3ORX

PDPK1 (3-phosphoinositide-dependent protein kinase 1)
Group: AGC
Uniprot: PDPK1_HUMAN
Organism: Homo sapiens
Domain boundary: 82 - 342
Resolu: 2.204

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Active DFGin BLAminus in-in in-in 1F8 Allosteric 75 - 359 1
B Active DFGin BLAminus in-in in-in 1F8 Allosteric 77 - 359 2
C Active DFGin BLAminus in-in in-in 1F8 Allosteric 75 - 359 1
D Active DFGin BLAminus in-in in-in 1F8 Allosteric 76 - 359 1
E Active DFGin BLAminus in-in in-in 1F8 Allosteric 76 - 359 10
F None DFGin BLAminus in-none in-in 1F8 Allosteric 75 - 359 10
G Active DFGin BLAminus in-in in-in 1F8 Allosteric 75 - 359 10
H Active DFGin BLAminus in-in in-in 1F8 Allosteric 75 - 359 10
Representative sequence - Chain H
53 63 73 83
gamdpefmdg taaeprpgag slqhaqpppq pRKKRPEDFK
93 103 113 123
FGKILGEGSF STVVLARELA TSREYAIKIL EKRHIIKENK
133 143 153 163
VPYVTRERDV MSRLDHPFFV KLYFCFQDDE KLYFGLSYAK
173 183 193 203
NGELLKYIRK IGSFDETCTR FYTAEIVSAL EYLHGKGIIH
213 223 233 243
RDLKPENILL NEDMHIQITD FGTAKVLspe skqaranSFV
253 263 273 283
GTAQYVSPEL LTEKSACKSS DLWALGCIIY QLVAGLPPFR
293 303 313 323
AGNEYLIFQK IIKLEYDFPE KFFPKARDLV EKLLVLDATK
333 343 353
RLGCEEMEGY GPLKAHPFFE SVTWENLHQQ TPPKLT
Lower-case residues are disordered in structure.
Mutations: T148C
Phosphorylation: X241