8K5R

CDK9 (Cyclin-dependent kinase 9)
Group: CMGC
Uniprot: CDK9_HUMAN
Organism: Homo sapiens
Domain boundary: 19 - 315
Resolu: 3.751

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-out in-in VQE Type1 5 - 327 3
Representative sequence - Chain A
10 20 30 40
makqYDDNEC PFCDEVSKYE KLAKIgqgtf gEVFKARHRK
50 60 70 80
TGQRVALKKV LMENEKEGFP ITALREIKIL QLLKHENVVN
90 100 110 120
LIEICRTKAS PynrcKGSIY LVFDFCEHDL AGLLSNVLVK
130 140 150 160
FTLSEIKRVM QMLLNGLFYI HRNKILHRDM KAANVLITRD
170 180 190 200
GVLKLADFGL ARAFSLaknS QPNRYTNRVV TLWYRPPELL
210 220 230 240
LGERDYGPPI DLWGAGCIMA EMWTRSPIMQ GNTEQHQLAL
250 260 270 280
ISQLCGSITP EVWPNVDNYE lyekLELVKG QKRKVKDRLA
290 300 310 320
AYVRDPYALD LIDKLLVLDP AQRIDSEDAL EHDFFWSDPM
330
PSDLKGMlst
Lower-case residues are disordered in structure.
Mutations: S7D,V8N,K44R,Y138F,K280A,D307E,N311E
Phosphorylation: X186