8FAC

LRRK1 (Leucine-rich repeat serine/threonine-protein kinase 1)
Group: TKL
Uniprot: LRRK1_HUMAN
Organism: Homo sapiens
Domain boundary: 1238 - 1522
Resolu: 3.92

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGout None in-out out-none No_ligand No_ligand 341 - 2013 19
Representative sequence - Chain A
- - - 7
mdykdhdgdy kdhdidykdd ddklglevlf qgpmagmsqr
17 27 37 47
ppsmywcvgp eesavcpera metlngagdt ggkpstrggd
57 67 77 87
paarsrrteg iraayrrgdr ggardlleea cdqcasqlek
97 107 117 127
gqllsipaay gdlemvryll skrlvelpte ptddnpavva
137 147 157 167
ayfghtavvq elleslpgpc spqrllnwml alacqrghlg
177 187 197 207
vvkllvlthg adpesyavrk nefpvivrlp lyaaiksgne
217 227 237 247
diaifllrhg ayfcsyilld spdpskhllr kyfieasplp
257 267 277 287
ssypgktalr vkwshlrlpw vdldwlidis cqiteldlsa
297 307 317 327
nclatlpsvi pwglinlrkl nlsdnhlgel pgvqssdeii
337 347 357 367
csrlleidis snkLSHLPPG FLHLSKLQKL TASKNCLEKL
377 387 397 407
FEeenatnwi GLRKLQELDI SDNKLTELPA LFLHSFKSLN
417 427 437 447
SLNVSRNNLK VFPDPWACPL KCCKASRNAL ECLPDKMAVF
457 467 477 487
WKNHLKDVDF SENALKEVPL GLFQLDALMF LRLQGNQLAA
497 507 517 527
LPPQEKWTCR QLKTLDLSRN QLGKnedglk tkriaffttr
537 547 557 567
grqrsgteaa svLEFPAFLS ESLEVLCLND NHLDTVPPSV
577 587 597 607
CLLKSLSELY LGNNPGLREL PPELGQLGNL WQLDTEDLTI
617 627 637 647
SNVPAeiqke gpkAMLSYLR AQlrkaekcK LMKMIIVGPP
657 667 677 687
RQGKSTLLEI LQTGRAPQVV HGEATIRTTK WELQRPAGSR
697 707 717 727
AKVESVEFNV WDIGGPASMA TVNQCFFTDK ALYVVVWNLA
737 747 757 767
LGEEAVANLQ FWLLNIEAKA PNAVVLVVGT HLDLIEAKFR
777 787 797 807
VERIATLRAY VLALCRSPSG SRATGFPDIT FKHLHEISCK
817 827 837 847
SLEGQEGLRQ LIFHVTCSMk dvgstigcqr lagrlIPRSY
857 867 877 887
LSLQEAVLAE QQRRSRDDDV QYLTDRQLEQ LVEQTPDNDI
897 907 917 927
KDYEDLQSAI SFLIETGTLL HFPdtshglr nLYFLDPIWL
937 947 957 967
SECLQRIFNI KGSRSVAKNG VIRAEDLRML lvgtgFTQQT
977 987 997 1007
EEQYFQFLAK FEIALPVAND SYLLPHLLPS KPGLDTHGMR
1017 1027 1037 1047
HPTANTIQRV FKMSFVPVGF WQRFIARMLI SLAEMDLQLf
1057 1067 1077 1087
enkkntksrn rkvtiysftg nqrNRCSTFR VKRNQTIYWQ
1097 1107 1117 1127
EGLLVTFDGG YLSVESSDVN WKKKKSGGMK IVCQSEvrdf
1137 1147 1157 1167
SAMAFITDHV NSLIDQWFPA LTATESDGTP LMEQYVPCPV
1177 1187 1197 1207
CETawaqhtd pseksedVQY FDMEDCVLTA IERDFISCPR
1217 1227 1237 1247
HPDLPVPLQE LVPELFMTDF PARLFLENSK LEHSEDEGSV
1257 1267 1277 1287
LGQGGSGTVI YRARYQGQPV AVKRFHIKKf knfanvpadt
1297 1307 1317 1327
MLRHLRATDA MKNFSEFRQE ASMLHALQHP CIVALIGISI
1337 1347 1357 1367
HPLCFALELA PLSSLNTVLS ENArdsSFIP LGHMLTQKIA
1377 1387 1397 1407
YQIASGLAYL HKKNIIFCDL KSDNILVWSL DVKEHINIKL
1417 1427 1437 1447
SDYGISRQsf hegalgvegt pgyqapeirp riVYDEKVDM
1457 1467 1477 1487
FSYGMVLYEL LSgqrpalgh hQLQIAKKLS KGIRPVLGQP
1497 1507 1517 1527
EEVQFRRLQA LMMECWDTKP EKRPLALSVV SQMKDPTFAT
1537 1547 1557 1567
FMYELCCGKQ TAFFSSQGQE YTVVFWDGKE ESRNYTVVNT
1577 1587 1597 1607
EKGLMEVQRM CCPGMKVSCQ LQVQRSLWTA TEDQKIYIYT
1617 1627 1637 1647
LkgmcplnTP QQALDTPAVV TCFLAVPVIK KNSYLVLAGL
1657 1667 1677 1687
ADGLVAVFPV VRGTPKDSCS YLCSHTANRS KFSIADEDAR
1697 1707 1717 1727
QNPYPVKAME VVNSGSEVWY SNGPGLLVID CASLEICRRL
1737 1747 1757 1767
EPYMAPSMVT SVVCSSEGRG EEVVWCLDDK ANSLVMYHST
1777 1787 1797 1807
TYQLCARYFC GVPSPLRDMF PVRpldtepp aashtanpkv
1817 1827 1837 1847
pegdsiadvs imyseelgtq ilihqesltd ycsmssysss
1857 1867 1877 1887
pprqaarsps slpsspasss svpfstdced sdmlhtpgaa
1897 1907 1917 1927
sdrsehdltp mdgetfsQHL QAVKILAVRD LIWVPRRGGD
1937 1947 1957 1967
VIVIGLekds gaQRGRVIAV LKARELTPHG VLVDAAVVAK
1977 1987 1997 2007
DTVVCTFENE NTEWCLAVWR GWGAREFDIF YQSYEELGRL

EACTRKrr
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None