TBK1 (Serine/threonine-protein kinase TBK1)

Group: OTHER
Uniprot: TBK1_HUMAN
Domain boundary: 7 - 304


Total number of chains: 26
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-Q9UHD2-K1A
DFGin BLBplus 9 4IWOA
DFGin None 9 6RSUA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q9UHD2-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 312 None None 0
4EUUA 1.8 Active DFGin BLAminus in-in in-in BX7 Type1 2 - 307 D135N X172 0
4EUUB 1.8 Active DFGin BLAminus in-in in-in BX7 Type1 2 - 307 D135N X172 0
4EUTA 2.6 Inactive DFGin BLAminus in-in in-out BX7 Type1 2 - 385 D135N None 0
4EUTB 2.6 Inactive DFGin BLAminus in-in in-out BX7 Type1 2 - 385 D135N None 0
4IW0A 4.0 Active DFGin BLAminus in-in in-in BX7 Type1 2 - 657 D135N X172 0
6O8BA 3.4 Inactive DFGin BLAminus out-out in-in BX7 Type1 2 - 656 D135N,S172E None 0
6O8BB 3.4 Inactive DFGin BLAminus in-in out-in BX7 Type1 2 - 654 D135N,S172E None 0
6NT9A 3.3 Inactive DFGin BLBplus out-out none-out No_ligand No_ligand 1 - 658 D135N None 15
6NT9B 3.3 Inactive DFGin BLBplus out-out none-out No_ligand No_ligand 1 - 658 D135N None 15
5W5VA 3.645 Inactive DFGin BLBplus out-out none-none ANW Type1 1 - 657 None None 17
6BODA 3.197 Inactive DFGin BLBplus out-out out-none E0P Type1 1 - 657 None None 12
6RSTA 3.29 Inactive DFGin BLBplus out-out out-in KHQ Type1 2 - 657 None None 10
4IWOA 2.61 Inactive DFGin BLBplus out-out out-in 1H4 Type1 2 - 657 S172A None 10
4IM0A 2.4 Inactive DFGin BLBplus out-out none-none 1FV Type1 1 - 657 D135N None 16
4IM2A 2.5 Inactive DFGin BLBplus out-out none-none BX7 Type1 1 - 657 D135N None 16
4IM3A 3.342 Inactive DFGin BLBplus out-out none-none BX7 Type1 1 - 657 D135N None 24
6BNYA 3.341 Inactive DFGin None out-out none-none E0M Type1 1 - 657 None None 16
6BOEA 3.598 Inactive DFGin None out-out none-in E0S Type1 1 - 657 None None 16
6CQ0A 3.19 Inactive DFGin None out-out none-out F8M Type1 1 - 657 None None 14
6CQ4A 3.2 Inactive DFGin None out-out none-in F8P Type1 1 - 657 None None 16
6CQ5A 3.354 Inactive DFGin None out-out none-none F8S Type1 1 - 657 None None 18
6RSRA 3.15 Inactive DFGin None out-out out-in KHT Type1 2 - 657 None None 10
6RSUA 2.75 Inactive DFGin None out-out out-in KJB Type1 2 - 657 None None 10
4IWPA 3.065 Inactive DFGin None out-out out-in BX7 Type1 2 - 657 S172A None 10
4IWQA 3.0 Inactive DFGin None out-out out-in 1FV Type1 2 - 657 S172A None 10

TBK1 (Serine/threonine-protein kinase TBK1)

