.0841 Saltbr-in 2.7839 HRD-in -67.1, -52.15 94.08, -12.98 in-in-out SNCiio in-out ActLoopNT-in 2.8873 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -77.58, 160.1 APE9-dihe-na -88.06, -179.74 APE8-dihe-in -58.69, 121.39 APE8-rot-in 292.94 APE67-dihe-in -60.06, -26.47 -51.84, -44.89 APE12-dist-in 8.141 APE11-dist-out 5.7967 APE10-dist-out 8.3426 APE9-dist-in 3.6447 None None None XRAY 2.63 0.203 0.25 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 5t8q Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6MYNA Q9WUL6 334 675 942.0 K6Y:703 Type1.5_Back Inactive DFGin 5.1368 13.8806 BLAminus -121.09, -179.21 64.35, 97.99 -102.4, 19.51 282.69, 72.09 -66.21, -2.29 in-in in 8.8415 Saltbr-in 2.6701 HRD-in -70.62, -38.19 91.03, -21.2 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -76.89, 156.88 APE9-dihe-na -86.23, -169.86 APE8-dihe-in -63.06, 125.06 APE8-rot-in 312.86 APE67-dihe-in -61.65, -34.22 -58.42, -43.68 APE12-dist-in 8.1031 APE11-dist-out 5.6721 APE10-dist-out 8.4081 APE9-dist-in 4.0072 None None None XRAY 2.744 0.187 0.255 A 347.0 322.0 6 33 27 6 [[402, 653]] 1.0 6myn Mus musculus STE_MAP3K14_MOUSE STE 2.6e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6MYNB Q9WUL6 334 675 942.0 K6Y:704 Type1.5_Back Inactive DFGin 5.1708 13.8429 BLAminus -133.39, 173.74 70.58, 94.89 -101.57, 16.76 286.07, 93.48 -60.65, -21.51 in-in in 9.0517 Saltbr-in 2.7087 HRD-in -71.03, -48.5 91.31, -17.46 in-in-out SNCiio in-out ActLoopNT-in 2.7611 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -69.02, 159.13 APE9-dihe-na -93.8, -178.7 APE8-dihe-in -50.89, 123.45 APE8-rot-in 297.3 APE67-dihe-in -64.52, -23.1 -64.98, -38.0 APE12-dist-in 7.5881 APE11-dist-out 5.5248 APE10-dist-out 8.2165 APE9-dist-in 3.7889 None None None XRAY 2.744 0.187 0.255 B 347.0 328.0 0 33 33 0 [[402, 653]] 1.0 6myn Mus musculus STE_MAP3K14_MOUSE STE 2.6e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8OA Q9WUL6 334 675 942.0 76Z:705 Type1.5_Back Inactive DFGin 5.3291 12.7939 BLAminus -130.48, -174.75 59.89, 70.22 -92.56, 28.1 305.24, 102.53 -70.28, -19.79 in-in in 8.7317 Saltbr-in 2.877 HRD-in -67.09, -53.86 93.11, -2.16 in-in-out SNCiio in-out ActLoopNT-in 2.9907 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -87.39, -178.86 APE9-dihe-na -87.38, -155.91 APE8-dihe-in -79.02, 126.4 APE8-rot-in 302.71 APE67-dihe-in -62.36, -21.86 -53.04, -50.1 APE12-dist-in 8.1427 APE11-dist-out 6.5038 APE10-dist-in 7.8287 APE9-dist-in 3.7497 None None None XRAY 2.41 0.207 0.256 A 349.0 324.0 4 33 29 4 [[402, 653]] 1.0 5t8o Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8OB Q9WUL6 334 675 942.0 76Z:704 Type1.5_Back Inactive DFGin 5.3123 12.8396 BLAminus -141.26, -176.18 60.16, 69.96 -93.23, 19.11 305.72, 98.23 -59.16, -21.35 in-in in 8.7301 Saltbr-in 2.7033 HRD-in -67.59, -51.02 93.64, -7.3 in-in-out SNCiio in-out