CMGC_CDK6 (Cyclin-dependent kinase 6)

Total number of chains: 26
Active chains: 2
Uniprot: CDK6_HUMAN
Kinase Domain Residues: 13 - 300
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 14 53.8% 1BLXA
DFGin BLAminus 7 26.9% AF-Q00534-K1A
None None 3 11.5% 1BI7A
DFGout BBAminus 2 7.7% 1G3NA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q00534-K1A 5 308 326.0 No_ligand No_ligand Active DFGin 6.771 14.728 BLAminus -140.24, 177.31 56.04, 67.41 -80.05, 15.55 284.76, 75.76 -58.04, -32.13 in-in in 8.81 Saltbr-in 2.787 HRD-in -73.88, -44.42 61.53, 16.75 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, 164.12 APE9-dihe-na 61.54, 132.8 APE8-dihe-in -56.24, 134.15 APE8-rot-in 300.06 APE67-dihe-in -67.13, -21.01 -45.92, -44.13 APE12-dist-in 13.244 APE11-dist-in 10.621 APE10-dist-in 6.758 APE9-dist-in 3.334 None None None AF2 -1.0 1.0 1.0 A 304 304 0 0 0 0 [[13, 300]] 1.0 AF-Q00534-K1 CMGC_CDK6_HUMAN CMGC 1.7e-84 290.6 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
AF-Q00534-K3A 5 308 326.0 No_ligand No_ligand Active DFGin 6.755 14.052 BLAminus -141.13, 174.77 58.35, 68.06 -75.37, 12.32 290.73, 88.15 -57.5, -32.61 in-in in 8.889 Saltbr-in 2.688 HRD-in -75.96, -47.08 64.65, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.24, 160.42 APE9-dihe-na 65.22, 133.26 APE8-dihe-in -54.75, 128.92 APE8-rot-in 300.67 APE67-dihe-in -65.95, -20.43 -44.18, -45.38 APE12-dist-in 12.925 APE11-dist-in 10.403 APE10-dist-in 6.739 APE9-dist-in 3.382 None None None AF2 -1.0 1.0 1.0 A 304 304 0 0 0 0 [[13, 300]] 1.0 AF-Q00534-K3 CMGC_CDK6_HUMAN CMGC 1.7e-84 290.6 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1JOWB 10 300 326.0 No_ligand No_ligand Inactive DFGin 6.727 15.023 BLAminus -143.17, -174.86 45.68, 74.32 -84.53, 6.74 272.41, 93.29 -67.4, 30.79 in-in in 9.242 Saltbr-in 2.978 HRD-out -82.73, 103.96 -82.7, 19.42 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.92, 134.37 APE9-dihe-na 72.23, 143.48 APE8-dihe-in -63.4, 126.62 APE8-rot-in 304.06 APE67-dihe-in -56.36, -50.19 -5.31, -62.69 APE12-dist-in 13.6 APE11-dist-in 10.037 APE10-dist-in 7.838 APE9-dist-in 3.613 None None None XRAY 3.1 0.266 0.323 B 308 277 14 0 0 0 [[13, 300]] 1.0 1jow CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1XO2B 11 305 326.0 FSE:309 Type1 Inactive DFGin 6.502 14.702 BLAminus -132.98, 172.02 59.21, 74.76 -88.91, 20.55 283.32, 68.44 -44.15, -35.3 in-in in 8.743 Saltbr-in 3.061 HRD-out -85.07, 78.58 -67.33, 22.2 in-in-out SNCiio in-out ActLoopNT-in 3.338 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiii APE10-dihe-na 164.8, 150.39 APE9-dihe-na 92.32, 88.21 APE8-dihe-out 8.61, -70.63 APE8-rot-in 284.27 APE67-dihe-out -64.29, 1.58 166.09, -58.48 APE12-dist-in 13.616 APE11-dist-in 10.571 APE10-dist-in 6.341 APE9-dist-in 4.041 None None None XRAY 2.9 0.26 0.313 B 308 289 6 0 0 0 [[13, 300]] 1.0 1xo2 CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
2EUFB 10 305 326.0 LQQ:401 Type1 Inactive DFGin 6.742 15.113 BLAminus -125.92, -175.17 38.68, 92.34 -97.81, 21.98 278.38, 80.53 -77.62, -1.18 in-in in 9.256 Saltbr-in 2.949 HRD-out -101.19, 86.94 -86.95, 32.9 in-in-in SNCiii in-in ActLoopNT-in 3.113 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.02, 158.17 APE9-dihe-na 54.99, 142.49 APE8-dihe-in -69.93, 155.33 APE8-rot-in 306.39 APE67-dihe-in -58.36, -34.39 -40.4, -57.67 APE12-dist-in 13.965 APE11-dist-in 10.682 APE10-dist-in 7.331 APE9-dist-in 3.405 None None None XRAY 3.0 0.233 0.306 B 308 282 14 0 0 0 [[13, 300]] 1.0 2euf CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
2F2CB 9 305 326.0 AP9:401 Type1 Inactive DFGin 6.893 15.405 BLAminus -127.17, -179.2 48.55, 92.44 -107.16, 18.48 275.51, 74.53 -71.78, 1.3 in-in in 9.396 Saltbr-in 3.162 HRD-out -79.29, 111.25 -106.02, 47.09 in-in-in SNCiii in-in ActLoopNT-in 3.21 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.64, 138.13 APE9-dihe-na 71.15, 144.6 APE8-dihe-in -64.15, 145.52 APE8-rot-in 323.67 APE67-dihe-in -51.16, -25.63 -52.09, -42.38 APE12-dist-in 13.856 APE11-dist-in 10.198 APE10-dist-in 7.274 APE9-dist-in 3.821 None None None XRAY 2.8 0.241 0.301 B 308 280 17 0 0 0 [[13, 300]] 1.0 2f2c CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
