8GUW

AURKA (Aurora kinase A)
Group: CAMK
Uniprot: AURKA_HUMAN
Organism: Homo sapiens
Domain boundary: 133 - 383
Resolu: 2.7

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus out-out in-out ADP Type1 506 - 388 7
B Inactive DFGin ABAminus out-out none-none ADP Type1 507 - 390 13
C Inactive DFGin ABAminus out-out none-none ADP Type1 506 - 388 14
Representative sequence - Chain C
514 524 129 139
gEDFRSGSEA FDLIAQDEEE FNKSKKRQWA LEDFEIGRPL
149 159 169 179
GKGKFGNVYL AREKQSKFIL ALKVLFKAQL EKAGVEHQLR
189 199 209 219
REVEIQSHLR HPNILRLYGY FHDATRVYLI LEYAPLGTVY
229 239 249 259
RELQKLSKFD EQRTATYITE LANALSYCHS KRVIHRDIKP
269 279 289 299
ENLLLGSAGE LKIADFGWsv hapssrrttl agTLDYLPPE
309 319 329 339
MIEgrmhDEK VDLWSLGVLC YEFLVGKPPF EANTYQETYK
349 359 369 379
RISRVEFTFP DFVTEGARDL ISRLLKHNPS QRPMLREVLE
389 399
HPWITANSSk psnaqnkesa skqs
Lower-case residues are disordered in structure.
Mutations: C290A,C393A
Phosphorylation: None