TYR_CSK (Tyrosine-protein kinase CSK)

Total number of chains: 6
Active chains: 2
Uniprot: CSK_HUMAN
Kinase Domain Residues: 195 - 442
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 66.7% AF-P41240-K1A
DFGin None 1 16.7% 3D7TA
DFGinter BABtrans 1 16.7% 1BYGA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CSK AF-P41240-K1A P41240 187 450 450.0 No_ligand No_ligand Active DFGin 6.6521 13.535 BLAminus -140.79, -177.99 59.59, 64.54 -78.38, 12.67 306.05, 102.77 -61.1, -25.22 in-in in 8.1962 Saltbr-in 2.7358 HRD-in -70.43, -41.16 67.95, -18.12 in-in-in SNCiii in-in ActLoopNT-in 2.8769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.56, 123.03 APE9-dihe-in -88.67, 146.06 APE8-dihe-in -75.96, 77.27 APE8-rot-na 35.35 APE67-dihe-in -78.8, -11.64 -44.39, -38.44 APE12-dist-na 6.5042 APE11-dist-na 8.9123 APE10-dist-na 11.3592 APE9-dist-in 6.5893 None None None AF2 -1.0 1.0 1.0 A 264.0 264.0 0 25 25 0 [[195, 442]] 1.0 AF-P41240-K1 TYR_CSK_HUMAN TYR 9.8e-88 299.7 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK AF-P41240-K3A P41240 187 450 450.0 No_ligand No_ligand Active DFGin 6.2212 13.4734 BLAminus -145.47, -178.85 59.36, 64.73 -75.42, 10.96 301.5, 97.04 -62.16, -23.27 in-in in 8.2394 Saltbr-in 2.7226 HRD-in -72.51, -40.22 68.56, -17.15 in-in-in SNCiii in-in ActLoopNT-in 2.8418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.79, 119.28 APE9-dihe-in -93.33, 145.64 APE8-dihe-in -75.85, 78.3 APE8-rot-na 36.93 APE67-dihe-in -78.58, -5.36 -44.65, -34.4 APE12-dist-na 10.4169 APE11-dist-na 7.2915 APE10-dist-na 10.113 APE9-dist-in 6.074 None None None AF2 -1.0 1.0 1.0 A 264.0 264.0 0 25 25 0 [[195, 442]] 1.0 AF-P41240-K3 TYR_CSK_HUMAN TYR 9.8e-88 299.7 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.8478 13.7273 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.7085 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269.0 249.0 14 25 11 14 [[195, 442]] 1.0 3d7t TYR_CSK_HUMAN TYR 5.7e-87 297.2 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.8596 7.9227 BABtrans -99.17, 153.06 -105.84, -7.01 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.7753 Saltbr-out 12.6461 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2924 None None None XRAY 2.4 0.199 0.287 A 278.0 246.0 16 25 13 12 [[195, 442]] 1.0 1byg TYR_CSK_HUMAN TYR 1.2e-87 299.5 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK 3D7UA P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.0244 13.1175 BLAminus -139.73, -167.84 53.51, 74.77 -92.77, 23.91 306.2, 90.91 -52.72, -52.05 in-in in 8.2613 Saltbr-in 2.5434 HRD-in -75.91, -39.41 59.37, 3.93 in-in-none SNCiin in-none ActLoopNT-in 2.9033 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 146.18 APE9-dihe-in -90.57, 133.68 APE8-dihe-in -63.86, 107.61 APE8-rot-na 30.93 APE67-dihe-in -66.76, -13.54 -46.29, -47.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.8958 APE9-dist-in 4.9451 None None None XRAY 4.111 0.294 0.302 A 263.0 257.0 6 25 19 6 [[195, 442]] 1.0 3d7u TYR_CSK_HUMAN TYR 9.6e-88 299.8 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK 3D7UC P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.0239 13.1185 BLAminus -139.69, -167.9 53.63, 74.8 -92.81, 23.87 306.29, 90.94 -52.77, -51.99 in-in in 8.2621 Saltbr-in 2.5433 HRD-in -75.91, -39.47 59.39, 4.04 in-in-none SNCiin in-none ActLoopNT-in 2.9045 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 146.11 APE9-dihe-in -90.53, 133.8 APE8-dihe-in -64.03, 107.64 APE8-rot-na 30.96 APE67-dihe-in -66.6, -13.57 -46.35, -47.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.8973 APE9-dist-in 4.9454 None None None XRAY 4.111 0.294 0.302 C 263.0 257.0 6 25 19 6 [[195, 442]] 1.0 3d7u TYR_CSK_HUMAN TYR 9.6e-88 299.8 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK

TYR_CSK (Tyrosine-protein kinase CSK)

Total number of chains: 12