4TTHB 15 304 326.0 24V:401 Type1 Inactive DFGin 7.053 14.854 BLAminus -136.81, 177.52 52.47, 95.63 -109.58, 39.77 286.15, 91.76 -71.8, -40.79 in-in in 9.129 Saltbr-in 2.789 HRD-out -102.39, 94.9 -104.34, 68.83 in-in-in SNCiii in-in ActLoopNT-in 3.252 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.29, 152.64 APE9-dihe-na 67.44, 140.58 APE8-dihe-in -63.98, 151.04 APE8-rot-in 319.37 APE67-dihe-in -73.24, -23.99 -38.29, -46.84 APE12-dist-in 12.826 APE11-dist-in 9.491 APE10-dist-in 6.216 APE9-dist-in 4.144 None None None XRAY 2.9 0.24 0.337 B 326 256 36 0 0 0 [[13, 300]] 1.0 4tth CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1BLXA 5 309 326.0 No_ligand No_ligand Inactive DFGin 6.935 13.415 BLBplus -139.23, 165.84 68.87, 48.15 -131.52, 168.28 58.33, 85.97 101.68, -5.37 out-out out 12.255 Saltbr-out 12.131 HRD-in -72.33, -60.4 83.55, -18.06 out-out-out SNCooo out-out ActLoopNT-out 9.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -102.91, 106.37 APE9-dihe-na -91.13, 130.29 APE8-dihe-in -87.97, 125.58 APE8-rot-in 300.99 APE67-dihe-in -64.51, -23.63 -104.72, 5.04 APE12-dist-out 17.591 APE11-dist-out 20.784 APE10-dist-out 21.398 APE9-dist-out 11.198 None None None XRAY 1.9 0.2 0.253 A 326 305 0 0 0 0 [[13, 300]] 1.0 1blx CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
6OQLA 11 301 326.0 N1A:4000 Type1 Inactive DFGin 7.186 13.556 BLBplus -142.57, 172.64 61.61, 62.34 -148.67, 166.91 54.06, 85.4 70.04, 10.58 out-out out 13.089 Saltbr-out 10.816 HRD-in -65.94, -47.43 77.13, -10.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 129.84 APE8-dihe-in -122.53, 117.07 APE8-rot-in 280.27 APE67-dihe-in -66.18, -14.51 -90.0, 2.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.551 None None None XRAY 2.707 0.206 0.253 A 291 263 28 0 0 13 [[13, 300]] 1.0 6oql CMGC_CDK6_HUMAN CMGC 1.5e-84 290.9 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
6OQOA 11 301 326.0 N1J:401 Type1 Inactive DFGin 7.003 13.335 BLBplus -144.38, 168.34 59.02, 67.74 -149.9, 163.53 61.12, 90.35 80.35, -5.76 out-out out 13.043 Saltbr-out 10.562 HRD-in -67.24, -41.13 65.21, -8.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.71 APE8-dihe-in -99.71, 122.4 APE8-rot-in 274.77 APE67-dihe-in -67.83, -16.91 -97.69, 6.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.683 None None None XRAY 1.977 0.218 0.264 A 291 269 22 0 0 13 [[13, 300]] 1.0 6oqo CMGC_CDK6_HUMAN CMGC 1.5e-84 290.9 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
8I0MA 11 301 326.0 NJ6:401 Type1 Inactive DFGin 6.558 13.702 BLBplus -148.9, 164.2 63.1, 60.43 -141.6, 158.36 69.2, 85.06 87.02, -3.21 out-none out 12.038 Saltbr-none 999.0 HRD-in -57.52, -54.36 79.68, -19.79 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -65.96 APE8-dihe-in -92.33, 118.65 APE8-rot-in 304.47 APE67-dihe-in -71.06, -15.04 -105.38, 8.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.235 None None None XRAY 2.777 0.207 0.282 A 301 260 31 0 0 13 [[13, 300]] 1.0 8i0m CMGC_CDK6_HUMAN CMGC 1.7e-84 290.7 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
3NUPA 12 300 326.0 3NU:900 Type1 Inactive DFGin 6.783 13.356 BLBplus -142.88, 177.12 54.87, 45.68 -131.6, 163.83 59.77, 81.52 87.55, 4.0 out-out out 12.506 Saltbr-out 9.799 HRD-in -60.43, -51.93 89.02, -45.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.75 APE8-dihe-in -107.13, 133.85 APE8-rot-out 84.72 APE67-dihe-in -63.04, -10.35 -104.49, 6.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.996 None None None XRAY 2.6 0.238 0.264 A 307 252 37 0 0 14 [[13, 300]] 1.0 3nup CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
3NUXA 10 301 326.0 3NV:900 Type1 Inactive DFGin 6.873 13.292 BLBplus -143.89, 171.54 63.4, 54.63 -144.8, 172.65 57.86, 82.79 76.25, 2.65 out-out out 12.353 Saltbr-out 9.913 HRD-in -49.51, -54.71 79.15, -21.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.28 APE8-dihe-in -130.53, 110.3 APE8-rot-in 288.09 APE67-dihe-in -53.29, -19.42 -91.07, -4.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.052 None None None XRAY 2.7 0.243 0.266 A 307 261 31 0 0 13 [[13, 300]] 1.0 3nux CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