ActLoopNT-in 2.9868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -79.62, 174.72 APE9-dihe-na -91.83, -158.34 APE8-dihe-in -74.9, 119.81 APE8-rot-in 307.01 APE67-dihe-in -63.35, -25.62 -50.24, -44.81 APE12-dist-in 8.3924 APE11-dist-out 6.5184 APE10-dist-out 8.1053 APE9-dist-in 3.8213 None None None XRAY 2.41 0.207 0.256 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 5t8o Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4YA Q9WUL6 334 675 942.0 ELZ:703 Type1.5_Back Inactive DFGin 5.1644 13.7241 BLAminus -129.11, 179.68 62.4, 86.21 -93.91, 21.44 289.83, 80.88 -62.78, -24.8 in-in in 9.0072 Saltbr-in 2.642 HRD-in -69.29, -46.97 88.72, -8.32 in-in-out SNCiio in-out ActLoopNT-in 2.7805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.2, 153.67 APE9-dihe-na -78.66, -165.16 APE8-dihe-in -65.61, 130.43 APE8-rot-in 311.25 APE67-dihe-in -64.52, -34.52 -58.39, -43.9 APE12-dist-in 8.2388 APE11-dist-out 5.826 APE10-dist-out 8.4194 APE9-dist-in 3.7974 None None None XRAY 2.65 0.198 0.249 A 349.0 322.0 6 33 27 6 [[402, 653]] 1.0 6g4y Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4YB Q9WUL6 334 675 942.0 ELZ:703 Type1.5_Back Inactive DFGin 5.2637 13.8091 BLAminus -134.24, 178.64 62.43, 89.83 -99.19, 18.57 283.0, 77.95 -63.77, -24.4 in-in in 8.9016 Saltbr-in 2.7359 HRD-in -66.43, -48.94 90.56, -10.86 in-in-out SNCiio in-out ActLoopNT-in 2.9963 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.15, 159.75 APE9-dihe-na -86.68, -172.94 APE8-dihe-in -58.77, 125.44 APE8-rot-in 304.63 APE67-dihe-in -61.38, -24.2 -57.73, -44.28 APE12-dist-in 7.8647 APE11-dist-out 5.6529 APE10-dist-out 8.3132 APE9-dist-in 3.8525 None None None XRAY 2.65 0.198 0.249 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 6g4y Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4ZA Q9WUL6 334 675 942.0 ELW:701 Type1.5_Back Inactive DFGin 5.4261 13.096 BLAminus -133.74, 179.23 63.46, 77.99 -92.65, 34.68 300.68, 89.07 -75.31, -15.82 in-in in 8.7728 Saltbr-in 2.5657 HRD-in -64.0, -41.26 85.79, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.9076 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -84.16, 157.49 APE9-dihe-na -78.44, -164.13 APE8-dihe-in -68.18, 137.72 APE8-rot-in 304.89 APE67-dihe-in -61.49, -31.98 -66.59, -45.66 APE12-dist-in 7.9005 APE11-dist-out 5.6679 APE10-dist-out 8.445 APE9-dist-in 3.8019 None None None XRAY 2.84 0.237 0.283 A 349.0 322.0 6 33 27 6 [[402, 653]] 1.0 6g4z Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4ZB Q9WUL6 334 675 942.0 ELW:701 Type1.5_Back Inactive DFGin 5.4021 13.5178 BLAminus -153.04, 179.69 56.59, 83.46 -95.76, 28.68 293.85, 85.42 -76.39, -12.38 in-in in 8.9595 Saltbr-in 2.8428 HRD-in -76.5, -47.53 102.5, -55.24 in-in-out SNCiio in-out ActLoopNT-in 2.7605 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -75.31, 167.36 APE9-dihe-na -87.61, -162.83 