TYR_FLT3 (Receptor-type tyrosine-protein kinase FLT3)

Total number of chains: 10
Active chains: 2
Family: TYR
Uniprot: FLT3_HUMAN
Kinase Domain Residues: 610 - 945
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 5 50.0% 6IL3A
DFGout BBAminus 3 30.0% 4XUFB
DFGin BLAminus 2 20.0% AF-P36888-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P36888-K1A 602 953 993.0 No_ligand No_ligand Active DFGin 6.952 14.131 BLAminus -143.23, 178.77 67.08, 55.14 -77.02, 14.59 286.19, 76.14 -61.49, -31.53 in-in in 7.479 Saltbr-in 2.698 HRD-in -78.74, -43.23 66.6, -14.38 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 89.83 APE9-dihe-in -111.39, 151.17 APE8-dihe-in -77.59, 83.68 APE8-rot-na 35.47 APE67-dihe-in -70.07, -16.26 -43.63, -37.27 APE12-dist-na 14.296 APE11-dist-na 8.237 APE10-dist-na 9.896 APE9-dist-in 6.019 None None None AF2 -1.0 1.0 1.0 A 352 352 0 0 0 0 [[610, 945]] 1.0 AF-P36888-K1 TYR_FLT3_HUMAN TYR 4.1e-102 346.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
AF-P36888-K3A 602 953 993.0 No_ligand No_ligand Active DFGin 7.284 13.543 BLAminus -131.51, -179.63 57.0, 62.49 -72.98, 8.43 287.44, 96.64 -61.83, -29.79 in-in in 7.854 Saltbr-in 2.785 HRD-in -79.97, -43.81 68.78, -8.23 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.33, 109.47 APE9-dihe-in -88.85, 151.32 APE8-dihe-in -79.53, 61.94 APE8-rot-na 36.79 APE67-dihe-in -68.95, -18.44 -45.43, -42.99 APE12-dist-na 14.447 APE11-dist-na 8.8 APE10-dist-na 12.322 APE9-dist-in 7.394 None None None AF2 -1.0 1.0 1.0 A 352 352 0 0 0 0 [[610, 945]] 1.0 AF-P36888-K3 TYR_FLT3_HUMAN TYR 4.1e-102 346.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
4XUFA 600 947 993.0 P30:1001 Type2 Inactive DFGout 16.033 10.199 BBAminus -143.0, -176.09 -145.89, 109.83 -79.74, 65.35 291.29, 82.28 -88.07, 125.53 in-in in 7.677 Saltbr-in 3.131 HRD-out -82.56, 115.59 -72.64, -20.56 in-out-in SNCioi out-in ActLoopNT-out 16.548 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.53, 147.84 APE9-dihe-in -146.85, 149.22 APE8-dihe-in -75.18, 95.57 APE8-rot-na 28.09 APE67-dihe-in -79.56, 0.39 -65.83, -40.86 APE12-dist-na 17.001 APE11-dist-na 12.675 APE10-dist-na 12.5 APE9-dist-in 7.157 None None None XRAY 3.2 0.299 0.32 A 297 270 27 0 0 0 [[610, 945]] 1.0 4xuf TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
4XUFB 600 946 993.0 P30:1001 Type2 Inactive DFGout 15.62 10.103 BBAminus -144.31, -175.77 -146.27, 108.35 -80.93, 70.68 293.11, 82.52 -83.4, -47.41 in-in in 7.893 Saltbr-in 2.608 HRD-out -84.03, 114.48 -73.98, -19.45 in-out-in SNCioi out-in ActLoopNT-out 16.539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.34, 144.93 APE9-dihe-in -152.45, 148.59 APE8-dihe-in -76.73, 96.39 APE8-rot-na 28.9 APE67-dihe-in -79.15, 1.24 -66.13, -41.05 APE12-dist-na 17.725 APE11-dist-na 13.515 APE10-dist-na 12.373 APE9-dist-in 7.579 None None None XRAY 3.2 0.299 0.32 B 297 274 22 0 0 0 [[610, 945]] 1.0 4xuf TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
