MARK2 (Serine/threonine-protein kinase MARK2)

Group: CAMK
Uniprot: MARK2_HUMAN
Domain boundary: 53 - 304


Total number of chains: 13
Spatial Dihedral Chains Representative
DFGin BLAminus 6 AF-Q7KZI7-K1A
DFGin ABAminus 3 3IECB
DFGin None 3 5KZ8A
None None 1 5KZ7B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
3IECB 2.2 Inactive DFGin ABAminus out-out in-in No_ligand No_ligand 49 - 363 R146W None 0
3IECD 2.2 Inactive DFGin ABAminus out-in in-in No_ligand No_ligand 49 - 363 R146W None 0
5EAKB 2.8 Inactive DFGin ABAminus in-in none-out 24R Type1 51 - 363 None None 13
AF-Q7KZI7-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 45 - 312 None None 0
3IECA 2.2 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 49 - 363 R146W None 0
3IECC 2.2 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 49 - 363 R146W None 0
5EAKA 2.8 None DFGin BLAminus in-in none-out 24R Type1 47 - 362 None None 11
8TXYA 2.1 None DFGin BLAminus in-out none-out SJ0 Type1 48 - 363 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None 11
8TXYB 2.1 None DFGin BLAminus out-out none-out SJ0 Type1 47 - 363 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None 12
5KZ7A 3.2 Inactive DFGin None in-out none-none 6Z2 Type1 48 - 363 None None 16
5KZ8A 3.21 Inactive DFGin None in-out none-out 6Z5 Type1 48 - 363 None None 14
5KZ8B 3.21 Inactive DFGin None in-out none-none 6Z5 Type1 48 - 363 None None 16
5KZ7B 3.2 Inactive None None in-out none-none 6Z2 Type1 48 - 363 None None 16

MARK2 (Serine/threonine-protein kinase MARK2)

Group: CAMK
Total number of chains: 29
Spatial Dihedral Chains Representative
DFGin BLAminus 8 AF-Q7KZI7-K1A
DFGin ABAminus 3 3IECB
DFGin None 9 2WZJA
None None 9 1Y8GA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MARK2_HUMAN 3IECB 2.2 Inactive DFGin ABAminus out-out in-in No_ligand No_ligand 49 - 363 R146W None 0
Homo sapiens MARK2_HUMAN 3IECD 2.2 Inactive DFGin ABAminus out-in in-in No_ligand No_ligand 49 - 363 R146W None 0
Homo sapiens MARK2_HUMAN 5EAKB 2.8 Inactive DFGin ABAminus in-in none-out 24R Type1 51 - 363 None None 13
Homo sapiens MARK2_HUMAN AF-Q7KZI7-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 45 - 312 None None 0
Homo sapiens MARK2_HUMAN 3IECA 2.2 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 49 - 363 R146W None 0
Homo sapiens MARK2_HUMAN 3IECC 2.2 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 49 - 363 R146W None 0
Homo sapiens MARK2_HUMAN 5EAKA 2.8 None DFGin BLAminus in-in none-out 24R Type1 47 - 362 None None 11
Homo sapiens MARK2_HUMAN 8TXYA 2.1 None DFGin BLAminus in-out none-out SJ0 Type1 48 - 363 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None 11
Homo sapiens MARK2_HUMAN 8TXYB 2.1 None DFGin BLAminus out-out none-out SJ0 Type1 47 - 363 I59L,K66V,V81I,L97I,V113I,M129T,S133K,G134N,S197G None 12
Homo sapiens MARK2_HUMAN 5KZ7A 3.2 Inactive DFGin None in-out none-none 6Z2 Type1 48 - 363 None None 16
Homo sapiens MARK2_HUMAN 5KZ8A 3.21 Inactive DFGin None in-out none-out 6Z5 Type1 48 - 363 None None 14
Homo sapiens MARK2_HUMAN 5KZ8B 3.21 Inactive DFGin None in-out none-none 6Z5 Type1 48 - 363 None None 16
Homo sapiens MARK2_HUMAN 5KZ7B 3.2 Inactive None None in-out none-none 6Z2 Type1 48 - 363 None None 16
Rattus norvegicus MARK2_RAT 2WZJC 2.786 None DFGin BLAminus out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJD 2.786 None DFGin BLAminus out-none out-out No_ligand No_ligand 46 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2R0IA 2.202 Inactive DFGin None in-in none-out No_ligand No_ligand 48 - 363 E318A None 16
Rattus norvegicus MARK2_RAT 2R0IB 2.202 Inactive DFGin None in-in none-out No_ligand No_ligand 48 - 363 E318A None 16
Rattus norvegicus MARK2_RAT 2WZJA 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJB 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJE 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJF 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 1ZMUA 2.9 Inactive None None in-out none-out No_ligand No_ligand 51 - 363 None None 18
Rattus norvegicus MARK2_RAT 1ZMUB 2.9 Inactive None None in-in none-out No_ligand No_ligand 48 - 363 None None 18
Rattus norvegicus MARK2_RAT 1Y8GA 2.501 Inactive None None in-out none-out No_ligand No_ligand 49 - 363 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1Y8GB 2.501 Inactive None None in-out none-out No_ligand No_ligand 48 - 362 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1ZMWA 2.802 Inactive None None in-out none-out No_ligand No_ligand 49 - 363 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1ZMWB 2.802 Inactive None None out-out none-out No_ligand No_ligand 48 - 362 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1ZMVA 3.105 Inactive None None out-none none-out No_ligand No_ligand 51 - 363 K82R None 18
Rattus norvegicus MARK2_RAT 1ZMVB 3.105 Inactive None None out-none none-out No_ligand No_ligand 48 - 363 K82R None 18