4AUAA 11 301 326.0 4AU:1302 Type1 Inactive DFGin 7.032 13.256 BLBplus -130.01, 167.95 69.37, 42.19 -121.21, 161.4 53.47, 84.48 72.88, 23.3 out-out out 12.041 Saltbr-out 9.037 HRD-in -66.37, -55.39 77.48, -16.23 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.55 APE8-rot-in 292.07 APE67-dihe-in -65.6, -16.73 -101.32, 6.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.21 0.277 A 307 256 35 0 0 14 [[13, 300]] 1.0 4aua CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
4EZ5A 11 301 326.0 0RS:900 Type1 Inactive DFGin 7.052 13.627 BLBplus -119.91, 171.33 64.54, 57.96 -141.61, 162.82 58.38, 88.35 70.11, 18.02 out-out out 12.624 Saltbr-out 8.57 HRD-in -57.54, -53.72 81.36, -19.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.66 APE8-dihe-in -129.19, 112.89 APE8-rot-in 283.8 APE67-dihe-in -69.75, -12.17 -102.86, 6.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.763 None None None XRAY 2.7 0.22 0.287 A 307 258 33 0 0 13 [[13, 300]] 1.0 4ez5 CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
5L2IA 10 301 326.0 LQQ:900 Type1 Inactive DFGin 7.412 14.457 BLBplus -139.28, -177.12 58.29, 50.79 -135.47, 155.77 57.98, 89.15 79.14, 67.19 out-out out 13.948 Saltbr-out 9.625 HRD-in -64.06, -51.87 80.46, -27.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.65 APE8-dihe-in -110.64, 110.6 APE8-rot-in 294.84 APE67-dihe-in -51.14, -31.66 -93.52, -5.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.223 None None None XRAY 2.75 0.235 0.304 A 307 260 32 0 0 14 [[13, 300]] 1.0 5l2i CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
5L2SA 11 301 326.0 6ZV:900 Type1 Inactive DFGin 7.034 13.147 BLBplus -129.61, 174.4 56.46, 62.44 -144.49, 164.8 59.63, 81.23 77.19, 4.3 out-out out 12.729 Saltbr-out 9.879 HRD-in -65.53, -55.45 76.08, -19.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.73 APE8-dihe-in -85.78, 132.38 APE8-rot-in 274.16 APE67-dihe-in -62.41, -20.14 -109.4, 6.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.637 None None None XRAY 2.27 0.209 0.249 A 307 263 28 0 0 13 [[13, 300]] 1.0 5l2s CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
5L2TA 11 301 326.0 6ZZ:900 Type1 Inactive DFGin 6.739 13.945 BLBplus -139.16, 167.76 59.19, 51.95 -133.32, 167.21 60.46, 88.9 69.38, 20.92 out-out out 12.558 Saltbr-out 10.803 HRD-in -61.15, -57.88 81.24, -15.91 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.88 APE8-dihe-in -124.55, 125.45 APE8-rot-in 275.24 APE67-dihe-in -59.03, -24.86 -106.3, 7.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.697 None None None XRAY 2.37 0.215 0.258 A 307 261 30 0 0 13 [[13, 300]] 1.0 5l2t CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
9D8UA 11 301 326.0 A1AZ4:401 Type1 Inactive DFGin 7.179 13.555 BLBplus -137.97, 167.41 62.6, 56.18 -147.49, 166.64 58.07, 71.65 87.08, -0.38 out-out out 12.245 Saltbr-out 10.337 HRD-in -63.4, -56.01 80.72, -17.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.47 APE8-dihe-in -133.17, 114.19 APE8-rot-in 282.35 APE67-dihe-in -60.0, -21.77 -100.35, 6.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.724 None None None XRAY 2.0 0.219 0.253 A 307 263 28 0 0 13 [[13, 300]] 1.0 9d8u CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
9PE7A 10 301 326.0 A1CIF:900 Type1 Inactive DFGin 6.872 13.127 BLBplus -137.4, 169.29 57.4, 61.63 -142.77, 164.35 61.09, 86.59 91.92, -16.71 out-out out 12.416 Saltbr-out 9.93 HRD-in -63.73, -52.58 73.19, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 162.46 APE9-dihe-na -100.9, 174.34 APE8-dihe-in -134.69, 96.5 APE8-rot-in 306.93 APE67-dihe-in -54.43, -27.6 -93.0, -5.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.373 APE9-dist-out 12.123 E21V,K26T,T106R,Q149E None None XRAY 2.05 0.216 0.267 A 307 262 30 0 0 12 [[13, 300]] 1.0 9pe7 CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
