7CGA

MAPK12 (Mitogen-activated protein kinase 12)
Group: CMGC
Uniprot: MK12_HUMAN
Organism: Homo sapiens
Domain boundary: 27 - 311
Resolu: 3.15

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 9 - 353 0
B Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 9 - 353 0
C Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 9 - 353 0
D Inactive DFGin ABAminus in-in in-out No_ligand No_ligand 9 - 353 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
        15         25         35         45 
sNASGFYRQE VTKTAWEVRA VYRDLQPVGS GAYGAVCSAV 
        55         65         75         85 
DGRTGAKVAI KKLYRPFQSE LFAKRAYREL RLLKHMRHEN 
        95        105        115        125 
VIGLLDVFTP DETLDDFTDF YLVMPFMGTD LGKLMKHEKL 
       135        145        155        165 
GEDRIQFLVY QMLKGLRYIH AAGIIHRDLK PGNLAVNEDC 
       175        185        195        205 
ELKILDFGLA RQADSEMTGY VVTRWYRAPE VILNWMRYTQ 
       215        225        235        245 
TVDIWSVGCI MAEMITGKTL FKGSDHLDQL KEIMKVTGTP 
       255        265        275        285 
PAEFVQRLQS DEAKNYMKGL PELEKKDFAS ILTNASPLAV 
       295        305        315        325 
NLLEKMLVLD AEQRVTAGEA LAHPYFESLH DTEDEPQVQK 
       335        345 
YDDSFDDVDR TLDEWKRVTY KEVLSFKP
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None