APE8-dihe-in -75.19, 128.1 APE8-rot-in 313.31 APE67-dihe-in -65.77, -37.36 -61.29, -36.54 APE12-dist-in 8.2989 APE11-dist-out 5.7085 APE10-dist-out 8.3911 APE9-dist-in 4.4734 None None None XRAY 2.84 0.237 0.283 B 349.0 325.0 3 33 33 0 [[402, 653]] 1.0 6g4z Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3EA Q9WUL6 334 675 942.0 0WC:703 Type1.5_Back Inactive DFGin 5.1558 13.7613 BLAminus -129.62, -178.57 63.15, 82.98 -90.42, 23.68 290.2, 83.31 -61.59, -18.74 in-in in 8.7472 Saltbr-in 2.8086 HRD-in -64.95, -51.87 89.19, -10.98 in-in-out SNCiio in-out ActLoopNT-in 2.8691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -78.23, 157.95 APE9-dihe-na -71.36, -163.95 APE8-dihe-in -71.27, 124.75 APE8-rot-in 309.17 APE67-dihe-in -65.54, -23.61 -51.24, -44.73 APE12-dist-none 999.0 APE11-dist-out 6.0143 APE10-dist-out 8.0273 APE9-dist-in 3.6449 None None None XRAY 2.5 0.194 0.24 A 352.0 314.0 14 33 20 13 [[402, 653]] 1.0 4g3e Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3EB Q9WUL6 334 675 942.0 0WC:702 Type1.5_Back Inactive DFGin 5.1026 13.5173 BLAminus -129.17, 177.81 70.18, 90.15 -102.73, 22.25 291.45, 78.59 -59.31, -24.41 in-in in 8.5915 Saltbr-in 2.7755 HRD-in -72.56, -53.02 93.13, -15.07 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -64.27, 153.75 APE9-dihe-na -81.32, -170.71 APE8-dihe-in -61.86, 122.9 APE8-rot-in 310.87 APE67-dihe-in -61.15, -18.04 -57.3, -45.26 APE12-dist-in 7.5342 APE11-dist-out 5.518 APE10-dist-in 7.9628 APE9-dist-in 3.5786 None None None XRAY 2.5 0.194 0.24 B 352.0 325.0 3 33 33 0 [[402, 653]] 1.0 4g3e Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 7SZRA Q9WUL6 334 675 942.0 DYQ:705 Type1.5_Back Inactive DFGin 5.3839 13.1632 BLAminus -150.45, 171.3 64.47, 75.42 -97.33, 20.51 300.27, 102.05 -64.41, -20.38 in-in in 8.6521 Saltbr-in 2.8732 HRD-in -74.28, -50.61 101.92, -41.73 in-in-out SNCiio in-out ActLoopNT-in 3.0908 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.27, 177.1 APE9-dihe-na -83.91, -162.92 APE8-dihe-in -68.03, 141.95 APE8-rot-in 293.13 APE67-dihe-in -65.61, -31.01 -61.59, -49.24 APE12-dist-in 8.364 APE11-dist-out 6.5063 APE10-dist-in 7.9664 APE9-dist-in 4.1501 None None None XRAY 2.8 0.231 0.264 A 352.0 321.0 7 33 28 5 [[402, 653]] 1.0 7szr Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 7SZRB Q9WUL6 334 675 942.0 DYQ:703 Type1.5_Back Inactive DFGin 5.3842 13.6324 BLAminus -148.35, -178.99 59.07, 69.09 -87.42, 25.62 294.88, 88.69 -71.68, -15.63 in-in in 8.6279 Saltbr-in 2.7384 HRD-in -67.73, -57.72 101.4, -23.38 in-in-out SNCiio in-out ActLoopNT-in 2.6781 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -78.22, -176.51 APE9-dihe-na -100.28, -164.1 APE8-dihe-in -66.28, 130.87 APE8-rot-in 292.19 APE67-dihe-in -63.52, -31.66 -61.98, -40.47 APE12-dist-in 8.138 APE11-dist-out 6.2182 APE10-dist-out 8.1052 APE9-dist-in 3.8517 None None None XRAY 2.8 0.231 0.264 B 352.0 328.0 0 33 33 0 [[402, 653]] 1.0 7szr Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14