4RT7A 599 950 993.0 P30:1001 Type2 Inactive DFGout 16.28 10.691 BBAminus -148.52, -175.77 -147.58, 109.4 -60.96, -39.74 289.53, 78.87 49.01, -101.54 in-in in 7.641 Saltbr-in 2.987 HRD-out -100.49, 123.78 -88.21, -0.63 in-out-in SNCioi out-in ActLoopNT-out 16.567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.24, 104.7 APE9-dihe-in -116.44, 148.12 APE8-dihe-in -77.95, 71.82 APE8-rot-na 30.09 APE67-dihe-in -65.85, -17.18 -55.85, -43.14 APE12-dist-na 17.729 APE11-dist-na 14.052 APE10-dist-na 12.022 APE9-dist-in 7.443 None None None XRAY 3.1 0.224 0.268 A 415 274 78 0 0 0 [[610, 945]] 1.0 4rt7 TYR_FLT3_HUMAN TYR 7.6e-102 346.1 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
1RJBA 572 947 993.0 No_ligand No_ligand Inactive DFGout 15.684 8.363 None -155.78, -170.12 -125.78, 107.33 -104.31, 21.16 225.91, 48.71 -54.59, -36.41 in-in in 7.817 Saltbr-in 2.593 HRD-out -115.43, 117.74 -85.28, 1.33 in-out-in SNCioi out-in ActLoopNT-out 18.03 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.87, 97.23 APE9-dihe-in -99.06, 130.66 APE8-dihe-in -82.4, 63.28 APE8-rot-na 34.53 APE67-dihe-in -68.25, -12.12 -43.78, -45.7 APE12-dist-na 16.758 APE11-dist-na 16.147 APE10-dist-na 11.945 APE9-dist-in 7.298 None None None XRAY 2.1 0.23 0.248 A 344 298 27 0 0 0 [[610, 945]] 1.0 1rjb TYR_FLT3_HUMAN TYR 9.9e-103 348.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
6JQRA 571 951 993.0 C6F:1001 Type1 Inactive DFGout 15.394 10.885 None -119.73, 157.71 -104.23, 115.68 77.2, 999.0 255.94, 91.42 999.0, 999.0 in-in in 8.326 Saltbr-in 2.804 HRD-out -98.26, 117.82 -85.48, 11.47 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -131.05, 100.76 APE9-dihe-in -103.87, 123.04 APE8-dihe-in -78.74, 70.62 APE8-rot-na 34.5 APE67-dihe-in -69.1, -11.06 -54.04, -46.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.223 None None None XRAY 2.2 0.181 0.213 A 330 301 29 0 0 6 [[610, 945]] 1.0 6jqr TYR_FLT3_HUMAN TYR 8.5e-103 349.1 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
8XB1A 573 950 993.0 ZX3:1001 Type1 Inactive DFGout 16.785 8.503 None -137.58, 174.85 -120.11, 128.8 51.2, 999.0 176.42, 95.47 999.0, 999.0 in-in in 8.465 Saltbr-in 3.255 HRD-out -103.79, 107.3 -84.06, 13.74 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.92, 110.72 APE9-dihe-in -112.36, 129.93 APE8-dihe-in -83.81, 80.36 APE8-rot-na 31.64 APE67-dihe-in -69.59, -10.43 -56.56, -46.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.957 None None None XRAY 2.85 0.236 0.287 A 346 304 23 0 0 6 [[610, 945]] 1.0 8xb1 TYR_FLT3_HUMAN TYR 1e-102 348.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