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 75.0% AF-P41240-K1A
DFGin ABAminus 1 8.3% 1K9AB
DFGin None 1 8.3% 3D7TA
DFGinter BABtrans 1 8.3% 1BYGA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CSK CSK_HUMAN AF-P41240-K1A P41240 187 450 450.0 No_ligand No_ligand Active DFGin 6.6521 13.535 BLAminus -140.79, -177.99 59.59, 64.54 -78.38, 12.67 306.05, 102.77 -61.1, -25.22 in-in in 8.1962 Saltbr-in 2.7358 HRD-in -70.43, -41.16 67.95, -18.12 in-in-in SNCiii in-in ActLoopNT-in 2.8769 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.56, 123.03 APE9-dihe-in -88.67, 146.06 APE8-dihe-in -75.96, 77.27 APE8-rot-na 35.35 APE67-dihe-in -78.8, -11.64 -44.39, -38.44 APE12-dist-na 6.5042 APE11-dist-na 8.9123 APE10-dist-na 11.3592 APE9-dist-in 6.5893 None None None AF2 -1.0 1.0 1.0 A 264.0 264.0 0 25 25 0 [[195, 442]] 1.0 AF-P41240-K1 Homo sapiens TYR_CSK_HUMAN TYR 9.8e-88 299.7 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_HUMAN AF-P41240-K3A P41240 187 450 450.0 No_ligand No_ligand Active DFGin 6.2212 13.4734 BLAminus -145.47, -178.85 59.36, 64.73 -75.42, 10.96 301.5, 97.04 -62.16, -23.27 in-in in 8.2394 Saltbr-in 2.7226 HRD-in -72.51, -40.22 68.56, -17.15 in-in-in SNCiii in-in ActLoopNT-in 2.8418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.79, 119.28 APE9-dihe-in -93.33, 145.64 APE8-dihe-in -75.85, 78.3 APE8-rot-na 36.93 APE67-dihe-in -78.58, -5.36 -44.65, -34.4 APE12-dist-na 10.4169 APE11-dist-na 7.2915 APE10-dist-na 10.113 APE9-dist-in 6.074 None None None AF2 -1.0 1.0 1.0 A 264.0 264.0 0 25 25 0 [[195, 442]] 1.0 AF-P41240-K3 Homo sapiens TYR_CSK_HUMAN TYR 9.8e-88 299.7 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_HUMAN 3D7TA P41240 188 450 450.0 STU:6335 Type1 Inactive DFGin 4.8478 13.7273 None -129.86, -75.48 -112.49, 120.17 -68.38, 132.53 310.55, 71.3 -108.94, 999.0 in-in in 9.7085 Saltbr-in 3.505 HRD-in -84.81, -41.33 76.65, -6.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.32 APE8-rot-na 27.67 APE67-dihe-in -57.33, -30.65 -43.31, -55.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K361A,K362A None None XRAY 2.899 0.239 0.278 A 269.0 249.0 14 25 11 14 [[195, 442]] 1.0 3d7t Homo sapiens TYR_CSK_HUMAN TYR 5.7e-87 297.2 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.8596 7.9227 BABtrans -99.17, 153.06 -105.84, -7.01 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.7753 Saltbr-out 12.6461 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2924 None None None XRAY 2.4 0.199 0.287 A 278.0 246.0 16 25 13 12 [[195, 442]] 1.0 1byg Homo sapiens TYR_CSK_HUMAN TYR 1.2e-87 299.5 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_HUMAN 3D7UA P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.0244 13.1175 BLAminus -139.73, -167.84 53.51, 74.77 -92.77, 23.91 306.2, 90.91 -52.72, -52.05 in-in in 8.2613 Saltbr-in 2.5434 HRD-in -75.91, -39.41 59.37, 3.93 in-in-none SNCiin in-none ActLoopNT-in 2.9033 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 146.18 APE9-dihe-in -90.57, 133.68 APE8-dihe-in -63.86, 107.61 APE8-rot-na 30.93 APE67-dihe-in -66.76, -13.54 -46.29, -47.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.8958 APE9-dist-in 4.9451 None None None XRAY 4.111 0.294 0.302 A 263.0 257.0 6 25 19 6 [[195, 442]] 1.0 3d7u Homo sapiens TYR_CSK_HUMAN TYR 9.6e-88 299.8 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_HUMAN 3D7UC P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.0239 13.1185 BLAminus -139.69, -167.9 53.63, 74.8 -92.81, 23.87 306.29, 90.94 -52.77, -51.99 in-in in 8.2621 Saltbr-in 2.5433 HRD-in -75.91, -39.47 59.39, 4.04 in-in-none SNCiin in-none ActLoopNT-in 2.9045 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 146.11 APE9-dihe-in -90.53, 133.8 APE8-dihe-in -64.03, 107.64 APE8-rot-na 30.96 APE67-dihe-in -66.6, -13.57 -46.35, -47.