TTBK1 (Tau-tubulin kinase 1)

Group: CK1
Uniprot: TTBK1_HUMAN
Domain boundary: 34 - 295


Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 13 AF-Q5TCY1-K1A
DFGin ABAminus 7 7Q8WA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
8XPZA 2.6 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 20 - 312 None None 0
7QHWAAA 2.8 Inactive DFGin ABAminus in-in in-in CGI Type1 21 - 313 None None 0
7QHWCCC 2.8 Inactive DFGin ABAminus in-in in-in CGI Type1 21 - 312 None None 0
7Q8VA 2.13 Inactive DFGin ABAminus in-in in-in 9IV Type1 21 - 312 None None 0
7Q8WA 2.02 Inactive DFGin ABAminus in-in in-in 9IO Type1 21 - 312 None None 0
4BTMA 2.54 Inactive DFGin ABAminus in-in in-in F8E Type1 21 - 312 None None 0
4BTMB 2.54 Inactive DFGin ABAminus in-in in-in F8E Type1 21 - 313 None None 0
AF-Q5TCY1-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 26 - 303 None None 0
4NFMA 2.12 None DFGin BLAminus in-none in-in No_ligand No_ligand 22 - 314 None None 0
4NFNA 1.42 Active DFGin BLAminus in-in in-in 2KC Type1 22 - 314 None None 0
4BTJA 2.16 Active DFGin BLAminus in-in in-in ADP Type1 21 - 312 None None 0
4BTJB 2.16 Active DFGin BLAminus in-in in-in ATP Type1 21 - 313 None None 0
7ZHNA 1.85 Active DFGin BLAminus in-in in-in VP7 Type1.5_Back 21 - 313 None None 0
7ZHOA 2.08 Active DFGin BLAminus in-in in-in IQR Type1.5_Back 21 - 317 None None 0
7ZHPA 1.8 Active DFGin BLAminus in-in in-in IQY Type1.5_Back 21 - 313 None None 0
7ZHQA 1.8 Active DFGin BLAminus in-in in-in IRD Type1.5_Back 21 - 313 None None 0
7JXXA 1.56 Active DFGin BLAminus in-in in-in VP7 Type1.5_Back 22 - 312 None None 2
7JXYA 2.15 Active DFGin BLAminus in-in in-in VSY Type1.5_Back 23 - 312 None None 0
7JXYB 2.15 Active DFGin BLAminus in-in in-in VSY Type1.5_Back 20 - 312 None None 5
4BTKA 2.0 Active DFGin BLAminus in-in in-in DTQ Type1.5_Back 22 - 311 None None 0

TTBK1 (Tau-tubulin kinase 1)

Group: CK1
Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 13 AF-Q5TCY1-K1A
DFGin ABAminus 7 7Q8WA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TTBK1_HUMAN 8XPZA 2.6 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 20 - 312 None None 0
Homo sapiens TTBK1_HUMAN 7QHWAAA 2.8 Inactive DFGin ABAminus in-in in-in CGI Type1 21 - 313 None None 0
Homo sapiens TTBK1_HUMAN 7QHWCCC 2.8 Inactive DFGin ABAminus in-in in-in CGI Type1 21 - 312 None None 0
Homo sapiens TTBK1_HUMAN 7Q8VA 2.13 Inactive DFGin ABAminus in-in in-in 9IV Type1 21 - 312 None None 0
Homo sapiens TTBK1_HUMAN 7Q8WA 2.02 Inactive DFGin ABAminus in-in in-in 9IO Type1 21 - 312 None None 0
Homo sapiens TTBK1_HUMAN 4BTMA 2.54 Inactive DFGin ABAminus in-in in-in F8E Type1 21 - 312 None None 0
Homo sapiens TTBK1_HUMAN 4BTMB 2.54 Inactive DFGin ABAminus in-in in-in F8E Type1 21 - 313 None None 0
Homo sapiens TTBK1_HUMAN AF-Q5TCY1-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 26 - 303 None None 0
Homo sapiens TTBK1_HUMAN 4NFMA 2.12 None DFGin BLAminus in-none in-in No_ligand No_ligand 22 - 314 None None 0
Homo sapiens TTBK1_HUMAN 4NFNA 1.42 Active DFGin BLAminus in-in in-in 2KC Type1 22 - 314 None None 0
Homo sapiens TTBK1_HUMAN 4BTJA 2.16 Active DFGin BLAminus in-in in-in ADP Type1 21 - 312 None None 0
Homo sapiens TTBK1_HUMAN 4BTJB 2.16 Active DFGin BLAminus in-in in-in ATP Type1 21 - 313 None None 0
Homo sapiens TTBK1_HUMAN 7ZHNA 1.85 Active DFGin BLAminus in-in in-in VP7 Type1.5_Back 21 - 313 None None 0
Homo sapiens TTBK1_HUMAN 7ZHOA 2.08 Active DFGin BLAminus in-in in-in IQR Type1.5_Back 21 - 317 None None 0
Homo sapiens TTBK1_HUMAN 7ZHPA 1.8 Active DFGin BLAminus in-in in-in IQY Type1.5_Back 21 - 313 None None 0
Homo sapiens TTBK1_HUMAN 7ZHQA 1.8 Active DFGin BLAminus in-in in-in IRD Type1.5_Back 21 - 313 None None 0
Homo sapiens TTBK1_HUMAN 7JXXA 1.56 Active DFGin BLAminus in-in in-in VP7 Type1.5_Back 22 - 312 None None 2
Homo sapiens TTBK1_HUMAN 7JXYA 2.15 Active DFGin BLAminus in-in in-in VSY Type1.5_Back 23 - 312 None None 0
Homo sapiens TTBK1_HUMAN 7JXYB 2.15 Active DFGin BLAminus in-in in-in VSY Type1.5_Back 20 - 312 None None 5
Homo sapiens TTBK1_HUMAN 4BTKA 2.0 Active DFGin BLAminus in-in in-in DTQ Type1.5_Back 22 - 311 None None 0

TTBK1 (Tau-tubulin kinase 1)

No non-human structures known.