9PE8A 10 301 326.0 A1AZ4:900 Type1 Inactive DFGin 6.899 13.659 BLBplus -142.58, 169.73 58.15, 57.43 -142.05, 162.94 60.73, 87.1 90.15, -1.28 out-out out 12.52 Saltbr-out 10.538 HRD-in -63.72, -53.62 75.1, -13.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -96.93, 99.74 APE9-dihe-na -63.53, -36.01 APE8-dihe-out -46.15, -45.04 APE8-rot-in 290.86 APE67-dihe-in -62.06, -18.22 -50.05, -43.62 APE12-dist-none 999.0 APE11-dist-out 22.605 APE10-dist-out 18.244 APE9-dist-out 11.069 E21V,K26T,T106R,Q149E None None XRAY 1.8 0.226 0.252 A 307 267 25 0 0 11 [[13, 300]] 1.0 9pe8 CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1G3NA 9 301 326.0 No_ligand No_ligand Inactive DFGout 14.675 9.892 BBAminus -115.48, -176.08 -168.57, 74.07 -76.02, -16.59 307.15, 93.49 72.37, 14.12 out-out out 10.661 Saltbr-out 9.156 HRD-in -69.86, -49.14 66.22, -4.18 out-out-out SNCooo out-out ActLoopNT-out 17.861 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -94.25, 121.42 APE9-dihe-na -44.98, -30.35 APE8-dihe-out -56.59, -32.65 APE8-rot-out 195.22 APE67-dihe-in -65.39, -8.25 -48.23, -36.14 APE12-dist-out 15.541 APE11-dist-out 14.228 APE10-dist-out 9.401 APE9-dist-out 11.423 None None None XRAY 2.9 0.242 0.262 A 326 293 0 0 0 0 [[13, 300]] 1.0 1g3n CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1G3NE 9 301 326.0 No_ligand No_ligand Inactive DFGout 14.573 9.874 BBAminus -121.76, -170.59 -172.45, 69.19 -70.15, -21.22 308.9, 94.69 77.16, 17.44 out-out out 10.733 Saltbr-out 9.134 HRD-in -74.97, -52.72 72.24, -5.97 out-out-out SNCooo out-out ActLoopNT-out 17.927 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -97.51, 117.17 APE9-dihe-na -42.0, -32.22 APE8-dihe-out -56.92, -29.46 APE8-rot-out 199.83 APE67-dihe-in -62.83, -3.26 -50.13, -41.56 APE12-dist-out 15.537 APE11-dist-out 14.158 APE10-dist-out 9.35 APE9-dist-out 11.369 None None None XRAY 2.9 0.242 0.262 E 326 293 0 0 0 0 [[13, 300]] 1.0 1g3n CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1BI7A 10 301 326.0 No_ligand No_ligand Inactive None 999.0 9.758 None -170.1, 162.69 -136.18, 134.84 -117.93, -15.33 297.22, 134.92 61.04, -10.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -58.88, -42.03 63.16, -46.96 none-out-out SNCnoo out-out ActLoopNT-out 17.63 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na 179.73, 155.05 APE9-dihe-na -105.22, 41.81 APE8-dihe-out 41.63, 88.32 APE8-rot-out 46.51 APE67-dihe-in -64.37, -21.64 -120.99, 23.38 APE12-dist-out 19.821 APE11-dist-out 15.332 APE10-dist-out 14.107 APE9-dist-out 12.359 None None None XRAY 3.4 0.227 0.33 A 326 269 23 0 0 0 [[13, 300]] 1.0 1bi7 CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1BI8A 11 301 326.0 No_ligand No_ligand Inactive None 999.0 10.219 None -147.23, -176.7 -161.05, 88.19 -92.41, -13.56 315.57, 75.06 62.33, 29.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.61, -46.68 64.66, -14.96 none-out-out SNCnoo out-out ActLoopNT-out 18.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -154.93, 142.33 APE9-dihe-na -92.29, 151.53 APE8-dihe-in -79.87, 102.71 APE8-rot-out 127.41 APE67-dihe-in -60.55, -8.52 -110.27, 4.64 APE12-dist-out 20.28 APE11-dist-out 15.093 APE10-dist-out 14.662 APE9-dist-out 12.873 None None None XRAY 2.8 0.255 0.308 A 326 264 27 0 0 0 [[13, 300]] 1.0 1bi8 CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
1BI8C 11 301 326.0 No_ligand No_ligand Inactive None 999.0 10.219 None -147.19, -176.7 -161.05, 88.21 -92.44, -13.54 315.59, 75.04 62.3, 29.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.64, -46.66 64.63, -14.95 none-out-out SNCnoo out-out ActLoopNT-out 18.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -154.92, 142.33 APE9-dihe-na -92.31, 151.47 APE8-dihe-in -79.81, 102.66 APE8-rot-out 127.46 APE67-dihe-in -60.5, -8.58 -110.27, 4.6 APE12-dist-out 20.281 APE11-dist-out 15.093 APE10-dist-out 14.662 APE9-dist-out 12.873 None None None XRAY 2.8 0.255 0.308 C 326 264 27 0 0 0 [[13, 300]] 1.0 1bi8 CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6

CMGC_CDK6 (Cyclin-dependent kinase 6)

Total number of chains: 26
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 14 53.8% 1BLXA
DFGin BLAminus 7 26.9% AF-Q00534-K1A
None None 3 11.5% 1BI7A