MARK2 (Serine/threonine-protein kinase MARK2)

Group: CAMK
Total number of chains: 16
Spatial Dihedral Chains Representative
DFGin BLAminus 2 2WZJC
DFGin None 6 2WZJA
None None 8 1Y8GA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Rattus norvegicus MARK2_RAT 2WZJC 2.786 None DFGin BLAminus out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJD 2.786 None DFGin BLAminus out-none out-out No_ligand No_ligand 46 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2R0IA 2.202 Inactive DFGin None in-in none-out No_ligand No_ligand 48 - 363 E318A None 16
Rattus norvegicus MARK2_RAT 2R0IB 2.202 Inactive DFGin None in-in none-out No_ligand No_ligand 48 - 363 E318A None 16
Rattus norvegicus MARK2_RAT 2WZJA 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJB 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJE 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 2WZJF 2.786 Inactive DFGin None out-none out-out No_ligand No_ligand 49 - 363 K82R,T208E None 0
Rattus norvegicus MARK2_RAT 1ZMUA 2.9 Inactive None None in-out none-out No_ligand No_ligand 51 - 363 None None 18
Rattus norvegicus MARK2_RAT 1ZMUB 2.9 Inactive None None in-in none-out No_ligand No_ligand 48 - 363 None None 18
Rattus norvegicus MARK2_RAT 1Y8GA 2.501 Inactive None None in-out none-out No_ligand No_ligand 49 - 363 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1Y8GB 2.501 Inactive None None in-out none-out No_ligand No_ligand 48 - 362 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1ZMWA 2.802 Inactive None None in-out none-out No_ligand No_ligand 49 - 363 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1ZMWB 2.802 Inactive None None out-out none-out No_ligand No_ligand 48 - 362 T208A,S212A None 13
Rattus norvegicus MARK2_RAT 1ZMVA 3.105 Inactive None None out-none none-out No_ligand No_ligand 51 - 363 K82R None 18
Rattus norvegicus MARK2_RAT 1ZMVB 3.105 Inactive None None out-none none-out No_ligand No_ligand 48 - 363 K82R None 18