STK3 (Serine/threonine-protein kinase 3)

Group: STE
Uniprot: STK3_HUMAN
Domain boundary: 27 - 278


Total number of chains: 16
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-Q13188-K1A
DFGin BLAplus 1 6AO5A
DFGin ABAminus 1 5DH3B
DFGin BLBminus 8 4LGDA
DFGin None 1 4LG4F
None None 1 4LG4D
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
5DH3B 2.468 Inactive DFGin ABAminus out-in in-in 5BS Type1 18 - 302 None X174,X180 0
AF-Q13188-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 19 - 286 None None 0
8A66A 1.901 Active DFGin BLAminus in-in in-in 5BS Type1 24 - 303 None X180 1
8A66B 1.901 Active DFGin BLAminus in-in in-in 5BS Type1 18 - 304 None X174,X180,X268 0
5DH3A 2.468 Inactive DFGin BLAminus out-out in-in 5BS Type1 19 - 307 None X174,X180 0
6AO5A 2.955 Inactive DFGin BLAplus out-out none-out ANP Type1 28 - 488 D146N None 12
4LG4A 2.42 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 18 - 308 D146N None 0
4LG4B 2.42 Inactive DFGin BLBminus out-out none-out No_ligand No_ligand 18 - 308 D146N None 4
4LG4C 2.42 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 18 - 307 D146N None 0
4LG4E 2.42 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 18 - 308 D146N None 6
4LGDA 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 16 - 488 D146N None 0
4LGDB 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 10 - 488 D146N None 0
4LGDC 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 12 - 490 D146N None 0
4LGDD 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 11 - 489 D146N None 0
4LG4F 2.42 Inactive DFGin None out-out none-out No_ligand No_ligand 18 - 310 D146N None 17
4LG4D 2.42 Inactive None None out-out none-out No_ligand No_ligand 26 - 308 D146N None 18

STK3 (Serine/threonine-protein kinase 3)

Group: STE
Total number of chains: 16
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-Q13188-K1A
DFGin BLAplus 1 6AO5A
DFGin ABAminus 1 5DH3B
DFGin BLBminus 8 4LGDA
DFGin None 1 4LG4F
None None 1 4LG4D
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens STK3_HUMAN 5DH3B 2.468 Inactive DFGin ABAminus out-in in-in 5BS Type1 18 - 302 None X174,X180 0
Homo sapiens STK3_HUMAN AF-Q13188-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 19 - 286 None None 0
Homo sapiens STK3_HUMAN 8A66A 1.901 Active DFGin BLAminus in-in in-in 5BS Type1 24 - 303 None X180 1
Homo sapiens STK3_HUMAN 8A66B 1.901 Active DFGin BLAminus in-in in-in 5BS Type1 18 - 304 None X174,X180,X268 0
Homo sapiens STK3_HUMAN 5DH3A 2.468 Inactive DFGin BLAminus out-out in-in 5BS Type1 19 - 307 None X174,X180 0
Homo sapiens STK3_HUMAN 6AO5A 2.955 Inactive DFGin BLAplus out-out none-out ANP Type1 28 - 488 D146N None 12
Homo sapiens STK3_HUMAN 4LG4A 2.42 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 18 - 308 D146N None 0
Homo sapiens STK3_HUMAN 4LG4B 2.42 Inactive DFGin BLBminus out-out none-out No_ligand No_ligand 18 - 308 D146N None 4
Homo sapiens STK3_HUMAN 4LG4C 2.42 Inactive DFGin BLBminus in-in out-out No_ligand No_ligand 18 - 307 D146N None 0
Homo sapiens STK3_HUMAN 4LG4E 2.42 Inactive DFGin BLBminus out-out out-out No_ligand No_ligand 18 - 308 D146N None 6
Homo sapiens STK3_HUMAN 4LGDA 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 16 - 488 D146N None 0
Homo sapiens STK3_HUMAN 4LGDB 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 10 - 488 D146N None 0
Homo sapiens STK3_HUMAN 4LGDC 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 12 - 490 D146N None 0
Homo sapiens STK3_HUMAN 4LGDD 3.05 Inactive DFGin BLBminus out-out out-out ANP Type1 11 - 489 D146N None 0
Homo sapiens STK3_HUMAN 4LG4F 2.42 Inactive DFGin None out-out none-out No_ligand No_ligand 18 - 310 D146N None 17
Homo sapiens STK3_HUMAN 4LG4D 2.42 Inactive None None out-out none-out No_ligand No_ligand 26 - 308 D146N None 18

STK3 (Serine/threonine-protein kinase 3)

No non-human structures known.