8BUO

CDK12 (Cyclin-dependent kinase 12)
Group: CMGC
Uniprot: CDK12_HUMAN
Organism: Homo sapiens
Domain boundary: 727 - 1020
Resolu: 3.58

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
B Inactive DFGin ABAminus in-in in-in RLC Type1 715 - 1040 0
E Active DFGin BLAminus in-in in-in RLC Type1 715 - 1040 0
H Inactive DFGin None in-in in-in RLC Type1 715 - 1044 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain H
       718        728        738        748 
gggrrqTESD WGKRCVDKFD IIGIIGEGTY GQVYKAKDKD 
       758        768        778        788 
TGELVALKKV RLDNEKEGFP ITAIREIKIL RQLIHRSVVN 
       798        808        818        828 
MKEIVTDKQD ALDFKKDKGA FYLVFEYMDH DLMGLLESGL 
       838        848        858        868 
VHFSEDHIKS FMKQLMEGLE YCHKKNFLHR DIKCSNILLN 
       878        888        898        908 
NSGQIKLADF GLARLYNSEE SRPYTNKVIT LWYRPPELLL 
       918        928        938        948 
GEERYTPAID VWSCGCILGE LFTKKPIFQA NLELAQLELI 
       958        968        978        988 
SRLCGSPCPA VWPDVIRLPY FNTMKPKKQY RRRLREEFSF 
       998       1008       1018       1028 
IPSAALDLLD HMLTLDPSKR CTAEQTLQSD FLKDVELSKM 
      1038       1048 
APPDLPHWQD CHELWSkkrr rqrq
Lower-case residues are disordered in structure.
Mutations: K965R
Phosphorylation: X893