DFGout BBAminus 2 7.7% 1G3NA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK6_HUMAN AF-Q00534-K1A Q00534 5 308 326.0 No_ligand No_ligand Active DFGin 6.771 14.728 BLAminus -140.24, 177.31 56.04, 67.41 -80.05, 15.55 284.76, 75.76 -58.04, -32.13 in-in in 8.81 Saltbr-in 2.787 HRD-in -73.88, -44.42 61.53, 16.75 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.17, 164.12 APE9-dihe-na 61.54, 132.8 APE8-dihe-in -56.24, 134.15 APE8-rot-in 300.06 APE67-dihe-in -67.13, -21.01 -45.92, -44.13 APE12-dist-in 13.244 APE11-dist-in 10.621 APE10-dist-in 6.758 APE9-dist-in 3.334 None None None AF2 -1.0 1.0 1.0 A 304 304 0 0 0 0 [[13, 300]] 1.0 AF-Q00534-K1 Homo sapiens CMGC_CDK6_HUMAN CMGC 1.7e-84 290.6 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN AF-Q00534-K3A Q00534 5 308 326.0 No_ligand No_ligand Active DFGin 6.755 14.052 BLAminus -141.13, 174.77 58.35, 68.06 -75.37, 12.32 290.73, 88.15 -57.5, -32.61 in-in in 8.889 Saltbr-in 2.688 HRD-in -75.96, -47.08 64.65, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.24, 160.42 APE9-dihe-na 65.22, 133.26 APE8-dihe-in -54.75, 128.92 APE8-rot-in 300.67 APE67-dihe-in -65.95, -20.43 -44.18, -45.38 APE12-dist-in 12.925 APE11-dist-in 10.403 APE10-dist-in 6.739 APE9-dist-in 3.382 None None None AF2 -1.0 1.0 1.0 A 304 304 0 0 0 0 [[13, 300]] 1.0 AF-Q00534-K3 Homo sapiens CMGC_CDK6_HUMAN CMGC 1.7e-84 290.6 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1JOWB Q00534 10 300 326.0 No_ligand No_ligand Inactive DFGin 6.727 15.023 BLAminus -143.17, -174.86 45.68, 74.32 -84.53, 6.74 272.41, 93.29 -67.4, 30.79 in-in in 9.242 Saltbr-in 2.978 HRD-out -82.73, 103.96 -82.7, 19.42 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.92, 134.37 APE9-dihe-na 72.23, 143.48 APE8-dihe-in -63.4, 126.62 APE8-rot-in 304.06 APE67-dihe-in -56.36, -50.19 -5.31, -62.69 APE12-dist-in 13.6 APE11-dist-in 10.037 APE10-dist-in 7.838 APE9-dist-in 3.613 None None None XRAY 3.1 0.266 0.323 B 308 277 14 0 0 0 [[13, 300]] 1.0 1jow Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1XO2B Q00534 11 305 326.0 FSE:309 Type1 Inactive DFGin 6.502 14.702 BLAminus -132.98, 172.02 59.21, 74.76 -88.91, 20.55 283.32, 68.44 -44.15, -35.3 in-in in 8.743 Saltbr-in 3.061 HRD-out -85.07, 78.58 -67.33, 22.2 in-in-out SNCiio in-out ActLoopNT-in 3.338 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iiii APE10-dihe-na 164.8, 150.39 APE9-dihe-na 92.32, 88.21 APE8-dihe-out 8.61, -70.63 APE8-rot-in 284.27 APE67-dihe-out -64.29, 1.58 166.09, -58.48 APE12-dist-in 13.616 APE11-dist-in 10.571 APE10-dist-in 6.341 APE9-dist-in 4.041 None None None XRAY 2.9 0.26 0.313 B 308 289 6 0 0 0 [[13, 300]] 1.0 1xo2 Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 2EUFB Q00534 10 305 326.0 LQQ:401 Type1 Inactive DFGin 6.742 15.113 BLAminus -125.92, -175.17 38.68, 92.34 -97.81, 21.98 278.38, 80.53 -77.62, -1.18 in-in in 9.256 Saltbr-in 2.949 HRD-out -101.19, 86.94 -86.95, 32.9 in-in-in SNCiii in-in ActLoopNT-in 3.113 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.02, 158.17 APE9-dihe-na 54.99, 142.49 APE8-dihe-in -69.93, 155.33 APE8-rot-in 306.39 APE67-dihe-in -58.36, -34.39 -40.4, -57.67 APE12-dist-in 13.965 APE11-dist-in 10.682 APE10-dist-in 7.331 APE9-dist-in 3.405 None None None XRAY 3.0 0.233 0.306 B 308 282 14 0 0 0 [[13, 300]] 1.0 2euf Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 2F2CB Q00534 9 305 326.0 AP9:401 Type1 Inactive DFGin 6.893 15.405 BLAminus -127.17, -179.2 48.55, 92.44 -107.16, 18.48 275.51, 74.53 -71.78, 1.3 in-in in 9.396 Saltbr-in 3.162 HRD-out -79.29, 111.25 -106.02, 47.09 in-in-in SNCiii in-in ActLoopNT-in 3.21 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.64, 138.13 APE9-dihe-na 71.15, 144.6 APE8-dihe-in -64.15, 145.52 APE8-rot-in 323.67 APE67-dihe-in -51.16, -25.63 -52.09, -42.38 APE12-dist-in 13.856 APE11-dist-in 10.198 APE10-dist-in 7.274 APE9-dist-in 3.821 None None None XRAY 2.8 0.241 0.301 B 308 280 17 0 0 0 [[13, 300]] 1.0 2f2c Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 4TTHB Q00534 15 304 326.0 24V:401 Type1 Inactive DFGin 7.053 14.854 BLAminus -136.81, 177.52 52.47, 95.63 -109.58, 39.77 286.15, 91.76 -71.8, -40.79 