MKNK2 (MAP kinase-interacting serine/threonine-protein kinase 2)

Group: CAMK

Uniprot: MKNK2_HUMAN

Domain boundary: 83 - 368

Total number of chains: 14

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	1	AF-Q9HBH9-K1A
DFGin	BLBminus	1	8XFMA
DFGin	BLBplus	9	6CJEA
DFGin	None	1	2AC5A
DFGout	BBAminus	1	2AC3A
DFGout	None	1	6JLRA

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
AF-Q9HBH9-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	75 - 376	None	None	0
8XFMA	2.6	Inactive	DFGin	BLBminus	in-in	out-out	A1LU6	Type1	73 - 372	None	None	19
2HW7A	2.71	Inactive	DFGin	BLBplus	in-in	none-out	STU	Type1	72 - 371	D228G	None	23
6CJ5A	2.8	Inactive	DFGin	BLBplus	in-in	none-out	F4G	Type1	72 - 371	D228G	None	23
6CJEA	3.36	Inactive	DFGin	BLBplus	in-in	none-out	F4A	Type1	72 - 371	D228G	None	21
6CJHA	3.6	Inactive	DFGin	BLBplus	in-in	none-out	ET8	Type1	72 - 371	D228G	None	23
6CJWA	3.38	Inactive	DFGin	BLBplus	out-in	none-out	FYV	Type1	72 - 371	D228G	None	23
6CJYA	3.05	Inactive	DFGin	BLBplus	in-in	none-out	F4J	Type1	72 - 371	D228G	None	23
6CK3A	2.9	Inactive	DFGin	BLBplus	in-in	none-out	F67	Type1	72 - 371	D228G	None	23
6CK6A	3.32	Inactive	DFGin	BLBplus	in-in	none-out	N45	Type1	72 - 371	D228G	None	23
6CKIA	2.95	Inactive	DFGin	BLBplus	in-in	none-out	FZJ	Type1	72 - 371	D228G	None	23
2AC5A	3.2	Inactive	DFGin	None	in-in	none-out	No_ligand	No_ligand	72 - 370	D228G	None	21
2AC3A	2.1	Inactive	DFGout	BBAminus	in-in	out-out	No_ligand	No_ligand	72 - 369	None	None	19
6JLRA	2.901	Inactive	DFGout	None	in-in	out-out	BV9	Type1	72 - 369	None	None	20

MKNK2 (MAP kinase-interacting serine/threonine-protein kinase 2)

Group: CAMK

Total number of chains: 14

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	1	AF-Q9HBH9-K1A
DFGin	BLBminus	1	8XFMA
DFGin	BLBplus	9	6CJEA
DFGin	None	1	2AC5A
DFGout	BBAminus	1	2AC3A
DFGout	None	1	6JLRA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Homo sapiens	MKNK2_HUMAN	AF-Q9HBH9-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	75 - 376	None	None	0
Homo sapiens	MKNK2_HUMAN	8XFMA	2.6	Inactive	DFGin	BLBminus	in-in	out-out	A1LU6	Type1	73 - 372	None	None	19
Homo sapiens	MKNK2_HUMAN	2HW7A	2.71	Inactive	DFGin	BLBplus	in-in	none-out	STU	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	6CJ5A	2.8	Inactive	DFGin	BLBplus	in-in	none-out	F4G	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	6CJEA	3.36	Inactive	DFGin	BLBplus	in-in	none-out	F4A	Type1	72 - 371	D228G	None	21
Homo sapiens	MKNK2_HUMAN	6CJHA	3.6	Inactive	DFGin	BLBplus	in-in	none-out	ET8	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	6CJWA	3.38	Inactive	DFGin	BLBplus	out-in	none-out	FYV	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	6CJYA	3.05	Inactive	DFGin	BLBplus	in-in	none-out	F4J	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	6CK3A	2.9	Inactive	DFGin	BLBplus	in-in	none-out	F67	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	6CK6A	3.32	Inactive	DFGin	BLBplus	in-in	none-out	N45	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	6CKIA	2.95	Inactive	DFGin	BLBplus	in-in	none-out	FZJ	Type1	72 - 371	D228G	None	23
Homo sapiens	MKNK2_HUMAN	2AC5A	3.2	Inactive	DFGin	None	in-in	none-out	No_ligand	No_ligand	72 - 370	D228G	None	21
Homo sapiens	MKNK2_HUMAN	2AC3A	2.1	Inactive	DFGout	BBAminus	in-in	out-out	No_ligand	No_ligand	72 - 369	None	None	19
Homo sapiens	MKNK2_HUMAN	6JLRA	2.901	Inactive	DFGout	None	in-in	out-out	BV9	Type1	72 - 369	None	None	20

MKNK2 (MAP kinase-interacting serine/threonine-protein kinase 2)

No non-human structures known.