STE_MAP3K14 (Mitogen-activated protein kinase kinase kinase 14)

Total number of chains: 20
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 20 100.0% 4G3CB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MAP3K14 M3K14_MOUSE 4G3CA Q9WUL6 334 675 942.0 No_ligand No_ligand Inactive DFGin 5.0894 13.864 BLAminus -140.15, 168.19 68.68, 97.29 -102.08, 21.93 283.63, 73.63 -53.77, -27.47 in-in in 8.7806 Saltbr-in 2.5233 HRD-in -64.69, -51.77 93.59, -17.71 in-in-out SNCiio in-out ActLoopNT-in 2.8351 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -57.77, 133.1 APE9-dihe-na -80.94, -159.93 APE8-dihe-in -68.53, 122.42 APE8-rot-in 308.39 APE67-dihe-in -57.63, -22.6 -55.47, -45.8 APE12-dist-none 999.0 APE11-dist-out 5.8898 APE10-dist-out 8.64 APE9-dist-in 3.9125 None None None XRAY 2.15 0.19 0.225 A 352.0 315.0 13 33 20 13 [[402, 653]] 1.0 4g3c Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3CB Q9WUL6 334 674 942.0 No_ligand No_ligand Inactive DFGin 5.205 13.7156 BLAminus -140.13, 170.16 66.8, 96.03 -98.78, 20.47 288.84, 72.74 -55.79, -27.24 in-in in 8.8516 Saltbr-in 2.5694 HRD-in -63.41, -51.56 90.19, -12.99 in-in-out SNCiio in-out ActLoopNT-in 2.8445 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -71.12, 155.95 APE9-dihe-na -82.82, -165.23 APE8-dihe-in -66.56, 124.25 APE8-rot-in 308.77 APE67-dihe-in -56.64, -26.52 -59.22, -45.11 APE12-dist-in 7.4182 APE11-dist-out 5.9438 APE10-dist-in 7.9408 APE9-dist-in 3.8266 None None None XRAY 2.15 0.19 0.225 B 352.0 327.0 0 33 33 0 [[402, 653]] 1.0 4g3c Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3GA Q9WUL6 345 675 942.0 0WA:60701 Type1 Inactive DFGin 6.1401 14.6613 BLAminus -144.18, 178.52 59.7, 98.13 -104.99, 25.09 285.83, 82.79 -56.18, -30.33 in-in in 8.6239 Saltbr-in 2.9352 HRD-in -64.61, -51.31 100.72, -19.25 in-in-out SNCiio in-out ActLoopNT-in 2.9092 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -60.09, 149.14 APE9-dihe-na -93.14, -147.96 APE8-dihe-in -58.17, 130.96 APE8-rot-in 317.12 APE67-dihe-in -54.98, -23.01 -61.63, -48.39 APE12-dist-in 7.7466 APE11-dist-out 5.4156 APE10-dist-out 8.5443 APE9-dist-in 4.0073 V408L None None XRAY 2.5 0.201 0.252 A 350.0 310.0 12 33 21 12 [[402, 653]] 1.0 4g3g Mus musculus STE_MAP3K14_MOUSE STE 1.8e-61 213.9 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3FA Q9WUL6 345 675 942.0 0WB:60701 Type1 Inactive DFGin 6.2731 14.5948 BLAminus -136.37, 175.76 68.62, 93.96 -104.2, 24.58 286.67, 80.03 -56.69, -30.64 in-in in 8.6506 Saltbr-in 2.9203 HRD-in -65.67, -50.45 97.82, -16.82 in-in-out SNCiio in-out ActLoopNT-in 2.9293 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -54.09, 143.29 APE9-dihe-na -88.45, -137.31 APE8-dihe-in -75.01, 123.85 APE8-rot-in 304.54 APE67-dihe-in -61.42, -21.03 -49.54, -48.2 APE12-dist-in 7.8748 APE11-dist-out 5.4072 APE10-dist-out 8.539 APE9-dist-in 4.0353 None None None XRAY 1.642 0.18 0.208 A 336.0 310.0 12 33 21 12 [[402, 653]] 1.0 4g3f Mus musculus STE_MAP3K14_MOUSE STE 2.4e-61 213.5 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8PA Q9WUL6 333 675 942.0 774:701 Type1 Inactive DFGin 5.1018 13.8045 BLAminus -130.87, 175.13 69.52, 94.01 -101.96, 23.87 285.11, 73.05 -59.46, -26.18 in-in in 9.006 Saltbr-in 2.7386 HRD-in -69.86, -50.42 89.41, -11.67 in-in-out SNCiio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -64.72, 153.21 APE9-dihe-na -72.6, -162.93 APE8-dihe-in -75.35, 131.12 APE8-rot-in 300.5 APE67-dihe-in -63.26, -20.39 -65.5, -41.36 APE12-dist-in 7.4619 APE11-dist-out 5.7575 APE10-dist-out 8.2507 APE9-dist-in 3.7106 None None None XRAY 2.32 0.183 0.232 A 349.0 327.0 2 33 31 2 [[402, 653]] 1.0 5t8p Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8PB Q9WUL6 334 675 942.0 774:703 Type1 Inactive DFGin 5.3776 13.5444 BLAminus -127.14, 177.51 72.71, 87.14 -92.81, 20.99 291.61, 75.87 -63.65, -25.7 in-in in 8.9114 Saltbr-in 2.5083 HRD-in -65.09, -50.1 85.06, -10.38 in-in-out SNCiio in-out ActLoopNT-in 2.7987 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -74.16, 162.0 APE9-dihe-na -79.09, -170.16 APE8-dihe-in -64.98, 125.11 APE8-rot-in 302.43 APE67-dihe-in -61.26, -24.69 -62.41, -39.39 APE12-dist-in 7.5025 APE11-dist-out 5.6794 APE10-dist-in 7.7557 APE9-dist-in 3.6835 None None None XRAY 2.32 0.183 0.232 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 5t8p Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8QA Q9WUL6 334 675 942.0 76Y:706 Type1 Inactive DFGin 5.1837 14.0061 BLAminus -130.74, 160.83 73.75, 94.38 -94.56, 17.14 282.45, 79.25 -53.65, -26.76 in-in in 9.089 Saltbr-in 2.8007 HRD-in -67.78, -51.7 101.68, -12.67 in-in-out SNCiio in-out ActLoopNT-in 2.8432 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -75.45, 153.73 APE9-dihe-na -75.91, -172.31 APE8-dihe-in -63.49, 125.47 APE8-rot-in 302.64 APE67-dihe-in -65.75, -24.83 -54.0, -46.19 APE12-dist-in 8.6361 APE11-dist-out 5.4008 APE10-dist-out 8.4398 APE9-dist-in 3.5743 None None None XRAY 2.63 0.203 0.25 A 349.0 323.0 5 33 28 5 [[402, 653]] 1.0 5t8q Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8QB Q9WUL6 334 675 942.0 76Y:707 Type1 Inactive DFGin 5.4082 14.1271 BLAminus -145.17, 162.25 64.87, 96.91 -100.45, 25.61 283.18, 79.59 -62.55, -21.3 in-in in 9.0841 Saltbr-in 2.7839 HRD-in -67.1, -52.15 94.08, -12.98 in-in-out SNCiio in-out ActLoopNT-in 2.8873 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -77.58, 160.1 APE9-dihe-na -88.06, -179.74 APE8-dihe-in -58.69, 121.39 APE8-rot-in 292.94 APE67-dihe-in -60.06, -26.47 -51.84, -44.89 APE12-dist-in 8.141 APE11-dist-out 5.7967 APE10-dist-out 8.3426 