5X02A 573 947 993.0 F6M:61001 Type1 Inactive DFGout 16.513 10.739 None -127.36, 175.28 -155.15, 109.24 -131.05, 124.01 44.79, 98.96 -130.39, -30.78 in-in in 8.384 Saltbr-in 2.731 HRD-out -116.89, 102.0 -82.02, 12.69 in-out-in SNCioi out-in ActLoopNT-out 16.242 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.0, 95.48 APE9-dihe-in -95.25, 120.88 APE8-dihe-in -74.85, 69.27 APE8-rot-na 28.28 APE67-dihe-in -69.28, -8.01 -53.09, -46.19 APE12-dist-na 13.326 APE11-dist-na 13.814 APE10-dist-na 9.943 APE9-dist-in 7.056 None None None XRAY 2.401 0.236 0.277 A 347 305 19 0 0 0 [[610, 945]] 1.0 5x02 TYR_FLT3_HUMAN TYR 1e-102 348.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
6IL3A 569 947 993.0 A9R:1001 Type1 Inactive DFGout 18.066 9.991 None -137.72, 178.19 -114.58, 103.78 -95.53, 10.02 188.73, 81.27 -62.27, -30.79 in-in in 7.904 Saltbr-in 2.662 HRD-out -112.71, 117.58 -85.2, 6.2 in-out-in SNCioi out-in ActLoopNT-out 17.318 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.53, 103.3 APE9-dihe-in -108.39, 121.39 APE8-dihe-in -81.48, 71.82 APE8-rot-na 34.93 APE67-dihe-in -74.41, -7.85 -52.12, -42.1 APE12-dist-na 15.686 APE11-dist-na 15.45 APE10-dist-na 11.161 APE9-dist-in 7.233 None None None XRAY 2.5 0.185 0.219 A 370 310 18 0 0 0 [[610, 945]] 1.0 6il3 TYR_FLT3_HUMAN TYR 1.3e-102 348.6 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3

TYR_FLT3 (Receptor-type tyrosine-protein kinase FLT3)

Total number of chains: 10
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 5 50.0% 6IL3A
DFGout BBAminus 3 30.0% 4XUFB
DFGin BLAminus 2 20.0% AF-P36888-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FLT3_HUMAN AF-P36888-K1A P36888 602 953 993.0 No_ligand No_ligand Active DFGin 6.952 14.131 BLAminus -143.23, 178.77 67.08, 55.14 -77.02, 14.59 286.19, 76.14 -61.49, -31.53 in-in in 7.479 Saltbr-in 2.698 HRD-in -78.74, -43.23 66.6, -14.38 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 89.83 APE9-dihe-in -111.39, 151.17 APE8-dihe-in -77.59, 83.68 APE8-rot-na 35.47 APE67-dihe-in -70.07, -16.26 -43.63, -37.27 APE12-dist-na 14.296 APE11-dist-na 8.237 APE10-dist-na 9.896 APE9-dist-in 6.019 None None None AF2 -1.0 1.0 1.0 A 352 352 0 0 0 0 [[610, 945]] 1.0 AF-P36888-K1 Homo sapiens TYR_FLT3_HUMAN TYR 4.1e-102 346.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN AF-P36888-K3A P36888 602 953 993.0 No_ligand No_ligand Active DFGin 7.284 13.543 BLAminus -131.51, -179.63 57.0, 62.49 -72.98, 8.43 287.44, 96.64 -61.83, -29.79 in-in in 7.854 Saltbr-in 2.785 HRD-in -79.97, -43.81 68.78, -8.23 in-in-in SNCiii in-in ActLoopNT-in 2.899 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.33, 109.47 APE9-dihe-in -88.85, 151.32 APE8-dihe-in -79.53, 61.94 APE8-rot-na 36.79 APE67-dihe-in -68.95, -18.44 -45.43, -42.99 APE12-dist-na 14.447 APE11-dist-na 8.8 APE10-dist-na 12.322 APE9-dist-in 7.394 None None None AF2 -1.0 1.0 1.0 A 352 352 0 0 0 0 [[610, 945]] 1.0 AF-P36888-K3 Homo sapiens TYR_FLT3_HUMAN TYR 4.1e-102 346.