in-in in 9.129 Saltbr-in 2.789 HRD-out -102.39, 94.9 -104.34, 68.83 in-in-in SNCiii in-in ActLoopNT-in 3.252 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.29, 152.64 APE9-dihe-na 67.44, 140.58 APE8-dihe-in -63.98, 151.04 APE8-rot-in 319.37 APE67-dihe-in -73.24, -23.99 -38.29, -46.84 APE12-dist-in 12.826 APE11-dist-in 9.491 APE10-dist-in 6.216 APE9-dist-in 4.144 None None None XRAY 2.9 0.24 0.337 B 326 256 36 0 0 0 [[13, 300]] 1.0 4tth Homo sapiens CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1BLXA Q00534 5 309 326.0 No_ligand No_ligand Inactive DFGin 6.935 13.415 BLBplus -139.23, 165.84 68.87, 48.15 -131.52, 168.28 58.33, 85.97 101.68, -5.37 out-out out 12.255 Saltbr-out 12.131 HRD-in -72.33, -60.4 83.55, -18.06 out-out-out SNCooo out-out ActLoopNT-out 9.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -102.91, 106.37 APE9-dihe-na -91.13, 130.29 APE8-dihe-in -87.97, 125.58 APE8-rot-in 300.99 APE67-dihe-in -64.51, -23.63 -104.72, 5.04 APE12-dist-out 17.591 APE11-dist-out 20.784 APE10-dist-out 21.398 APE9-dist-out 11.198 None None None XRAY 1.9 0.2 0.253 A 326 305 0 0 0 0 [[13, 300]] 1.0 1blx Homo sapiens CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 6OQLA Q00534 11 301 326.0 N1A:4000 Type1 Inactive DFGin 7.186 13.556 BLBplus -142.57, 172.64 61.61, 62.34 -148.67, 166.91 54.06, 85.4 70.04, 10.58 out-out out 13.089 Saltbr-out 10.816 HRD-in -65.94, -47.43 77.13, -10.28 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 129.84 APE8-dihe-in -122.53, 117.07 APE8-rot-in 280.27 APE67-dihe-in -66.18, -14.51 -90.0, 2.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.551 None None None XRAY 2.707 0.206 0.253 A 291 263 28 0 0 13 [[13, 300]] 1.0 6oql Homo sapiens CMGC_CDK6_HUMAN CMGC 1.5e-84 290.9 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 6OQOA Q00534 11 301 326.0 N1J:401 Type1 Inactive DFGin 7.003 13.335 BLBplus -144.38, 168.34 59.02, 67.74 -149.9, 163.53 61.12, 90.35 80.35, -5.76 out-out out 13.043 Saltbr-out 10.562 HRD-in -67.24, -41.13 65.21, -8.04 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 127.71 APE8-dihe-in -99.71, 122.4 APE8-rot-in 274.77 APE67-dihe-in -67.83, -16.91 -97.69, 6.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.683 None None None XRAY 1.977 0.218 0.264 A 291 269 22 0 0 13 [[13, 300]] 1.0 6oqo Homo sapiens CMGC_CDK6_HUMAN CMGC 1.5e-84 290.9 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 8I0MA Q00534 11 301 326.0 NJ6:401 Type1 Inactive DFGin 6.558 13.702 BLBplus -148.9, 164.2 63.1, 60.43 -141.6, 158.36 69.2, 85.06 87.02, -3.21 out-none out 12.038 Saltbr-none 999.0 HRD-in -57.52, -54.36 79.68, -19.79 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -65.96 APE8-dihe-in -92.33, 118.65 APE8-rot-in 304.47 APE67-dihe-in -71.06, -15.04 -105.38, 8.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.235 None None None XRAY 2.777 0.207 0.282 A 301 260 31 0 0 13 [[13, 300]] 1.0 8i0m Homo sapiens CMGC_CDK6_HUMAN CMGC 1.7e-84 290.7 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 3NUPA Q00534 12 300 326.0 3NU:900 Type1 Inactive DFGin 6.783 13.356 BLBplus -142.88, 177.12 54.87, 45.68 -131.6, 163.83 59.77, 81.52 87.55, 4.0 out-out out 12.506 Saltbr-out 9.799 HRD-in -60.43, -51.93 89.02, -45.83 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.75 APE8-dihe-in -107.13, 133.85 APE8-rot-out 84.72 APE67-dihe-in -63.04, -10.35 -104.49, 6.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.996 None None None XRAY 2.6 0.238 0.264 A 307 252 37 0 0 14 [[13, 300]] 1.0 3nup Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 3NUXA Q00534 10 301 326.0 3NV:900 Type1 Inactive DFGin 6.873 13.292 BLBplus -143.89, 171.54 63.4, 54.63 -144.8, 172.65 57.86, 82.79 76.25, 2.65 out-out out 12.353 Saltbr-out 9.913 HRD-in -49.51, -54.71 79.15, -21.0 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -52.28 APE8-dihe-in -130.53, 110.3 APE8-rot-in 288.09 APE67-dihe-in -53.29, -19.42 -91.07, -4.