APE9-dist-in 3.6447 None None None XRAY 2.63 0.203 0.25 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 5t8q Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6MYNA Q9WUL6 334 675 942.0 K6Y:703 Type1.5_Back Inactive DFGin 5.1368 13.8806 BLAminus -121.09, -179.21 64.35, 97.99 -102.4, 19.51 282.69, 72.09 -66.21, -2.29 in-in in 8.8415 Saltbr-in 2.6701 HRD-in -70.62, -38.19 91.03, -21.2 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -76.89, 156.88 APE9-dihe-na -86.23, -169.86 APE8-dihe-in -63.06, 125.06 APE8-rot-in 312.86 APE67-dihe-in -61.65, -34.22 -58.42, -43.68 APE12-dist-in 8.1031 APE11-dist-out 5.6721 APE10-dist-out 8.4081 APE9-dist-in 4.0072 None None None XRAY 2.744 0.187 0.255 A 347.0 322.0 6 33 27 6 [[402, 653]] 1.0 6myn Mus musculus STE_MAP3K14_MOUSE STE 2.6e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6MYNB Q9WUL6 334 675 942.0 K6Y:704 Type1.5_Back Inactive DFGin 5.1708 13.8429 BLAminus -133.39, 173.74 70.58, 94.89 -101.57, 16.76 286.07, 93.48 -60.65, -21.51 in-in in 9.0517 Saltbr-in 2.7087 HRD-in -71.03, -48.5 91.31, -17.46 in-in-out SNCiio in-out ActLoopNT-in 2.7611 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -69.02, 159.13 APE9-dihe-na -93.8, -178.7 APE8-dihe-in -50.89, 123.45 APE8-rot-in 297.3 APE67-dihe-in -64.52, -23.1 -64.98, -38.0 APE12-dist-in 7.5881 APE11-dist-out 5.5248 APE10-dist-out 8.2165 APE9-dist-in 3.7889 None None None XRAY 2.744 0.187 0.255 B 347.0 328.0 0 33 33 0 [[402, 653]] 1.0 6myn Mus musculus STE_MAP3K14_MOUSE STE 2.6e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8OA Q9WUL6 334 675 942.0 76Z:705 Type1.5_Back Inactive DFGin 5.3291 12.7939 BLAminus -130.48, -174.75 59.89, 70.22 -92.56, 28.1 305.24, 102.53 -70.28, -19.79 in-in in 8.7317 Saltbr-in 2.877 HRD-in -67.09, -53.86 93.11, -2.16 in-in-out SNCiio in-out ActLoopNT-in 2.9907 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -87.39, -178.86 APE9-dihe-na -87.38, -155.91 APE8-dihe-in -79.02, 126.4 APE8-rot-in 302.71 APE67-dihe-in -62.36, -21.86 -53.04, -50.1 APE12-dist-in 8.1427 APE11-dist-out 6.5038 APE10-dist-in 7.8287 APE9-dist-in 3.7497 None None None XRAY 2.41 0.207 0.256 A 349.0 324.0 4 33 29 4 [[402, 653]] 1.0 5t8o Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 5T8OB Q9WUL6 334 675 942.0 76Z:704 Type1.5_Back Inactive DFGin 5.3123 12.8396 BLAminus -141.26, -176.18 60.16, 69.96 -93.23, 19.11 305.72, 98.23 -59.16, -21.35 in-in in 8.7301 Saltbr-in 2.7033 HRD-in -67.59, -51.02 93.64, -7.3 in-in-out SNCiio in-out ActLoopNT-in 2.9868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -79.62, 174.72 APE9-dihe-na -91.83, -158.34 APE8-dihe-in -74.9, 119.81 APE8-rot-in 307.01 APE67-dihe-in -63.35, -25.62 -50.24, -44.81 APE12-dist-in 8.3924 APE11-dist-out 6.5184 APE10-dist-out 8.1053 APE9-dist-in 3.8213 None None None XRAY 2.41 0.207 0.256 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 