AlphaFold2 models of the active form of human typical protein kinase domains

A complete set of active models of all 437 catalytic human protein kinases constructed with AlphaFold2 (see readme file)

Download the tar.gz file here.

A complete set of active structures of 155 catalytic human protein kinases currently available in the PDB (see readme file)

Download the tar.gz file here.

Kincore_standalone2: Python3 code for calculating the conformational state of typical protein kinases. Calculates all the parameters for determining whether a kinase is active

Link to github here.

FASTA files of sequences used to model 437 human catalytic typical protein kinase domains with AlphaFold2

Download the tar.gz file here.

FASTA files of orthologs and close paralogs for all 437 human catalytic typical protein kinase domains

Download the tar.gz file here.

Preprint: AlphaFold2 models of the active form of all 437 catalytically-competent typical human kinase domains (available soon on bioRxiv)

Download the preprint here.

Slides from ISMB-3DSIG talk (July 25, 2023): Combining structural bioinformatics and deep-learning-based protein structure prediction: AlphaFold2 models of all 437 catalytically competent human kinases in the active form

Download the slides here.