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.8973 APE9-dist-in 4.9454 None None None XRAY 4.111 0.294 0.302 C 263.0 257.0 6 25 19 6 [[195, 442]] 1.0 3d7u Homo sapiens TYR_CSK_HUMAN TYR 9.6e-88 299.8 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AB P32577 4 450 450.0 No_ligand No_ligand Inactive DFGin 6.8929 13.2512 ABAminus -126.67, -31.48 -105.21, 104.3 -96.95, 20.84 313.04, 97.71 -54.1, -35.57 in-in in 8.0928 Saltbr-in 2.7995 HRD-in -78.05, -50.03 75.37, -11.97 in-in-out SNCiio in-out ActLoopNT-in 2.9669 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 36.75, 86.37 APE9-dihe-in -111.3, 142.08 APE8-dihe-in -43.06, 124.99 APE8-rot-na 328.49 APE67-dihe-in -68.64, -18.99 -69.6, -40.29 APE12-dist-na 999.0 APE11-dist-na 8.6281 APE10-dist-na 11.3906 APE9-dist-in 5.7296 None None None XRAY 2.5 0.246 0.288 B 450.0 441.0 6 25 19 6 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AC P32577 6 450 450.0 No_ligand No_ligand Inactive DFGin 6.6568 15.4761 BLAminus -144.72, -165.48 62.53, 67.82 -97.34, 23.04 306.56, 102.45 -61.41, -33.26 in-out in 9.3171 Saltbr-out 7.0952 HRD-in -68.86, -48.56 73.33, -7.65 out-in-out SNCoio in-out ActLoopNT-in 2.7487 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.78 APE8-dihe-in -55.4, 149.02 APE8-rot-na 325.4 APE67-dihe-in -45.76, -33.99 -100.01, -55.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7467 None None None XRAY 2.5 0.246 0.288 C 450.0 438.0 7 25 18 7 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AD P32577 6 450 450.0 No_ligand No_ligand Inactive DFGin 6.5403 15.677 BLAminus -141.77, -160.29 58.4, 68.03 -94.47, 17.88 302.46, 106.04 -51.33, -46.11 in-out in 9.4163 Saltbr-out 7.6391 HRD-out -100.52, 90.27 -71.04, 28.05 out-in-out SNCoio in-out ActLoopNT-in 2.885 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.48 APE8-dihe-in -68.73, 155.34 APE8-rot-na 333.53 APE67-dihe-in -50.19, -22.42 -116.25, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.694 None None None XRAY 2.5 0.246 0.288 D 450.0 433.0 5 25 20 5 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AA P32577 6 450 450.0 No_ligand No_ligand None DFGin 7.0246 13.1182 BLAminus -139.67, -167.82 53.56, 74.8 -92.76, 23.85 306.26, 90.9 -52.74, -52.0 in-in in 8.2615 Saltbr-in 2.5428 HRD-in -75.98, -39.34 59.35, 3.94 in-in-none SNCiin in-none ActLoopNT-in 2.9044 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 146.13 APE9-dihe-in -90.54, 133.78 APE8-dihe-in -64.01, 107.63 APE8-rot-na 30.9 APE67-dihe-in -66.63, -13.65 -46.3, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.8965 APE9-dist-in 4.9458 None None None XRAY 2.5 0.246 0.288 A 450.0 439.0 6 25 19 6 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AE P32577 6 450 450.0 No_ligand No_ligand None DFGin 7.0922 13.2581 BLAminus -146.71, -160.87 54.34, 70.46 -91.62, 10.82 305.62, 97.99 -48.96, -34.07 in-in in 8.2888 Saltbr-in 2.883 HRD-in -65.92, -42.65 69.57, -7.6 in-in-none SNCiin in-none ActLoopNT-in 2.7462 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -24.03 APE8-dihe-in -56.09, 81.03 APE8-rot-na 329.53 APE67-dihe-in -74.61, -12.37 -42.29, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4486 None None None XRAY 2.5 0.246 0.288 E 450.0 440.0 5 25 20 5 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AF P32577 6 450 450.0 No_ligand No_ligand None DFGin 6.9744 13.0235 BLAminus -148.25, -167.92 53.96, 74.84 -98.55, 12.15 314.23, 95.66 -46.18, -47.42 in-in in 9.2919 Saltbr-in 3.3527 HRD-in -62.43, -56.65 81.59, -9.03 in-in-none SNCiin in-none ActLoopNT-in 2.9639 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -158.7 APE8-rot-na 325.52 APE67-dihe-in -74.12, -11.41 -136.71, -76.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.246 0.288 F 450.0 436.0 9 25 16 9 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK

TYR_CSK (Tyrosine-protein kinase CSK)

Total number of chains: 6