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 4XUFA P36888 600 947 993.0 P30:1001 Type2 Inactive DFGout 16.033 10.199 BBAminus -143.0, -176.09 -145.89, 109.83 -79.74, 65.35 291.29, 82.28 -88.07, 125.53 in-in in 7.677 Saltbr-in 3.131 HRD-out -82.56, 115.59 -72.64, -20.56 in-out-in SNCioi out-in ActLoopNT-out 16.548 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.53, 147.84 APE9-dihe-in -146.85, 149.22 APE8-dihe-in -75.18, 95.57 APE8-rot-na 28.09 APE67-dihe-in -79.56, 0.39 -65.83, -40.86 APE12-dist-na 17.001 APE11-dist-na 12.675 APE10-dist-na 12.5 APE9-dist-in 7.157 None None None XRAY 3.2 0.299 0.32 A 297 270 27 0 0 0 [[610, 945]] 1.0 4xuf Homo sapiens TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 4XUFB P36888 600 946 993.0 P30:1001 Type2 Inactive DFGout 15.62 10.103 BBAminus -144.31, -175.77 -146.27, 108.35 -80.93, 70.68 293.11, 82.52 -83.4, -47.41 in-in in 7.893 Saltbr-in 2.608 HRD-out -84.03, 114.48 -73.98, -19.45 in-out-in SNCioi out-in ActLoopNT-out 16.539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.34, 144.93 APE9-dihe-in -152.45, 148.59 APE8-dihe-in -76.73, 96.39 APE8-rot-na 28.9 APE67-dihe-in -79.15, 1.24 -66.13, -41.05 APE12-dist-na 17.725 APE11-dist-na 13.515 APE10-dist-na 12.373 APE9-dist-in 7.579 None None None XRAY 3.2 0.299 0.32 B 297 274 22 0 0 0 [[610, 945]] 1.0 4xuf Homo sapiens TYR_FLT3_HUMAN TYR 5.8e-103 349.6 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 4RT7A P36888 599 950 993.0 P30:1001 Type2 Inactive DFGout 16.28 10.691 BBAminus -148.52, -175.77 -147.58, 109.4 -60.96, -39.74 289.53, 78.87 49.01, -101.54 in-in in 7.641 Saltbr-in 2.987 HRD-out -100.49, 123.78 -88.21, -0.63 in-out-in SNCioi out-in ActLoopNT-out 16.567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.24, 104.7 APE9-dihe-in -116.44, 148.12 APE8-dihe-in -77.95, 71.82 APE8-rot-na 30.09 APE67-dihe-in -65.85, -17.18 -55.85, -43.14 APE12-dist-na 17.729 APE11-dist-na 14.052 APE10-dist-na 12.022 APE9-dist-in 7.443 None None None XRAY 3.1 0.224 0.268 A 415 274 78 0 0 0 [[610, 945]] 1.0 4rt7 Homo sapiens TYR_FLT3_HUMAN TYR 7.6e-102 346.1 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 1RJBA P36888 572 947 993.0 No_ligand No_ligand Inactive DFGout 15.684 8.363 None -155.78, -170.12 -125.78, 107.33 -104.31, 21.16 225.91, 48.71 -54.59, -36.41 in-in in 7.817 Saltbr-in 2.593 HRD-out -115.43, 117.74 -85.28, 1.33 in-out-in SNCioi out-in ActLoopNT-out 18.03 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -130.87, 97.23 APE9-dihe-in -99.06, 130.66 APE8-dihe-in -82.4, 63.28 APE8-rot-na 34.53 APE67-dihe-in -68.25, -12.12 -43.78, -45.7 APE12-dist-na 16.758 APE11-dist-na 16.147 APE10-dist-na 11.945 APE9-dist-in 7.298 None None None XRAY 2.1 0.23 0.248 A 344 298 27 0 0 0 [[610, 945]] 1.0 1rjb Homo sapiens TYR_FLT3_HUMAN TYR 9.9e-103 348.