5E8X

TGFBR1 (TGF-beta receptor type-1)
Group: TKL
Uniprot: TGFR1_HUMAN
Organism: Homo sapiens
Domain boundary: 205 - 494
Resolu: 1.45

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in STU Type1 200 - 503 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
       206        216        226        236 
ghmTIARDIV LQESVGKGRF GEVWRGKWRG EEVAVKIFSS 
       246        256        266        276 
REERSWFREA EIFQTVMLRH ENILGFIAAD NKDNGTWTQL 
       286        296        306        316 
WLVTDFHEHG NLFDYLNRYT VTVEGMIKLA LSTASGLAHL 
       326        336        346        356 
HMEIVGTQGK PAIAHRDLKS KNILVKKNGT CCICDFGLAV 
       366        376        386        396 
RHDSATDTID IAPNHRVGTK RYMAPEVLDD SINMKHFESF 
       406        416        426        436 
KRADIYAMGL VFWEIARRCS IGGIHEDYQL PYYDLVPSDP 
       446        456        466        476 
SVEEMRKVVC EQKLRPNIPN RWQSCEALRV MAKIMRECWY 
       486        496 
ANGAARLTAL RIKKTLSQLS QQEGIKM
Lower-case residues are disordered in structure.
Mutations: T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F
Phosphorylation: None