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.052 None None None XRAY 2.7 0.243 0.266 A 307 261 31 0 0 13 [[13, 300]] 1.0 3nux Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 4AUAA Q00534 11 301 326.0 4AU:1302 Type1 Inactive DFGin 7.032 13.256 BLBplus -130.01, 167.95 69.37, 42.19 -121.21, 161.4 53.47, 84.48 72.88, 23.3 out-out out 12.041 Saltbr-out 9.037 HRD-in -66.37, -55.39 77.48, -16.23 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.55 APE8-rot-in 292.07 APE67-dihe-in -65.6, -16.73 -101.32, 6.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.21 0.277 A 307 256 35 0 0 14 [[13, 300]] 1.0 4aua Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 4EZ5A Q00534 11 301 326.0 0RS:900 Type1 Inactive DFGin 7.052 13.627 BLBplus -119.91, 171.33 64.54, 57.96 -141.61, 162.82 58.38, 88.35 70.11, 18.02 out-out out 12.624 Saltbr-out 8.57 HRD-in -57.54, -53.72 81.36, -19.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -53.66 APE8-dihe-in -129.19, 112.89 APE8-rot-in 283.8 APE67-dihe-in -69.75, -12.17 -102.86, 6.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.763 None None None XRAY 2.7 0.22 0.287 A 307 258 33 0 0 13 [[13, 300]] 1.0 4ez5 Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 5L2IA Q00534 10 301 326.0 LQQ:900 Type1 Inactive DFGin 7.412 14.457 BLBplus -139.28, -177.12 58.29, 50.79 -135.47, 155.77 57.98, 89.15 79.14, 67.19 out-out out 13.948 Saltbr-out 9.625 HRD-in -64.06, -51.87 80.46, -27.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.65 APE8-dihe-in -110.64, 110.6 APE8-rot-in 294.84 APE67-dihe-in -51.14, -31.66 -93.52, -5.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.223 None None None XRAY 2.75 0.235 0.304 A 307 260 32 0 0 14 [[13, 300]] 1.0 5l2i Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 5L2SA Q00534 11 301 326.0 6ZV:900 Type1 Inactive DFGin 7.034 13.147 BLBplus -129.61, 174.4 56.46, 62.44 -144.49, 164.8 59.63, 81.23 77.19, 4.3 out-out out 12.729 Saltbr-out 9.879 HRD-in -65.53, -55.45 76.08, -19.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.73 APE8-dihe-in -85.78, 132.38 APE8-rot-in 274.16 APE67-dihe-in -62.41, -20.14 -109.4, 6.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.637 None None None XRAY 2.27 0.209 0.249 A 307 263 28 0 0 13 [[13, 300]] 1.0 5l2s Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 5L2TA Q00534 11 301 326.0 6ZZ:900 Type1 Inactive DFGin 6.739 13.945 BLBplus -139.16, 167.76 59.19, 51.95 -133.32, 167.21 60.46, 88.9 69.38, 20.92 out-out out 12.558 Saltbr-out 10.803 HRD-in -61.15, -57.88 81.24, -15.91 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.88 APE8-dihe-in -124.55, 125.45 APE8-rot-in 275.24 APE67-dihe-in -59.03, -24.86 -106.3, 7.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.697 None None None XRAY 2.37 0.215 0.258 A 307 261 30 0 0 13 [[13, 300]] 1.0 5l2t Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 9D8UA Q00534 11 301 326.0 A1AZ4:401 Type1 Inactive DFGin 7.179 13.555 BLBplus -137.97, 167.41 62.6, 56.18 -147.49, 166.64 58.07, 71.65 87.08, -0.38 out-out out 12.245 Saltbr-out 10.337 HRD-in -63.4, -56.01 80.72, -17.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 138.47 APE8-dihe-in -133.17, 114.19 APE8-rot-in 282.35 APE67-dihe-in -60.0, -21.77 -100.35, 6.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.724 None None None XRAY 2.0 0.219 0.253 A 307 263 28 0 0 13 [[13, 300]] 1.0 9d8u Homo sapiens CMGC_CDK6_HUMAN CMGC 1.8e-84 290.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 9PE7A Q00534 10 301 326.0 A1CIF:900 Type1 Inactive DFGin 6.872 13.127 BLBplus -137.4, 169.29 57.4, 61.63 -142.77, 164.35 61.09, 86.59 91.92, -16.71 out-out out 12.416 Saltbr-out 9.93 HRD-in -63.73, -52.58 73.19, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 162.46 APE9-dihe-na -100.9, 174.34 APE8-dihe-in -134.69, 96.5 APE8-rot-in 306.93 APE67-dihe-in -54.43, -27.6 -93.0, -5.