6B3E

CDK12 (Cyclin-dependent kinase 12)
Group: CMGC
Uniprot: CDK12_HUMAN
Organism: Homo sapiens
Domain boundary: 727 - 1020
Resolu: 3.06

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in CJM Type1 717 - 1036 0
C Active DFGin BLAminus in-in in-in CJM Type1 719 - 1036 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain C
       726        736        746        756 
sdWGKRCVDK FDIIGIIGEG TYGQVYKAKD KDTGELVALK 
       766        776        786        796 
KVRLDNEKEG FPITAIREIK ILRQLIHRSV VNMKEIVTDK 
       806        816        826        836 
qdaldfkkdk GAFYLVFEYM DHDLMGLLES GLVHFSEDHI 
       846        856        866        876 
KSFMKQLMEG LEYCHKKNFL HRDIKCSNIL LNNSGQIKLA 
       886        896        906        916 
DFGLARLYNS EESRPYTNKV ITLWYRPPEL LLGEERYTPA 
       926        936        946        956 
IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC 
       966        976        986        996 
PAVWPDVIKL PYFNTMKPKK QYRRRLREEF SFIPSAALDL 
      1006       1016       1026       1036 
LDHMLTLDPS KRCTAEQTLQ SDFLKDVELS KMAPPDLPHW


Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X893