4U6R

ERN1 (Serine/threonine-protein kinase/endoribonuclease IRE1)
Group: OTHER
Uniprot: ERN1_HUMAN
Organism: Homo sapiens
Domain boundary: 569 - 832
Resolu: 2.5

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus out-out in-in 3E4 Type1.5_Back 561 - 963 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
         -          -        552        562 
mghnhrhkhh hhhhhhenly fqgpgsspsl eqddgdeeTS 
       572        582        592        602 
VVIVGKISFC PKDVLGHGAE GTIVYRGMFD NRDVAVKRIL 
       612        622        632        642 
PECFSFADRE VQLLRESDEH PNVIRYFCTE KDRQFQYIAI 
       652        662        672        682 
ELCAATLQEY VEQKDFAHLG LEPITLLQQT TSGLAHLHSL 
       692        702        712        722 
NIVHRDLKPH NILISMPNAH GKIKAMISDF GLCKKLAVGR 
       732        742        752        762 
HSFSRRSGVP GTEGWIAPEM LSEDCKENPT YTVDIFSAGC 
       772        782        792        802 
VFYYVISEGS HPFGKSLQRQ ANILLGACSL DCLHPEKHED 
       812        822        832        842 
VIARELIEKM IAMDPQKRPS AKHVLKHPFF WSLEKQLQFF 
       852        862        872        882 
QDVSDRIEKE SLDGPIVKQL ERGGRAVVKM DWRENITVPL 
       892        902        912        922 
QTDLRKFRTY KGGSVRDLLR AMRNKKHHYR ELPAEVRETL 
       932        942        952        962 
GTLPDDFVCY FTSRFPHLLA HTYRAMELCS HERLFQPYYF 
       972 
Heppepqppv tpdal
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None