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 6JQRA P36888 571 951 993.0 C6F:1001 Type1 Inactive DFGout 15.394 10.885 None -119.73, 157.71 -104.23, 115.68 77.2, 999.0 255.94, 91.42 999.0, 999.0 in-in in 8.326 Saltbr-in 2.804 HRD-out -98.26, 117.82 -85.48, 11.47 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -131.05, 100.76 APE9-dihe-in -103.87, 123.04 APE8-dihe-in -78.74, 70.62 APE8-rot-na 34.5 APE67-dihe-in -69.1, -11.06 -54.04, -46.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.223 None None None XRAY 2.2 0.181 0.213 A 330 301 29 0 0 6 [[610, 945]] 1.0 6jqr Homo sapiens TYR_FLT3_HUMAN TYR 8.5e-103 349.1 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 8XB1A P36888 573 950 993.0 ZX3:1001 Type1 Inactive DFGout 16.785 8.503 None -137.58, 174.85 -120.11, 128.8 51.2, 999.0 176.42, 95.47 999.0, 999.0 in-in in 8.465 Saltbr-in 3.255 HRD-out -103.79, 107.3 -84.06, 13.74 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.92, 110.72 APE9-dihe-in -112.36, 129.93 APE8-dihe-in -83.81, 80.36 APE8-rot-na 31.64 APE67-dihe-in -69.59, -10.43 -56.56, -46.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.957 None None None XRAY 2.85 0.236 0.287 A 346 304 23 0 0 6 [[610, 945]] 1.0 8xb1 Homo sapiens TYR_FLT3_HUMAN TYR 1e-102 348.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 5X02A P36888 573 947 993.0 F6M:61001 Type1 Inactive DFGout 16.513 10.739 None -127.36, 175.28 -155.15, 109.24 -131.05, 124.01 44.79, 98.96 -130.39, -30.78 in-in in 8.384 Saltbr-in 2.731 HRD-out -116.89, 102.0 -82.02, 12.69 in-out-in SNCioi out-in ActLoopNT-out 16.242 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.0, 95.48 APE9-dihe-in -95.25, 120.88 APE8-dihe-in -74.85, 69.27 APE8-rot-na 28.28 APE67-dihe-in -69.28, -8.01 -53.09, -46.19 APE12-dist-na 13.326 APE11-dist-na 13.814 APE10-dist-na 9.943 APE9-dist-in 7.056 None None None XRAY 2.401 0.236 0.277 A 347 305 19 0 0 0 [[610, 945]] 1.0 5x02 Homo sapiens TYR_FLT3_HUMAN TYR 1e-102 348.9 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
FLT3_HUMAN 6IL3A P36888 569 947 993.0 A9R:1001 Type1 Inactive DFGout 18.066 9.991 None -137.72, 178.19 -114.58, 103.78 -95.53, 10.02 188.73, 81.27 -62.27, -30.79 in-in in 7.904 Saltbr-in 2.662 HRD-out -112.71, 117.58 -85.2, 6.2 in-out-in SNCioi out-in ActLoopNT-out 17.318 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -132.53, 103.3 APE9-dihe-in -108.39, 121.39 APE8-dihe-in -81.48, 71.82 APE8-rot-na 34.93 APE67-dihe-in -74.41, -7.85 -52.12, -42.1 APE12-dist-na 15.686 APE11-dist-na 15.45 APE10-dist-na 11.161 APE9-dist-in 7.233 None None None XRAY 2.5 0.185 0.219 A 370 310 18 0 0 0 [[610, 945]] 1.0 6il3 Homo sapiens TYR_FLT3_HUMAN TYR 1.3e-102 348.6 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3

TYR_FLT3 (Receptor-type tyrosine-protein kinase FLT3)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name