5t8o Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4YA Q9WUL6 334 675 942.0 ELZ:703 Type1.5_Back Inactive DFGin 5.1644 13.7241 BLAminus -129.11, 179.68 62.4, 86.21 -93.91, 21.44 289.83, 80.88 -62.78, -24.8 in-in in 9.0072 Saltbr-in 2.642 HRD-in -69.29, -46.97 88.72, -8.32 in-in-out SNCiio in-out ActLoopNT-in 2.7805 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.2, 153.67 APE9-dihe-na -78.66, -165.16 APE8-dihe-in -65.61, 130.43 APE8-rot-in 311.25 APE67-dihe-in -64.52, -34.52 -58.39, -43.9 APE12-dist-in 8.2388 APE11-dist-out 5.826 APE10-dist-out 8.4194 APE9-dist-in 3.7974 None None None XRAY 2.65 0.198 0.249 A 349.0 322.0 6 33 27 6 [[402, 653]] 1.0 6g4y Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4YB Q9WUL6 334 675 942.0 ELZ:703 Type1.5_Back Inactive DFGin 5.2637 13.8091 BLAminus -134.24, 178.64 62.43, 89.83 -99.19, 18.57 283.0, 77.95 -63.77, -24.4 in-in in 8.9016 Saltbr-in 2.7359 HRD-in -66.43, -48.94 90.56, -10.86 in-in-out SNCiio in-out ActLoopNT-in 2.9963 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -74.15, 159.75 APE9-dihe-na -86.68, -172.94 APE8-dihe-in -58.77, 125.44 APE8-rot-in 304.63 APE67-dihe-in -61.38, -24.2 -57.73, -44.28 APE12-dist-in 7.8647 APE11-dist-out 5.6529 APE10-dist-out 8.3132 APE9-dist-in 3.8525 None None None XRAY 2.65 0.198 0.249 B 349.0 328.0 0 33 33 0 [[402, 653]] 1.0 6g4y Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4ZA Q9WUL6 334 675 942.0 ELW:701 Type1.5_Back Inactive DFGin 5.4261 13.096 BLAminus -133.74, 179.23 63.46, 77.99 -92.65, 34.68 300.68, 89.07 -75.31, -15.82 in-in in 8.7728 Saltbr-in 2.5657 HRD-in -64.0, -41.26 85.79, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.9076 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -84.16, 157.49 APE9-dihe-na -78.44, -164.13 APE8-dihe-in -68.18, 137.72 APE8-rot-in 304.89 APE67-dihe-in -61.49, -31.98 -66.59, -45.66 APE12-dist-in 7.9005 APE11-dist-out 5.6679 APE10-dist-out 8.445 APE9-dist-in 3.8019 None None None XRAY 2.84 0.237 0.283 A 349.0 322.0 6 33 27 6 [[402, 653]] 1.0 6g4z Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 6G4ZB Q9WUL6 334 675 942.0 ELW:701 Type1.5_Back Inactive DFGin 5.4021 13.5178 BLAminus -153.04, 179.69 56.59, 83.46 -95.76, 28.68 293.85, 85.42 -76.39, -12.38 in-in in 8.9595 Saltbr-in 2.8428 HRD-in -76.5, -47.53 102.5, -55.24 in-in-out SNCiio in-out ActLoopNT-in 2.7605 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -75.31, 167.36 APE9-dihe-na -87.61, -162.83 APE8-dihe-in -75.19, 128.1 APE8-rot-in 313.31 APE67-dihe-in -65.77, -37.36 -61.29, -36.54 APE12-dist-in 8.2989 APE11-dist-out 5.7085 APE10-dist-out 8.3911 APE9-dist-in 4.4734 None None None XRAY 2.84 0.237 0.283 B 349.0 325.0 3 33 33 0 [[402, 653]] 1.0 6g4z Mus musculus STE_MAP3K14_MOUSE STE 2.7e-61 213.4 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3EA