Group: OTHER
Total number of chains: 30
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-Q9UHD2-K1A
DFGin BLAplus 2 4JLCA
DFGin BLBplus 11 6O8CA
DFGin None 9 6RSUA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TBK1_HUMAN AF-Q9UHD2-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 312 None None 0
Homo sapiens TBK1_HUMAN 4EUUA 1.8 Active DFGin BLAminus in-in in-in BX7 Type1 2 - 307 D135N X172 0
Homo sapiens TBK1_HUMAN 4EUUB 1.8 Active DFGin BLAminus in-in in-in BX7 Type1 2 - 307 D135N X172 0
Homo sapiens TBK1_HUMAN 4EUTA 2.6 Inactive DFGin BLAminus in-in in-out BX7 Type1 2 - 385 D135N None 0
Homo sapiens TBK1_HUMAN 4EUTB 2.6 Inactive DFGin BLAminus in-in in-out BX7 Type1 2 - 385 D135N None 0
Homo sapiens TBK1_HUMAN 4IW0A 4.0 Active DFGin BLAminus in-in in-in BX7 Type1 2 - 657 D135N X172 0
Homo sapiens TBK1_HUMAN 6O8BA 3.4 Inactive DFGin BLAminus out-out in-in BX7 Type1 2 - 656 D135N,S172E None 0
Homo sapiens TBK1_HUMAN 6O8BB 3.4 Inactive DFGin BLAminus in-in out-in BX7 Type1 2 - 654 D135N,S172E None 0
Homo sapiens TBK1_HUMAN 6NT9A 3.3 Inactive DFGin BLBplus out-out none-out No_ligand No_ligand 1 - 658 D135N None 15
Homo sapiens TBK1_HUMAN 6NT9B 3.3 Inactive DFGin BLBplus out-out none-out No_ligand No_ligand 1 - 658 D135N None 15
Homo sapiens TBK1_HUMAN 5W5VA 3.645 Inactive DFGin BLBplus out-out none-none ANW Type1 1 - 657 None None 17
Homo sapiens TBK1_HUMAN 6BODA 3.197 Inactive DFGin BLBplus out-out out-none E0P Type1 1 - 657 None None 12
Homo sapiens TBK1_HUMAN 6RSTA 3.29 Inactive DFGin BLBplus out-out out-in KHQ Type1 2 - 657 None None 10
Homo sapiens TBK1_HUMAN 4IWOA 2.61 Inactive DFGin BLBplus out-out out-in 1H4 Type1 2 - 657 S172A None 10
Homo sapiens TBK1_HUMAN 4IM0A 2.4 Inactive DFGin BLBplus out-out none-none 1FV Type1 1 - 657 D135N None 16
Homo sapiens TBK1_HUMAN 4IM2A 2.5 Inactive DFGin BLBplus out-out none-none BX7 Type1 1 - 657 D135N None 16
Homo sapiens TBK1_HUMAN 4IM3A 3.342 Inactive DFGin BLBplus out-out none-none BX7 Type1 1 - 657 D135N None 24
Homo sapiens TBK1_HUMAN 6BNYA 3.341 Inactive DFGin None out-out none-none E0M Type1 1 - 657 None None 16
Homo sapiens TBK1_HUMAN 6BOEA 3.598 Inactive DFGin None out-out none-in E0S Type1 1 - 657 None None 16
Homo sapiens TBK1_HUMAN 6CQ0A 3.19 Inactive DFGin None out-out none-out F8M Type1 1 - 657 None None 14
Homo sapiens TBK1_HUMAN 6CQ4A 3.2 Inactive DFGin None out-out none-in F8P Type1 1 - 657 None None 16
Homo sapiens TBK1_HUMAN 6CQ5A 3.354 Inactive DFGin None out-out none-none F8S Type1 1 - 657 None None 18
Homo sapiens TBK1_HUMAN 6RSRA 3.15 Inactive DFGin None out-out out-in KHT Type1 2 - 657 None None 10
Homo sapiens TBK1_HUMAN 6RSUA 2.75 Inactive DFGin None out-out out-in KJB Type1 2 - 657 None None 10
Homo sapiens TBK1_HUMAN 4IWPA 3.065 Inactive DFGin None out-out out-in BX7 Type1 2 - 657 S172A None 10
Homo sapiens TBK1_HUMAN 4IWQA 3.0 Inactive DFGin None out-out out-in 1FV Type1 2 - 657 S172A None 10
Mus musculus TBK1_MOUSE 4JL9A 3.1 Inactive DFGin BLAplus out-out out-out BX7 Type1 2 - 656 None None 7
Mus musculus TBK1_MOUSE 4JLCA 3.0 Inactive DFGin BLAplus out-out out-out SU6 Type1 2 - 656 None None 7
Mus musculus TBK1_MOUSE 6O8CA 3.17 Inactive DFGin BLBplus out-out none-none BX7 Type1 2 - 651 S172A None 14
Mus musculus TBK1_MOUSE 6O8CB 3.17 Inactive DFGin BLBplus out-out none-out BX7 Type1 2 - 653 S172A None 14

TBK1 (Serine/threonine-protein kinase TBK1)

Group: OTHER
Total number of chains: 4
Spatial Dihedral Chains Representative
DFGin BLAplus 2 4JLCA
DFGin BLBplus 2 6O8CA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus TBK1_MOUSE 4JL9A 3.1 Inactive DFGin BLAplus out-out out-out BX7 Type1 2 - 656 None None 7
Mus musculus TBK1_MOUSE 4JLCA 3.0 Inactive DFGin BLAplus out-out out-out SU6 Type1 2 - 656 None None 7
Mus musculus TBK1_MOUSE 6O8CA 3.17 Inactive DFGin BLBplus out-out none-none BX7 Type1 2 - 651 S172A None 14
Mus musculus TBK1_MOUSE 6O8CB 3.17 Inactive DFGin BLBplus out-out none-out BX7 Type1 2 - 653 S172A None 14