5Y25

EGFR (Epidermal growth factor receptor)
Group: TYR
Uniprot: EGFR_HUMAN
Organism: Homo sapiens
Domain boundary: 712 - 970
Resolu: 3.102

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAplus in-in none-in 8LU Type1 698 - 1017 16
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       700        710        720        730 
mhhhhhHAPN QALLRILKET EFKKIKVLGS GAFGTVYKGL 
       740        750        760        770 
WIPEGEKVKI PVAIKELrea TSPKANKEIL DEAYVMASVD 
       780        790        800        810 
NPHVCRLLGI CLTSTVQLIM QLMPFGCLLD YVREHKDNIG 
       820        830        840        850 
SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA RNVLVKTPQH 
       860        870        880        890 
VKITDFGRAk llgaeekeyh aeggkVPIKW MALESILHRI 
       900        910        920        930 
YTHQSDVWSY GVTVWELMTF GSKPYDGIPA SEISSILEKG 
       940        950        960        970 
ERLPQPPICT IDVYMIMVKC WMIDADSRPK FRELIIEFSK 
       980        990       1000       1010 
MARDPQRYLV IQGDERMHLP SPTDSNFyra lmdeedmDDV 
      1020 
VDADEYLipq qg
Lower-case residues are disordered in structure.
Mutations: T790M,L858R
Phosphorylation: None