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.373 APE9-dist-out 12.123 E21V,K26T,T106R,Q149E None None XRAY 2.05 0.216 0.267 A 307 262 30 0 0 12 [[13, 300]] 1.0 9pe7 Homo sapiens CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 9PE8A Q00534 10 301 326.0 A1AZ4:900 Type1 Inactive DFGin 6.899 13.659 BLBplus -142.58, 169.73 58.15, 57.43 -142.05, 162.94 60.73, 87.1 90.15, -1.28 out-out out 12.52 Saltbr-out 10.538 HRD-in -63.72, -53.62 75.1, -13.85 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -96.93, 99.74 APE9-dihe-na -63.53, -36.01 APE8-dihe-out -46.15, -45.04 APE8-rot-in 290.86 APE67-dihe-in -62.06, -18.22 -50.05, -43.62 APE12-dist-none 999.0 APE11-dist-out 22.605 APE10-dist-out 18.244 APE9-dist-out 11.069 E21V,K26T,T106R,Q149E None None XRAY 1.8 0.226 0.252 A 307 267 25 0 0 11 [[13, 300]] 1.0 9pe8 Homo sapiens CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1G3NA Q00534 9 301 326.0 No_ligand No_ligand Inactive DFGout 14.675 9.892 BBAminus -115.48, -176.08 -168.57, 74.07 -76.02, -16.59 307.15, 93.49 72.37, 14.12 out-out out 10.661 Saltbr-out 9.156 HRD-in -69.86, -49.14 66.22, -4.18 out-out-out SNCooo out-out ActLoopNT-out 17.861 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -94.25, 121.42 APE9-dihe-na -44.98, -30.35 APE8-dihe-out -56.59, -32.65 APE8-rot-out 195.22 APE67-dihe-in -65.39, -8.25 -48.23, -36.14 APE12-dist-out 15.541 APE11-dist-out 14.228 APE10-dist-out 9.401 APE9-dist-out 11.423 None None None XRAY 2.9 0.242 0.262 A 326 293 0 0 0 0 [[13, 300]] 1.0 1g3n Homo sapiens CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1G3NE Q00534 9 301 326.0 No_ligand No_ligand Inactive DFGout 14.573 9.874 BBAminus -121.76, -170.59 -172.45, 69.19 -70.15, -21.22 308.9, 94.69 77.16, 17.44 out-out out 10.733 Saltbr-out 9.134 HRD-in -74.97, -52.72 72.24, -5.97 out-out-out SNCooo out-out ActLoopNT-out 17.927 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -97.51, 117.17 APE9-dihe-na -42.0, -32.22 APE8-dihe-out -56.92, -29.46 APE8-rot-out 199.83 APE67-dihe-in -62.83, -3.26 -50.13, -41.56 APE12-dist-out 15.537 APE11-dist-out 14.158 APE10-dist-out 9.35 APE9-dist-out 11.369 None None None XRAY 2.9 0.242 0.262 E 326 293 0 0 0 0 [[13, 300]] 1.0 1g3n Homo sapiens CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1BI7A Q00534 10 301 326.0 No_ligand No_ligand Inactive None 999.0 9.758 None -170.1, 162.69 -136.18, 134.84 -117.93, -15.33 297.22, 134.92 61.04, -10.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -58.88, -42.03 63.16, -46.96 none-out-out SNCnoo out-out ActLoopNT-out 17.63 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na 179.73, 155.05 APE9-dihe-na -105.22, 41.81 APE8-dihe-out 41.63, 88.32 APE8-rot-out 46.51 APE67-dihe-in -64.37, -21.64 -120.99, 23.38 APE12-dist-out 19.821 APE11-dist-out 15.332 APE10-dist-out 14.107 APE9-dist-out 12.359 None None None XRAY 3.4 0.227 0.33 A 326 269 23 0 0 0 [[13, 300]] 1.0 1bi7 Homo sapiens CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1BI8A Q00534 11 301 326.0 No_ligand No_ligand Inactive None 999.0 10.219 None -147.23, -176.7 -161.05, 88.19 -92.41, -13.56 315.57, 75.06 62.33, 29.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.61, -46.68 64.66, -14.96 none-out-out SNCnoo out-out ActLoopNT-out 18.029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -154.93, 142.33 APE9-dihe-na -92.29, 151.53 APE8-dihe-in -79.87, 102.71 APE8-rot-out 127.41 APE67-dihe-in -60.55, -8.52 -110.27, 4.64 APE12-dist-out 20.28 APE11-dist-out 15.093 APE10-dist-out 14.662 APE9-dist-out 12.873 None None None XRAY 2.8 0.255 0.308 A 326 264 27 0 0 0 [[13, 300]] 1.0 1bi8 Homo sapiens CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CDK6_HUMAN 1BI8C Q00534 11 301 326.0 No_ligand No_ligand Inactive None 999.0 10.219 None -147.19, -176.7 -161.05, 88.21 -92.44, -13.54 315.59, 75.04 62.3, 29.42 none-none none 999.0 Saltbr-none 999.0 HRD-in -60.64, -46.66 64.63, -14.95 none-out-out SNCnoo out-out ActLoopNT-out 18.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -154.92, 142.33 APE9-dihe-na -92.31, 151.47 APE8-dihe-in -79.81, 102.66 APE8-rot-out 127.46 APE67-dihe-in -60.5, -8.58 -110.27, 4.6 APE12-dist-out 20.281 APE11-dist-out 15.093 APE10-dist-out 14.662 APE9-dist-out 12.873 None None None XRAY 2.8 0.255 0.308 C 326 264 27 0 0 0 [[13, 300]] 1.0 1bi8 Homo sapiens CMGC_CDK6_HUMAN CMGC 2.3e-84 290.2 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6

CMGC_CDK6 (Cyclin-dependent kinase 6)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name