Q9WUL6 334 675 942.0 0WC:703 Type1.5_Back Inactive DFGin 5.1558 13.7613 BLAminus -129.62, -178.57 63.15, 82.98 -90.42, 23.68 290.2, 83.31 -61.59, -18.74 in-in in 8.7472 Saltbr-in 2.8086 HRD-in -64.95, -51.87 89.19, -10.98 in-in-out SNCiio in-out ActLoopNT-in 2.8691 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -78.23, 157.95 APE9-dihe-na -71.36, -163.95 APE8-dihe-in -71.27, 124.75 APE8-rot-in 309.17 APE67-dihe-in -65.54, -23.61 -51.24, -44.73 APE12-dist-none 999.0 APE11-dist-out 6.0143 APE10-dist-out 8.0273 APE9-dist-in 3.6449 None None None XRAY 2.5 0.194 0.24 A 352.0 314.0 14 33 20 13 [[402, 653]] 1.0 4g3e Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 4G3EB Q9WUL6 334 675 942.0 0WC:702 Type1.5_Back Inactive DFGin 5.1026 13.5173 BLAminus -129.17, 177.81 70.18, 90.15 -102.73, 22.25 291.45, 78.59 -59.31, -24.41 in-in in 8.5915 Saltbr-in 2.7755 HRD-in -72.56, -53.02 93.13, -15.07 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -64.27, 153.75 APE9-dihe-na -81.32, -170.71 APE8-dihe-in -61.86, 122.9 APE8-rot-in 310.87 APE67-dihe-in -61.15, -18.04 -57.3, -45.26 APE12-dist-in 7.5342 APE11-dist-out 5.518 APE10-dist-in 7.9628 APE9-dist-in 3.5786 None None None XRAY 2.5 0.194 0.24 B 352.0 325.0 3 33 33 0 [[402, 653]] 1.0 4g3e Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 7SZRA Q9WUL6 334 675 942.0 DYQ:705 Type1.5_Back Inactive DFGin 5.3839 13.1632 BLAminus -150.45, 171.3 64.47, 75.42 -97.33, 20.51 300.27, 102.05 -64.41, -20.38 in-in in 8.6521 Saltbr-in 2.8732 HRD-in -74.28, -50.61 101.92, -41.73 in-in-out SNCiio in-out ActLoopNT-in 3.0908 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.27, 177.1 APE9-dihe-na -83.91, -162.92 APE8-dihe-in -68.03, 141.95 APE8-rot-in 293.13 APE67-dihe-in -65.61, -31.01 -61.59, -49.24 APE12-dist-in 8.364 APE11-dist-out 6.5063 APE10-dist-in 7.9664 APE9-dist-in 4.1501 None None None XRAY 2.8 0.231 0.264 A 352.0 321.0 7 33 28 5 [[402, 653]] 1.0 7szr Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14
MAP3K14 M3K14_MOUSE 7SZRB Q9WUL6 334 675 942.0 DYQ:703 Type1.5_Back Inactive DFGin 5.3842 13.6324 BLAminus -148.35, -178.99 59.07, 69.09 -87.42, 25.62 294.88, 88.69 -71.68, -15.63 in-in in 8.6279 Saltbr-in 2.7384 HRD-in -67.73, -57.72 101.4, -23.38 in-in-out SNCiio in-out ActLoopNT-in 2.6781 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -78.22, -176.51 APE9-dihe-na -100.28, -164.1 APE8-dihe-in -66.28, 130.87 APE8-rot-in 292.19 APE67-dihe-in -63.52, -31.66 -61.98, -40.47 APE12-dist-in 8.138 APE11-dist-out 6.2182 APE10-dist-out 8.1052 APE9-dist-in 3.8517 None None None XRAY 2.8 0.231 0.264 B 352.0 328.0 0 33 33 0 [[402, 653]] 1.0 7szr Mus musculus STE_MAP3K14_MOUSE STE 2.8e-61 213.3 4.0 252.0 249.0 535 536 537 539 541 431 442 446 514 516 515 517.0 580 568 563 562 561 560 559 558 557 472 Mitogen-activated protein kinase kinase kinase 14