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 83.3% 1K9AD
DFGin ABAminus 1 16.7% 1K9AB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CSK CSK_RAT 1K9AB P32577 4 450 450.0 No_ligand No_ligand Inactive DFGin 6.8929 13.2512 ABAminus -126.67, -31.48 -105.21, 104.3 -96.95, 20.84 313.04, 97.71 -54.1, -35.57 in-in in 8.0928 Saltbr-in 2.7995 HRD-in -78.05, -50.03 75.37, -11.97 in-in-out SNCiio in-out ActLoopNT-in 2.9669 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 36.75, 86.37 APE9-dihe-in -111.3, 142.08 APE8-dihe-in -43.06, 124.99 APE8-rot-na 328.49 APE67-dihe-in -68.64, -18.99 -69.6, -40.29 APE12-dist-na 999.0 APE11-dist-na 8.6281 APE10-dist-na 11.3906 APE9-dist-in 5.7296 None None None XRAY 2.5 0.246 0.288 B 450.0 441.0 6 25 19 6 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AC P32577 6 450 450.0 No_ligand No_ligand Inactive DFGin 6.6568 15.4761 BLAminus -144.72, -165.48 62.53, 67.82 -97.34, 23.04 306.56, 102.45 -61.41, -33.26 in-out in 9.3171 Saltbr-out 7.0952 HRD-in -68.86, -48.56 73.33, -7.65 out-in-out SNCoio in-out ActLoopNT-in 2.7487 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.78 APE8-dihe-in -55.4, 149.02 APE8-rot-na 325.4 APE67-dihe-in -45.76, -33.99 -100.01, -55.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7467 None None None XRAY 2.5 0.246 0.288 C 450.0 438.0 7 25 18 7 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AD P32577 6 450 450.0 No_ligand No_ligand Inactive DFGin 6.5403 15.677 BLAminus -141.77, -160.29 58.4, 68.03 -94.47, 17.88 302.46, 106.04 -51.33, -46.11 in-out in 9.4163 Saltbr-out 7.6391 HRD-out -100.52, 90.27 -71.04, 28.05 out-in-out SNCoio in-out ActLoopNT-in 2.885 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.48 APE8-dihe-in -68.73, 155.34 APE8-rot-na 333.53 APE67-dihe-in -50.19, -22.42 -116.25, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.694 None None None XRAY 2.5 0.246 0.288 D 450.0 433.0 5 25 20 5 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AA P32577 6 450 450.0 No_ligand No_ligand None DFGin 7.0246 13.1182 BLAminus -139.67, -167.82 53.56, 74.8 -92.76, 23.85 306.26, 90.9 -52.74, -52.0 in-in in 8.2615 Saltbr-in 2.5428 HRD-in -75.98, -39.34 59.35, 3.94 in-in-none SNCiin in-none ActLoopNT-in 2.9044 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 146.13 APE9-dihe-in -90.54, 133.78 APE8-dihe-in -64.01, 107.63 APE8-rot-na 30.9 APE67-dihe-in -66.63, -13.65 -46.3, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.8965 APE9-dist-in 4.9458 None None None XRAY 2.5 0.246 0.288 A 450.0 439.0 6 25 19 6 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AE P32577 6 450 450.0 No_ligand No_ligand None DFGin 7.0922 13.2581 BLAminus -146.71, -160.87 54.34, 70.46 -91.62, 10.82 305.62, 97.99 -48.96, -34.07 in-in in 8.2888 Saltbr-in 2.883 HRD-in -65.92, -42.65 69.57, -7.6 in-in-none SNCiin in-none ActLoopNT-in 2.7462 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -24.03 APE8-dihe-in -56.09, 81.03 APE8-rot-na 329.53 APE67-dihe-in -74.61, -12.37 -42.29, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.4486 None None None XRAY 2.5 0.246 0.288 E 450.0 440.0 5 25 20 5 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CSK CSK_RAT 1K9AF P32577 6 450 450.0 No_ligand No_ligand None DFGin 6.9744 13.0235 BLAminus -148.25, -167.92 53.96, 74.84 -98.55, 12.15 314.23, 95.66 -46.18, -47.42 in-in in 9.2919 Saltbr-in 3.3527 HRD-in -62.43, -56.65 81.59, -9.03 in-in-none SNCiin in-none ActLoopNT-in 2.9639 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -158.7 APE8-rot-na 325.52 APE67-dihe-in -74.12, -11.41 -136.71, -76.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.246 0.288 F 450.0 436.0 9 25 16 9 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 7.8e-87 297.0 1.0 260.0 260.0 331 332 333 335 337 222 236 240 311 313 312 314.0 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK