4CXA

CDK12 (Cyclin-dependent kinase 12)
Group: CMGC
Uniprot: CDK12_HUMAN
Organism: Homo sapiens
Domain boundary: 727 - 1020
Resolu: 3.15

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in ANP Type1 718 - 1050 1
C None DFGin BLAminus in-none in-in No_ligand No_ligand 718 - 1048 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain C
       722        732        742        752 
smtesDWGKR CVDKFDIIGI IGEGTYGQVY KAKDKDTGEL 
       762        772        782        792 
VALKKVRLDN EKEGFPITAI REIKILRQLI HRSVVNMKEI 
       802        812        822        832 
VTDKQDALDF KKDKGAFYLV FEYMDHDLMG LLESGLVHFS 
       842        852        862        872 
EDHIKSFMKQ LMEGLEYCHK KNFLHRDIKC SNILLNNSGQ 
       882        892        902        912 
IKLADFGLAR LYNSEESRPY TNKVITLWYR PPELLLGEER 
       922        932        942        952 
YTPAIDVWSC GCILGELFTK KPIFQANLEL AQLELISRLC 
       962        972        982        992 
GSPCPAVWPD VIKLPYFNTM KPKKQYRRRL REEFSFIPSA 
      1002       1012       1022       1032 
ALDLLDHMLT LDPSKRCTAE QTLQSDFLKD VELSKMAPPD 
      1042       1052 
LPHWQDCHEL WSKKRRrqrq
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: X893