8XU4

MAPKAPK2 (MAP kinase-activated protein kinase 2)
Group: CAMK
Uniprot: MAPK2_HUMAN
Organism: Homo sapiens
Domain boundary: 63 - 325
Resolu: 3.4

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 351 12
B Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 351 11
C Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 48 - 351 11
D Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 349 11
E Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 353 8
F Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 353 11
G Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 348 9
H Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 358 10
I Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 347 14
J Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 350 15
K Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 348 11
L Inactive DFGin ABAminus in-in in-none No_ligand No_ligand 47 - 354 13
Representative sequence - Chain L
56 66 76 86
HVKSGLQIKK NAIIDDYKVT SQVLglgiNG KVLQIFNKRT
96 106 116 126
QEKFALKMLQ DCPKARREVE LHWRASQCPH IVRIVDVYEN
136 146 156 166
LYAGRKCLLI VMECLDGGEL FSRIQdrgdq aFTEREASEI
176 186 196 206
MKSIGEAIQY LHSINIAHRD VKPENLLYTS KRPNAILKLT
216 226 236 246
DFGFAKETTg hnslttpcyt pyYVAPEVLg pekYDKSCDM
256 266 276 286
WSLGVIMYIL LCGYPPFYsn hglaispGMK TRIRMGQYEF
296 306 316 326
PNPEWSEVSE EVKMLIRNLL KTEPTQRMTI TEFMNHPWIM
336 346 356
QSTKVPQTPL HTSRVLKEDK ERWEDVKEem tsalatmr
Lower-case residues are disordered in structure.
Mutations: S216G
Phosphorylation: None