4TT7

ALK (ALK tyrosine kinase receptor)
Group: TYR
Uniprot: ALK_HUMAN
Organism: Homo sapiens
Domain boundary: 1116 - 1385
Resolu: 2.1

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin ABAminus in-in out-out COM COM Allosteric Allosteric 1095 - 1400 2
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
      1103       1113       1123       1133 
MNYCFAGKTS SISDLKEVPR KNITLIRGLG hgafGEVYEG 
      1143       1153       1163       1173 
QVSgmpndps PLQVAVKTLP EVCSEQDELD FLMEALIISK 
      1183       1193       1203       1213 
FNHQNIVRCI GVSLQSLPRF ILLELMAGGD LKSFLRETRP 
      1223       1233       1243       1253 
RpsqPSSLAM LDLLHVARDI ACGCQYLEEN HFIHRDIAAR 
      1263       1273       1283       1293 
NCLLTCPGPG RVAKIGDFGM ARDIYRASyy RKGGCAMLPV 
      1303       1313       1323       1333 
KWMPPEAFME GIFTSKTDTW SFGVLLWEIF SLGYMPYPSK 
      1343       1353       1363       1373 
SNQEVLEFVT SGGRMDPPKN CPGPVYRIMT QCWQHQPEDR 
      1383       1393       1403          - 
PNFAIILERI EYCTQDPDVI NTALPIEygp lveeeekleh 

hhhhh
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None