CAMK_CAMKK2 (Calcium/calmodulin-dependent protein kinase kinase 2)

Total number of chains: 21
Active chains: 20
Uniprot: KKCC2_HUMAN
Kinase Domain Residues: 165 - 446
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 100.0% AF-Q96RR4-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-Q96RR4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
AF-Q96RR4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6CMJA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F6J Type1 161 - 463 0 SEP345,SEP400,TPO462 None Calcium/calmodulin-dependent protein kinase kinase 2
6CMJB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F6J Type1 161 - 462 0 SEP345,SEP400,TPO462 None Calcium/calmodulin-dependent protein kinase kinase 2
5UY6A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8R4 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
5UYJA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8R7 Type1 161 - 449 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
5VT1A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9JS Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6BKUA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DXV Type1 162 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6BLEA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34U Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6BQLA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI9 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6BQPA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6T2 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6BQQA 1.8 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii R78 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6BRCB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E5J Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
8TUCA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii O7I Type1 161 - 449 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
2ZV2A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 609 Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
5YV8A 1.927 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 91L Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
5YVAA 2.574 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 91X Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
5YVBA 2.02 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 92C Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
5YVCA 2.02 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SU6 Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
5YV9A 2.53 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 91O Type1.5_Back 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2
6BRCA 2.2 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii E5J Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2

CAMK_CAMKK2 (Calcium/calmodulin-dependent protein kinase kinase 2)

Total number of chains: 21
Active chains: 20
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 100.0% AF-Q96RR4-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KKCC2_HUMAN AF-Q96RR4-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN AF-Q96RR4-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 157 - 454 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6CMJA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F6J Type1 161 - 463 0 SEP345,SEP400,TPO462 None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6CMJB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F6J Type1 161 - 462 0 SEP345,SEP400,TPO462 None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5UY6A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8R4 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5UYJA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8R7 Type1 161 - 449 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5VT1A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9JS Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6BKUA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DXV Type1 162 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6BLEA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 34U Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6BQLA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI9 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6BQPA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6T2 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6BQQA 1.8 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii R78 Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6BRCB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E5J Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 8TUCA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii O7I Type1 161 - 449 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 2ZV2A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 609 Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5YV8A 1.927 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 91L Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5YVAA 2.574 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 91X Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5YVBA 2.02 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 92C Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5YVCA 2.02 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SU6 Type1 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 5YV9A 2.53 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 91O Type1.5_Back 160 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens
KKCC2_HUMAN 6BRCA 2.2 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii E5J Type1 161 - 448 0 None None Calcium/calmodulin-dependent protein kinase kinase 2 Homo sapiens

CAMK_CAMKK2 (Calcium/calmodulin-dependent protein kinase kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism